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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Characteristics of Obstructive Anuria Patients in a Tertiary Hospital in East Java, Indonesia Wicaksono, Fandy; Rizaldi, Fikri; Soebadi, Doddy M
Folia Medica Indonesiana Vol. 57, No. 3
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Abstract

Obstructive uropathy is an obstruction of urinary passage which may lead to anuria, a condition where urine production is less than 50 to 100 ml in 24 hours. The varying etiologies and underlying pathophysiology among different cases based on different demographics can make it difficult for physicians to decide the proper management. Therefore, we aimed to evaluate the clinical profile and management of anuria patients in Dr. Soetomo General Academic Hospital over a four-year period. This was a descriptive study with a retrospective approach evaluating all patients with anuria admitted from January 2016 to December 2019. Patient data taken from the medical record were presented descriptively. A total of 176 patients were obtained. Only 161 patients were included. Most of the patients were female (n=100, 62.11%) aged 51 to 60 years old (n=63, 39.1%). Postrenal obstruction due to urinary stone was the most frequent etiology (n=86, 53.4%). Consequently, some patients developed hydronephrosis, which was mostly dominated by the bilateral (n=130, 80.8%) and severe types (n=75, 46.6%). A total of 129 patients (80.1%) underwent hemodialysis. Most of the patients were treated with definitive treatment (n=46, 38.7%). Normalization of renal function mostly occurred in patients who underwent percutaneous nephrostomy (PNS) before giving a definitive treatment.
Decrease of LDL Cholesterol Through The Increase of HDL Cholesterol by Administering Garcinia mangostana L. Peel Extract in White Mice As'ari, Hasyim
Folia Medica Indonesiana Vol. 57, No. 4
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Abstract

Highlight: • Ethanol extract of Garcinia mangostana L. peel reduce malondialdehyde. • Garcinia mangostana L. peel extract can increase non-radical products which impact in decreasing LDL cholesterol and increasing HDL cholesterol. Abstract: Atherosclerosis contributes to coronary heart disease which may lead to fatality. High cholesterol consumption, stress, and smoking can increase LDL cholesterol in the blood. Consumption of unsaturated fats, high fiber foods, exercise, quitting smoking, losing weight, and giving hypolipidemic drugs, especially herbs, can increase HDL cholesterol and decrease LDL cholesterol. Garcinia mangostana L. peel extract can decrease LDL cholesterol by increasing reverse HDL cholesterol transport to the liver. The study used post test control group design. This study was experimental laboratory research with population of hypercholesterolemic male white mice aged 3-4 weeks with 100-200 grams weight. The HDL and LDL cholesterol data were collected through an enzymatic method by spectrophotometer. This study used analysis of variance (Anova) with significance level of α <0.05. The experiment divided the subjects into positive and negative control groups with dosage variations of 50, 150, 250, and 350 mg/kgBW. Examination of hypercholesterolemia in white mice was conducted on the 8th day. The examination of HDL and LDL cholesterol given peel extract of Garcinia mangostana L. was conducted on the 22nd day. The analysis showed that giving Garcinia mangostana L. peel extract for various dosages could significantly decrease LDL cholesterol and increase HDL cholesterol (p <0.05). Peel extract of Garcinia mangostana L. that contained mangosteen could increase non-radical products that could prevent the transfer of ester cholesterol from HDL to VLDL which impact in increasing HDL cholesterol and decreasing LDL cholesterol.
A Model of Performance Evaluation for Healthcare Workers Based on Satisfaction and Remuneration (Financial and Non-Financial) Wahyuhadi, Joni; Hidayah, Nur; Aini, Qurratul
Folia Medica Indonesiana Vol. 58, No. 4
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Abstract

Highlights: • This study aimed to formulate an evaluation model of the performance of health workers. • Employee performance targets and employee satisfaction were assessed by considering the financial and non-financial remuneration, Job Description Index (JDI), competencies, and motivation. • The performance evaluation model for health workers shows the importance of remuneration for government agencies, employees, and employee performance. Abstract: This study aimed to formulate an evaluation model of the performance of health workers from the perspective of financial and non-financial satisfaction and remuneration. The research method used was a literature study with a literature review approach. The research findings were the healthcare workers' performance evaluation model based on satisfaction and remuneration. The evaluation was conducted by assessing the employee performance targets (sasaran kerja pegawai/SKP) and employee satisfaction related to the financial and non-financial remuneration, Job Description Index (JDI), competencies, and motivation. In addition, this model has been also used for the evaluation of performance appraisal based on remuneration among employees (i.e. health workers) in government agencies, especially hospitals.
Differences in the Development of Language and Social Independence in Children with Speech Delay and Sensorineural Hearing Loss based on the Age for Early Intervention and the Duration of Auditory-Verbal Therapy Purwanti, Zamrotu Iva; Romdhoni, Achmad Chusnu; Suryawan, Ahmad; Purnami, Nyilo; Ariningtyas, Ninuk Dwi
Folia Medica Indonesiana Vol. 59, No. 4
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Abstract

Highlights : • This study explored the significance of auditory-verbal therapy as an early intervention for children with speech delay and sensorineural hearing loss, a topic that deserves further research in developing countries such as Indonesia. • The findings highlight the significance of age and therapy duration on the language development of children with speech delay and sensorineural hearing loss. Abstract Speech delay is primarily attributed to sensorineural hearing loss, which may significantly impact a child's language development and social independence. Consistent and periodic auditory-verbal therapy as an early intervention has the potential to positively influence language development, thereby fostering independence in children. The objective of the research was to examine the differences in the development of language and social independence among children who have speech delay and sensorineural hearing loss at the children's age for early intervention and with the duration of auditory-verbal therapy taken into consideration. The research employed an analytical-observational design with a cross-sectional approach and total sampling. The sample comprised 29 children who were undergoing the weekly routine of auditory-verbal therapy at Yayasan Aurica, Surabaya, Indonesia. The tool utilized in this study was the Pre-Screening Developmental Questionnaire. The data underwent bivariate analysis, specifically using the Chi-squared test with a significance level set at a p-value of <0.05. The language development analysis resulted in a p-value of 0.013 for the age variable and a p-value of 0.019 for the therapy duration variable. Meanwhile, the social independence analysis yielded a p-value of 0.229 for the age variable and a p-value of 0.111 for the therapy duration variable. In conclusion, the influence of age on early intervention had a significant difference from that of the duration of auditory-verbal therapy on the language development of children with speech delay and sensorineural hearing loss. Conversely, age and therapy duration did not exert any meaningful difference in terms of their influence on the children's social independence development.
Age and Sex Characteristics of Dermatophytosis in Gianyar, Indonesia Budiapsari, Putu Indah; Purnama, Ni Kadek Ari; Widiawati, Sayu
Folia Medica Indonesiana Vol. 60, No. 1
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Abstract

Highlights: 1. Although dermatophytes may typically cause mild infections, it is crucial to conduct continuous research due to their potential to cause severe diseases in individuals who are highly susceptible to infection. 2. This study offers insight into the increased risk of developing dermatophytosis for female and adult individuals compared to male and younger individuals. Abstract Dermatophytosis is a superficial fungal infection caused by a filamentous fungus that attacks keratinized tissues on the skin, nails, and hair. The clinical manifestation of dermatophytosis is determined by the source. In addition, it can be influenced by host-related factors, such as age, sex, and race. These are significant epidemiological factors, although the association between these factors and susceptibility to infection has not been clarified. Therefore, this study aimed to determine the association between the incidence of dermatophytosis and host-related factors (i.e., age and sex) in Gianyar Regency, Indonesia. This observational study used a cross-sectional design and total sampling. A total of 100 samples were collected from the medical records of patients diagnosed with dermatophytosis. The Chi-square test was employed to determine the correlation between the independent and dependent variables with a p-value of <0.05. The data were analyzed using IBM SPSS Statistics for Windows, version 22.0 (IBM Corp., Armonk, N.Y., USA). The majority of patients with dermatophytes infection were adults over the age of 19 (74%) and females (57%). The most prevalent type of dermatophytosis was tinea corporis (36%). The Chi-square test revealed a significant association between the type of dermatophytosis and the variables being examined, namely age (p = 0.025; OR = 1.978; 95% CI = 1.087-3.599) and sex (p = 0.003; OR = 2.357; 95% CI = 1.334-4.162). In conclusion, the manifestation of certain types of dermatophytosis is associated with age and sex. The findings of this study recommend enhancing the detection of dermatophytosis infection, especially in adults (>19 years old) and women.
Excision of Recurrent Hemangioma in Hand with Reconstruction Using Abdominal Flap Tua, Ivan Joalsen Mangara; Ardan, Andi Mohammad; Pagehgiri, Hari Daswin; Sukamto, Amy Rosalie; Dwipayana, Made Angga Putra
Folia Medica Indonesiana Vol. 58, No. 2
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Abstract

Highlights: • Hemangioma of the hand is a challenging case due to the need to maximize eradication of the mass while minimizing damage to the healthy tissue to preserve the physiologic function of the hand. • The reconstruction of the defect also needs to be taken into account to maintain the cosmetical appearance. • Collaborative multidisciplinary work is essential to achieve these demands and maintain the patient's quality of life. Abstract: Hemangiomas are known for their typical involution with age. However, around 40% of cases require intervention. Hemangioma in hand is challenging because the hand function and the aesthetic appearance need to be preserved. Hereby we reported a 21-year-old woman with a recurrent hemangioma on the left hand in Abdul Wahab Sjahranie Hospital, Samarinda, Indonesia. The patient's previous surgery was ineffective since the mass reappeared in the same area. We performed surgical excision and reconstruction with an abdominal flap. One-month and one-year postoperative follow-up indicated good flap viability and preserved hand functions without the need for amputation. This report also emphasizes the importance of collaboration from multiple surgical and medical fields to allow favorable outcomes in this case.
The profile of the level of endogenous no in migraine sufferers Saleh, Arman Yurisaldi; Machfoed, Hasan; Kuntoro, Kuntoro
Folia Medica Indonesiana Vol. 52, No. 4
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Abstract

Migraine is a health problem which had big impact. A neurochemistry change in the dura, that is the increase of the amount of nitrite oxide, originated from an excessive NOS (inducible NOS) activation during ictal. Some researchers assume NO as a main cause of the pain intensity in ictal. Migraine diagnosis is guided by the International Headache Society. Hopefully, this examination can be used as a more objective diagnosis in the future. Methode of this research is descriptive analytic. This study to find the level of endogenous exhaled NO on 91 subject, consisting of 30 normal people, 31 interictal, 30 ictal. An exclusion was done previously. A validation equipment and measurement had been done in accordance with American Thoracic Association guidance. The result is level of endogenous exhaled NO on the normal group (median=5), interictal group (median=11), ictal group (median=14). Coefficient correlation between VAS and level endogenous exhaled NO was 0,815. So, there is an increase of the NO endogen level in the normal people, migraine interictal, and ictal. Strong correlation between intensity of pain (VAS) and level endogenous exhaled NO during ictal.
Case report: intraprocedural stent thrombosis in percutaneous coronary angioplasty Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 52, No. 1
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Abstract

Stent thrombosis is a rare complication of PCI but associated with STEMI and sudden cardiac death. Intra procedural stent thrombosis (IPST) was defined new or increasing (compared with baseline) thrombus within or adjacent to a deployed stent occurring the index PCI procedure whether occlusive or nonocclusive. We describe a case with double vessel disease who has complication cardiac arrest and intra procedural stent thrombosis in LAD and Left Main coronary artery after deployed stent in bifurcation LAD-D1. Thrombectomy and rescucitation were performed, and the patient completed her hospital course without complications.
Correlation between blood glucose level and thinking concentration Marbun, Putri Itonami Gaol; Mardiani, Tengku Helvi
Folia Medica Indonesiana Vol. 52, No. 3
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Cognition function specifically about thinking concentration has not much yet been studied. Society view shown that glucose has role thinking quality. Few studies shown that glucose has role in specific memory quality but not in complex thinking. This study purpose to see correlation between blood glucose level with thinking concentration before eating (preprandial), after eating (postprandial), and the effect of blood glucose rise on thinking concentration. Subjects that accomplished study's requirement were recruited until forty six people and were followed within thirty minutes. Blood Glucose level was measured by glucose meter at initial admission, thinking concentration were measured with trail making test at initial admission, and compared after eating on the thirtieth minute. Descriptive analytic shown that preprandial blood glucose level in all subject is 55-119 mg/dl with 98.2 mg/dl mean. Postprandial blood glucose level in all subject is 103-171 mg/dl with 134.5 mg/dl mean. Preprandial thinking concentration in all subject is 28-93 seconds with 56.42 seconds mean. Postprandial thinking concentration in all subject is 24-73 seconds with 47.5 seconds mean. Correlation analysis showed that no significance between preprandial blood glucose level and thinking concentration (p = 0.556), postprandial blood glucose level and thinking concentration (p = 0.533), and increase in blood glucose and thinking concentration (p= 0.928). In conclusion there is no significant correlation between blood glucose level and thinking concentration.
Nt-probnp level changes after combination therapy with bisoprolol and ace-inhibitor in patient with heart failure Risthanti, Reine Risa; Aminuddin, Muhammad; Suharjono, Suharjono
Folia Medica Indonesiana Vol. 52, No. 4
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Abstract

Heart failure (HF) is the final common stage of many diseases of the heart. NT-proBNP levels are increased in HF and correlate well with ventricular wall stress and severity of HF. Combination therapy with Bisoprolol and ACE-inhibitor decreases NT-proBNP level in patient with HF. The use of Bisoprolol as a combination with ACE-inhibitor is still dominate in outpatient setting at Dr. Soetomo teaching hospital. The objective of this study is to analyze NT-proBNP level changes as an indicator in cardiac function after combination therapy with Bisoprolol and ACE-inhibitor in patient with HF.Methods: This study was prospective, observational and conducted in outpatient setting. Consecutive patients who meet the inclusion criteria of the study were included. Blood samples were taken at pre and 2 months post combination therapy with Bisoprolol and ACE-inhibitor, then NT-proBNP level was measured with IMMULITE®. There were 14 patients enrolled in this study (7 males, 7 females). The result showed that NT-proBNP 2 months post combination therapy with Bisoprolol and ACE-inhibitor is significantly decreased than baseline with mean baseline of NT-proBNP level is 4191.43 ± 4367.277 pg/ml to 2786.79 ± 2485.199 pg/ml (p=0.025). From a total 14 patients, 9 patients had NT-proBNP decreases >20% (20.1% – 56.4%) and 3 patients had NT-proBNP decreases <20% (1.8%, 6.6%, and 12.4%). There were 2 patients with NT-proBNP increases >40% (43.4% and 40.4%). In conclusion, there was a significant decreases in NT-proBNP level after 2 months combination therapy with Bisoprolol and ACE-inhibitor in patient with HF.

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