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Journal of Pharmascience
Published by Universitas Lambung Mangkurat
ISSN : 23555386     EISSN : 24609560     DOI : https://doi.org/10.20527/jps.v13i1
Core Subject :
ournal of Pharmascience accepts scientific articles as original reasearch articles and review articles on pharmacy and health. Journal of Pharmascience publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Clinical Pharmacy Community Pharmacy Pharmacology Natural Pharmacy Pharmaceutical Chemistry Pharmaceutical Technology Pharmaceutical Management Pharmaceutical Education Apart from the topics above, the Journal of Pharmascience also accepts other manuscripts in the health field, such as: Validation and development of analytical methods for a variety of samples, including food Implementation and analysis of a variety of surveys related to medical therapy, disease, health procedures, and other aspects of health
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Articles 362 Documents
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Uji Aktivitas Antioksidan Ekstrak Etanol dan Fraksi N-Heksan Kulit Buah Naga Merah (Hylocereus polyrhizus) Sri Wahdaningsih
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13135

Abstract

Antioksidan merupakan suatu senyawa atau zat yang mampu memperlambat, menunda, ataupun mencegah terjadinya proses reaksi radikal bebas dalam oksidasi lipid. Kulit buah naga merah memiliki manfaat sebagai sumber antioksidan dikarenakan kaya akan kandungan senyawa polifenol. Kulit buah naga juga mengandung alkaloid, terpenoid, flavonoid, fenolik, tiamin, niasin, piridoksin, kobalamin, karoten, fitoalbumin, vitamin A, vitamin C, dan vitamin E yang bermanfaat sebagai antioksidan. Penelitian bertujuan untuk mengetahui bagaimana nilai IC50 dari ekstrak etanol dan fraksi n-heksan kulit buah naga merah yang berpotensi memiliki aktivitas antioksidan. Metode yang digunakan untuk menguji aktivitas antioksidan pada ekstrak etanol dan fraksi n-heksan kulit buah naga merah adalah dengan DPPH. Hasil yang diperoleh yaitu nilai IC50 dari ekstrak etanol kulit buah naga merah 2.060 μg/ml, fraksi N-Heksan 4.012 μg/ml, dan vitamin C sebagai kontrol positif memiliki nilai IC50 sebesar 1,905 μg/ml. Aktivitas antioksidan dari ekstrak etanol dan fraksi N-Heksan lebih rendah dibandingkan vitamin C. Kata Kunci: DPPH, IC50, Vitamin C, Antioksidan  Antioxidants are compounds or substances that can slow down, delay, or prevent the occurrence of free radical reactions in lipid oxidation. Red dragon fruit peel is useful as a source of antioxidants because it is rich in polyphenolic compounds. Dragon fruit skin also contains alkaloids, terpenoids, flavonoids, phenolics, thiamine, niacin, pyridoxine, cobalamin, carotene, phytoalbumin, vitamin A, vitamin C, and vitamin E which are useful as antioxidants. This study aimed to determine the IC50 value of the ethanolic extract and the n-hexane fraction of red dragon fruit peel which is thought to have antioxidant activity. The method used to test the antioxidant activity of the ethanol extract and the n-hexane fraction of red dragon fruit peel was DPPH. The results obtained were the IC50 value of the ethanolic extract of red dragon fruit peel 2.060 μg/ml, the N-Hexan fraction was 4.012 μg/ml, and vitamin C as a positive control had an IC 50 value of 1,905 μg/ml. The antioxidant activity of the ethanol extract and N-Hexane fraction was lower than that of vitamin C.
Review: Kandungan Kimia Jahe Merah (Zingiber officinale var. Rubrum) dan Pembuktian In Silico sebagai Inhibitor SARS-CoV-2 Putri Natasya Br Siregar; Katrina Imaculata Tema Pedha; Katharina Floransia Walburga Resmianto; Noviayanti Chandra; Vinsensia Nalita Maharani; Florentinus Dika Octa Riswanto
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13149

Abstract

Pada akhir tahun 2019, dunia dilanda wabah COVID-19. Penyakit yang disebabkan oleh virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) yang dapat menular secara cepat melalui droplet pada saat seseorang batuk, bersin, bahkan saat berbicara. Penyebaran virus ini dapat dicegah dengan meningkatkan sistem imun tubuh. Jahe merah merupakan salah satu tanaman yang mengandung banyak senyawa kimia yang dapat menjadi imunomodulator bagi tubuh. Jumlah senyawa minyak atsiri, gingerol, dan diarilheptanoid yang terkandung dalam jahe merah secara berturut-turut sebanyak 194, 85, dan 28 jenis. Studi in silico dapat digunakan untuk memprediksi potensi dari jahe merah sebagai imunomodulator. Metode ini terbukti dapat menganalisis senyawa yang memiliki potensi klinis dalam periode yang singkat dan biaya yang murah. Dari hasil penelusuran beberapa penelitian dengan pendekatan in silico, diperoleh hasil bahwa senyawa kimia dalam jahe merah memiliki aktivitas inhibitor SARS-CoV-2 diantaranya adalah cyanin, gingeronone A, dan quercetin. Kata Kunci: Jahe Merah, SARS-CoV-2, Immunomodulator, In Silico, Molecular Docking   At the end of 2019, the world was hit by the COVID-19 outbreak. A disease caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus which can be transmitted quickly through droplets when a person coughs, sneezes, or even talks. The spread of this virus can be prevented by increasing the body's immune system. Red ginger is a plant that contains many chemical compounds that can be an immunomodulator for the body. The number of volatile oil compounds, gingerols, and diarylheptanoids contained in red ginger were 194, 85, and 28 types, respectively. In silico studies can be applied to predict the potential of red ginger as immunomodulator. This method is proven to be able to analyze compounds that have clinical potential in a short period and low cost. It was found that cyanin, gingeronone A, and quercetin were potential compounds in the red ginger with SARS-CoV-2 inhibitory according to several reports using in silico approach. 
Aktivitas Renoprotektif Daun Kelor (Moringa oleifera Lamk) pada Tikus Model Diabetes Mellitus Tipe 2 Miranda Dewi; Suryono Suryono; Pipiet Wulandari
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13188

Abstract

Indonesia negara dengan kekayaan alam yang dapat dimanfaatkan sebagai bahan pangan, papan dan kesehatan. Daun kelor merupakan bagian dari sumber kekayaan alam Indonesia. Daun kelor memiliki senyawa aktif flavonoid yang memiliki khasiat antioksidan sehingga dapat membantu menurunkan stress oksidatif pada multiorgan akibat hiperglikemia, misalnya pada ginjal. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak daun kelor (Moringa oleifera Lamk.) terhadap kadar serum kreatinin tikus Wistar jantan yang diinduksi streptozotosin. Penelitian ini merupakan penelitian true experimental design dengan rancangan post test only control group design. Penelitian ini menggunakan 28 ekor tikus Wistar jantan (Rattus novergicus) sebagai populasi dengan berat 200-300 gram yang dibagi menjadi 7 kelompok melalui metode simple random sampling. Pemberian dosis ekstrak daun kelor dibagi menjadi 5 kelompok yaitu dengan dosis 62,5 kgBB, 125, 250, 500, dan 1000 mg/kgBB. Analisis data yang digunakan adalah uji korelasi Spearman. Pada penelitian ini menunjukkan p< 0,001 yang dapat disimpulkan bahwa adanya korelasi yang signifikan antara dosis ekstrak daun kelor dan kadar serum kreatinin. Kata Kunci: Daun Kelor, Streptozotosin, Hiperglikemik Indonesia is a country with natural resources that can be used as food, basic necessities and health. Moringa leaves are part of Indonesia's natural resources. Moringa leaves have flavonoid active compounds that have antioxidant properties so that they can help reduce oxidative stress in multiple organs due to hyperglycemia, for example in the kidneys. The purpose of this study was to determine the effect of giving moringa leaf extract (Moringa oleifera Lamk) on serum creatinine levels of male Wistar rats induced by streptozotocin. This research is a true experimental design with a post test only control group design. This study used 28 male Wistar rats (Rattus novergicus) as a population weighing 200-300 grams which were divided into 7 groups through simple random sampling method. The doses of moringa leaf extract were divided into 5 groupsdoses of 62.5, 125, 250, 500 and 1000 mg/kgBW. Analysis of the data used was the Spearman correlation test (p < 0.001) which could be concluded that the correlation between the dose of moringa leaf extract and serum creatinine levels had a significant effect.
Essential Oil and Ethanolic Extract of Curcuma Inhibits Mammae Tumors in Rats Induction by DMBA Akhmad Endang Zainal Hasan; Ekowati Handharyani; Sri Wahyuni
Journal of Pharmascience Vol. 9 No. 1 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.13215

Abstract

Curcuminoids and xanthorizol are active components that may act as anticancer in the rhizome of Curcuma xanthorrhiza. The purpose of this study was to determine the content of the class of compounds in curcuma extract and essential oil using the phytochemical screening test method, the Folin-Ciocalteu method to determine the total phenolic content and the AlCl3 method for the total fentuconoid content. In addition, the activity of curcuma in inhibiting the influence of DMBA on the growth of breast cancer in rats was determined. Curcuma extract used is the result of extraction using 70% ethanol on an industrial scale. Total phenolic content and flavonoid extract of curcuma were determined by spectrophotometer. Inhibition testing of tumors formed due to DMBA induction was carried out by administering temulawak extract at doses of 35, 70, 140, 210 and 280 mg/kg body weight. Based on the phytochemical analysis, the ethanol extract of curcuma contained terpenoids, alkaloids, phenolic compounds and flavonoids. The results of the analysis of the ethanol extract of curcuma contained total phenols and flavonoids with concentrations of 42.96 mg GAE/g and 3.96 mg QE/g, respectively. The group that was given curcuma extract as the control group (p<0.05) had a significant difference. Based on the Mann-Whitney analysis, the third group with a dose of 140 mg/kg BW had the highest effect on tumor inhibition. The hope is that the development of curcuma extract into a standardized herbal medicine so that it can be used for the treatment of breast cancer can use the results of this research.
Formulasi Gel Ekstrak Daun Sosor Bebek (Kalanchoe pinnata (Lam.) Per.) dengan Kombinasi Carbophol 980 dan Cremophor RH 40 Kartiningsih Kartiningsih; Rika Damayanti; Anarisa Budiati
Journal of Pharmascience Vol. 10 No. 1 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13272

Abstract

Daun sosor bebek (Kalanchoe pinnata P.) merupakan tanaman obat yang diketahui memiliki aktivitas antiseptik. Tujuan dari penelitian ini untuk melihat pengaruh konsentrasi Carbophol 980 dan Cremophor RH 40 terhadap mutu fisik dan pH sediaan gel ekstrak kental daun sosor bebek yang dianalisa dengan metode ANOVA satu arah. Daun sosor bebek diekstrasi dengan metode maserasi menggunakan etanol 96%, kemudian diformulasikan menjadi sediaan gel dengan kombinasi Carbophol 980 sebagai gelling agent dan Cremophor RH 40 sebagai wetting agent. Sediaan gel dibuat 8 formula dengan variasi konsentrasi Carbophol 980 0,5% dan 1,0%, dan Cremophor RH 40 0,5%; 1,0%; 1,5%; dan 2.,%. Sediaan gel yang diperoleh dilakukan evaluasi meliputi pemeriksaan organoleptik, homogenitas, viskositas dan sifat alir, kemampuan menyebar, dan pH. Sediaan gel yang diperoleh berwarna coklat, berbau parfum, dan jernih, viskositas pada rpm 0,5 berkisar 430,67–1015, 33 dPa.s, sifat alir plastis, kemampuan menyebar 2491,20–2111,77 mm2, pH 5,0–5,6. Hasil uji statistic menggunakan ANOVA satu arah dengan α 5%, didapat bahwa variasi konsentrasi Carbophol 980 dan Cremophor RH 40 memberikan perbedaan yang bermakna terhadap viskositas, kemampuan menyebar, dan pH. Berdasarkan hasil evaluasi didapatkan formula 5 yang menggunakan Carbophol 980 dan Cremophor RH 40 pada konsentrasi 0,5% sebagai formula terbaik.       Kata Kunci: Variasi onsentrasi, Carbophol 980, Cremophor RH 40, Gel, Ekstrak Daun Sosor Bebek  Duck bill leaf (Kalanchoe pinnata P.) is a medicinal plant known to have antiseptic activity. The purpose of this study was to examine the effect of the concentration of Carbophol 980 and Cremophor RH 40 on the physical quality and pH of the thick extract gel preparations of duck bill of leaf extract which was analyzed by one way ANOVA method. Duck bill leaves were extracted by maceration method using 96% ethanol, then formulated into a gel preparation with a combination of Carbophol 980 as a gelling agent and Cremophor Rh 40 as a wetting agent. The gel preparations were made of 8 formulas with various concentrations of Carbophol 980 0.5% and 1.0%, and Cremophor RH 40 0.5%, 1.0%, 1.5%, and 2.0%. The obtained gel preparations were evaluated including organoleptic examination, homogeneity, viscosity and flowability, dispersibility, and pH. The gel preparation obtained was brown in color, smelled of perfume, and was clear, viscosity at rpm 0.5 ranged from 430.67–1015, 33 dPa.s, plastic flowability, dispersibility 2491.20–2111.77 mm2, pH 5.0–5.6. The results of statistical tests using one-way ANOVA with 5%, it was found that variations in the concentration of Carbophol 980 and Cremophor RH 40 gave significant differences in viscosity, dispersibility, and pH. Based on the evaluation results obtained formula 5 which uses Carbophol 980 and Cremophor RH 40 at a concentration of 0.5% as the best formula.
Efek Afrodisiaka dari Ekstrak Batang Bajakah Kalalawit (Uncaria gambir Roxb.) terhadap Tikus Jantan Galur Wistar (Rattus novergicus) Rollando Rollando; Arum Ardanareswari; FX Haryanto Susanto; Eva Monica
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13289

Abstract

Bajakah kalalawit (BK) secara empiris digunakan sebagai obat tradisional untuk meningkatkan daya tahan seksual. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak dari batang BK terhadap aktivitas seksual tikus putih (Rattus norvegicus) jantan dengan parameter pendekatan, menunggang, dan kawin. Desain penelitian yaitu rancangan acak lengkap dengan 5 perlakuan dan induksi selama 3 hari. Batang BK dimaserasi dengan etanol 96%. Kontrol negatif diinduksi dengan CMC-Na 0,5% dan kontrol positif diinduksi dengan sildenafil sitrat pada dosis 10 mg/KgBB. P1, P2, dan P3 masing-masing diinduksi ekstrak batang BK pada dosis 150 mg/KgBB, 200 mg/KgBB, dan 250 mg/KgBB/hari. Aktivitas pendekatan, menunggang, dan kawin pada hewan uji yang telah diinduksi diamati menggunakan libidometer. Hasil penelitian menunjukkan bahwa pemberian ekstrak batang BK dapat meningkatkan aktivitas seksual tikus putih jantan pada dosis 150 mg/KgBB/hari jika dibandingkan dengan kelompok kontrol dan kelompok perlakuan yang lain. Kata Kunci: Uncaria gambir Roxb, Tikus Jantan, Afrodisiaka, Libidometer Bajakah kalalawit (BK) is empirically used as a traditional medicine to increase sexual endurance. This study aimed to analyze the effect of administration of BK stem extract on the sexual activity of white male rats (Rattus norvegicus) with the parameters of introduction, climbing, and coitus. The research design was a Completely Randomized Design with five treatments and three days of induction. BK stems were macerated with 96% ethanol. Negative control was induced with 0.5% CMC-Na and positive control was induced with sildenafil citrate at 10 mg/kg BW. P1, P2, and P3 were induced by BK stem extract at dose of 150 mg/kg BW/day, 200 mg/kg BW/day, and 250 mg/kg BW/day, respectively. Introduction, climbing and coitus activities in the induced test of male rats were observed using libidometer. The results showed that the induction of BK stem extract could increase the sexual activity of male rats at dose of 150 mg/kg BW/day compared to the control group and other treatment groups. 
Pengaruh Konsentrasi Ekstrak Metanol Biji Pepaya (Carica papaya) Terhadap Aktivitas Antioksidan dalam Sediaan Masker Gel Peel-Off Nita Safitri; Dina Rahmawanty; Destria Indah Sari
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13296

Abstract

Ekstrak metanol biji C. papaya memiliki aktivitas antioksidan dengan nilai IC50 sebesar 53,41 ppm. Antioksidan dapat menghambat radikal bebas sehingga dapat diolah menjadi sediaan kosmetik masker gel peel-off. Penelitian ini bertujuan untuk menentukan nilai IC50  pada sediaan masker gel peel-off ekstrak metanol biji C. papayadan menentukan pengaruh konsentrasi ekstrak metanol biji C. papaya terhadap aktivitas antioksidan dalam sediaan masker gel peel-offmenggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil). Sampel pembanding asam askorbat dan masker gel peel-off dengan variasi konsentrasi ekstrak sebesar 0,25% (F1); 0,5% (F2) dan 1% (F3). Formulasi masker gel peel-off menggunakan PVA dan HPMC sebagai gelling agent, metil paraben dan propil paraben sebagai pengawet, gliserin sebagai humektan dan aquadest sebagai pelarut. Nilai IC50 asam askorbat yaitu 7,304±0,2208 ppm. Nilai IC50  masker gel peel-off yaitu 273,226±0,0432 ppm (F1); 266,127±0,0600 ppm (F2); dan 198,049±0,0726 ppm (F3). Analisis data menunjukkan bahwa variasi konsentrasi ekstrak metanol biji C. papaya berpengaruh secara signifikan terhadap aktivitas antioksidan masker gel peel-off. Kata Kunci : Antioksidan, DPPH, Ekstrak Metanol Biji Pepaya, Masker Gel Peel-Off  The antioxidant activity of methanol extract of C. papaya seeds has the IC50 value of 53.41 ppm. Antioxidants can inhibit free radicals therefore they can be processed into cosmetic preparations peel-off gel masks. This study aims to determine IC50  value of peel-off gel mask preparation of extracted C. papaya seeds and to determine effect of methanol extract concentration of C. papaya seeds on the antioxidant activity on peel-off gel mask preparation using DPPH method (2,2-diphenyl-1-picrylhydrazyl). The comparison samples were ascorbic acid and peel-off gel mask with the extract concentrations variety of 0.25% (F1); 0.5% (F2) and 1% (F3). The peel-off gel mask formulation used PVA and HPMC as the gelling agents, methyl paraben and propyl paraben as the preservatives, glycerin as the humectant and aquadest as the solvent. The result showed the IC50 ascorbic acid value as 7.304±0.2208 ppm and IC50 peel-off gel mask value as 273.226±0.0432 ppm (F1); 266.127±0.0600 ppm (F2); and 198.049±0.0726 ppm (F3). Data analysis showed that the concentration variety of C. papaya seeds methanol extract caused a significant effect on the antioxidant activity of peel-off gel masks.
Hasil Uji Toksisitas Subkronis Temulawak Terhadap Nilai Hemoglobin, Hematokrit, dan Leukosit Tikus Akhmad Endang Zainal Hasan; Husnawati Husnawati; Siti Wachidatun Zulaikha
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13374

Abstract

Herbal yang berperan sebagai antioksidan dan antikanker diantaranya temulawak. Penelitian pengaruh ekstrak temulawak terhadap hematologi tikus pada pengujian keamanan subkronis dilakukan pada penelitian ini.  Parameter hematologi yang ditentukan adalah nilai hemoglobin, hematokrit, dan jumlah leukosit. Hewan coba yang digunakan adalah tikus jantan dan betina dari galur Sprague Dawley. Herbal yang diberikan sebagai pengobatan adalah ekstrak etanol 70% temulawak yang diberikan sebanyak 5 hari dalam seminggu selama 28 hari dengan dosis bertingkat mulai dari 45 mg/Kg BB hingga 5.625 mg/kg BB. Hasil yang diperoleh adalah perlakuan terakhir tidak ada tikus yang mati. Berdasarkan pengukuran diperoleh nilai hemoglobin antara 12,57-17,97 g/dL, nilai hematokrit antara 31,77-51,57%, dan jumlah leukosit antara 5,01-23.22x103 sel/μL (normal). Kesimpulan dari penelitian ini adalah bahwa dosis lebih besar dari 5625 mg/kg BB merupakan nilai LD50 untuk ekstrak etanol 70% temulawak. Pemberian ekstrak etanol 70% temulawak hingga dosis 5.625 mg/kg BB selama 28 hari pada tikus jantan dan betina memberikan efek penurunan terhadap nilai hemoglobin, hematokrit, dan leukosit, namun nilainya masih dalam batas normal. Tidak ada perbedaan nyata antara tikus jantan dan betina pada hasil pengukuran nilai hemoglobin, hematokrit, dan leukosit. Kata Kunci: Dosis, Hematologi, Subkronis, Temulawak, Tikus  Herbs that act as antioxidants and anticancer include temulawak. Research on the effect of temulawak extract on rat hematology in subchronic safety testing was carried out in this study. The determined hematological parameters were the value of hemoglobin, hematocrit and the number of leukocytes. The experimental animals used were male and female rats from the Sprague Dawley strain. The herbs given as treatment were an ethanolic extract of 70% temulawak which was given 5 days a week for 28 days with a graduated dose ranging from 45 mg/Kg BW to 5625 mg/kg BW. The results obtained are the last treatment no rat died. Based on the measurement of hemoglobin values obtained between 12.57 to 17.97 g/dL, hematocrit values obtained between 31.77 to 51.57% and leukocyte counts obtained between 5.01 to 23.22x103 cells/μL were still in the normal range. The conclusion of this study is that a dose greater than 5,625 mg/kg BW is the LD50 value for the ethanol extract of 70% temulawak. Giving 70% ethanol extract of temulawak until a dose of 5,625 mg/kg BW for 28 days to male and female rats had a decreasing effect on hemoglobin, hematocrit, and leukocyte values, but the values were still within normal limits. There is no significant difference between male and female rats in the measurement results of hemoglobin, hematocrit, and leukocyte values. 
TATALAKASANA TERKINI HIPERTENSI PULMONER PADA ANAK Dyahris Koentartiwi; Ardhanis Ramadhanti; Ervan Aditya Putra Chafid
Journal of Pharmascience Vol. 10 No. 2 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.13407

Abstract

Hipertensi pulmoner (HP) merupakan suatu kondisi dimana terjadi peningkatan tekanan vaskular paru yang berkaitan dengan berbagai etiologi. Pada anak, sekitar 50% HP seringkali ditemukan pada pasien dengan penyakit jantung bawaan dengan left-to-right shunt, penyakit pulmonal, gangguan perkembangan paru serta idiopatik. Insiden HP pada anak secara umum dilaporkan sebesar 4-10 kasus per 1 juta anak per tahun. Terapi koreksi secara operatif atau kateterisasi masih menjadi pilihan utama untuk koreksi HP. Namun tingkat morbiditas dan mortalitas paska koreksi dilaporkan cukup tinggi. Oleh karena itu, beberapa studi terus mengkaji dan mengembangkan pilihan terapi untuk HP. Beberapa diantaranya adalah terapi vasodilator dengan PDE-5, CCB, analog prostasiklin dan inhalasi NO. Karena etiologi yang sangat komplek dan belum banyak bukti klinis atau konsensus tentang tatalaksana HP pada anak, maka pemilihan terapi HP yang sesuai masih cukup sulit. Pada prinsipnya tujuan utama dari terapi HP adalah meningkatkan angka harapan hidup dan memfasilitasi pasien agar dapat melakukan aktivitas secara mandiri tanpa limitasi. Tujuan dari penulisan tinjauan kepustakaan ini adalah untuk membahas tentang tatalaksana terkini HP pada anak sehingga diharapkan dapat menambah pengetahuan dan referensi sebagai dasar praktis klnis tentang tatalaksana HP pada anak. Kata Kunci: Penyakit Jantung Bawaan, Hipertensi Pulmoner, Anak, Left-to-right Shunt, Vasodilator Pulmonary hypertension (PH) is a condition in which pulmonary vascular pressure increases and associated with diverse diseases or etiology.  In children, 50% of PAH cases are caused by CHD, especially due to large left-to-right shunts. Another causes were developmental lung diseases and idiopatic PH. The estimated incidence of sustained PH in all categories was reported at 4–10 cases per million children per year. Corrective procedures by surgery or catheterization are the therapies of choice for reversible PH. Since morbidity and mortality due to PAH after correction is high, many recent studies have been done on the evaluation in treatment option of PH. Several vasodilator therapy including sildenafil (Phosphodiesterase type 5 inhibitor), Calcium Channel Blocker, Prostacyclin Analogs and Nitric Oxide were recommendation therapy. Various etiologies and lack of consensus make it difficulty in management of PH. The ultimate goal of treatment should be improved survival and to facilitate normal activities of childhood without self-limitation. Therefore, this review was aimed to discuss about recent management of PH in children.
Evaluasi Docking Molekular Potensi β-Sitosterol dari Kelakai (Stenochlaena palustris) sebagai Inhibi-tor Estrogen Receptor Noer Komari; Tazkia Safarina; Mirza Maulana Ahmad; Nugi Maulana; Eko Suhartono; Samsul Hadi
Journal of Pharmascience Vol. 9 No. 2 (2022): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13412

Abstract

 Tumbuhan khas rawa Kalimantan yang banyak dikaitkan dengan kesehatan adalah Kelakai (Stenochlaena palustris). Kelakai mengandung senyawa kimia antioksidan, antibakteri, antijamur, antianemia dan antiinflamasi. β-sitosterol adalah fitosterol penting di tumbuhan kelakai. β-sitosterol dikatakan mampu menekan pertumbuhan sel kanker payudara. Protein penting dalam perkembangan sel kanker payudara adalah Estrogen Receptor (ER) yang juga merupakan target protein untuk kerja obat. Penelitian ini bertujuan melihat potensi senyawa β-sitosterol sebagai inhibitor ER secara in silico. Energi bebas Gibbs (ΔG), koefisien inhibisi (Ki) dan interaksi ligan dengan residu ER dianalisis sebagai parameter docking. Sifat farmakokinetik β-sitosterol diprediksi menggunakan server web pkCSM dan SwissADME. Hasil molekular docking menunjukkan bahwa β-sitosterol membentuk kompleks dengan ER dengan energi bebas Gibbs (ΔG) = -5,27 kkal/mol dan raloxifene = -5,71 Kkal/mol. β-sitosterol berinteraksi dengan residu Gln-441, Asn-439, Met-438, Ala-493, Leu-495, Arg-503, Gln-499, Gln-502, Gln-506 dan raloxifene berinteraksi dengan residu Phe-425, Met-421, Leu-428, Ile-424, Met-388, Leu-391, Leu-387, Phe-404, Met-502, Met 348, Leu-525, Leu-346, Asp-347, Glu-348, Ala-350, Pro-515, Asp547, Trp-383, Met-383, Glu-524, Val-528, Trp-383, Asn-502, Pro-508, Leu-589, Val-524, Val-327. β-sitosterol tidak bersifat hepatotoksik dan tidak menyebabkan alergi kulit. Protein ER berinteraksi stabil dengan β-sitosterol dengan Sembilan residu. β-sitosterol berpotensi sebagai kandidat obat antikanker dengan menghambat pertumbuhan ER. Kata kunci: raloxifene, kanker payudara, in silico, target protein, SwissADME   A typical plant of the Borneo swamp that is widely associated with health is Kelakai (Stenochlaena palustris). Kelakai contains antioxidant, antibacterial, antifungal, antianemic and anti-inflammatory chemical compounds. β-sitosterol is an important phytosterol in Stenochlaena palustris. β-sitosterol is said to be able to suppress the growth of breast cancer cells. An important protein in the development of breast cancer cells is the Estrogen Receptor (ER) which is also a protein target for drug action. This study aims to see the potential of β-sitosterol compounds as ER inhibitors in silico. Gibbs free energy (ΔG), inhibition coefficient (Ki) and ligand interaction with ER residues were analyzed as docking parameters. The pharmacokinetic properties of β-sitosterol were predicted using pkCSM and SwissADME web servers. The results of molecular docking showed that β-sitosterol formed a complex with ER with Gibbs free energy (ΔG) = -5.27 kcal/mol and raloxifene = -5.71 kcal/mol. β-sitosterol interacts with Gln-441, Asn-439, Met-438, Ala-493, Leu-495, Arg-503, Gln-499, Gln-502, Gln-506 residues and raloxifene interacts with Phe-425, Met-421, Leu-428, Ile-424, Met-388, Leu-391, Leu-387, Phe-404, Met-502, Met 348, Leu-525, Leu-346, Asp-347, Glu-348 , Ala-350, Pro-515, Asp547, Trp-383, Met-383, Glu-524, Val-528, Trp-383, Asn-502, Pro-508, Leu-589, Val-524, Val-327 residues. β-sitosterol is not hepatotoxic and does not cause skin allergies. The ER protein interacts stably with β-sitosterol with nine residues. β-sitosterol has potential as an anticancer drug candidate by inhibiting ER growth.

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