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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Rare Diagnosis of a Proliferating Pilar Tumor in a Facial Hairline Cryst Imran, Farrah-Hani; Imami, Nabilah Hasna; Wen, Adzim Poh Yuen
Folia Medica Indonesiana Vol. 58, No. 1
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Abstract

Highlight: • Sebaceous cyst or epidermoid cyst is a benign capsulated tumour on the scalp region, face, neck, and trunk that subepidermal nodule filled with keratin. • Proliferating Pilar Tumours (PPT) are rare tumours was found in hair follicle. • Sebaceous cyst diagnose on facial hairline tumour turned out to be a rare Proliferating Pilar Tumour (PPT). Abstract: Sebaceous cyst, also known as an epidermoid cyst, is a subepidermal nodule filled with keratin and it is a benign capsulated tumor. It is often located on the scalp region, face, neck, and trunk; but can be found elsewhere such as the scrotum, genitalia, fingers, and buccal mucosa. Proliferating Pilar Tumors (PPT) are rare tumors. It is derived from the external root sheath of the hair follicle. These tumors are like irregular subcutaneous nodules and often appear on the scalp. This case report was about a 59 years old woman who came to the hospital following excision of a frontal lump elsewhere, with a sebaceous cyst as the initial diagnosis. From the histopathologic examination, grossly there was a whitish and greyish lump with a soft outer surface. Microscopically, there were malignancy signs with areas with keratinization. The tumor formed a solid pattern of enlarged cells with moderate to marked nuclear pleomorphism with vesicular nuclei, prominent nucleoli, and abundant pale eosinophilic to clear cytoplasm. There was also much free keratinous debris noted and numerous foci of calcification identified within the tumor. Mitotic figures with abnormal forms were frequently seen. The final diagnosis after the histopathological examination was Proliferating Pilar Tumour with focal malignancies. In conclusion, facial hairline tumor differentially diagnosed as a sebaceous cyst turned out to be a rare Proliferating Pilar Tumor (PPT). Following histopathological confirmation, the patient was referred for further management by a specialist team.
Front Matter Vol. 55, No. 3 September (2019) Matter, Front
Folia Medica Indonesiana Vol. 55, No. 3
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This study was conducted to identify the presence of icaA and icaD genes in S. epidermidis and to analyze the relationship between the presence of icaA and icaD genes with the ability of in vitro biofilm formation in S. epidermidis. S. epidermidis isolates from patients and healthy people were collected and PCR was examined to detect icaA and icaD genes. which then continued to examine the ability of biofilm formation by the method of Congo Red Agar. The results of this genotypic and phenotypic examination were then tested for correlation with statistical tests using SPSS 23.0. A total of 40 S. epidermidis isolates were collected, consisting of 20 clinical isolates and 20 isolates of normal flora. The icaA gene was positive in 5 isolates (12.5%), and 8 isolates (20%) were positive for the icaD gene, 3 isolates with icaA and icaD were both positive. One hundred percent of isolates with icaA or icaD positively formed biofilms, but there were 15 isolates (42.9%) who did not have the icaA gene but showed the ability to form biofilms, while 12 isolates (37.5%) who did not have the icaD gene also formed biofilms. Fifty percent of S. epidermidis isolates showed the ability to form biofilms at CRA. The Fisher Exact test showed a significant relationship between the icaA gene and the ability of biofilm formation (p=0.047 (p<0.05)) as well as the icaD gene (p=0.03 (p<0.05)). The icaA and icaD genes have a significant relationship to biofilm formation in S. epidermidis. There was another mechanism in the formation of biofilms that are not dependent on the ica gene.
Provision of arak bali reduces spermatozoa quality of white rats (rattus norvegicus) Antari, Ni Wayan Sukma; Hayati, Alfiah; Winarni, Dwi
Folia Medica Indonesiana Vol. 52, No. 4
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This study aimed to determine the effect of arak bali on the quality of spermatozoa include morphology, motility, viability, membrane integrity of spermatozoa rat (Rattus norvegicus). The study was conducted in two phases: the first phase of the deployment of questionnaires conducted in five districts in Bali to determine the type and frequency of arak bali consumption and phase II made arak bali giving treatment in experimental animals. This study used 24 male rats (170-200 grams), divided into four groups: one control and three treatments (by arak bali containing 40% alcohol as much as 0.1 and 0.5 mL and 0.1 mL much alcohol synthesis, for 45 days. the results showed that of the five districts in Bali, most people consume arak bali commercial and most of the frequency of consumption of the week more than one bottle (350 mL). the provision of arak bali in experimental animals, degrade the quality (morphology, motility, viability, membrane integrity), the greater the volume given declining spermatozoa quality.
Effects of Dexamethasone on Contralateral Testicular Immune Response in Wistar Strain Rats with Unilateral Testicular Torsion Kustono, Andri; Sudiana, I Ketut; Rizaldi, Fikri; Tarmono, Tarmono
Folia Medica Indonesiana Vol. 54, No. 1
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The aim of this study was to prove the effects of dexamethasone on immune responses in rats with testicular torsion. This was an experimental study with post test only control group design. In this study, 27 rats were randomly divided into 3 groups. In normal or sham group (CN) orchidectomy was performed on the right testis on day 14. The positive control group (CP) had testicular torsion for 10 h, then manual detorsion was performed after 4 h, and on day 14 orchidectomy was performed on ipsilateral and contralateral testes. The treatment group (N) had testicular torsion for 10 h and received 10 mg/kgBW dexamethasone subcutaneously 30 minutes before manual detorsion 4 hours later, and on day 14 orchidectomy was performed to ipsilateral and contralateral testes. The spermatogonium count was calculated based on the average number of intratubular seminiferous tubule section observed in contralateral testicular incision with Haematoxiliyn Eosin (HE) staining. IgG count was calculated based on the average number of extratubular seminiferous tubules observed at 5 contralateral testicular incision with immunohistochemical staining (IHC). The number of spermatogonia was significantly different between CN and CP, CN and N, and CP and N (p<0.05). IgG production also showed significant differences between CN and CP, CN and N, as well as CP and N (p<0.05). In conclusion, administration of dexamethasone provides a protective effect on spermatogonium count and IgG production on a 10-hour testicular torsion.
Four Weeks Exercise in Vary Intensities Reduce More Inguinal Fat Than Perigonadal Fat in Mice Lutfi, Ahmad Rukhani; Liben, Paulus; Herawati, Lilik
Folia Medica Indonesiana Vol. 57, No. 2
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Staphylococcus aureus (S. aureus) is the most common pathogen in humans that causes various infections. A variety of infections due to S. aureus are related to virulence factors, one of which is Toxic Shock Syndrome Toxin-1 (TSST-1) as the main cause of Toxic Shock Syndrome (TSS). This study aimed to explore the genetic pattern of the tsst-1 genes among MSSA and MRSA from clinical isolates of patients at Dr. Soetomo General Academic Hospital, Surabaya-Indonesia. This study performed a PCR test on 106 clinical samples of S. aureus isolated to determine the presence of the tsst-1 genes; subsequently, this study also performed phylogenetic analysis. The positive tsst-1 genes were found in 3 (5.7%) MSSA isolates and 2 (3.8%) MRSA isolates from 106 samples that were divided into 53 MSSA isolated and 53 MRSA isolates. There was no significant difference between the tsst-1 genes on both the MSSA and MRSA bacteria (p = 0.648). The positive tsst-1 genes were found in 1 (4.5%) of pus specimens and 2 (16.7%) of blood specimens from MSSA isolates. However, the positive tsst-1 genes were found in neither sputum nor urine specimens. The genes were found in 2 (16.7%) of blood specimens from MRSA isolates. Based on the phylogenetic tree, Indonesian tsst-1 isolated belonged to the same clade as Japan, Iran, Iraq, India, Egypt, and the United Kingdom. The prevalence of tsst-1 genes of both MSSA and MRSA from clinical isolates in Dr. Soetomo General Academic Hospital Surabaya was 5.7% and 3.8%, respectively. The tsst-1 genes of Surabaya-Indonesia, Japan, Iran, Iraq, India, Egypt, and the United Kingdom belonged to the same clade.
Lower Level of Interleukin-6 and Hepcidin Found in Lower Density of Physical Exercise among Athlete During Pandemic of Covid-19 Purwani, Deni; Sulistiawati, Sulistiawati; Purwanto, Bambang
Folia Medica Indonesiana Vol. 57, No. 2
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The pandemic of Covid-19 affected entire daily human life worldwide, including sports activities among athletes. An athlete was pushed to suit their routine activities with a new health protocol for Covid-19 prevention. Some of them were programmed to train at home with a moderate density of exercise, but others were still in a high density of exercise. This study compared the serum level of hemoglobin (Hb), interleukin-6 (IL-6), and hepcidin among athletes with a high versus moderate exercise density training program during the pandemic. Thirty-four indoor soccer athletes of a soccer football school in Malang voluntarily registered as a subject. Half of them received moderate exercise density exercise programs, and others received high-density exercise programs during June-July 2020. Interleukin-6 and hepcidin level mean was found significantly lower in the moderate group compared to the high-density group. Hemoglobin level mean was found not different between those groups. The lower density of exercise influenced on IL-6 and hepcidin serum level of athlete, but not on hemoglobin level.
The effect of administering mangosteen rind extract (garnicia mangostana l) compared with glimepiride to the blood sugar levels of white male rat (rattus norwegicus l) induced by streptozotocin As'ari, Hasyim; Mahartini, Dewi Mutmainnah
Folia Medica Indonesiana Vol. 52, No. 4
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The purpose of this study is to prove the differential effect of administering the mangosteen Rind extract due to lowering the blood sugar levels of Winstar white male rats induced by streptozotosin (STZ). This study used a randomized design of the ramdomized posttest only control group design. The sample consisted of 4 groups with a sample size of 7 animals each group of rats. All samples were prepared STZ induction of diabetes with a single dose of 50 mg/Kg BW through intraperitoneal (IP). K0 (control group; given 1% CMC 1 cc/day), K1 (treatment group 1; given 0,054 mg glimepiride/200 grBW, K2 (treatment group 2; given mangosteen Rind extract 50 mg/Kg BW), K3 (treatment group 3; given the mangosteen Rind extract 100 mg/Kg BW). Timing of therapy in each group was for 7 days. Shapiro-Wilk normality test (a=0.05) in the BW D variable data, pre-post STZ GDP and D GDP. Testing homogeneity used Levene's test. When data distribution was normal and homogenous, it used an ANOVA deferential test. When data distribution was normal and inhomogeneous, it proceed to apply T-test with 2 free samples. The results: 1) There were significant differences between K0 D GDP with K1 (p=0.015), K0 to K2 (p=0.003) and group K0 to K3 (p=0.002), 2) Whereas no difference was shown in the K1 with K2 (p=0.442), K1 to K3 (p=0,401) and K2 to K3 (p=0.878). Conclusion: The administration of mangosteen Rind extract doses of 50 and 100 mg/kg bw/day did not differ in lowering blood sugar levels compared with glimepiride administration of a dose of 0.054 mg/200 grBW rat/day. Mangosteen Rind extract dose of 100 mg/kg bw/day and 50 mg/kg bw/day did not provide a significant difference in lowering blood sugar levels.
Lymphocyte-t type th1 and th2 activity difference of lung tissue on heligmosomoides polygyrus nematode and mycobacterium tuberculosis sequential co-infection Wulandari, Laksmi; Amin, Muhammad; Soedarto, Soedarto; Soegiarto, Gatot
Folia Medica Indonesiana Vol. 53, No. 2
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Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis that are often associated with uneffectiveness of the BCG vaccine and the high worm infection. The objective of this study was to determine the differences in the activity of Limfosit T type Th1 (IFN-g) and Th2 (IL-4) in lung tissue on Heligmosomoides polygyrus nematode and Mycobacterium tuberculosis sequential co-infection. This research using 49 mice were divide into 7 groups treated with infection by Mycobacterium tuberculose inhaled and Heligmosomoides polygyrus orally within 8 and 16 weeks. The levels of IFN-g in peripheral blood serum (89.929 + 3.533 pg/mL) resembles the pattern of the percentage of lymphocytes T CD4+ Th1 in lung tissue (3.246 + 0.519%) and peripheral blood (4.950 + 0.237%), while the levels IL-4 in the peripheral blood serum (20.782 + 4.043%) resembles the pattern of the percentage of lymphocytes T CD4+ Th2 in intestinal tissue (1.048 + 0.359%) and peripheral blood (1.196 + 0.557%). In conclusion, there is difference in the activity of lymphocytes T type Th1 and Th2 but it does not affect the immune response to Mycobacterium tuberculosis infection.
Profile of Secondary Glaucoma at a Tertiary Hospital in East Java Komaratih, Evelyn; Rindiastuti, Yuyun; Primitasari, Yulia
Folia Medica Indonesiana Vol. 56, No. 1
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Glaucoma is the leading cause of irreversible blindness. The aim of this study was to review the profile of secondary glaucoma cases visiting a tertiary hospital in East Java. This is retrospective observational study, completed case records of new patients with secondary glaucoma who presented to glaucoma clinic from January 2014 to April 2016 were included. Out of the 363 case records screened, 66 cases were found to eligible for inclusion. The evaluation included a detailed history and examination performed including vision, anterior segment examination, intraocular pressure (IOP), gonioscopy, and fundus evaluation. Diagnosis of secondary glaucoma was made on the basis of presence of a secondary cause for presence of raised IOP. 66 cases were eligible for inclusion in the study, most of the cases was occurred in the range age 21-50 years. The male female ratio was 1.3:1. Frequent causes of secondary glaucoma were lens factor 30.8%, steroid induced 29.5%, uveitic 20.5%, neovascular15.4%, and surgical complication 3.8%. Most patients with secondary glaucoma have poor vision < 0.1 with high IOP at presentation. Assessment and early detection of underlying cause is the key guide to treatment strategy.
Front Matter Vol. 56, No. 2 June (2020) Matter, Front
Folia Medica Indonesiana Vol. 56, No. 2
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