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JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Published by Universitas Negeri Malang
ISSN : 25496565     EISSN : 25496573     DOI : 10.17966
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
JC-T (Journal Cis-Trans) : jurnal kimia dan terapannya is published by Universitas Negeri Malang, Faculty of Mathematics and Science, Chemistry Department.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 101 Documents
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Aktivitas Antioksidan dan Identifikasi Senyawa Metabolit Sekunder dari Ekstrak Batang Dahu (Dracontomelon dao) Tarso Rudiana; Nani Suryani; Haerul Anwar
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p008

Abstract

Dahu (Dracontomelon dao) belongs to the Anacardiaceae family which contains various secondarymetabolites that can be used as a source of natural antioxidants. The aim of this study was to extractsecondary metabolites from stems bark of D. dao, determine their antioxidant activity and analyze the contentof secondary metabolites using LC-MS/MS. The stem samples of D. dao were extracted in stages with varioustypes of solvents such as methanol ethyl acetate, and n-hexane. Each extract was analyzed for its antioxidantactivity using the 2,2-diphenyl-1 picrylhydrazyl (DPPH) method. The most active extracts werecharacterized by LC-MS/MS. The stem methanol extract of D. dao showed the best antioxidant activity withan IC50 value of 30.86 ppm, followed by ethyl acetate extract with an IC50 of 200.83 ppm and n-hexane extractwith an IC50 value of 348 ppm. Identification results with LC-MS/MS methanol extract containingtributylamine, medroxyprogesterone acetate, and flavanones.
Model QSAR dari Turunan 3- tersubstitusi 4-Anilino Kumarin terhadap Aktivitas Anti-kanker Pankreas Daratu Eviana Kusuma Putri; Harno Dwi Pranowo; Anugrah Ricky Wijaya; Aman Santoso
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p013

Abstract

Quantitative structure-activity relationship (QSAR) from 3-substituted 4-anilino coumarin derivativesas anti pancreas cancer had been successfully generated and validated. The 3-substituted 4-anilinocoumarin derivatives structures and their biological activities were taken from the research of Luo et al.Each structure of 3-substituted 4-anilino coumarin derivatives was optimized using DFT/BPV86 6-31Gmethod. The QSAR models were generated by Multi Linear Regression (MLR) and the best model gainedwas: Log IC50 = 4,02 + (-7,126 x qC7) + (-5,709 x qC8) + (6,845 x qC18); n = 18; r2 train = 0.701; r2 test = 0.849, Fkal/Ftab = 3,269; SEE = 0.230. From this model, Log IC50 of pancreas cancer from 3-substituted 4- anilino coumarin derivatives can be reduced by modifying qC7, qC8, dan qC18 as the coefficient values ofeach descriptor.
Material Hibrida Mg/Al-HT Terinterkalasi Asam 3,4,5-Trihidroksibenzoat Dengan Metode Kopresipitasi Melalui Mikro Reaktor-T Danar Danar; Sri Juari Santosa; Eko Sri Kunarti
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p020

Abstract

The material of Mg/Al hydrotalcite (Mg/Al-HT-ATBH) intercalated with 3,4,5-trihydroxybenzoic acid(THBA) had been successfully synthesized by coprecipitation using a T-type microchannel reactor. Thesynthesized hybrids were characterized by XRD and FT-IR. The result showed that intercalation of THBAinto Mg/Al-HT-THBA reached optimum condition at medium acidity equal to pH 8 with molar ratio ofMg2+:Al3+: THBA was 2:1:0,5. Characterization using FT-IR and XRD showed that THBA was intercalated in the interlayer of Mg/Al-HT-THBA replacing NO3-ions. The value of basal spacing d003 shifted from 11.27° to 6.74° and therefore the interlayer distance increased from 7.84 to 13.10 Å.
Pengaruh Konsentrasi dan Ukuran Partikel Logam Mg terhadap Karakter Magnesium/Grafena Berlapis Nano (Mg/GBN) Fajar Hutagalung; Rikson Siburian; Ab Malik Marwan Ali
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p027

Abstract

Since graphene was synthesized in 2004, it has been widely used in electrochemical energy storagedevices and a number of other applications. This study aims to determine the effect of concentration and size ofMg metal particles on the structure, morphology, and electrical conductivity of Mg/Graphene nano sheets(GNS). This research is a laboratory experiment and descriptive research. GNS was synthesized by using amodified Hummers’ method. Mg 10, 20, 30 and 40 weight % /GNS were synthesized by using impregnationmethod using Mg salt (MgCl2.6H2O) as the precursor. Characterizations carried out on each material usingXRD (2θ = 26,768° – 26,938° for C(002) GNS and 2θ = 44,669° – 44,686° for Mg (102)), SEM-EDX and Conductometer proved that the graphene surface is able to reduce Mg2+ metal ions to Mg0 and to control the size and distribution of Mg metal particles deposited on the surface of the graphene sheets. Meanwhile, Mg metal particles that have been deposited are able to inhibit the agglomeration and re-stacking of graphene sheets so that it can increase the electron mobility and electrical conductivity of graphene
Optimasi Biodegradasi Lignoselulosa oleh Kapang Pelapuk Kayu (KPK) Indigenous Paecilomyces Inflatus Pnum sebagai Alternatif Pengolahan Limbah Taman Kampus Menuju “Green Campus UM” Rohilian Wisaldi; Evi Susanti
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 6 No. 1 (2022)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v6i12022p001

Abstract

The purpose of this study is to find out the influence of Paecilomyces inflatus PnUM cell count and fermentation time in decreasing lignin levels, crude protein levels, and crude fat levels of Pahitan grass from campus park waste can be processed into ruminant animal feed. This study is a laboratory experiment using the Method of Complete Randomized Design (CRD) with variations in the number of spores (8.08 x 106; 2.02 x 107 ; and 4.04 x 107 cells) and fermentation time (7, 14, and 21 days). Stages of this research: (1) Preparation of grass waste, (2) Preparation of suspension of spores isolates of wood-decay fungi Indigenous Paecilomyces inflatus PnUM, (3) Fermentation of garden waste by Indigenous Paecilomyces inflatus PnUM, and (4) Analysis of lignin levels, crude fat levels, and crude protein levels.The test was carried out in two repetitions. The best treatment using 2.02 x 107 cells with a fermentation duration of seven days produced grass with lignin levels 14.13%±0,04, crude fat levels 2.75%, crude protein levels 11.71%±0,1. Fermentation uses Wood-decay fungi Indigenous Paecilomyces inflatus PnUM as an alternative to treatment of pahitan grass waste potentially enough to provide ruminant forage feed alternatives and support UM's Green Campus program.
Eksplorasi Senyawa Bioaktif pada Sayur Meti (Ulothrix sp.) dari Perairan Desa Liliboi, Propinsi Maluku Ivonne Telussa; Fensia Analda Souhoka; Arielno Sahalessy
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 6 No. 1 (2022)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v6i12022p009

Abstract

Maluku's marine potential is a source of plentiful food for coastal populations. The quantity of algaeprovides sustenance for coastal populations, such as meti veggies, which are consumed by the people ofLiliboi Village in Maluku. Information about the types of algae and the composition of bioactive compoundsfrom meti veggies is not yet known. This study aims to identify the morphology and examine thephytochemical content of bioactive compounds in meti vegetables from the coastal waters of Liliboi Village.The research was carried out through several stages, namely morphological observations, extraction ofbioactive compounds by the maceration method using methanol as a solvent, and phytochemical testing ofbioactive compounds in meti vegetables from the coastal waters of Liliboi Village. The results showed thatthe morphology of this meti vegetable had a cell shape similar to that of algae from the division Chlorophyta,genus Ulothrix. Ulothrix is a filamentous algae. Meti vegetables had protein and lipid contents of 31,7820,057 mg/L and 55,045 0,046%, respectively. Phytochemical analysis showed that the methanol extractincludes bioactive compounds such as alkaloids, flavonoids, steroids, saponins, and phenols. The flavonoidcontent of methanol extract is relatively high, at 506,140±0,574 mg/L.
Kadar Flavonoid dan Fenolik Ekstrak Daun Waru (Hibiscus tiliaceus) Serta Aktivitasnya Sebagai Antioksidan Lina Oktavia Rahayu; Oktavina Kartika Putri; Rizki Daniar Manggarani
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 6 No. 1 (2022)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v6i12022p017

Abstract

Waru leaf (Hibiscus tiliaceus) is plant that contains natural flavonoids and phenolic compounds and isuseful as an antioxidant. Flavonoids and phenolics can be extracted optimally if using a suitable extractionsolvents. This study aims to determine the total flavonoid, phenolic, and antioxidant levels of waru leaf extractusing several extraction solvents. The total flavonoid content was tested using the AlCl3 colorimetric method,total phenolic content using the Folin-Ciocalteu method, and antioxidant levels using the DPPH method.The total flavonoid content of the extract with methanol, ethanol, and water solvents respectively 121,630 ±2,014 gQE/g; 133,190 ± 1,434 gQE/g; 78.320 ± 1.799 gQE/g. The total phenolic content of the extract withmethanol, ethanol, and water solvents were 9,151,480 ± 58,969 gGAE/g; 7,978,610 ± 84,845 gGAE/g;4,789,690 ± 14,576 gGAE/g. Extract with methanol solvent has very weak antioxidant activity (IC50 =710,680 ± 3,747 g/mL). Extract with ethanol solvent has very weak antioxidant activity (IC50 = 989.150 ±0.798 g/mL). Extract with water solvent has very weak antioxidant activity (IC50 = 1,643,480 ± 1,828 g/mL).Ethanol extract had the highest total flavonoid content. Methanol extract had the highest total phenoliccontent and very weak antioxidant activity
Penerapan Response Surface Methodology dalam Optimasi Kondisi Proses Ekstraksi Antosianin pada Limbah Kulit Kakao dengan Metode Maserasi Menggunakan Pelarut Etanol Istiqomah Rahmawati; Boy Arief Fachri; Nurtsulutsiyah Nurtsulutsiyah; Yakub Hendrikson Manurung; Muhammad Reza; Bekti Palupi; Meta Fitri Rizkiana; Helda Wika Amini
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 6 No. 1 (2022)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v6i12022p024

Abstract

Anthocyanins are present in high concentration in cocoa peels. The purpose of this study is to identifythe relationship between each input variables and to develop predictive models used in optimizing theconditions of the anthocyanin extraction process. Extraction of anthocyanins in cocoa peels was carriedout using the maceration method. Extraction process conditions such as particle size (0,105; 0,125; 0,149;0,177; 0,25 mm), material/solvent ratio (0,0045; 0,0125; 0,0375; 0,0625; 0,0795 g/mL), and optimumextraction time (7,5; 24; 48; 72; 79 hour) in the extraction process will affect the obtained concentration ofanthocyanin. The Design Expert vs11 program with Response Surface Methodology (RSM) Box-BehnkenDesign was used for research and select process conditions from a combination of factors producing theoptimal responses. Relationship between variables and the response of anthocyanin concentration wasmodeled by Y=0,2129-0,0483A+0,0816B+0,0069C-0,0219AB-0,0271AC+0,0174BC+0,0298A2 -0,0349B2 +0,0504C2 (A is particle size; B is the ratio of cocoa peel/ethanol; and C is extraction time). The optimal response value of anthocyanin concentration is 0,479 M, with the condition of the particle size at the extraction process of 0,105 mm; the ratio of cocoa peel/ethanol of 0.0625 w/v; extraction time of 72 hours.
Modifikasi Screen Printed Carbon Electrode Menggunakan Cerium dan Optimasi Kondisi Percobaan Biosensor Elektrokimia untuk Deteksi DNA Mitokondria Sus Scrofa Maulida Fajriyah; Yenni Wahyuni Hartati; Anni Anggraeni; Shabarni Gaffar; Yusuf Rohmatullah
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 6 No. 1 (2022)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v6i12022p031

Abstract

The use of cerium in sensor applications has been widely develop. In this research, electrochemicalbiosensors have been developed to support Sus scrofa mitochondrial DNA using SPCE-Ce. The surface ofthe SPCE electrode before and after an electrodeposition with cerium, was characterized using SEM andcyclic voltammetry (CV). The design of pork nucleotide sequence as DNA probes, was determined usingNCBI blast program and T-Coffee. The DNA probe was immobilized to SPCE-Ce trough electrostaticinteractions between the surface of cerium and the DNA phosphate backbone. The probe-target DNAhybridization was characterized using DPV. The result of the characterization using SEM showed a flat anduniform of electrode surface for SPCE-Ce than the bare SPCE surface. The voltammogram cyclic shows anincrease in the peak of the ferrycianide current for SPCE-Ce. The result of the DNA probe sequence designare 5’-TATTIATACCAATCACTAIC-3’ which shows 100% homology with pig DNA and 0% homology withchicken and beef DNA. The linear equation of target concentration is I = 0.0303 [target DNA] + 3.947 forthe target DNA concentration range 5 – 30 µg/mL, and the LOD value is 1.44 µg/mL. This biosensor can be used to determine pig mtDNA concentration in the real samples
Penentuan Nilai Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) Ekstrak Etanol Daun Pandan (Pandanus Amaryllifolius Roxb) Terhadap Bakteri Streptococcus Mutans Niamul Faza Assauqi; Mutista Hafshah; Rais Nur Latifah
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 7 No. 1 (2023)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v7i12023p001

Abstract

Streptococcus mutans is one of the microorganisms in the oral cavity that can cause cavities. Preventionthat can be done to avoid this disease with mouthwash that contains antiseptic. Alternative methods can bedeveloped by utilizing natural ingredients as the basic ingredients for making mouthwash. Fragrant pandanleaves (Pandanus amaryllifolius roxb) contain several active compounds including flavonoids, tannins, andalkaloids that have the potential to have antibacterial activity. This study aims to determine the value of theMinimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of pandan leafethanol extract against Streptococcus mutans bacteria. Fragrant pandan leaf extract was obtained bymaceration method using 70% ethanol solvent with various concentrations of 0.36%, 0.78%, 1.56%, 3.12%,6.25%, 12.5%, 25%, 50 %, and 100%. The determination of the MIC value was carried out by the liquiddilution method using a UV-Vis Spectrophotometer. While the determination of the value of MBC is done bythe Spread plate method. The results showed that the MIC value was at a concentration of 6.25% because itwas able to inhibit the growth of bacteria. While the MBC value is at a concentration of 25%, where at thatconcentration there are no bacterial colonies growing.

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