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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Analysis of Differences of Serum Thromboxane B2 Level after Taking Acetosal in Acute Thrombotic Stroke with Diabetes Mellitus and Non-Diabetes Mellitus Hadiyanti, Nur; Hasmono, Didik; Islam, Mohammad Saiful
Folia Medica Indonesiana Vol. 54, No. 1
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Endothelial dysfunction and vascular injuries are the early processes in thrombogenesis leading to thrombotic stroke. These processes trigger platelet activation characterized by synthesis of Thromboxane A2, potent agonist in platelet aggregation. Acetosal (ASA) 100 mg usually given to thrombotic stroke patients exerts its pharmacological effect by inhibition of TxA2 synthesis, thus could prevent thrombus formation. Diabetes mellitus (DM) as risk factor of thrombotic stroke exhibits an increase in TxA2 synthesis. It is not known whether ASA 100 mg could inhibit TxA2 adequately in diabetic patients. This study aimed to analyze the differences of serum TxA2 level, which was measured by serum TxB2 level as stabile metabolite of TxA2, after taking ASA 100 mg in diabetic and non-diabetic thrombotic stroke patients. This prospective observational study was held in Neurology Department of Dr. Soetomo Hospital, Surabaya. Total 27 patients, consisted of 15 patients with DM and 12 patients with non-DM were enrolled. Serum TxB2 was measured before and after 5-7 days 100 mg ASA 100 administration. Mean value of serum TxB2 level before and after taking ASA was 16.43 ± 16.08 ng/mL and 2.93 ± 1.83 ng/mL in diabetic and 27.36 ± 21.04 ng/mL and 5.36 ± 4.06 ng/mL in non-diabetic group. Mean reduction of serum TxB2 level in diabetic and non-diabetic group was 13.49 ± 15.9 ng/mL and 22.00 ± 21.65 ng/mL. There were significant differences in serum TxB2 level after taking ASA 100 mg in diabetic and non-diabetic group but the mean reduction of serum TxB2 level were not significantly different.
Analysis of High Dose and Long-Term Prednisone Therapy on Trap 5B Level Change in Children with Steroid Sensitive Nephrotic Syndrome Setyani, Dessy Surya; Qibtiyah, Mariyatul; Asmaningsih, Ninik; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 54, No. 2
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Nephrotic syndrome is a condition which is characterized by protein leakage from the blood to the urine through glomeruli. It leads to hypoproteinemia and generalised oedema. Patients with nephrotic syndrome need high dose and long term glucocorticoid such as prednisone. High dose and long term glucocorticoid can increase bone resorption. Biological marker is a valuable tool to evaluate efficacy of therapy. TRAP 5B is a sensitive biological marker for bone resorption because it reflects the number of osteoclasts. TRAP 5B is not affected by renal dysfunction and food. It also has a low diurnal variation than other bone resorption marker. The aim of this study was to analyze the changes of TRAP 5B levels at induction and alternate phase in children with steroid sensitive nephrotic syndrome. This observational prospective study was conducted from May to October 2016. Venous blood samples obtained at 08.00-10.00 am. TRAP5B levels were measured before and after induction phase and after alternate phase using ELISA. Fifteen patients were included in this study (60% boys). Majority of their age was 6 - <12 years and 40% were dependent steroid NS. TRAP 5B serum levels in induction phase increased by 37.41%±56.22%. In alternate phase, TRAP 5B serum levels increased by 28.75%±66.55% compared to the induction phase. However, the level change of both phases were not significant. As a conclusion, TRAP 5B levels increased in induction and alternate phase after high dose and long-term prednisone treatment in nephrotic syndrome.
Effect of Good Hygiene Sanitation and Personal Hygiene Depot Management of Refill Drinking Water on the Quality of Drinking Water Reviewed from Most-Probable-Number Coliform in Kediri Indasah, Indasah
Folia Medica Indonesiana Vol. 54, No. 4
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Drinking water is a basic human need and must meet health requirements. Drinking water depots are a means of filling drinking water which is in the process of processing raw water using treatment and sterilization system. Drinking water depots as providers of drinking water must also meet the requirements of sanitation hygiene and personal hygiene management must also be maintained so that the water produced meets health requirements. The purpose of this study was to determine the effect of sanitation hygiene and personal hygiene management of refill drinking water depots on the quality of drinking water in terms of the Most Probable Number Coliform in Kediri. The research design used was analytic observational with cross sectional approach. The population of all refill drinking water depots in Kediri is 57, with the sampling technique that is Simple Random Sampling, where a portion of refill drinking water depots in Kediri are 50. Data is collected by check list, questionnaire and laboratory examination. The results showed that most of the hygiene sanitation of the drinking water depot had fulfilled the requirements of 77%, the drinking water personal hygiene depot was good as much as 85% and those who met the drinking water requirements were 70%. The results of the hygiene feasibility analysis showed the value of Sig 0.000<0.05 (R=0.935) means that there was an effect of hygiene sanitation quality with water quality in terms of the Most Probable Number Coliform. While the personal hygiene value of Sig 0.001 <0.05 (R = 0.528) indicates that there is a personal hygiene influence with water quality in terms of the Most Probable Number Coliform. The results of Logistic Regression test showed that there were effects of sanitation hygiene and personal hygiene management of refill drinking water depots with water quality in terms of the Most Probable Number Coliform with a significance value = 0.000
Front Matter Vol. 55, No. 2 June (2019) Matter, Front
Folia Medica Indonesiana Vol. 55, No. 2
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Diagnosis and Management of Adrenal Crisis in 46XX Congenital Adrenal Hyperplasia Infant Rochmah, Nur; Faizi, Muhammad; Kusumastuti, Neurinda Permata; Samadhi, Leonardo Ferryanto Mak; Deakandi, Wika Yuli
Folia Medica Indonesiana Vol. 58, No. 3
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Highlight: • The diagnosis and therapy of Congenital Adrenal Hyperplasia (CAH) children with Adrenal crisis (AC) case report. • Adrenal crisis (AC) is a life-threatening emergency that contributes to the high death rate of children with adrenal insufficiency. • The early detection and prompt treatment can improve the outcomes of patients with CAH and AC. Abstract: Adrenal crisis is the acute complication of the patient with congenital adrenal hyperplasia. Congenital adrenal hyperplasia (CAH) is a rare condition. Children with CAH commonly come to the emergency room due to acute complications. The condition has high mortality and thus needs early recognition. Newborn screening for CAH in Indonesia is not routinely performed and has not been suggested yet. The purpose of this case report was to report a case of adrenal crisis in a congenital adrenal hyperplasia patient focused on diagnosis and therapy. A female, 10 months old infant, was admitted to the emergency department with a chief complaint of a decrease of consciousness for 3 hours before admission and frequent vomiting since born. On physical examination, there was clitoromegaly. Laboratory showed 17-OH progesterone: 173 ng/dL (7-77 ng/dL) and karyotyping: 46 XX. Management of adrenal crisis is a stress dose of hydrocortisone and rehydration. Education is the key to optimal outcomes and normal growth and development.
Identification of Pathogenic Bacteria in Food Samples from Cafeterias of a University in Denpasar, Indonesia , Anak Agung Ayu Lila Paramasatiari; , Putu Indah Budiapsari; Suryanditha, Putu Arya; Widhidewi, Ni Wayan
Folia Medica Indonesiana Vol. 58, No. 4
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Highlights: • Eschericia colli was the most contaminant bacteria among food samples from Warmadewa Cafeterias • Further suggestions to increase the hygiene in food processing must be offered. Abstract : Foodborne diseases still remain a problem especially in public areas. This study aimed to identify pathogenic bacteria in foods sold at the cafeterias of Universitas Warmadewa, Denpasar, Indonesia. The presence of pathogenic bacteria in the food samples was identified using the brain heart infusion (BHI) agar for the growth of Escherichia coli and Streptococcus aureus, selenite for Shigella and Salmonella, and alkaline peptone for Vibrio cholerae, then bacterial culture was conducted to identify the species. The results showed that Escherichia coli were found in two food samples, kangkong and jinggo rice, with the colony counts of 50-118. Escherichia coli was the most commonly found contaminant in food samples from the Warmadewa Cafeterias. Further suggestions must be offered to increase hygiene in the food processing by advising the stalls' owners to serve good foods and conducting regular inspections to assess the food quality.
Expressions of β-Tryptase and Chymase in Lung Mast Cells due to Anaphylactic Shock through Histopathological Appearance at Different Post-Mortem Intervals Putra, Biqisthi Ari; Susilo, Imam; Yudianto, Ahmad
Folia Medica Indonesiana Vol. 59, No. 1
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Highlights: • The post-mortem interval is related to tryptase and chymase expressions in anaphylactic shock incidence • Forensic experts can utilize tryptase and chymase as markers of anaphylactic (non-anaphylactoid) shock that occurs in the lungs. Abstract: Anaphylactic shock is a hypersensitivity response, a commonly type I hypersensitivity involving immunoglobulin E (IgE). It is caused by an antigen-antibody reaction that occurs immediately after a sensitive antigen enters the circulation. Anaphylactic shock is a clinical manifestation of anaphylaxis that is distributive shock, characterized by hypotension due to sudden blood vessel vasodilation and accompanied by a collapse in blood circulation that can result in death. β-tryptase and mast cell chymase expressions in the lungs of histopathological specimens that had experienced anaphylactic shock were examined at different post-mortem intervals in this study. A completely randomized design (CRD) method was employed by collecting lung samples every three hours within 24 hours of death, and then preparing histopathological and immunohistochemical preparations. The mast cell tryptase and chymase expressions were counted and summed up in each field of view, and the average was calculated to represent each field of view. The univariate analysis yielded p-values of 0.008 at the 15-hour post-mortem interval, and 0.002 at the 12-hour post-mortem interval. It was concluded that tryptase and chymase can be utilized as markers of anaphylactic (non-anaphylactoid) shock in the lungs.
Factors that Influence Stunting in the Maratua District of Berau, Indonesia Tambunan, Risa Haryati; Nurbaeti, Elis
Folia Medica Indonesiana Vol. 60, No. 1
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Highlights: 1. This study investigated the factors contributing to stunting in a remote area, which has not received sufficient attention from key stakeholders. 2. The findings of this study can serve as a reference for the government in addressing stunting through intervention strategies that incorporate paternal roles to improve children's nutritional status. Abstract Stunting is a community health problem with significant impacts. The estimated prevalence rate of stunting was 24.4% in Indonesia and 25.7% in the Berau Regency. Stunting is a growth disorder caused by chronic malnutrition during the first 1,000 days of life. It is characterized by a height-for-age Z-score below -2 standard deviations from the child growth standards median of the World Health Organization, an insufficient growth rate, and a reduced potential final height. The contributing factors to stunting include maternal variables, as mothers are the primary caregivers. The objective of this study was to determine the factors for stunting and specifically investigate if there is a relationship between maternal employment and stunting in the Maratua District of Berau, Indonesia. This study used a cross-sectional research design. The sample size was determined using the Sample Size Calculator from the World Health Organization for a two-sided test (α = 0.05; β = 0.2; p1 = 0.63; p2 = 0.25; 95% CI). The data were collected from the nutrition report and anthropometric measurements at Maratua Primary Healthcare Center. The research was carried out at the Integrated Health Posts (Pos Layanan Terpadu/ Posyandu) in the Maratua District. The toddlers (n = 56) were examined with their parental consent. Toddlers with overnutrition, obesity, and acute infectious diseases were excluded from this study. The data were processed using Chi-square and Fisher tests (p < 0.05). In the analysis, no significant relationship was found between stunting and maternal employment. However, the results revealed that fathers who were not fishermen had a 6.3 times greater risk of having stunted toddlers compared to fathers who worked as fishermen. Fathers with a junior high school degree showed a 6.1 times higher risk of having stunted toddlers than fathers with different educational levels. In conclusion, stunting in the Maratua District is associated with the fathers' educational attainment and employment.
Knowledge on The Risk of The Ischemic Heart Disease Estimation by WHO Charts in Cempaka Baru, Indonesia Fitriani, Hasna Luthfiah; Ridwan, Karina Ajeng DA
Folia Medica Indonesiana Vol. 58, No. 3
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Highlights: • The risk estimation of ischemic heart disease. • High blood pressure and cholesterol levels affect Ischemic heart disease. Abstract: In 2018, Indonesia became the country with the second-highest number of deaths and disabilities (DALYs) due to ischemic heart disease. Based on Riskesdas data in 2018, Jakarta is one of the provinces with a high percentage (1.9%) of ischemic heart disease. Risk factors for ischemic heart disease that are not treated quickly will increase the severity of ischemic heart disease in the future. Therefore, this study was to provide education regarding the assessment of risk estimation for ischemic heart disease with WHO/ISH charts among participants in Cempaka Baru sub-district. This study used pre-test and post-test questionnaires. After the seminars, the interview and examination results were carried out as well as calculating the estimated risk of ischemic heart disease using the WHO chart. These charts were divided into low risk (<10%), moderate (10-20%), and severe (>20%). The evaluation was conducted by comparing the pre-test and post-test results, which indicated that the knowledge level increased significantly from the Paired T-Test with a p-value = 0.000 (p<0.05). The significant estimation of high risk of ischemic heart disease for high blood pressure was 72.7% (p=0.023) and total cholesterol level was 66.7% (p=0.049). The increasing knowledge of the stratification risk of ischemic heart disease with the WHO chart was expected to reduce the risk of ischemic heart disease in the future.
Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust Yahaya, Tajudeen Olanrewaju; Salisu, Titilola; Musa, Mohammed; Izuafa, Abdulrazaq; Obi, Chidiebere; Ribah, Samuel; Abubakar, Suleiman
Folia Medica Indonesiana Vol. 59, No. 2
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Highlights: 1. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies. 2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. Abstract Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, followed by the extracts of Z. officinale, M. oleifera, T. occidentalis, and H. sabdariffa, respectively. These findings suggested that the selected vegetables and spices have the properties to ameliorate the effects of cement dust exposure. Therefore, individuals residing in close proximity to cement plants are encouraged to consume these vegetables and spices.

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