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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 571 Documents
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Effect of cognitive behavioral therapy for serotonin level, depression score and quality of life in cervical cancer patients Soetrisno, Soetrisno; Sulistyowati, Sri; Respati, Supriyadi Hari; Nasrudin, Muhamad
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients' quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.
The effect of soursop leaf extract on pancreatic beta cell count and fasting blood glucose in male wistar rats exposed to a high-fat diet and streptozotocin Astini, Dewa Ayu Agung Alit Suka; Gunawan, H Ari; Santoso, R Mochamad Wirono Aman; Andajani, Susilowati; Basori, Ahmad
Folia Medica Indonesiana Vol. 53, No. 1
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Abstract

Based on some researches known that soursop leaf extract can improve beta cell injury. The aims of this study was to analyze the effect of soursop leaf extract on fasting blood glucose (FBG) and pancreatic beta cell number in male Wistar rats wich were exposed to a high-fat diet and streptozotocin. This study design is the only randomized posttest control group design. The total sample size is 50 male Wistar rats. The independent variable: high-fat diet, STZ, and soursop leaf extract; the dependent variable: pancreatic beta cells number, and FBG3. Data tested for normality with Kolmogorov-Smirnov (a=0.05) and tested of homogeneity with Levene (a =0.05). Comparison test between groups with Kruskal-Wallis (a=0.05), followed by Mann Whitney. Correlation test with Pearson (a=0.05) between dose of the soursop leaf extract and FBG3, and between dose and the number of pancreatic beta cells. The results of this study showed that the soursop leaf extract at a dose of 100 mg/kg and 150 mg/kg have an effect on fasting blood glucose levels and panreatic beta cells number;2)There is a significant negative correlation between the orograstric lavage of soursop leaf extract with FBG3 (r=-0.647;p<0.001), the increasing doses of soursop leaf extract, further lowering fasting blood glucose levels;3)There is a significant positive correlation between the orograstric lavage of soursop leaf extract with the number of pancreatic beta cells (r=0,759;p<0,001), the increasing doses of soursop leaf extract, further increasing pancreatic beta cells number. In conclusion, increasing doses of soursop leaf extract, further lowering fasting blood glucose and increasing the number of pancreatic beta cells.
Chondroregenerative Potential of Platelet-Rich Fibrin (PRF)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously Widyatmika, Putu Ardhy Parama; Noer, Muhammad Sjaifuddin; Hutagalung, Magda Rosalina
Folia Medica Indonesiana Vol. 58, No. 4
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Abstract

Highlights: • This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage. • The formation of newly-regenerated chondrocyte, the thickness of type II collagen, and the rate of cartilage resorption following the subcutaneous implantation were assessed. • BCPRF is highly biocompatible and can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material. Abstract: The invention of alternative implants with regenerative potential comparable to autologous cartilage continues to be encouraged due to high morbidity of the donor site related to autologous harvesting process. This research attempted an invention of alternative implant using tissue engineering techniques in the form of endogenous regeneration by combining decellularized bovine cartilage scaffold with platelet-rich fibrin (BCPRF) that was implanted subcutaneously. The study aimed to compare the chondroregenerative potential between BCPRF and autologous cartilage in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen produced, and the rate of cartilage resorption following the subcutaneous implantation. This study was conducted in a pretest-posttest control group design using New Zealand white rabbits. Forty-eight experimental samples were divided into two groups, then treated with subcutaneous implantation of BCPRF and autologous cartilage respectively. The results were evaluated after six weeks of implantation. Thirty-nine samples were evaluated. There was a significant difference found from both groups in terms of the formation of newly-regenerated chondrocyte, the thickness of type II collagen (p=0.000), and the implant resorption rate (p=0.000). The microscopic images demonstrated a superior chondroregenerative potential in the group receiving implantation of autologous cartilage compared to the group receiving BCPRF. The chondroregenerative potential for autologous cartilage and BCPRF differed significantly in terms of the formation of newly-regenerated chondrocyte, the deposition of type II collagen matrix, as well as the resorption rate.
Correlation between Cell Proliferation with Cervical Lymphoid Node Status in Nasopharyngeal Carcinoma Patients Nugroho, Puguh Setyo; Yusuf, Muhtarum; Hidayati, Titiek Ahadiyah
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Several studies showed that the index of nasopharyngeal carcinoma (NPC) cell growth could be used to assess the carcinogenesis interaction factor, development and prognosis of NPC. Cell proliferation index could always be assessed with Ki-67 protein expression test. This research was conducted to study the correlation between cell proliferation index with cervical lymphoid node status in NPC in clinical manifestation to asses the progressivity and prognosis on NPC patients. This study used cross sectional design. Biopsy tissue specimen were acquired from 35 NPC patients clinically divided into four criteria of cervical lymphoid node status (N0, N1, N2 and N3). Expression of Ki-67 protein was acquired by immunohistochemistry test using monoclonal rabbit antibody anti-human Ki-67 clone 901-325-091911 (Biocare Medical, LCC. 4040 Pike Line, CA 94520 USA). The measurement of Ki-67 protein was conducted by pathology consultant. Spearman statistic test was performed to asses the correlation between Ki-67 protein expression and cervical lymphoid node status. The statistical significance was defined as p<0.05. Positive expression of Ki-67 protein was found in 33 patients; 4 patients with N0 (11.43%), 5 patients with N1 (14.29%), 9 patients with N2 (25.71%), and 15 patients with N3. Negative expression of Ki-67 protein was found in 2 patients with N0 (5.71%). The Spearman test resulted at p=0.0001 with correlation coefficient of 0.758. The correlation between Ki-67 protein expression with cervical lymphoid node resulted in a significant correlation (p<0.05). In conclusion, cell proliferation index has correlation with cervical lymphoid node status in NPC patients.
Body height estimation based on percutaneous foot length and breadth of javanese females Mochtar, Nur Mujaddidah; Gunawan, Ari; Artaria, Myrtati Dyah; Andajani, Susilowati
Folia Medica Indonesiana Vol. 53, No. 1
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Abstract

Body height estimation is one of important parameters used for establishing the individuality in cases of mutilated bodies or found body parts. It is not rare that in the cases of mutilation the police authority would only give the body parts or remaining skeletons of the victims. The aims of the study were to find body height estimation formula based on percutaneous of foot length and foot breadth in Javanese females at Surabaya Muhammadiyah University. The type of research design was cross-sectional observational study. Samples were Javanese females student at Muhammadiyah University of Surabaya , which was selected as the sample unit . The samples are in this study was Two-hundred and twenty-two people.The variabel independent of this research are foot length and foot breath, the variabel dependent is body height. Data were analyzed using normality test with Kolmogorov Smirnoff (a>0,05), Pearson correlation test (a<0,05) and linear regression test (a <0,05) to get body height estimation formula. The results of this study is, 1) A significant correlation between foot length and body height (r = 0,731), 2) A significant correlation between foot breadth and body height (r-0,323), 3) A significant correlation between foot length, foot breadth and body height (r=0,732), 4) The body height estimation formula based on foot length is 688,435 +3,745*foot length, 5) The body height estimation formula based on foot breadth is = 1273,002 + 2,942*foot breadth, and 6) The body height estimation formula based on foot length and foot breadth is 695,227 + 3,805*foot length – 0,229*foot breadth. As a conclusion of this study is the obtained estimation formula of body height based on foot length and foot breadth of Javanese females is 695,227 + 3,805*foot length – 0,229*foot breadth.
Isolation of streptomyces sp. From lapindo mud soil, sidoarjo, east java province, indonesia as a larvicide candidate against aedes aegypti Yotopranoto, Subagyo; Kurnijasanti, Rochmah; Rohmah, Etik Ainun
Folia Medica Indonesiana Vol. 53, No. 2
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Abstract

Streptomyces sp. is a bacterium that can live in many kind of habitations e.i. marine, sea sponge, coastal area, soil, desert soil, river bank etc. Many antibiotics and secondary metabolites are produced by this bacterium. Several secondary metabolites of the bacterium can be used as an insecticide against insects including mosquito larva.The purpose of this study was to search and isolate until species of Streptomyces sp. from Sidoarjo Lapindo mud soil in East Java province that can be used as a larvicide against Aedes aegypti larva, the dengue haemorrhagic fever vector.The method of study was to collect several mud soil samples from Sidoarjo Lapindo. The collected samples were cultured in ISP-4 media for producing mix-cultures. Then, to isolate the suspected colony of Streptomyces sp. by culturing again in several replications on ISP-4 media in petri-dish. The pure isolates were cultured in ISP-4 slant media. There were could be obtained eight pure isolates of Streptomyces sp.The characterization of 16S rRNA of Streptomyces sp. was done in order to determine the species. DNA isolation was done and followed by DNA sequencing, then compared to Gene Bank with BLAST program. The results showed that the sequence nucleotide bases of Streptomyces Sp-D6 had high similarity to Streptomyces sp. 171524, beside the sequence nucleotide bases of Streptomyces Sp-D7 and Sp-D9 had high similarity to Strepto-myces sp. ACT-01578 and ACT-175695. These three species can be used as larvicide candidate against Ae. aegypti.
Pci in patient with heavy calcified lesion. Management and balloon rupture complication Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 51, No. 4
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Abstract

Balloon angioplasty in calcified coronary lesions may have a decreased success rate and an increased incidence of complications. This lesion remain a technical challenge in interventional cardiology despite novel approaches and devices. We describe a case with heavy calcified coronary lesion in LAD that was not only resistant to high-pressure inflation of conventional, non-compliant balloons and cutting balloon but the inflations also results in balloon rupture. Even, the first balloon became fracture and entrapment in LAD. The fractured balloon could be removed using second baloon inflation in LCX. The angioplasty balloon was successfully performed after rotational atherectomy by rotablator and succesfully continued by implantation stent DES.
Case report: use of intra-aortic balloon pump (iabp) in high-risk percutaneous coronary intervention procedure Oktaviono, Yudi Her
Folia Medica Indonesiana Vol. 51, No. 3
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Abstract

Intra-aortic balloon pump (IABP) is often used in patients who undergo high risk percutaneous coronary intervention (PCI) procedures, particularly if associated with hemodynamic impairment. However, this device is still underused in this center. In this case report, a 65-year old male patient with triple vessel disease (chronic total occluded left anterior descending artery-LAD, and significant stenoses of left circumflex and right coronary arteries), low ejection fraction and preprocedure blood pressure, was reported to have IABP support applied before PCI. The intervention to penetrate the occluded LAD was not success. After procedure, the patient was observed in intensive care unit. Weaning of IABP was performed after about 30 hours usage, without complication.
Toxicity of 32.2 kDa MW Escherichia coli Pili Adhesin Isolated from Infertile Male Semen in Reproductive System Sukarjati, Sukarjati; Amilah, Susie; Sudjarwo, Sudjarwo
Folia Medica Indonesiana Vol. 54, No. 2
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Escherichia coli (E. coli) is the leading cause of male genital tract infection with no symptoms of infertility. Protein E. coli pili hemagglutinin isolated from infertile male sperm with 32.2 kDa MW acts as adhesion in spermatozoa. This study aimed to prove whether E. coli pili adhesin 32.2 kDa MW is toxic to male reproductive system. Samples consisted of spermatozoa of 30 guinea pigs divided into three groups: control, immunized with E. coli pili adhesin 32.2 kDa MW protein, and transurethral infected E. coli. Observations of sperm motility, vitality and morphology were performed under a microscope. MDA levels and sperm DNA damage were measured by a spectrophotometer and comet assay method and observed using a fluorescent microscope. There was no difference between control and immunization group of E. coli pili adhesin in motility (p=0.499), vitality (p=0.817) and morphology (p=0.176); between control and transuretral infection groups in motility (p=0.000), vitality (p=0.000) and morphology (p=0.000); and between control and both treatment groups in motility (p=0.001), vitality (p=0,000) and morphology (p=0.000). Histologic analysis showed E. coli pili adhesin of 32.2 kDa MW immunization group did not suffer from testicular tissue damage, while the positive group showed a deterioration of seminiferous tubular cells. MDA levels differed between immunization group E. coli pili, transurethral infection group, and control (p=0.024) and between transurethral and control (p=0.007) groups. However, between control and immunized group with E. coli pili protein showed no difference (p=0.251). DNA damage differed (p=0.000) between immunized group with E. coli pili, transurethral infection and control group; between control and transurethral infected group (p=0.000); and between transurethral infection group and E. coli pili protein immunization group (p=0.000). However, between control and E. coli pili immunization group showed no difference (p=0.600). In conclusion, E. coli pili adhesin 32.2 kDa MW protein is not toxic for sperm quality and the quality of sperm molecules.
Shoe insole for eccentric activities on daily application prevents muscular damage and improves fasting blood glucose Abdullah, Ahmad; Kusuma, Herdianty; Asnar, Elyana; Purwanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 4
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Abstract

The eccentric contraction has been proven to improve Glut-1 expression in muscle and fasting glucose levels in mice. The same eccentric contraction occurs in human being when walking or running while wearing high heels. Innovation on the eccentric contraction with high heels can be done by using a specific shoe insole. The design of the rear insole is made thicker than the front. The purpose of this study was to determine the effects of insole use specified for eccentric activities on daily work shoes on the skeletal muscle damage after wearing the specified insole. Skeletal muscle damage was measured based on sTnI level. This was experimental study with pretest-posttest design. The subjects involved were non-diabetic woman workers in Faculty of Medicine of Universitas Airlangga, and were divided into two groups. Each group represented group members who wore 5-degree and 10-degree insoles respectively. The angle used for the shoe insoles were 5° and 10° respectively. These insoles were worn on weekdays for one week. Blood was taken one day after the subjects stop wearing the insoles. Data results showed that the levels of fasting blood glucose (FBG) of subjects who wore the 10-degree insole had a value of p<0.05. The use of insole lead to decreased levels of fasting blood glucose (FBG). This study found that the sTnI levels in the 5-degree and 10-degree insole groups had no significant effect on troponin I skeletal muscle levels before and after treatment.

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