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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 15 Documents
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Search results for , issue "Vol. 56, No. 4" : 15 Documents clear
Effect of Ethanol Extract of Mangosteen Peel on Serum Malondialdehyde and Leukotriene B4 Levels in Male White Rats (Rattus norvegicus) Wistar Strain Exposed with Electric Cigarette Smoke Santoso, Jemima Lewi; Notopuro, Harianto; Qurnianingsih, Ema
Folia Medica Indonesiana Vol. 56, No. 4
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This study aims to analyze the administration of mangosteen peel ethanol extract at different doses can reduce levels of malondialdehyde (MDA) and leukotriene B4 (LTB4) serum in male white rats (Rattus norvegicus) Wistar strains exposed to electric cigarette smoke. Electric cigarette induces mitochondrial ROS production and triggers oxidative stress. Antioxidants are needed by the body if there are many free radicals, for example mangosteen peel. This laboratory experimental study uses a randomized post test only control group design. Thirty male white rats were divided into 5 groups randomly (KK, KR, P1, P2, P3). KK given 0.5% Na-CMC, KR given smoke and 0.5% Na-CMC, P1, P2, P3 given smoke and mangosteen peel ethanol extract 100, 200, 300 mg / kg weight. Data were tested for normality and homogeneity tests. Data distribution was found not normal. Data were tested by Kruskal-Wallis Test and Mann-Whitney. Kruskal-Wallis Test results showed significant differences in MDA and LTB4 levels in each experimental group (KS, KR, P1, P2 and P3), p <0.05. Mann-Whitney test results showed a significant difference in the MDA levels of the KR against P3 and in the LTB4 level of the KR against P2 (p <0.05). The conclusion of the study was the administration of mangosteen peel ethanol extract can reduce MDA and LTB4 levels serum in male white rats (Rattus norvegicus) Wistar strains exposed to electric cigarette smoke.
Monitoring Serum Creatinine, Blood Urea Nitrogen in Patients Brain Injury with Mannitol Therapy Sari, Erni A; Suharjono, Suharjono; Wahyuhadi, Joni
Folia Medica Indonesiana Vol. 56, No. 4
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Increased intracranial pressure is a further effect of brain injury due to structural damage and osmotic and water imbalances (Edema). Mannitol works in the proximal tubules and mannitol in the absorption of tubular cells by the mechanism of pinocytosis. The fluid transfer will draw fluid into the intracellular, so that the cell will be switched and broke. This phenomenon is referred to as the phenomenon of "Nephrosis Osmotic", in which mannitol administration may occur as a result of accumulation of drugs in the kidneys due to prolonged exposure to mannitol in the kidney and given dosage. The effects of osmotic diuresis occurring plus the dose and duration of mannitol administration are reported to cause renal function disorders (Scr and BUN). The aim of this study was to analyze changes in serum creatinine and BUN in patients with brain injury from before receiving mannitol therapy and during mannitol treatment. From the results of the study the number of patients who met the inclusion criteria, 32 patients. Serum creatinine, the initial average of 0.85 ± 0.17 mg / dl and the last day of the mean SCr 0.74 ± 0.30 mg / dl. While the mean BUN (Blood Urea Nitrogen) was 11.27 ± 2.75 mg / dl and the mean last day was 17.08 mg / dl ± 8.59 mg / dl. From Serum Creatinine and BUN data it can be concluded that there is no significant change.
The Effect of Citrulline Supplementation on Lactic Acid Blood Level and Oxygen Saturation (SaO2) in Submaximal Physical Activity Fastabiqi, Ibrah; Asnar, Elyana; Harlina, Harlina
Folia Medica Indonesiana Vol. 56, No. 4
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An achievement in sport is one of the benchmarks of success of every athlete. One of the causes of the performance degradation is fatigue due to the formation of lactic acid. Supplements are proved to improve the performance in athletes. The purpose of this study was to determine the effect of citrulline supplementation on lactic acid levels and oxygen saturation on submaximal physical activity. Fatigue can be seen from lactic acid levels in subjects who have performed physical activity. This research method used randomized group pretest postest group design. The subjects used were male students of pencak silat airlangga university, and divided into two groups. The first group was given placebo and the second group was given citrulline. Each group was given the same treatment of three minutes of submaximal physical activity using an ergocycle. Before and after doing the activity the blood lactic acid and oxygen saturation of the subject was checked. The result of the data showed that lactic acid and oxygen saturation in both groups had p<0,05. Citrulline supplementation had effect on lactic acid and oxygen saturation. The results of the research showed that the group given with citrulline had significant effect on lactic acid and oxygen saturation before and after treatment.
Low Vision Management in A 5-Years-Old Due to Retinopathy of Prematurity for Life Quality Improvement Aritonang, Christina
Folia Medica Indonesiana Vol. 56, No. 4
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Introduction: Management of low vision in pediatric patients with greater result can affect their quality of life than in adult low vision patients.. Retinopathy of Prematurity is the main cause of blindness in children. A case study highlights the tertiary prevention (low vision examination and management) in a 5 year old boy with ROP related blindness to optimize his remaining visual capacity by using optical and non optical aids that support daily activity and educational learning. Case Report: A 5 year old boy with ROP related blindness visited to the low vision clinic after receiving the several treatments for ROP before. His visual acuities were light perception in the right eye and hand movement in the left eye using his current spectacle correction. He had anti VEGF bevacizumab intravitreal injection, vitrectomy and complicated cataract extraction history on the left eye. He wasdifficult to learn and read numbers and alphabets caused by visual impairment. Discussion : Upon evaluation by assessment low vision method, his distance visual acuity in the left eye was improved significantly up to 3/40 on LEA Acuity chart with +14.00D. His near vision became 10 M at 30 cm of reading distance (without near correction) and 4 M at 13 cm improved with +3.00 D by spectacle. The non optical aid devices as reading task were also suggested to improove continuous reading text without difficulty. Conclusion: ROP blindness can be preventable if appropriate, adequate and accessible screening programmes are available. Unfortunately, even with the current screening guidelines and recommended treatment of ROP, many babies suffer from blindness by this disease each year. Low vision assessment and management in pediatric patient with visual impairmentaccording to children's need can optimize the recent visual capability of low vision patient and give self care daily activity and educational learning.
Congenital Parameatal Urethral Cyst in The Male: A Case Report and Review of Literature Oktaviani, Dian Paramita; Hoetama, Sakti; Soetojo, Soetojo
Folia Medica Indonesiana Vol. 56, No. 4
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Purpose:: To report one case of parameatal urethral cyst. Background : Parameatal urethral cyst is a scarce congenital condition that was first reported in two males in 1956, until now in reported literature only found less than 50 cases, in both adults and children. Our patient, case of parameatal urethral cyst in a 5 years old boy is reported. Complete excision with total removal of the epithelium of the cyst is required management for the treatment and prevention of cyst reocurrance. Case Report:a 5 years old male with a cystic lesion around urethral meatus since birth. At least 5 month the parents complain distorted urinary flow and poor appearance, and no other urinary symptom, no history of trauma. On physical examination, cystic mass with spherical shape which was about 0.5 cm in diameter was found around external meatus. There was no inflammatory sign. And there was normal blood laboratory (blood counts and blood chemistry) and urine laboratory (urine analysis and urine culture). The patient undergo completely excision of the cyst under general anaesthesia, and remove all of the lining epithelium. Good appearance results were obtained after 2 months follow up, without meatal strictures and urine stream problems, and no postoperative complications or recurrence. Pathological : Squamous epithelial, granulation tissue with chronic inflamation. Conclusions :Parameatal urethral cyst is a very rare benign condition that is asymptomatic in most of the cases. It may be present since birth or appear later and is prevalent in young males. Its etiology remains unclear and treatment is by complete surgical excision to avoid complications and recurrence. Good cosmetic results were obtained in this case without any recurrence at two months follow up.Parameatal cyst, Glans penis, external meatus urethra, Urethral cyst
Oral Health Status and The Body Mass Index in Young Adults Rahmawan, Dzanuar; Kalanjati, Viskasari P; Abdurachman, Abdurachman
Folia Medica Indonesiana Vol. 56, No. 4
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Poor oral health has been reported to correlate to the body mass index (BMI) of the overweight and the obesity groups. These has yet widely studied in Indonesia. The aim of this study was to analysed the oral health, socioeconomy factors (FSE) and the BMI in the seemingly healthy university students in Kediri aged 18-21 years old. This cross-sectional study was conducted amongst male and female students of IIKBW, Kediri, Indonesia (n=150). We analysed their BMI from the body weight and height (kg/m2). Their oral health was determined by the DMFT index (decayed missing filled teeth index), the stimulated salivary flow rate (SSFR) and the gingival index (GI). FSE studied include father's highest education and monthly income, tooth brushing frequency in a day and dental floss habitual use. Data was analysed using SPSS 17 with level of significance of p<0.05. No significant differences in BMI, DMFT index, SSFR and GI respectively (p=0.411;p=0.037, p=0.880, p=0.142) between male and female groups. No significant corelation BMI with DMFT index, SSFR and GI, respectively (p=0.340, p=0.420, p=0,446). FSE are not significantly correlated to either the BMI, DMFT index, SSFR orGI (p > 0.05). There were 41.8% of males and 57.8% of females have "bad” score of DMFT and 98.6% of males and 92.1% of females have "bad” score of GI; 4.1% of males and 2.6% of females have low score of SSFR.Although we found no significant differences in the BMI and oral health parameters between genders, in the seemingly healthy young adults oral health hygiene could be compromised as found in the current study indicated by bad scores of DMFT, SSFR or GI. Here we found that either BMI or FSE was not significantly correlated to any of oral health parameters measured in the current study.
Epidemiology Study of Dengue Virus In Surabaya, Bogor, and Bangkalan, Indonesia 2008-2018 Soegijanto, Soegeng; Sucipto, Teguh Hari; Mulyatno, Kris Cahyo; Churrotin, Siti
Folia Medica Indonesiana Vol. 56, No. 4
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Dengue virus (DENV) is mosquito-borne viral diseases, transmitted by the vector mosquitoes such as Aedes sp. Infection with four serotypes of DENV-1 to 4. Indonesia, dengue haemorrhagic fever (DHF) was first recognized in 1968 in the cities of Jakarta and Surabaya. In 2007, we started DENV surveillance in Surabaya supported by the joined program of the Japan Initiative for Global Research Network on Infectious Disease (J-GRID) established the Indonesia-Kobe University Collaborative Research Center for Emerging and Reemerging Infectious Diseases (CRC-ERID). The results of serotype and genotype, in Surabaya and Bangkalan are similar with previous result in Indonesia, but especially in Bogor similar with Japan 2014. This study showed the importance of continuous virus surveillance in dengue endemic areas, in order to understand the dynamic of dengue infection disease in Indonesia.
The Influence of Anti-Hiv-1 Specific IgY In Inhibiting HIV-1 Infection in Binding Phase with Syncytium Examination of CD4 Receptor Density Using the Flowcytometry Method Maskoep, Wiwiek Indriyani; Nasronudin, Nasronudin; Khairunisa, Siti; Sudjarwo, Sri Agus
Folia Medica Indonesiana Vol. 56, No. 4
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HIV/ AIDS infections have increased and spread very quickly in the world, including in Indonesia. The absence of an effective vaccine and the fact that antiretroviral drugs can only suppress the progression of infection but cannot eradicate it lead to the efforts to find materials containing immunoglobulins that can replace the immune system which greatly declines in HIV/ AIDS patients. The successful use of specific IgY in other studies opens up opportunities for the use of anti-HIV-1 specific IgY as passive immunotherapy. This type of research is true experimental research design with post-test only control group design. IgY was obtained from Lohmann Laying hens chicken eggs immunized with the inactivated HIV-1 virus. The concentration of IgY was determined using the Bradford method and then the characterization test was continued using the AGPT, ELISA, SDS-PAGE and Western blot tests which showed anti-HIV-1 specific IgY. The results of the test showed specific anti-HIV-1 IgY was effective in inhibiting the formation of syncytium in HIV-1 infection against CD4+ T lymphocytes in the binding phase (entry stage) in the treatment group p-value 0.000 (p <0.05). The results of CD4 receptor density tests using the Flowcytometry method showed that specific anti-HIV-1 IgY was effective in inhibiting HIV-1 infection against CD4+ T lymphocytes in the binding phase (entry stage) in the treatment group p-value 0.047 (p <0.05).HIV/ AIDS infections have increased and spread very quickly in the world, including in Indonesia. The absence of an effective vaccine and the fact that antiretroviral drugs can only suppress the progression of infection but cannot eradicate it lead to the efforts to find materials containing immunoglobulins that can replace the immune system which greatly declines in HIV/ AIDS patients. The successful use of specific IgY in other studies opens up opportunities for the use of anti-HIV-1 specific IgY as passive immunotherapy. This type of research is true experimental research design with post-test only control group design. IgY was obtained from Lohmann Laying hens chicken eggs immunized with the inactivated HIV-1 virus. The concentration of IgY was determined using the Bradford method and then the characterization test was continued using the AGPT, ELISA, SDS-PAGE and Western blot tests which showed anti-HIV-1 specific IgY. The results of the test showed specific anti-HIV-1 IgY was effective in inhibiting the formation of syncytium in HIV-1 infection against CD4+ T lymphocytes in the binding phase (entry stage) in the treatment group p-value 0.000 (p <0.05). The results of CD4 receptor density tests using the Flowcytometry method showed that specific anti-HIV-1 IgY was effective in inhibiting HIV-1 infection against CD4+ T lymphocytes in the binding phase (entry stage) in the treatment group p-value 0.047 (p <0.05).
The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma Nurhidayat, Ade Apon; Afiati, Afiati; Usman, Hermin Aminah; Hernowo, Bethy Suryawathy
Folia Medica Indonesiana Vol. 56, No. 4
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Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nasopharyngeal carcinoma. This study used a retrospective case control analysis design, secondary data from medical records of patients diagnosed as undifferentiated nasopharyngeal carcinoma who received complete radiotherapy at the Radiation Oncology Department Dr Hasan Sadikin Bandung were taken. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of Cyclin D1 and VEGF was performed on paraffin blocks of patients' biopsy. Data analysis using Chi-Square test (p ≤0.05) , OR 95% CI. Cyclin D1 expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05) and the OR 4,385 (0.993-19.356), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). As conclusion, there were significant association between Cyclin D1 with radiotherapy respons in undifferentiated nasopharyngeal carcinoma. The stronger immunoexpression of Cyclin D1, the higher likelihood of radioresistancy. VEGF immunoexpression showed no significant association with radiotherapy response.
Front Matter Vol. 56, No. 4 December (2020) Matter, Front
Folia Medica Indonesiana Vol. 56, No. 4
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