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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Kota surabaya,
Jawa timur
INDONESIA
Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Articles 571 Documents
Assessment of the Rapid Immunochromatographic Test as a Diagnostic Tool for Norovirus Related Diarrhea in Children Ranuh, Reza Gunadi; Athiyyah, Alpha Fardah; PA, Deanty Ayu; Darma, Andy; Raharjo, Dadik; Shirakawa, Toshiro; Sudarmo, Subijanto Marto
Folia Medica Indonesiana Vol. 55, No. 1
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Abstract

In developing countries, Norovirus is the second-leading cause of acute diarrhea, after rotavirus. The approved gold standard method for diagnosis of norovirus infection is RT-PCR. The rapid immunochromatographic test is a novel and expedient method for diagnosing norovirus that is relatively affordable. However, the use of the rapid immunochromatographic test remains controversial because of its accuracy. This study aimed to explore whether the rapid immunochromatographic test could be used for diagnosing norovirus-related diarrhea in children. Rapid immunochromatographic test (QuickNaviTM-Norovirus2) and RT-PCR on stool samples was used to diagnose norovirus. Stool samples were obtained from pediatric patients aged between 1 and 60 months who had diarrhea and were admitted to the pediatric ward at Dr. Soetomo General Hospital Surabaya, between April 2013 and March 2014. Ninety-four subjects provided stool samples that were tested using QuickNaviTM-Noro2 and RT-PCR. Using the test, 64 samples tested positive for norovirus and 30 tested negatives. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the rapid immunochromatographic test were consecutively 90.3%, 42.9%, 43.8%, 90%, and 58.5%. RT-PCR was used to test all samples to assess the accuracy, which showed that one from 31 samples contained the GI strain (1.1%), while 30 samples (32%) contained the GII strain. This study definitively establishes that the rapid immunochromatography test is not sufficiently accurate for use as a screening or diagnostic tool in norovirus-related diarrhea cases in children.
Effect of Different Complementary Feeding on Iron Deficiency Anemia and Growth in Breastfed Infants: Home-Made VS Commercial Irawan, Roedi; Widjaja, Nur Aisiyah; Hanindita, Meta Herdiana
Folia Medica Indonesiana Vol. 55, No. 2
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Abstract

After approximately 6 months of age, term breastfed infants are increasingly depend on other sources of iron to avoid iron deficiency anemia, due to the depletion of the low concentration of iron in human milk. The appropriate complementary feeding must include a balance composition of foods containing an adequate amount of macro- and micronutrients to avoid iron deficiency anemia. This study aimed to compare the risk of iron deficiency and growth in breastfeed infants receiving commercial fortified complementary foods or home-made. A cross-sectional study was held on April-June 2016 to evaluate infants aged 6-24 months with breast feeding intake for 6 month of life. Complementary feeding practices were determined by questionnaire; an unquantified food frequency and feeding practices questionnaire was used to determine usual food intake. Biochemical assessment of haemoglobin (Hb), serum ferritin (SF) and serum iron (SI) level were measured. Anthropometric were assessed using WHO Child Growth Standard 2005. Statistical analysis used were Chi-square Test. Thirty eight infants were enrolled, mean age of 16.2 (SD 10.5) months. 17 infants consumed commercial complementary foods and 21 infants use home-made. Infants with home-made had lower Hb level, SF and SI than those receiving commercial complementary food, and had higher risk of underweight, stunted and wasted. Infants with home-made complementary food had lower haemoglobin, serum feritin and serum iron levels than those in fortified complementary food CF; and a higher risk of stunted and wasted than children with commercial fortified CF.
Transnasal Esophagoscopy Examination in Outpatient Unit, Department of Otorhinolaryngology Head and Neck Surgery, Dr. Soetomo Hospital, Surabaya Perdana, Rizka Fathoni
Folia Medica Indonesiana Vol. 56, No. 1
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Abstract

Esophagoscopy is the standard examination standard for evaluation, diagnosis, screening and surveillance of esophageal diseases. Although it is often done, esophagoscopy costs a lot, is inconvenient, and risks complications, including cardiopulmonary complications because patients usually require routine sedation in the implementation of conventional esophagoscopic procedures. The purpose of this study is to get an overview of the results of the implementation of transnasal esophagoscopy in Department of Otorhinolaryngology Head and Neck Surgery, Division of Broncho-oesophagology, Dr. Soetomo Hospital, Surabaya, between 1 September 2012 and 30 April 2015. This study was a retrospective descriptive study with a population of all patients undergoing esophagoscopic examinations during this period. Data is taken from medical records of new patients undergoing transnasal esophagoscopy. Inclusion criteria were all patients who had been tested for transnasal esophagoscopy, and exclusion criteria were incomplete medical record data. There were 35 patients who underwent transnasal esophagoscopy examination at Department of Otorhinolaryngology Head and Neck Surgery, Division of Broncho-oesophagology, Dr. Soetomo Hospital, Surabayaduring the study period. The mean of patients who participated in the study was 54.17 ± 14.02. 23 male patients (63.89%), while 12 female patients or 34.11%. Indications of dysfagi are found in all age groups, most in the age group 51-70 years. Metastases in head and neck malignancies are found in the age group 31 - 50 years and 51 - 70 years. Indications for heartburn are found in the age group 21-50 years and 51-70 years. In conclusion, the results of transnasal esophagoscopic examination showed that most patients had a normal picture (60%) and a positive picture with an esophageal abnormality of 40%. The most common features are lesions in the mucosal esophagus lumen, scar, masses and stenosis.
Development of Discharge Planning for Stroke Patients Rosadi, Muhammad Imron; Arofiati, Fitri
Folia Medica Indonesiana Vol. 59, No. 4
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Abstract

Highlights: 1. Given the frequent long-term complications of stroke, this study identified the ideal approach to discharge planning to improve the quality of life of patients and hospital care. 2. This study provides evidence supporting the effectiveness of a conventional discharge planning approach that incorporates specific educational intervention with interactive learning through audiovisual media. 3. The approaches presented in this study may offer valuable perspectives on enhancing health service provisions, particularly regarding the discharge planning process for nurses. Abstract The quality improvement of discharge planning is essential throughout the development of discharge planning, which guarantees a seamless transition of care for stroke patients and family preparedness. This systematic review aimed to analyze the development of discharge planning and its impact on stroke patients and their families. The research was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible pieces of literature were compiled from seven electronic databases, i.e., ScienceDirect, Scopus, PubMed, EBSCOhost, ProQuest, SAGE Journals, and Google Scholar. The literature search was performed using predetermined search terms, with specific criteria that included papers exclusively published in English and studies conducted in 2018–2022. The development of discharge planning showed a significant impact on stroke patients, as it could influence various aspects of their quality of life. This included improvements in physiological function, enhanced cognitive knowledge, increased satisfaction and self-efficacy, reduced stress levels and care burden, and the opportunity for families to adequately prepare for home-based patient care. This study concluded that integrating conventional with technology-based media is effective for developing discharge plans for stroke patients. The implementation of this novel approach in a health system can improve patient outcomes, family preparedness when providing care, and the quality of hospital care.
Knowledge and Attitude Have No Correlation with Implementation of Breast Self Examination (BSE) Winardi, Baksono; Novianty, Arini
Folia Medica Indonesiana Vol. 54, No. 3
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Abstract

This study aimed to know the existence of relationship between knowledge, attitude and implementation of BSE among midwifery students and mathematics students of Universitas Airlangga. This study used analytic observational method with cross-sectional approach. The sampling technique was the proportional sampling, consisting of 30 students of midwifery and 30 mathematics students. Analysis used was univariat and bivariat analysis with Spearman Rank. The significance level was 0.05 (5%). This study showed that 90% of midwifery students had good knowledge of BSE, 66.7% had sufficient attitude and 46.7% performed BSE in sufficient category. As many as 66.7% students of mathematics had sufficient knowledge about BSE, 63.4% had sufficient attitude and as many as 60% performed the BSE in the less category. The statistical test revealed p value = 0.267 for midwife respondents and 0.467 for mathematics respondents. Statistical test on the relationship between BSE attitude and implementation had p=0.100 for midwifery students and 0.407 for mathematics students. As a conclusion, there was no relationship of knowledge, attitude and implementation of BSE in the students of midwife and students of mathematics.
The Histopathological Features of Syphilis and Its Mimickers Purnamasari, Indah; Hidayati, Afif Nurul; Kusumastuti, Etty Hary; Effendy, Isaak
Folia Medica Indonesiana Vol. 59, No. 1
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Abstract

Highlights: • The importance of having a strong suspicion for syphilis and maintaining close contact between dermatologists and pathologists cannot be understated. • Understanding the clinical relationship and histopathological features of syphilis is crucial for accurate diagnosis and distinction from its histopathologic mimickers. Abstract: Settings Syphilis, also known as "the great imitator," is a sexually transmitted infection with a variety of clinical symptoms and histopathological similarities to other infectious diseases. Public health concerns about syphilis have grown significantly. Since 2000, there has been an increase in syphilis prevalence in the United States, with a 17.6% increase from 2015 to 2016. From 2000 to 2019, the number of syphilis cases throughout Asia increased from 0.9% to 30.9%, whilst the number of cases in Indonesia decreased from 22.5% to 14.4%. Specific serological tests for syphilis can usually detect and confirm the diagnosis and offer follow-up care in most cases. However, in certain instances, the clinical characteristics discovered during testing can be identical to those of other diseases, which may lead to inconsistent diagnosis. Considering that the diagnostic pathology is pertinent to the clinical circumstances, a histopathological investigation may be useful for differentiating syphilis mimickers. Pathology is essential for identifying potential syphilis patients with ambiguous clinical symptoms. This study's purpose was to assist dermatologists and pathologists in identifying "mimickers" that require a biopsy and in determining the correct diagnosis and treatment coutsed based on etiology.
Thiamine supplement therapy improves ejection fraction value in stage ii heart failure patients Jikrona, Rafi; Suharjono, Suharjono; Ahmad, Abraham
Folia Medica Indonesiana Vol. 53, No. 2
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Abstract

Thiamine, also called vitamin B1, is a water soluble vitamin that is involved in the formation of ATP in cells. The active metabolite of thiamine is a co-enzyme thiamine pyrophosphate (TPP) that plays an active role in carbohydrate metabolism and the formation of amino acid binding conjugates. Directly, thiamine may increase energy production in heart muscle cells through such mechanism, whereas in conditions of heart failure, a decrease in the contractility of heart muscle may be found. Therefore, thiamine supplementation is needed in stage II heart failure patients due to long-term use of furosemide that triggers the thiamine deficiency condition. Thiamine supplementation here is enabled to increase heart cells contractility which may ultimately increase the ejection fraction value of the heart muscle as a parameter of heart work efficiency measurement. The objective of this study was to evaluate the effect of thiamine administration as a therapeutic supplement in stage II of heart failure patients on the ejection fraction rate changes in pre and post thiamine supplement therapy for 28 days. The study was conducted using Cross Sectional Prospective Observational Analysis method between April and August 2016 in male patients with NYHA II heart failure who received furosemide therapy meeting the inclusion criteria at Heart Clinic Jemursari Islamic Hospital, Surabaya. Patients who fulfilled the inclusion and exclusion criteria in this study were 32 patients, 16 control patients and 16 treatment group patients between the ages of 35-75 years. During this study, after supplementation of thiamine 300 mg/day, 16 patients in the treatment group experienced an increase in ejection fraction rate (13.5%). The result of paired t test p=0.000 (p<α; α=0,05) showed significant difference between ejection fraction rate of pre and post thiamin supplementation. This study concluded that thiamine supplement therapy of 300 mg/day could increase the ejection fraction rate in patients of stage II heart failure.
The use of hydroxyethyl starch 200/0,5 as plasma subtitutes is safe in hypovolemic patients as indicated in changes of n-acetyl--glucosaminidase and creatinin serum parameters Shinta, Dewi Wara; Khotib, Junaidi; Rahardjo, Eddy; Rahmadi, Mahardian; Suprapti, Budi
Folia Medica Indonesiana Vol. 51, No. 4
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Abstract

Hydroxyethyl Starch (HES) is a compound that improves intravascular volume effectively and rapidly without causing tissue edema. However, HES also has renal safety profile which is still being debated. Based on clinical experience in Dr. Soetomo Hospital, the frequency of acute renal failure following HES 200/0.5 administration at a dose of less than 20 ml/kg (maximum dose) is very rare. The purpose of this study was to evaluate the effect of HES 200/0.5 at a dose of less than 20 ml/kg in patients undergoing surgery. N-acetyl-b-D-Glucosaminidase (NAG) per urine creatinine ratio and creatinine serum were used as main parameter to assess renal injury. This research was observational and prospective design in patients undergoing elective surgery at Gedung Bedah Pusat Terpadu, Dr. Soetomo Hospital, who requiring resuscitation therapy with HES 200/0.5 and met the inclusion and exclusion criteria. NAG was measured prior to surgery and 12 hours after administration of fluid therapy, while creatinine serum was observed before surgery and 48 hours after resuscitation. This study was conducted for three months, and obtained 50 subjects divided into 2 groups, crystalloid group and HES 200/0.5 group. Demographic and baseline characteristics did not differ between groups, except the total bleeding volume. Total bleeding in HES 200/0.5group was higher than crystalloid group (p <0.0001). The mean volume of fluid received in HES 200/0.5 group was 2042.0 ± 673.9 mL, higher when compared with that of crystalloid group (910.0 ± 592.0 ml). Doses of HES 200/0.5 received was 8.31 ± 4.86 ml/kg. Measurement of the of NAG/creatinine ratio and creatinine serum showed significant increase in both groups, but still within the normal range. In addition, the value of these two parameters did not differ between groups. In conclusion, HES 200/0.5 in a dose of less than 20 ml/kg is safe to use in patients who suffered from hypovolemic hemorrhage, without prior history of renal impairment.
Modified vac dressing in sternal wound infection management. Cheap and feasible technique in developing country Sembiring, Yan Efrata
Folia Medica Indonesiana Vol. 52, No. 3
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Abstract

Sternal wound infection is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. However, the VAC therapy system is expensive, requires extensive amounts of product and needs a power source at all times. Modified VAC dressing to treat sternal wound infection is cheap and feasible technique to use in develop country. This technique can be use as an alternative to the original vacuum-assisted closure and hadshown to serve its function in providing adequatevacuum pressure for wounds.
Epidemiology of fractures and dislocations in children Nugraha, Hans Kristian; Adiantono, Agus
Folia Medica Indonesiana Vol. 53, No. 1
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Abstract

Fracture is quite a common occurrence in the age group of children, with a fairly wide variety of epidemiology throughout the world, hence it could be considered as a major health problem. A retrospective study of all pediatric fractures presenting to Dr. Soegiri General Hospital Lamongan, Indonesiain 2015 was undertaken. It showed that 79.5% of children's fractures occurred in males and that 86.76% presented as a single fracture, whileelbow dislocation is the most prevalent dislocation in this study.Analysis of pediatric fractures shows that there is a trimodal distribution of single fracture with age, withdistal radius/ulna fracture as the most prevalent single fracture.The commonest cause of single fracture are road traffic accident, and the majority involve the upper limb. Those suggested that there should be more concern about road safety program in Indonesia.