cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
Location
Kota malang,
Jawa timur
INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 886 Documents
 84   85   86   87   88 
Combined Interleukin-6 and C-Reactive Protein Predict Severe Dengue: Development of a Prediction Model Sholihah, Nikmatus; Iskandar, Agustin; Ratridewi, Irene; Indiastari, Dewi; Putri, Hayati Rizki; Putra, Septian Dwi; Reinaldo, Kevin; Raissa, Mira; Wijayanto, Aditya; Yeftana, Sena
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.02.6

Abstract

Background: Dengue is still a major health problem in Indonesia and often leads to hospitalization. In severe cases, it can cause fluid leakage, bleeding, and organ damage. IL-6 and CRP are known to rise in more serious infections, but their combined usefulness is not yet clear. Objective: This study evaluates whether combined IL-6 and CRP levels can predict early severe dengue. Methods: This is an observational study of 82 patients with confirmed dengue infection treated in Dr. Saiful Anwar General Hospital, Malang, Indonesia, from July to September 2024. The severity status was classified according to the WHO 2009 severity classification. IL-6 was measured by enzyme-linked immunosorbent assay, and CRP was measured by immunoturbidimetry. Model performance was evaluated by logistic regression and receiver operating characteristic (ROC) analysis. Internal validation used 1,000 bootstrap resamples. Results: Both biomarkers showed significantly higher median values in severe cases than in non-severe cases (163.88 vs. 58.88 pg/mL and 8.07 vs. 2.43 mg/L, respectively; both p < 0.001). IL-6 (ρ = 0.562) and CRP (ρ = 0.481) showed moderate positive correlations with disease severity. Both biomarkers independently predicted severe dengue, with IL-6 (adjusted OR = 1.010, p = 0.004) and CRP (adjusted OR = 1.192, p = 0.009). The Brier score was 0.161, and the optimism-corrected AUC was 0.834. DeLong testing showed no significant difference between the combined model and IL-6 alone (p = 0.602) or CRP alone (p = 0.061). Conclusions: The combined IL-6 and CRP model shows potential for early prediction of severe dengue.
A Complex Pediatric Case: Cerebral Palsy Complicated by Severe Pneumonia and Atelectasis Gatiningrum, Anindita; Udin, Muchammad Fahrul
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.033.03.11

Abstract

Cerebral palsy (CP) is a non-progressive motor and cognitive disorder resulting from brain injury during development. Cerebral palsy (CP) promotes the development of respiratory disorders, including pneumonia and atelectasis. In this case, an 8-year-old male with cerebral palsy presented with complaints of shortness of breath, intermittent fever, productive cough, and decreased appetite. His respiratory rate was 28 beats per minute, SpO2 was 85%, and temperature was 37°C. Chest X-ray showed right pleural effusion with atelectasis, pneumonia in the left lung, emphysematous lung, and thoracic scoliosis. Bronchoscopy examination showed total atelectasis in the middle lobe of the right lung, with Streptococcus mitis or Streptococcus oralis identified through microbiological examination. Individuals with CP are susceptible to respiratory diseases due to neuromuscular impairment of the laryngeal muscles. This impairment can progress to atelectasis and pneumonia, representing the most common respiratory complications in CP. 
The Correlation of Infection Prevention and Control Knowledge and ESBL Carriage Rate among Healthcare Workers in a Hospital in Indonesia Fanani, Navalia Azkarifda; Krisniawati, Nia; Wicaksono, Madya Ardi; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.3

Abstract

Extended-spectrum beta-lactamase (ESBL) is an enzyme resulting from bacterial gene mutations that can restrict the activity of beta-lactam antibiotics, such as penicillin, the first, second, and third generation of cephalosporin, and monobactam, except cephamycin and carbapenem. ESBL can cause healthcare-associated infections (HAIs). Infection prevention and control (IPC) is a comprehensive effort to prevent HAIs in healthcare facilities. This research investigated the correlation between IPC knowledge level and the incidence of extended-spectrum beta-lactamase (ESBL) producing bacteria carriers in hospital healthcare workers. This research was conducted as observational analytical research using the quantitative and cross-sectional approaches. The research used purposive sampling, involving 61 healthcare workers at Banjarnegara Islamic Hospital. Research instruments included a 24-item questionnaire assessing IPC knowledge and rectal swabs intended to detect the incidence of ESBL carriers using the CHROMagar™ ESBL medium. Most respondents have a relatively good understanding of IPC, with a median score of 16 (25%). Of the 61 rectal swab samples, eight incidences of ESBL carriers were identified (13%). The isolates of the recognized carriers consist of five Escherichia coli (63%), two Klebsiella pneumoniae (25%), and one Acinetobacter baumannii (12%). Statistical analysis using the Mann-Whitney hypothesis test with the SPSS software showed a significant value of 0.493. Therefore, there is no correlation between IPC knowledge level and the incidence of extended-spectrum beta-lactamase-producing bacteria carriers in hospital healthcare workers.
Predictive Value of CA-125 for Endometriosis Staging at a Tertiary Hospital in Indonesia Angelia Ratnasari, Affi; Budi Hastuti, Uki Retno; Ismiaulia, Vidya
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.1

Abstract

Endometriosis, affecting around 176 million women globally, is typically diagnosed through invasive laparoscopic inspection and histological confirmation. Due to the invasiveness of this method, noninvasive diagnostic alternatives like serum CA-125 assays are gaining interest. This study aims to determine the correlation between the tumor marker CA-125 and the stages of endometriosis, as classified by the revised American Society for Reproductive Medicine (rASRM) score. Data were retrospectively collected from the medical records of 24 reproductive-age women diagnosed with endometriosis at Dr. Moewardi General Hospital in Surakarta City, Indonesia. The dataset included patient age, serum CA-125 levels, rASRM scores, comorbidities, and surgical history. Statistical analysis involved the use of Pearson Chi-Square tests for nominal variables and independent t-tests or Mann-Whitney U-tests for scaled variables to evaluate the association between endometriosis stages (grouped into Stage I-II and Stage III-IV) and CA-125 levels (categorized as normal or elevated). A significant correlation was observed between higher stages of endometriosis (stage III-IV) and elevated CA-125 levels (p=0.040). Additionally, normal CA-125 levels were significantly associated with lower stages of endometriosis (stage I-II) (p=0.046). Furthermore, an association was found between type 2 diabetes and elevated CA-125 levels (p=0.037). In conclusion, our study suggests that elevated CA-125 levels correlate with higher stages of endometriosis (stage III-IV) and type 2 diabetes, indicating its potential as a biomarker for endometriosis severity.
Catamenial Pneumothorax due to Suspected Thoracic Endometriosis Syndrome in a Woman with Adenomyosis and Cystoma Ovarii Antariksa, Genta; Dwikarlina, Intan; Sutrisno, Sutrisno; Yudhanto, Hendy Setyo
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.10

Abstract

Catamenial pneumothorax (CP) is a recurrent spontaneous pneumothorax during the menstruation period and is often associated with thoracic-pelvic endometriosis. This case study reported a 39-year-old woman who presented with recurrent shortness of breath, particularly during menstruation. The patient also experienced severe dysmenorrhea and difficulty getting pregnant. Despite a negative sputum test, a history of chest tube insertion and tuberculosis treatment were identified. Elevated levels of the CA-125 marker were observed in a previous examination. Physical examination revealed decreased fremitus sounds on the mediobasal side, chest expansion, and right lung breath sounds. The plain radiograph displayed a visceral pleural line, air-fluid level appearance, and the collapse of the right hemithorax accompanied by fibrosis. The patient underwent inpatient treatment and had a chest tube inserted. A decortication thoracotomy procedure was performed, and anatomical pathology microscopic examination of the right lung tissue revealed a non-specific chronic inflammatory process accompanied by fibrosis.
Remained Insect's Body Part in the Corneal Stroma: A Rare Case Report Abdillah, Fauzi; Widyanto, Ilham Aditya; Ariany, Dessira Rizka Tri
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.12

Abstract

Corneal foreign bodies are the second most common cornea disease after corneal abrasion. The causes of foreign bodies in the cornea vary, most often due to lack of eye protection. Patients with foreign bodies in the cornea usually complain pain, a lump in the eyes, visual acuity deficit, watery eyes, red eyes, sticky eyes, and photophobia. Rapid and effective treatment is needed to avoid the risk of worsening the patient's condition and decreasing vision or even permanent blindness. In this case, we report a 41-year-old male who suffered an eye injury due to insect's body parts remaining in the corneal stroma while riding a motorbike. Foreign body extraction, eye irrigation, topical and systemic antibiotics and steroids, topical cycloplegic are the various treatment modalities for better result. Further examination could be done to find out the chemical elements of insect's toxin so that more adequate therapies can be given. 
Human-induced Pluripotent Stem Cell Potential for Schizophrenia Therapy: A Literature Review Kusumadewi, Andrian Fajar; Adi, Winengku Basuki
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.6

Abstract

Schizophrenia is a severe and chronic mental disorder characterized by a neurodegenerative process. Currently, there has been no cure for schizophrenia. However, a newer significant potential for modeling and curing schizophrenia has been recognized in human-induced pluripotent stem cells (HiPSCs), which are obtained from adult somatic cell reprogramming. This study aimed to assess the potential of HiPSCs in schizophrenia by reviewing relevant scientific journals published in reputable databases such as Springer, Elsevier, Science Direct, Nature, and Pubmed, in the last 10 years. Research findings indicate that stem cells can help determine the effectiveness of antipsychotics and repair damaged neuronal cells in certain areas of the brain by transplanting programmed stem cells. The proliferative ability of neuronal cells in schizophrenia tends to decline, affecting their physiological neurogenesis. HiPSCs have the potential to return the neuronal function in schizophrenia, offering new hope in psychiatry. 
Overview of Tuberculosis Knowledge among SMK Telkom Malang Students R Sugiri, Yani Jane; Tantular, Rezki; Binharyanto, Adlan Pratama; Pratiwi, Eka; Muhammad, Iqbal; Asyari, Claudia Herda; Dini, Zata; Primaputri, Cindy Carissa; Lyono, Albert; Susanti, Lia; Delfianto, Dwiroza; Aprilen, Nisa; Suardana, I Made; Murti Dewi, Dian Ayu; Wikamto, Rifka
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.6

Abstract

Tuberculosis has emerged as a major global health challenge. Public knowledge about TB is crucial for its prevention, early detection, and management. Research conducted by the World Health Organization indicates that a good level of knowledge about Tuberculosis among the public can significantly enhance symptom recognition, timely medical care, and reduce the stigma. This study aims to describe the TB knowledge of SMK Telkom Malang students. A quasi-experimental pretest-posttest design was conducted involving 415 students, of whom 336 completed both assessments. TB knowledge was measured using a 10-item validated questionnaire and categorised as good, sufficient, or poor. The Wilcoxon signed-rank test was used for statistical analysis. They were then given health education about TB, after receiving health education about TB, 69 students did not consent to continue the study or complete the posttest and were therefore excluded, leaving 336 students as sample. Pretest demonstrated 225 students (67%) with good knowledge, 93 students (27,7%) with sufficient knowledge, and 18 students (5,3%) with poor knowledge, the overall median was 80, while posttest analysis revealed 264 students (78.6%) with good knowledge, 66 students (19.6%) with sufficient knowledge, and 6 students (1,8%) with poor knowledge, the overall median was 90 . The scores were compared using the Wilcoxon test with significantly improved score with a p-value of <0.001. In conclusion, health education significantly improved TB knowledge among students. Continued efforts to integrate TB education in schools are recommended to support TB control strategies.
Mohs Micrographic Surgery for Morpheaform Type Basal Cell Carcinoma: A Case Report Larasaty, Nanda Shaskia; Widiatmoko, Arif; Retnani, Diah Prabawati
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.9

Abstract

Morpheaform basal cell carcinoma (BCC) is an infiltrative and destructive type of BCC with a high recurrence, necessitating effective and minimally invasive management. Mohs Micrographic Surgery (MMS) is a treatment option for BCC with high conservation results of the entire tumor wall with minimal removal of surrounding healthy tissue, and the lowest recurrence rate compared to other treatment options.  In this study, we report a 48-year-old woman with dark spots on the left cheek area that had enlarged over the past year. Dermatological examinations showed hyperpigmentation patches with indistinct borders, irregular edges, and telangiectasis. Fine Needle Aspiration Biopsy (FNAB) confirmed BCC, and the patient underwent Mohs Micrographic Surgery (MMS) for tumor removal. The post-procedural follow-up showed a good outcome.
Small Creature, High Pressure: Compartment Syndrome as an Unusual Complication of Dengue Virus Infection: A Case Series Ayu Islami, Sonia; Suseno Bayuadi, Imam Suseno; Sukresno, Bayu; Bondan, Bondan; Ashmi Puspitasari, Ika; Ika Faramita, Nanditya; Kusuma Anjelin, Isabella
Jurnal Kedokteran Brawijaya Vol. 33 No. 4 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.04.12

Abstract

Dengue Hemorrhagic Fever (DHF) is a severe form of dengue infection characterized by plasma leakage, hemorrhagic manifestations, and organ involvement. Compartment syndrome, although rare in DHF, presents a significant challenge due to its limb-threatening nature and the delicate balance required in fluid management. We report two cases of DHF complicated by compartment syndrome occurring within a month in a single hospital. The first case involves a 41-year-old male referred with a 5-day history of fluctuating fever, who subsequently developed severe right leg pain and swelling. Despite initial management with IV fluids, antiemetics, and gastroprotective agents, the patient’s condition worsened, leading to the diagnosis of compartment syndrome. Emergency fasciotomy revealed significant muscle necrosis and bleeding. Despite aggressive resuscitation, the patient progressed to refractory shock and passed away. The second case followed a similar clinical course, highlighting the rapid progression from stable DHF to severe complications and the critical role of prompt surgical intervention. These cases illustrate the severe complications associated with DHF, particularly when complicated by conditions like compartment syndrome. Early recognition and a multidisciplinary approach are crucial. Managing such cases involves navigating the delicate balance of fluid resuscitation to prevent shock while avoiding worsening compartment pressures. DHF with compartment syndrome requires vigilant monitoring, early surgical intervention, and coordinated care among specialties. These cases highlight the necessity for further research into the interaction between DHF and compartment syndrome to guide more effective management strategies.

Page 86 of 89 | Total Record : 886

 84   85   86   87   88 

Filter by Year

2002 2026


Reset
Filter By Issues
All Issue Vol. 34 No. 2 (2026): Article in Press 2026 Vol. 34 No. 2 (2026) Vol. 34 No. 1 (2026) Vol. 33 No. 4 (2025) Vol. 33 No. 3 (2025) Vol. 33 No. 2 (2024) Vol. 33 No. 1 (2024) Vol. 33 Supplement 1 (2024) Vol. 32 No. 4 (2023) Vol. 32 No. 3 (2023) Vol. 32 No. 2 (2022) Vol. 32 No. 1 (2022) Vol. 32 Supplement 1 (2022) Vol. 32 Supplement 1 (2021) Vol 31, No 4 (2021) Vol. 31 No. 4 (2021) Vol. 31 No. 3 (2021) Vol 31, No 3 (2021) Vol. 31 Supplement 2 (2021) Vol 31, No 2 (2020) Vol 31, No 1 (2020) Vol 30, No 4 (2019) Vol 30, No 3 (2019) Vol 30, No 2 (2018) Vol 30, No. 1 (2018) Vol 29, No. 4 (2017) Vol 29, No. 3 (2017) Vol 29, No 3 (2016) Vol 29, No. 2 (2016) Vol 29, No 1 (2016) Vol 28, No 4 (2015) Vol 28, No 3 (2015) Vol 28, No 2 (2015) Vol 28, No 2 (2014) Vol 28, No 1 (2014) Vol 27, No 4 (2013) Vol 27, No 3 (2013) Vol 27, No 2 (2012) Vol 27, No 1 (2012) Vol 26, No 4 (2011) Vol 26, No 3 (2011) Vol 26, No 2 (2010) Vol 26, No 1 (2010) Vol 25, No 3 (2009) Vol 25, No 2 (2009) Vol 25, No 1 (2009) Vol 24, No 3 (2008) Vol 24, No 2 (2008) Vol 24, No 1 (2008) Vol 23, No 3 (2007) Vol 23, No 2 (2007) Vol 23, No 1 (2007) Vol 22, No 3 (2006) Vol 22, No 2 (2006) Vol 22, No 1 (2006) Vol 21, No 3 (2005) Vol 21, No 2 (2005) Vol 21, No 1 (2005) Vol 20, No 3 (2004) Vol 20, No 2 (2004) Vol 20, No 1 (2004) Vol 19, No 3 (2003) Vol 19, No 2 (2003) Vol 19, No 1 (2003) Vol 18, No 3 (2002) Vol 18, No 2 (2002) Vol 18, No 1 (2002) Article in Press 2 Article in Press More Issue