cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
mkb.fkunpad@gmail.com
Editorial Address
Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38 Bandung, 40161, Indonesia
Location
Kota bandung,
Jawa barat
INDONESIA
Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 651 Documents
 19   20   21   22   23 
Hubungan Ekspresi Ki-67 dengan Grading Histopatologi Liposarkoma Afiati, -; Hernowo, Bethy S.
Majalah Kedokteran Bandung Vol 45, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.841 KB)

Abstract

Liposarkoma merupakan salah satu tumor ganas jaringan lunak dan terbanyak ditemukan pada usia dewasa antara dekade 5 dan 7 serta jarang terjadi pada usia anak. Liposarkoma sering terjadi pada ekstremitas bawah (fosa poplitea dan paha bagian tengah), retroperitoneal, perirenal, mesenteric region, dan area bahu. Penelitian ini bersifat retrospektif dari 30 kasus liposarkoma yang diambil dari data Departemen Patologi Anatomi Rumah Sakit Dr. Hasan Sadikin Bandung yang terdiri atas 20 kasus low-grade liposarcoma dan 10 kasus high-grade liposarcoma. Penelitian dilakukan periode Februari–Mei 2011. Dilakukan pemeriksaan khusus imunohistokimia dengan menggunakan antibodi monoklonal Ki-67 yang berfungsi sebagai marker proliferasi sel, dengan tujuan melihat ekspresi Ki-67 dan apakah terdapat hubungan antara ekspresi Ki-67 dan grading histopatologi liposarkoma. Ekspresi dan intensitas warna Ki-67 pada sel tumor dibagi menjadi sangat rendah (<20% positif), rendah (20– 50% positif), sedang (50–80% positif) dan tinggi (>80% positif), sedangkan untuk intensitas warna Ki-67 dibagi menjadi lemah, sedang, dan kuat. Terdapat perbedaan yang signifikan antara ekspresi dan intensitas Ki-67 pada low-grade liposarcoma dan high-grade liposarcoma (p<0,0001). Simpulan, ekspresi Ki-67 yang tinggi dengan intensitas yang kuat hanya didapatkan pada high-grade liposarcoma yang juga berhubungan dengan progresivitas tumor. [MKB. 2013;45(3):187–91]Correlation of Ki-67 Expression with Histopathological Grading ofLiposarcomaLiposarcoma, a malignant tumor of mesenchymal origin, was one of the most common sarcomas of adults and occurs primarily in the fifth through seventh decades of life. The occurrence in children was rare. Liposarcoma were occur most frequently in the lower extremities (popliteal fossa and medial thigh), retroperitoneal, perirenal, mesenteric region and shoulder area. Retrospective study was conducted by reviewing the data from Pathology Anatomy Department Dr. Hasan Sadikin Hospital Bandung. There were 30 cases of liposarcoma, whereas lowgrade of liposarcoma 20 cases and high-grade of liposarcoma 10 cases. Research was done during February–May 2011. Immunohistochemical staining examination used monoclonal antibody Ki-67 as marker cell proliferation with the aim for looking Ki-67 expression and related with histopatholgy grade of liposarcoma. The tumor cells which showed Ki-67 expression were divided into very low (<20% positive), low (20–50% positive), moderate (50–80% positive) and high (>80% positive), whereas the intensity of Ki-67 staining was into weak, moderate and strong. There were significant differences between the Ki-67 expression and intensity level according to the histopathological types of liposarcoma (p<0.0001). In conclusions, Ki-67 expression increases with strong intensity of Ki-67 only in high-grade liposarcoma, so relates with progressivity of tumor. [MKB. 2013;45(3):187–91]DOI: http://dx.doi.org/10.15395/mkb.v45n3.149 
Gambaran Subtipe HIV-1 dengan Kadar CD4, Stadium Klinis, dan Infeksi Oportunistik Penderita HIV/AIDS di Kota dan Kabupaten Jayapura, Papua Widiyanti, Mirna; Sandy, Semuel
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.632 KB) | DOI: 10.15395/mkb.v48n1.738

Abstract

Jumlah kasus HIV/AIDS di Indonesia akhir Maret 2013 tercatat 103.759 kasus dan 43.347 kasus AIDS yang tersebar di Indonesia. Papua merupakan provinsi ketiga yang memiliki jumlah kasus HIV/AIDS cukup tinggi, yaitu 10.881 kasus HIV dan 7.795 kasus AIDS. Tujuan penelitian ini melihat distribusi subtipe HIV-1 yang dominan di Papua dan mengetahui hubungan subtipe HIV-1 dengan kadar CD4, stadium klinis, dan infeksi oportunistik penderita HIV/AIDS. Penelitian menggunakan rancangan potong lintang. Pemeriksaan subtipe HIV-1 menggunakan RT-PCR dan sekuensing. Penelitian dilaksanakan di RSUD Dok II, RS Abepura, dan RSUD Yowari Kabupaten Jayapura pada bulan November–Desember 2012. Data CD4, stadium klinis, dan jenis infeksi oportunistik dicatat melalui rekam medis pasien. Data dianalisis menggunakan uji statistik chi-kuadrat. Subtipe HIV-1 yang dominan ditemukan, yaitu CRF01_AE sebanyak 51 orang (54%) dan subtipe B sebanyak 43 orang (46%). Dari 94 pasien HIV sebanyak 62 orang (66%) menderita infeksi oportunistik TB paru dan beberapa menderita lebih dari satu jenis infeksi oportunistik. Uji statistik menunjukkan tidak ada hubungan bermakna subtipe HIV-1 dengan kadar CD4 dan stadium klinis, tetapi menunjukkan korelasi bermakna terhadap infeksi oportunistik. Simpulan ditemukan subtipe HIV-1 yang dominan di Papua adalah CRF01_AE dan infeksi oportunistik terbanyak pada penderita adalah tuberkulosis. [MKB. 2016;48(1):1–6]Kata kunci: CD4, infeksi oportunistik, stadium klinis, subtipe HIV-1 Overview of HIV-1 Subtype with CD4 Levels, Clinical Stage and Opportunistic Infections HIV/AIDS in City and Regency of Jayapura-PapuaAbstractThe number of HIV/AIDS cases recorded in March 2013 in Indonesia is 103,759 HIV cases and 43,347 AIDS cases. Papua is the province that has the third highest number HIV/AIDS cases with 10,881 HIV cases and 7,795 AIDS cases. The aim of this study was to identify the distribution of HIV-1 subtypes which are dominant in Papua and to identify opportunistic infections related to HIV/AIDS and their relationship with HIV-1 subtypes. This study is a cross-sectional study. The identification of HIV-1 was performed using nested-PCR and sequencing to look for HIV-1 subtypes. The study was conducted in Dok II, Abepura and Yowari VCT Hospital in Jayapura District during the period of November–December 2012. CD4 and opportunistic infections were retrieved from patient medical records. Data were analyzed statistically using chi-square test. The dominant HIV-1 subtypes found were subtype CRF01-AE, which was found in 51 people (54%), and subtype B, which was found in 43 people (46%). Of 94 HIV patients, 62 (66%) respondents suffered from pulmonary tubeculosis opportunistic infection and some patients suffered more than one type of opportunistic infections. There was no significant difference found between the HIV-1 subtypes, CD4 level, and clinicial stage. However, a significant correlation with opportunistic infections was found. It is concluded that the dominant HIV-1 subtype in Papua is CRF01_AE with tuberculosis as the most frequent opportunistic infection. [MKB. 2016;48(1):1–6]Key words: CD4, clinical stage, HIV-1 subtypes, opportunistic infection 
Inspiratory Muscle Trainer Effectiveness in Chronic Obstructive Pulmonary Disease Rehabilitation Program Nusdwinuringtyas, Nury; Islamadina, Balqis; Rumende, Cleopas Martin; Kamelia, Telly
Majalah Kedokteran Bandung Vol 51, No 1 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (625.998 KB) | DOI: 10.15395/mkb.v51n1.1600

Abstract

Chronic obstructive pulmonary disease (COPD) is marked by persistent respiratory disturbance which results in altered health status as well as functional capacity. Pulmonary rehabilitation (PR) is a part of comprehensive therapy in patients suffering from respiratory disturbance. This study focused on inspiratory muscles exercise using the inspiratory muscle trainer(IMT), which is a form of a weight training exercise. This experiment was conducted at the COPD outpatient clinic of Dr. Cipto Mangunkusumo Hospital during the period of September 2017 until April 2018. Patients were recruited consecutively. The criteria for inclusion were stable COPD patient with GOLD criteria A-D and never received prior exercise for pulmonary rehabilitation. Patients underwent interview about their medical history followed by spirometry testing using Carefusion® and  inspiratory muscle strength assessment using Micro RPM Carefusion®. The St George Respiratory Questionnaire (SGRQ) was used to assess the health status and the 6-minute walking test (6MWT) was conducted to assess the functional capacity. Subject exercised using IMT (Philips Respironic®) for eight weeks. Data were analyzed using paired t-test in statistical package for social sciences (SPSS) version 21. A total of 15 subjects with and average age of 65.6±8.40 years old were recruited. Pre-Post difference in inspiratory muscle strength was 11.31 cmH2O, showing a statistically significant impact. The significant impact was also shown clinically through the results of the Minimal Clinical Important Difference (MCID) on health status and functional capacity. The health status was evaluated using SGRQ with p exceeding 4%. A combined Pulmonary Rehabilitation (PR) and inspiratory muscles exercise program is proven to improve the health status and functional capacity.Key words: COPD, inspiratory muscle trainer, pulmonary rehabilitation, SGRQ, 6MWT Keefektifan Inspiratory Muscle Trainer Pada Program Rehabilitasi  Penyakit Paru Obstruktif KronikPenyakit paru obstruktif kronik (PPOK) ditandai dengan gangguan pernapasan yang persisten yang mengganggu status kesehatan dan kapasitas fungsional. Pulmonary rehabilitation (PR) merupakan bagian dari terapi komprehensif pasien dengan ganguan respirasi. Penelitian ini memfokuskan pada latihan otot inspirasi menggunakan inspiratory muscle trainer (IMT), suatu bentuk latihan otot pernapasan dengan pemberian beban. Eksperimen ini dilakukan di Rumah Sakit Cipto Mangunkusumo selama periode September 2017 hingga April 2018. Pasien direkrut secara consecutive sampling. Kriteria inklusi adalah pasien PPOK yang stabil dengan kriteria GOLD A-D yang belum pernah menerima latihan sebelumnya untuk rehabilitasi paru. Pasien menjalani wawancara, diuji dengan spirometri Carefusion®, dan kekuatan otot inspirasi dinilai menggunakan Micro RPM Carefusion®. St George Respiratory Questionnaire (SGRQ) digunakan untuk menilai status kesehatan dan 6-minute Walking Test (6MWT) dilakukan untuk menilai kapasitas fungsional. Subyek menggunakan alat IMT (Philips Respironic®) selama 8 minggu. Data dianalisis menggunakan SPSS versi 21 dengan uji T berpasangan. Subjek penelitian berjumlah 15 orang dengan rerata usia 65,6 ± 8,40 tahun. Kekuatan otot inspirasi awal didapatkan perubahan sebesar 11,31 cmH2O, yang memberikan dampak bermakna dilihat dengan pencapaian minimal clinical important difference (MCID) pada status kesehatan dan kapasitas fungsional. PR bersama dengan program latihanotot inspirasiterbukti memberikan hasil perbaikan status kesehatan dan kapasitas fungsional.Kata kunci: COPD, inspiratory muscle trainer, pulmonary rehabilitation, SGRQ, 6MWT 
Efektivitas Pemberian Antibiotik Disertai Lansoprazol pada Refluks Laringofaring dengan Infeksi Helicobacter pylori Nurrokhmawati, Yanti; Madiadipoera, Teti; Anggraeni, Ratna; Sarbini, Tonny Basriyadi
Majalah Kedokteran Bandung Vol 44, No 4 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (722.696 KB)

Abstract

Refluks laringofaring adalah aliran balik isi lambung ke daerah laringofaring dan dapat dipengaruhi oleh infeksi Helicobacter pylori. Regimen terapi untuk infeksi H. pylori terdiri atas proton pump inhibitor (PPI) dan dua jenis antibiotik yaitu amoksisilin dan klaritromisin. Peran PPI pada regimen ini masih diteliti. Dilakukan penelitian mengenai perbandingan efektivitas terapi antibiotik disertai PPI (lansoprazol) terhadap perbaikan gejala klinis dan kualitas hidup penderita refluks laringofaring dengan infeksi H. pylori. Penelitian ini dilakukan di Departemen THT-KL RS Dr. Hasan Sadikin Bandung periode September 2009-Desember 2010 merupakan randomized clinical trial dengan pengamatan open label.Data dianalisis dengan menggunakan uji t dan uji Mann Whitney. Penelitian ini melibatkan 26 subjek penelitian yang dibagi menjadi dua kelompok. Kelompok pertama diberikan regimen terapi H. pylori, berupa klaritromisin dan amoksisilin dengan lansoprazol dan kelompok kedua diberikan klaritromisin dan amoksisilin tanpa lansoprazol. Dilakukan pemeriksaan skor gejala refluks (SGR), skor temuan refluks (STR), dan penilaian kualitas hidup dengan kuesioner reflux qual short-form (RQS). Evaluasi dilakukan setelah 2 minggu. Didapatkan perbedaan bermakna (p=0,034) skor SGR pascaterapi pada kelompok perlakuan antibiotik kombinasi dengan lansoprazol. Tidak didapatkan perbedaan bermakna (p=0,169) pada perbaikan STR pascaterapi. Perbaikan skor RQS lebih baik pada kelompok perlakuan pertama dibandingkan dengan kelompok kedua (p=0,018). Disimpulkan bahwa pemberian campuran antibiotik kombinasi dan lansoprazol lebih efektif terhadap perbaikan gejala klinis dan kualitas hidup dibandingkan dengan tanpa lansoprazol. [MKB. 2012;44(4):224–32].Kata kunci: Helicobacter pylori, kualitas hidup, lansoprazol, refluks laringofaringThe Effectiveness of Antibiotics with Lansoprazole in the Treatment of Laryngopharyngeal Reflux with Helicobacter pylori InfectionAbstractLaryngopharyngeal Reflux (LPR) is a reflux of gastric content to the laryngopharyngeal and influenced by Helicobacter pylori infection. The treatment of H. pylori infection consists of proton pump inhibitor and two kinds of antibiotics, i.e. amoxicillin and clarithromycin. The role of PPI is currently being studied. The objectives of the research were to compare the effectiveness of antibiotics regimen with and without lansoprazole in reducing the level of the severity and quality of life improvement in LPR patients with H. pylori infection. Twenty six subjects were divided into two groups; the first group received antibiotics with lansoprazole and the second group received antibiotics without lansoprazole. The research subjects were assessed using reflux symptom index (RSI) questionnaire and reflux finding score (RFS) while the assessment on the quality of life was performed using reflux qual short-form (RQS) questionnaire. These data were obtained at baseline and after 2 weeks of treatment. The method was randomized clinical trial with open label observation and the analysis was conducted using t and Mann Whitney tests. There was a significant improvement in the RSI post treatment in the first group (p=0.034). The difference in RFS was not significantly different statistically between both groups (p=0.169). The RQS was significantly better statistically in the first group (p=0.018). It is concluded that treatment regimen with claritromicin, amoxycillin and lansoprazole is more effective in the treatment of LPR associated with H. pylori infection compared to without lansoprazole. [MKB. 2012;44(4):224–32].Key words: Helicobacter pylori, laryngopharyngeal reflux, lansoprazole, quality of life DOI: http://dx.doi.org/10.15395/mkb.v44n4.215
Gambaran eGFR Menurut CKD-EPI pada Penderita Thalassemia Mayor di Rumah Sakit Dr. Hasan Sadikin Bandung Doloksaribu, Rismauli; Husna, Rizka; Oehadian, Amaylia
Majalah Kedokteran Bandung Vol 49, No 1 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v49n1.980

Abstract

Peningkatan harapan hidup penderita thalassemia menyebabkan manifestasi penyakit pada berbagai organ, termasuk ginjal. Estimated glomerular filtration rate (eGFR) adalah penghitungan untuk mendeteksi gangguan dini fungsi ginjal, cara ini lebih dipercaya dibandingkan nilai kreatinin serum. The National Kidney Foundation merekomendasikan Chronic Kidney Disease  Epidemiology Collaboration (CKD-EPI) untuk mengestimasi laju filtrasi glomerulus. Penelitian ini bertujuan mengetahui gambaran eGFR menurut CKD-EPI  pasien thalassemia. Penelitian menggunakan metode deskriptif. Data diambil dari penderita thalassemia mayor rawat jalan di Klinik  Hematologi Onkologi Medik, Rumah Dr. Sakit Hasan Sadikin Bandung, mulai 1 Februari sampai dengan 31 Maret 2016. Diperiksa kadar kreatinin serum dan penghitungan eGFR berdasar atas CKD-EPI. Dari 108 subjek penelitian, didapatkan usia rata-rata 18 tahun dengan jumlah wanita sebanyak 61,1 %. Gambaran eGFR berdasarkan CKD-EPI: menunjukkan hiperfiltrasi glomerulus pada mayoritas pasien dengan eGFR >120 mL/menit.  Pemeriksaan fungsi ginjal pasien thalassemia diperlukan untuk memantau gangguan fungsi ginjal dan untuk pemilihan penggunaan jenis kelasi besi. [MKB. 2016;49(1):22–7]Kata kunci: CKD–EPI, eGFR, thalassemia eGFR Profile Based on CKD-EPI of Thalassemia Mayor Patients in Dr. Hasan Sadikin General Hospital BandungIncreased life expectancy of thalassemia patients has a consequence of various manifestations of the diseases in many organs including kidney. Estimated glomerular filtration rate (eGFR) can be used for detecting early renal dysfunctions due to the fact that this calculation is more accurate compared to creatinine serum measurement. The National Kidney Foundation recommends Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) for estimating GFR. The aim of this descriptive study was to describe eGFR profile based on CKD-EPI in thalassemia patients. Data were collected from ambulatory patients visiting the Hematology Oncology Medical Clinic of Dr. Hasan Sadikin General Hospital during the period of February 1, 2016 to March 31, 2016. Subjects were patients with thalassemia major. Creatinine serum level  and calculated eGFR based on CKD-EPI were evakyated.  One hundred and eightsubjects with a median age of 18 years participated in this study with 61.1%  of them were female. According to the Kidney Disease Improving Global Outcomes  ( KDIGO) 2012, the eGFR calculation based on CKD-EPI showed that the majority of patients experience glomerular hyperfiltration (eGFR >120 ml/mnt). In this study, most Thalassemia major patients showed glomerular hyperfiltration. Renal function test is needed to monitor renal function abnormalities and to choose  the type of iron chelation therapy to be implemented. [MKB. 2016;49(1):22–7]Key words: CKD-EPI, eGFR, thalassemia
Protektivitas, Reaksi Lokal dan Sistemik setelah Imunisasi dengan Vaksin Td pada Anak Sekolah Dasar di Indonesia Sundoro, Julitasari; Bachtiar, Novilia Sjafri; Syafriyal, -; Sari, Rini Mulia
Majalah Kedokteran Bandung Vol 46, No 3 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (667.057 KB)

Abstract

penelitian ini adalah untuk mengetahui reaksi dan respon imun setelah memperoleh 1 dosis vaksin Td. Penelitian ini merupakan Post Marketing Surveillance, dengan desain kohort pada anak sekolah dasar di Jawa Timur. Reaksi lokal dan sistemik dicatat pada kartu harian hingga 28 hari setelah imunisasi. Darah diambil sebelum dan 28 hari setelah imunisasi. Pengukuran antibodi menggunakan metode uji double antigen ELISA, dengan batas proteksi 0,01 IU/mL baik untuk anti-tetanus maupun anti-difteria. Pengamatan yang berlangsung dari Oktober 2010 hingga April 2011 ini melibatkan sebanyak 2978 anak sekolah dasar, termasuk 159 anak untuk kelompok respon imun. Sebanyak 1,18%-2,45% anak mengalami demam dengan instensitas mayoritas ringan. Reaksi lokal terbanyak adalah nyeri pada 30 menit setelah imunisasi 62,49% naik menjadi 83,38% pada hari ke-1, dan menurun pada hari berikutnya dengan intensitas mayoritas adalah ringan. Tidak ditemukan kejadian pasca imunisasi serius. Sebanyak 98,11% dan 99,37% anak terlindungi terhadap difteria dan tetanus dengan Geometric Mean Titer 1,2280 IU/mL (p=0,000) untuk anti-difteria dan 10,6068 IU/mL (p=0,009) untuk anti-tetanus. Simpulan, dari hasil pengamatan menunjukkan bahwa vaksin ini bersifat imunogenik dan aman setelah pemberian 1 (satu) dosis pada anak sekolah dasar.Kata kunci: Post Marketing Surveillance (PMS), reaksi lokal, reaksi sistemik, vaksin TdProtectivity, Local and Systemic Reactions Following Td Vaccination among Elementary School Students in IndonesiaTd vaccine is given to provide protection to tetanus and diphtheria in children 7 years of age or above. The objectives of this study are to evaluate the reactions and immune response after 1 dose of Td vaccine. This study is a post marketing surveillance with a cohort design among elementary school students in East Java. Systemic and local reactions were recorded in diary cards untill 28 days after immunization. Blood was collected before and 28 days after immunization. Antibody titers were measured using double antigen ELISA with cut off protection rate >0,01 IU/ml. Observation were done between October 2010 to April 2011 which involved 2978 included 159 subjects for immune response group. In this study, fever was occured in 1,18%-2,45% subjects at the first three days with mild in intensity and resolved immediately without any medication. The most often local reaction was pain in 62,49% subjects at 30 minutes after injection, and increased to 83,38% at day 1 after immunization, and decreased the day after, with the intensity mostly were mild. No serious adverse reactions was found. 98,11% and 99,37% subjects were protected to diphtheria and tetanus, with the Geometric Mean Titer 1,2280 IU/mL (p=0,000) for anti-diphtheria and 10,6068 IU/mL (p=0.009) for anti-tetanus. In conclusion, Td vaccine is safe and immunogenic after 1 (one) dose in school age children, and there were no serious adverse event. Keywords: local reactions, post marketing surveillance (PMS), systemic reactions, Td vaccine DOI: 10.15395/mkb.v46n3.315
Hubungan Rinitis Alergi dengan Kejadian Otitis Media Supuratif Kronik Diana, Fatma; Haryuna, T. Siti Hajar
Majalah Kedokteran Bandung Vol 49, No 2 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.534 KB) | DOI: 10.15395/mkb.v49n2.369

Abstract

Otitis media supuratif kronik (OMSK) merupakan infeksi telinga tengah yang berat, tidak hanya terjadi di negara berkembang, tetapi juga di negara maju. Prevalensi OMSK di dunia melibatkan 65–330 juta penduduk. Terdapat beberapa teori yang mengungkapkan peran rinitis alergi dalam terjadinya OMSK, teori yang paling banyak digunakan adalah disfungsi tuba eustachius. Penelitian ini merupakan penelitian analitik dengan pendekatan kasus-kontrol tanpa berpasangan. Pengambilan sampel dengan metode consecutive sampling sebanyak 80 responden yang terdiri atas 40 responden OMSK dan 40 responden non-OMSK yang datang ke Poliklinik THT RSUP H. Adam Malik Medan pada bulan Agustus–Oktober 2014. Seluruh responden dilakukan anamnesis, pemeriksaan telinga dan hidung, serta mengisi kuesioner Score for Allergic Rhinitis (SFAR). Hasil penelitian menunjukkan bahwa pada kelompok OMSK, 28 orang (70%) menderita rinitis alergi dan 12 orang (30%) tidak menderita rinitis alergi. Pada kelompok non-OMSK 6 orang (15%) menderita rinitis alergi dan 34 orang (85%) tidak menderita rinitis alergi. Terdapat hubungan yang signifikan antara rinitis alergi dan kejadian OMSK (p<0,001). Pasien rinitis alergi memiliki risiko 13 kali lebih besar untuk menderita OMSK dibanding dengan pasien tanpa rinitis alergi (OR=13,222; 95% IK=4,400–39,732). Probabilitas pasien rinitis alergi untuk menderita OMSK sebesar 92,9%. Simpulan, terdapat hubungan antara rinitis alergi dan kejadian OMSK. [MKB. 2017;49(2):79–85]   Kata kunci: Otitis media supuratif kronik, rinitis alergi, score for allergic rhinitis Relationship between Allergic Rhinitis and Incidence of Chronic Suppurative Otitis Media   Chronic suppurative otitis media (CSOM) is a severe infection of the middle ear that is seen not only in developing countries but also in industrialized countries. The prevalence of CSOM in the world involves 65–330 million people. There are some theories regarding the role of allergic rhinitis in CSOM patients with eustachian tube dysfunction theory as the most widely used theory. This was a non-matched case control analytical study on 80 respondents, 40 CSOM respondents and 40 non-CSOM respondents, who were sampled using consecutive sampling method at the Ear-Nose-Throat (ENT) clinic of H. Adam Malik General Hospital in August–October 2014. Anamnesis as well as ear and nose examinations were performed and all respondents fill out the Score For Allergic Rhinitis (SFAR) questionnaire. The results showed that in  CSOM group, 28 people (70%) suffered from allergic rhinitis and 12 people (30%) did not suffer from allergic rhinitis. In non-CSOM group, the numbers were 6 people (15%) and 34 (85%), respectively. There was a significant relationship between allergic rhinitis and the incidence of CSOM (p<0.001). Allergic rhinitis patients have a 13 times greater risk to suffer CSOM than patients without allergic rhinitis (OR=13.222, 95% CI=4.400–39.732). The probability of patients with allergic rhinitis to suffer CSOM is 92.9%. In conclusion, there is a relationship between allergic rhinitis and the incidence of CSOM. [MKB. 2017;49(2):79–85]   Key words: Allergic rhinitis, chronic suppurative otitis media, score for allergic rhintis 
Nilai Indeks Terapi Ekstrak Etanol Daun Dewa {Gynura pseudochina (Lour.) DC} dan Natrium Diklofenak pada Tikus Model Inflamasi Donaliazarti, Donaliazarti; Sitorus, Truly; Sigit, Josep I.; Sudjatno, Muchtan
Majalah Kedokteran Bandung Vol 44, No 2 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indeks terapi merupakan parameter keamanan obat yaitu perbandingan dosis yang menyebabkan kematian pada 50% hewan uji (DL50) dengan dosis yang menghasilkan efek terapi pada 50% hewan uji (DE50). Inflamasi merupakan proses dasar berbagai penyakit dan daun dewa {Gynura pseudochina (Lour.) DC} merupakan salah satu tanaman obat yang terbukti sebagai antiinflamasi. Penelitian ini bertujuan untuk mengetahui indeks terapi ekstrak etanol daun dewa dan obat antiinflamasi nonsteroid (OAINS) yang banyak digunakan yaitu natrium diklofenak. Penelitian dilakukan di Laboratorium Farmakologi Klinik Rumah Sakit Dr. Hasan Sadikin Fakultas Kedokteran Universitas Padjadjaran pada bulan Agustus–Oktober 2009. Penelitian ini menggunakan rancangan eksperimental laboratorium dengan rancangan acak lengkap. Nilai DE50 dihitung berdasarkan kemampuan menghambat pembesaran radang sampai maksimal 75% pada jam ke-5 setelah pemberian zat. Nilai DL50 dihitung berdasarkan jumlah tikus yang mati selama 14 hari setelah diberikan dosis tunggal per oral. Berdasarkan statistik probit, DE50 ekstrak etanol daun dewa (22,78 mg/kgBB) lebih besar daripada DE50 natrium diklofenak (1,13 mg/kgBB) dan DL50 ekstrak etanol daun dewa (28,352.84 mg/kgBB) lebih besar daripada DL50 natrium diklofenak (49,41 mg/kgBB). Indeks terapi ekstrak etanol daun dewa (1.245:1) sebagai antiinflamasi lebih besar daripada indeks terapi natrium diklofenak (44:1). Simpulan, dari segi keamanan, ekstrak etanol daun dewa lebih baik daripada natrium diklofenak pada tikus model inflamasi. [MKB. 2012;44(2):90–5].Kata kunci: Antiinflamasi, daun dewa, DE50, DL50, indeks terapi, natrium diklofenakTherapeutic Index of Dewa Leaf {Gynura pseudochina (Lour.) DC} Ethanol Extract and Sodium Diclofenac in Inflammation Rat ModelTherapeutic index, a drug safety parameter, is comparation between the dose at which 50% animals are dead (LD50) and the dose at which 50% animals exhibit the specified effect (ED50). Inflammation was a basic process in various diseases and Dewa leaf {Gynura pseudochina (Lour.) DC} was one of the herbal plants which has been proved as an anti-inflammatory. This study was conducted in order to know therapeutic index of Dewa leaf ethanol extract and sodium diclofenac, a common use non steroid anti inflammation drug (NSAID). The study was conducted in the Laboratory of Clinical Pharmacology Dr. Hasan Sadikin Hospital Faculty of Medicine Padjadjaran University in August–October 2009. This study used laboratory experimental design with a complete randomized block. Median effective dose was counted based on the ability to inhibit the inflammation process until maximal 75% in fifth hour after treatment. Median lethal dose was counted based on number animals dead until 14 days after single dose with oral administration. This research showed that ED50 of Dewa leaf ethanol extract (22.78 mg/kgBW) was bigger than ED50 of sodium diclofenac (1.13 mg/kgBW) and LD50 of Dewa leaf ethanol extract (28,352.84 mg/kgBW) was bigger than LD50 of sodium diclofenac (49.41 mg/kgBW). Therapeutic index of Dewa leaf ethanol extract (1,245:1) as anti-inflammatory was bigger than therapeutic index of sodium diclofenac (44:1). In conclusion, for a safetyness Dewa leaf ethanol extract is better than sodium diclofenac in inflammationrat model. [MKB. 2012;44(2):90–5].Key words: Anti-inflammatory, dewa leaf, ED50, LD50, sodium diclofenac, therapeutic index DOI: http://dx.doi.org/10.15395/mkb.v44n2.80
Korelasi Kadar Albumin Serum dengan Persentase Edema pada Anak Penderita Sindrom Nefrotik dalam Serangan Novina, -; Gurnida, Dida Akhmad; Sekarwana, Nanan
Majalah Kedokteran Bandung Vol 47, No 1 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (552.816 KB)

Abstract

Sindrom nefrotik (SN) merupakan kelainan glomerulus yang ditandai proteinuria masif, hipoalbuminemia, edema, dan hiperlipidemia. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar albumin serum dan persentase edema pada anak penderita SN dalam serangan. Suatu uji analitik korelasional rancangan cross-sectional dilakukan selama bulan Agustus 2009 sampai Januari 2010. Subjek penelitian adalah anak penderita SN dalam serangan, usia 1–14 tahun, berobat ke poliklinik atau dirawat di Rumah Sakit Dr. Hasan Sadikin dan RS Jejaring (RSU Cibabat dan RSU Ujung Berung). Persentase edema dihitung dengan mengurangi total body water (TBW) anak saat sakit dengan TBW ideal, kemudian hasilnya dipersentasekan dengan TBW ideal. Analisis statistik menggunakan Uji korelasi Spearman. Pada penelitian ini didapatkan 29 subjek terdiri atas 26 laki-laki dan 3 perempuan. Kadar albumin serum rata-rata 1,45 g/dL dan persentase edema 21,6%. Hasil Uji korelasi Spearman menunjukkan hubungan yang sangat bermakna (p=0,006) antara kadar albumin serum dan persentase edema (r=-0,501). Simpulan, terdapat hubungan negatif antara kadar albumin serum dan persentase edema pada anak penderita SN dalam serangan. [MKB. 2015;47(1):55–9]Kata kunci: Kadar albumin serum, persentase edema, sindrom nefrotik dalam seranganCorrelation Between Serum Albumin Levels and Percentage of Edema during Nephrotic Stage in Children with Nephrotic Syndrome Nephrotic syndrome (NS) is a glomerular disorder characterized by massive proteinuria, hypoalbuminemia, edema, and hyperlipidemia. The aim of this study was to evaluate the correlation between serum albumin levels and percentage of edema during nephrotic stage in children with NS. Cross-sectional design with correlational analytic was used in this study. The subjects of this study were outpatients and inpatients with NS during nephrotic stage, aged between 1 and 14 years old, admitted to Dr. Hasan Sadikin General Hospital Bandung, Cibabat Hospital, and Ujung Berung Hospital from August 2009 to January 2010. Percentage of edema was calculated by substracting total body water (TBW) during illness to ideal TBW, then divided the result by ideal TBW. Subjects were 29 children, consisted of 26 boys and 3 girls. Mean serum albumin levels was 1.45 g/dL and percentage of edema was 21.6%. Analysis using Spearman correlation test showed a highly significant correlation (p=0.006) between serum albumin levels and percentage of edema in children with NS during nephrotic stage (r=-0.501). In conclusion, there is a negative correlation between serum albumin levels and percentage of edema during nephrotic stage in children with NS. [MKB. 2015;47(1):55–9]Key words: Nephrotic syndrome, nephrotic stage, percentage of edema serum albumin levels    DOI: 10.15395/mkb.v47n1.408
Oral Manifestations of Systemic Lupus Erythematous and Its Comprehensive Management: Two Case Reports Rita Wardhani; Irna Sufiawati
Majalah Kedokteran Bandung Vol 50, No 1 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.551 KB) | DOI: 10.15395/mkb.v50n1.1234

Abstract

Systemic lupus erythematous (SLE) is an autoimmune collagen-vascular disease involving mucocutaneous and musculoskeletal systems as well as blood vessels that is characterized by diverse clinical manifestations, making it necessary to use a comprehensive multidisciplinary approach. Oral manifestations of SLE include oral ulcer, discoid lesions, oral lichen planus-like-lesion, oral candidiasis, and xerostomia. This study reports two cases of 19-year-old and 41-year-old female patients visiting the Oral Medicine Department Dr. Hasan Sadikin General Hospital in October 2016. These patients were referred by the Internal Medicine Department with SLE diagnosis, involving hematological, musculoskeletal and mucocutaneous systems. Extraoral examination revealed moon face in the first patient and malar rash and lips exfoliations in the second  patient. Intraoral examination revealed oral ulcers on buccal and labial mucosa as well palate in both patients. Both patients were given methyl prednisolone, calcium, and folic acid by the Internal Medicine Department. Oral ulcers were treated with prednisone mouthwash, nystatin oral suspension, and vitamin B12. The oral ulcer on palate was considered very difficult to resolve so that topical corticosteroid was required. Prednisone mouthwash was chosen as drug of choice due to its efficacy on oral mucosa and its ability to minimize the systemic adverse effects which were resolved in 6 week after starting treatment. Comprehensive multidisciplinary approach associated with oral manifestation of SLE has significant effects in decreasing disease severity and improving the quality of life in patients with SLE.Key words: Oral ulcers, prednisone mouthwash, systemic lupus erythematosus Manifestasi Oral Lupus Eritematosus Sistemik dan Manajemen Komprehensifnya: Dua Laporan KasusSistemik lupus eritematosus (SLE) adalah penyakit kolagen-vaskular autoimun, yang melibatkan sistem mukokutan, muskuloskeletal, dan pembuluh darah yang ditandai dengan manifestasi klinis yang bervariasi, sehingga diperlukan pendekatan multidisiplin yang komprehensif. Manifestasi oral SLE meliputi ulkus mulut lesi diskoid, lichen planus-like lesion, kandidiasis oral, dan serostomia. Pasien wanita berusia 19 tahun dan 41 tahun yang dirujuk dari departemen Penyakit Dalam pada Oktober 2016 dengan diagnosis SLE yang melibatkan hematologis, muskuloskeletal, dan mukokutan. Pemeriksaan ekstraoral menunjukkan moon face pada pasien pertama, dan malar rash serta pengelupasan bibir pada pasien kedua. Pemeriksaan intra oral mengungkapkan ulkus oral, mukosa labial, dan palatum pada kedua pasien. Kedua pasien diberikan metil prednisolone, kalsium, dan asam folat dari departemen Penyakit Dalam. Ulkus oral diobati dengan obat kumur prednison, suspensi oral Nistatin, dan vitamin B12 yang diberikan dalam 6 minggu pengobatan. Ulkus oral adalah salah satu manifestasi oral yang umum pada pasien SLE. Ulkus oral pada palatum dianggap sangat sulit diatasi sehingga dibutuhkan kortikosteroid topikal. Prednisone mouth wash dipilih sebagai obat pilihan sebagai anti-inflamasi pada mukosa oral dan meminimalkan efek samping sistemik. Pendekatan multidisiplin komprehensif yang terkait dengan manifestasi oral SLE memiliki efek signifikan dalam menurunkan tingkat keparahan penyakit dan meningkatkan kualitas hidup pada pasien SLE.Kata kunci: Lupus eritematosus sistemik, ulser oral, obat kumur prednison

Page 21 of 66 | Total Record : 651

 19   20   21   22   23 

Filter by Year

2012 2025


Reset
Filter By Issues
All Issue Vol 57, No 4 (2025) Vol 57, No 3 (2025) Vol 57, No 2 (2025) Vol 57, No 1 (2025) Vol 56, No 4 (2024) Vol 56, No 3 (2024) Vol 56, No 2 (2024) Vol 56, No 1 (2024) Vol 55, No 4 (2023) Vol 55, No 3 (2023) Vol 55, No 2 (2023) Vol 55, No 1 (2023) Vol 54, No 4 (2022) Vol 54, No 3 (2022) Vol 54, No 2 (2022) Vol 54, No 1 (2022) Vol 53, No 4 (2021) Vol 53, No 3 (2021) Vol 53, No 2 (2021) Vol 53, No 1 (2021) Vol 52, No 4 (2020) Vol 52, No 3 (2020) Vol 52, No 2 (2020) Vol 52, No 1 (2020) Vol 51, No 4 (2019) Vol 51, No 3 (2019) Vol 51, No 2 (2019) Vol 51, No 1 (2019) Vol 50, No 4 (2018) Vol 50, No 3 (2018) Vol 50, No 2 (2018) Vol 50, No 1 (2018) Vol 49, No 4 (2017) Vol 49, No 3 (2017) Vol 49, No 2 (2017) Vol 49, No 1 (2017) Vol 48, No 4 (2016) Vol 48, No 3 (2016) Vol 48, No 2 (2016) Vol 48, No 1 (2016) Vol 47, No 4 (2015) Vol 47, No 3 (2015) Vol 47, No 2 (2015) Vol 47, No 1 (2015) Vol 46, No 4 (2014) Vol 46, No 3 (2014) Vol 46, No 2 (2014) Vol 46, No 1 (2014) Vol 45, No 4 (2013) Vol 45, No 3 (2013) Vol 45, No 2 (2013) Vol 45, No 1 (2013) Vol 42, No 3 Vol 44, No 4 (2012) Vol 44, No 3 (2012) Vol 44, No 2 (2012) Vol 44, No 1 (2012) Vol 43, No 4 Vol 43, No 3 Vol 43, No 2 Vol 43, No 1 Vol 42, No 4 Vol 42, No 2 Vol 42, No 1 Vol 41, No 4 Vol 41, No 3 Vol 41, No 2 Vol 41, No 1 More Issue