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Indonesian Journal of Global Health Research
Published by Global Health Science Group
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr
Core Subject :
Indonesian Journal of Global Health Research is a open access, peer reviewed and refereed international journal. Indonesian Journal of Global Health Research aim to publish original research paper devoted to various area of all health sciences. Indonesian Journal of Global Health Research provides a forum for sharing timely and up-to-date publication of scientific research, health care and promoting the development of nursing, public health, community, environmental and occupational health. The journal publishes original research papers of health sciences. High priority will be given to articles on public, nursing, adolescent, community, environmental and occupational health, pharmaceutical technology, social pharmacy, traditional medicine, pharmacology, and so on.
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Articles 1,005 Documents
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Efficacy of Combined Channa Striata and Curcumin Supplementation to Enhance Quality of Life among NSCLC Patients Undergoing Chemotherapy: A Randomized, Double-Blind, Controlled Trial Ammayasyiro Uzhma; Noni Noviasari Soeroso; Setia Putra Tarigan; Muhammad Ichwan; Taufik Ashar; Guntur Berlian; Asep Aripin
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2184

Abstract

Chemotherapy remains a cornerstone treatment for non-small cell lung cancer (NSCLC), but treatment-related toxicities frequently contribute to nutritional deterioration and impaired quality of life (QoL). Nutritional supplementation may help support patients during treatment. This study evaluated the efficacy of combined Channa striata extract and Curcumin supplementation in improving health-related quality of life among patients with NSCLC undergoing chemotherapy. This study aimed to assess the effects of combined Channa striata extract and Curcumin supplementation on changes in health-related quality of life among patients with non–small cell lung cancer receiving chemotherapy. A randomized, double-blind, placebo-controlled trial was conducted among newly diagnosed NSCLC patients receiving chemotherapy. Participants were randomly assigned to receive either a combination of Channa striata extract and Curcumin (Striatamin®, PT Mega Medica) or placebo during two chemotherapy cycles. Quality of life was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) at baseline and after treatment. Thirty-two patients were enrolled, with 16 patients in each group. On the EORTC QLQ-C30 functional scale, social functioning improved significantly in the intervention group compared with the control group after the second chemotherapy cycle (45.06 ± 25.65 vs. 33.33, p = 0.049). The intervention group also demonstrated a significantly greater improvement in global health status than the control group (12.49 ± 12.57 vs. 8.27, p = 0.041). Although numerical improvements were observed in several symptom domains, no significant differences were found between groups on the symptom scale (p > 0.05). Administration of a combination of Channa striata and Curcumin up to the second chemotherapy cycle was shown to improve quality of life, particularly in the social functioning domain, and to significantly enhance overall health in patients with NSCLC.
The Effects of Superoxide Dismutase and Methylprednisolone Administration on Histopathological Findings in A Rat Model of Optic Neuritis Fara Haura Muradi; Bobby Ramses Erguna Sitepu; Delfi Delfi
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2195

Abstract

Optic neuritis (ON) is an idiopathic inflammatory demyelinating condition of the optic nerve, vulnerable to degeneration due to energy depletion, reactive oxygen species (ROS) accumulation, and mitochondrial dysfunction. Superoxide dismutase (SOD) may offer neuroprotective benefits by targeting redox dysregulation, helping to halt retinal and retinal ganglion cell (RGC) degeneration. When combined with methylprednisolone (MP), which reduces inflammation, this therapy may accelerate recovery and minimize optic nerve damage. The ASK1-p38 pathway further supports this combined mechanism. To evaluate the effects of SOD and MP administration on optic nerve damage in a rat model of optic neuritis. This randomized post-test only control group laboratory experiment involved 35 male Wistar rats allocated into five groups: sham, control, SOD, MP, and combination therapy. Optic neuritis was induced by lipopolysaccharide (LPS) injection into the optic nerve. Histopathological data were collected after 14 days of treatment through microscopic evaluation of retinal ganglion cell (RGC) counts, optic nerve edema, demyelination, and hemorrhage. Data were analyzed using One-Way ANOVA or Kruskal-Wallis tests. The combination group demonstrated the most favorable outcomes, with the highest average RGC count (195 cells), minimal optic nerve edema (p<0.001), and demyelination levels similar to normal. Combined administration of SOD and MP provided better histopathological outcomes—reflected in ganglion cell preservation, reduced edema, and minimal demyelination—than either treatment alone in this rat model of optic neuritis.
Effectiveness of Nursing-Led Interventions on Stoma Self-Care and Quality of Life in Patients with Urinary Diversion: Systematik Literatur Riview Fiza Paluphi Andita; Muhammad Muttaqien; Imanuella Imanuella; Nurur Rachman Machmudy; Fayza Asyahla Rihastara; Ika Yuni Widyawati
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2196

Abstract

Patients who undergo radical cystectomy with urinary diversion often have difficulty managing their stoma independently, which can affect their quality of life. Various nursing-led interventions have been developed to improve stoma care skills, but the available evidence remains varied. The objective of this study is to assess how nurse-led interventions affect stoma self-care and quality of life, and to identify the intervention elements that support these outcomes. Guided by the PRISMA 2020 guidelines, this study conducted a systematic literature review. As of January 2020 to March 2026, literature searches were performed in PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar. Fourteen out of 326 identified articles met the inclusion criteria. The JBI tool was used to evaluate methodological quality, followed by narrative synthesis. The PROSPERO registration number for this study protocol is CRD420261353559. Fourteen studies, including quasi-experimental trials and randomized controlled trials, were examined. Nurse-led interventions generally reduced peristomal complications and improved stoma self-care ability, self-efficacy, and quality of life. Stoma self-care and quality of life were consistently enhanced by interventions centered on education, stoma care skills training, and continuous care. Following radical cystectomy, patients’ quality of life and stoma self-care can be improved through nurse-led interventions. Although there is limited evidence supporting the promising outcomes of multidimensional and ongoing interventions, further research is needed to confirm these findings.
WhatsApp-Facilitated Empowerment of Health Cadres to Improve Knowledge and Blood Pressure Control among Adults with Hypertension: A Quasi-Experimental Study Maitha Annthonette Wulan Keloay; Ni Luh Jayanthi Desyani; Rommy David Watuseke; Semuel Tambuwun; Ellen Pesak; Ferry Efendi
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2207

Abstract

Hypertension constitutes a major public health concern and serves as a primary risk factor for cardiovascular disease, stroke, renal failure, and premature mortality. Successful hypertension control necessitates a comprehensive approach that relies not only on pharmacological therapy but also on enhancing patient health literacy. The sustainable empowerment of health cadres through WhatsApp-based education represents an effective strategy for improving patient knowledge, thereby promoting behavioral change and enhancing blood pressure control. To analyze the effect of health cadre empowerment via WhatsApp on the level of knowledge and hypertension control. Methods: This study employed a quasi-experimental design with a pretest-posttest control group approach. Data were collected using a purposive sampling method with specified inclusion and exclusion criteria, a total of 60 respondents were involved, consisting of a control group (n = 30) and an experimental group (n = 30). Knowledge levels and blood pressure were assessed in both groups at baseline and following the intervention. To evaluate the intervention effect, the pre-post change scores of both groups were analyzed using the Wilcoxon signed-rank test. The significance level was set at p < 0.05 for all analyses. Prior to the intervention, the majority of respondents in the control group (73.3%) and the experimental group (60.0%) had a sufficient level of knowledge. Following the intervention, all respondents in the experimental group (100%) achieved a good level of knowledge. The mean reduction in systolic blood pressure was (Δ = 14.10 mmHg), and diastolic blood pressure decreased by (Δ = 5.3 mmHg). The Wilcoxon test results indicated a significant difference between blood pressure before and after the intervention, both for systolic (Z = -4.813; p < 0.001) and diastolic (Z = -4.489; p < 0.001) measurements. The empowerment of health cadres through WhatsApp-based health education is effective in improving knowledge and reducing blood pressure among hypertensive patients.
Predictors of Anemia among Adolescent Girls: A Cross-Sectional Study Solikah Sriningsih; Bambang Budi Raharjo
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2211

Abstract

Anemia among adolescent girls remains a significant public health concern, particularly in developing countries, due to its negative impacts on reproductive health, cognitive development, academic performance, and future pregnancy outcomes. Iron deficiency, socioeconomic status, dietary behavior, menstrual characteristics, and inadequate nutritional knowledge are among the contributing factors associated with anemia in adolescents. This study aimed to analyze the association between parental income, maternal education, tea consumption habits, knowledge, attitudes, iron supplement adherence, menstrual characteristics, and the severity of anemia among adolescent girls at a public senior high school in Mataram, Indonesia. A quantitative study with a cross-sectional design was conducted among adolescent girls diagnosed with anemia at SMAN  Mataram. A total sampling technique was applied, involving 62 respondents who met the inclusion criteria. Data were collected using structured questionnaires assessing socioeconomic factors, health behaviors, knowledge, attitudes, iron supplement consumption, and menstrual conditions. The questionnaires demonstrated acceptable validity and reliability, with all items meeting validity criteria (r > 0.30) and Cronbach’s alpha values ranging from 0.79 to 0.87. The incidence and severity of anemia were determined based on hemoglobin screening data. Bivariate analysis was performed using the chi-square test with a significance level of p < 0.05. The findings showed significant associations between anemia severity and parental income (p = 0.004), maternal education level (p < 0.001), knowledge regarding anemia (p < 0.001), iron supplement adherence (p = 0.008), and menstrual conditions (p = 0.004). However, tea consumption habits (p = 0.753) and attitudes toward anemia prevention (p = 0.323) were not significantly associated with anemia severity among adolescent girls. Socioeconomic factors, anemia-related knowledge, iron supplement adherence, and menstrual characteristics were significantly associated with anemia severity among adolescent girls. Strengthening school-based anemia prevention programs, improving adolescent health literacy, and enhancing adherence to iron supplementation are essential strategies to reduce anemia among adolescents.
Analysis of Tertiary Prevention Efforts for Hypertension in Boyolali Regency Based on the Theory of Planned Behavior: Path Analysis Teguh Wibowo; Arsita Eka Prasetyawati; Erindra Budi Cahyanto; Sri Mulyani; Hafi Nurinasari
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2225

Abstract

Hypertension remains a major public health problem and a leading risk factor for cardiovascular morbidity and mortality. Effective tertiary prevention is needed to prevent complications and improve blood pressure control. The Theory of Planned Behavior (TPB) provides a framework for understanding preventive behaviors among patients with hypertension. A cross-sectional study involving 200 working-age patients with hypertension was conducted in Boyolali Regency, Central Java, Indonesia, from April to May 2026. Participants were selected through stratified multistage random sampling. Instrument validity was assessed using corrected item-total correlation (r≥0.30), and reliability using Cronbach’s alpha (α≥0.70). Blood pressure control was measured using a calibrated sphygmomanometer. Data were analyzed using Generalized Structural Equation Modeling (GSEM). Attitude (OR=3.43; p=0.003), subjective norms (OR=3.97; p=0.001), and perceived behavioral control (OR=5.42; p=0.001) significantly influenced intention. Intention (OR=13.28; p<0.001) and perceived behavioral control (OR=21.43; p<0.001) significantly influenced tertiary prevention efforts. Good tertiary prevention efforts were associated with controlled blood pressure (OR=20.94; p<0.001). Perceived behavioral control showed the strongest direct and indirect effects through intention. TPB effectively explains tertiary prevention efforts among working-age patients with hypertension. Strengthening perceived behavioral control and intention may improve self-management and blood pressure control.
Referral of Emergency Obstetric-Neonatal Cases by Village Midwives to Poned Health Centers Zakiah Zakiah; Defrin Defrin; Husna Yetti
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2229

Abstract

Basic Emergency Obstetric and Neonatal Services (PONED) provide emergency care for obstetric and neonatal conditions, including hypertensive disorders during pregnancy, shoulder dystocia, vacuum-assisted delivery, postpartum hemorrhage, puerperal infection, and respiratory disorders and seizures in newborns. Based on data from the Rokan Hulu District Health Office in 2024, there were 273 cases (50.83%) of high-risk maternal referrals and 48 cases (47.52%) of high-risk neonatal referrals originating from PONED health centers. This study aimed to identify the factors influencing the referral behavior of village midwives in obstetric and neonatal emergency cases and the appropriateness of referral indications to PONED Health Centers. This study employed a qualitative approach with a case study design. Informants were selected using purposive and snowball sampling techniques until data saturation was achieved. Data were collected through in-depth interviews, observations, and document review, and analyzed using thematic analysis. A total of eight informants participated in the study, consisting of one key informant (a PONED team member), five primary informants (village midwives), and two additional informants (the Head of the PONED Health Center and the Head of the Public Health Division at the District Health Office). The findings showed that the referral behavior of village midwives in obstetric and neonatal emergency cases was influenced by educational level, age, and geographical conditions. In addition, mentoring and supervision of village midwives, as well as quality assurance and supervision of PONED team services, contributed to improving the appropriateness of referrals for obstetric and neonatal emergency cases.
Narrative Review: Potential of Terminalia Catappa Leaf Extract as A Natural Agent for Burn Wound Healing Rifaa Dhiya Ulhaq; Yuli Subiakto; Syahrul Tuba
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2232

Abstract

Burn injuries induce oxidative stress, inflammation, and collagen degradation, impairing skin regeneration. Terminalia catappa L. (ketapang) has potential as a healing agent due to its rich bioactive compounds, including flavonoids, tannins, saponins, triterpenoids, and phytosterols. This narrative review aims to evaluate the wound-healing potential of Terminalia catappa L. extract based on preclinical evidence and its underlying pharmacological mechanisms. This structured narrative review aims to evaluate the wound healing potential of Terminalia catappa L. extract based on preclinical evidence and its underlying pharmacological mechanisms. Relevant scientific literature (2014–2023) was sourced from ScienceDirect, PubMed, ResearchGate, and Google Scholar, and analyzed using a qualitative thematic narrative synthesis. The major phytoconstituents of ketapang—including punicalagin, ellagic acid, gallic acid, luteolin, kaempferol, betulinic acid, and β-sitosterol—act synergistically to suppress oxidative stress via ROS scavenging and modulate inflammation by inhibiting NF-κB, MAPK, COX-2, iNOS, and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α). Additionally, the extract supports extracellular matrix regeneration by enhancing fibroblast proliferation and collagen deposition. Preclinical evidence demonstrates that ketapang extract accelerates wound contraction, re-epithelialization, and granulation tissue formation. In a second-degree burn model, a 25% methanolic ketapang leaf extract ointment provided optimal collagen density compared to 50% and 100% concentrations. In conclusion, ketapang extract shows promising potential for development into an effective topical preparation for burn wound healing.
The Effect of Video-Based Eye Exercise Education on Reducing Asthenopia Symptoms among Nurses: A Quasi-Experimental Study Renanta Adeel Sahasra Hukubun; F X Bobby Tyas Prastyanto
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2240

Abstract

The use of computers and digital screens in Electronic Health Record (EHR)-based nursing documentation may increase nurses visual workload and the risk of asthenopia, including dry eyes, blurred vision, difficulty focusing, and headaches. This condition requires attention as part of promotive and preventive efforts in Hospital Occupational Health and Safety (K3RS). Eye exercises are a non-pharmacological intervention that can be performed independently to reduce these symptoms. This study aimed to analyze the effect of video-based eye exercise education on reducing asthenopia symptoms among nurses. This study used a quasi-experimental design with a pre-test and post-test control group approach. A total of 36 nurses were selected using purposive sampling, consisting of 18 respondents in the intervention group and 18 respondents in the control group. The study used the Asthenopia Survey Questionnaire-11 (ASQ-11) to assess asthenopia symptoms among nurses. The ASQ-11 is a valid and reliable instrument, with a Cronbach's alpha of 0.89, split-half reliability of 0.82, and test-retest reliability of 0.90 (p < 0.001). intervention group received video-based eye exercise education for seven days. Data were analyzed using the Paired Sample T-Test, Welch Test, and Cohen’s Effect Size. The mean asthenopia score in the intervention group decreased from 25.67 to 13.17 after the intervention. The test results showed a significant difference before and after the intervention (p < 0.000), with a Cohen’s d value of 4.642. Video-based eye exercise education was effective in reducing asthenopia symptoms among nurses.
Prevalence and Risk Factors of Intestinal Parasitic Infections among Farmers in Developing Countries: A Literature Review Komang Surya Pradnyana Putra; I Kadek Swastika
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2241

Abstract

Intestinal parasitic infections remain a serious public health challenge in developing countries, particularly among high-risk population groups such as farmers and agricultural workers. This literature review aims to describe the prevalence of intestinal parasitic infections, identify the most dominant parasite species, and analyze associated risk factors in adult farmers and agricultural workers. A literature search was conducted across PubMed, Google Scholar, and ScienceDirect using Boolean keyword combinations for articles published between 2021 and 2026. Of 687 articles identified, 10 were screened, and four cross-sectional studies from Nepal, Senegal, and Ethiopia were selected based on pre-defined inclusion criteria: original research, adult populations aged ≥18 years, farmer or agricultural worker communities, and reporting of both prevalence and risk factors of intestinal parasitic infections. Results showed that the prevalence of intestinal parasitic infections ranged from 22.2% to 54% across study sites, with hookworms (Necator americanus/Ancylostoma duodenale) and Giardia lamblia as the most consistently dominant species.

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