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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

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Articles 150 Documents

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Profil Terapi Diare Akut pada Pasien Anak Rawat Inap di Rumah Sakit Bhayangkara Surabaya Sandra, Pipit; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Acute diarrhea in children is defined as defecation more than 3 times per day, with changes in the consistency of feces into fluids with or without mucus and blood lasting either less than a week or up to 14 days, but not more than 14 days in children or infant. Treatment of acute diarrhea can shorten the duration of diarrhea and eradicate the organism which causes the disease. The purpose of this research was to analyze the profile of acute diarrhea treatment in hospitalized pediatric patients at Bhayangkara Hospital Surabaya including the type, dosage, route and the timing of administration which is related to the patientâ€™s medical record data. This research is an observational study in the form of retrospective study in patients with acute diarrhea with a t o t a l sampling technique. The results showed the most commonly used medications for acute diarrhea in children were parenteral rehydration fluid of KDN-1 of (41 patients, 80%) with the most widely used dose (500 cc / 4 hours â†’ 1000 cc / 24 h) IV, t h e pa t t e r n o f single antibiotic use was (43 patients, 84%), the penicillin group, ampicillin, as many as (22 patients, 44%) with the most widely used dose (4 x 250 mg) IV, the most commonly prescribed single antibiotic when discharged from the hospital was cephalosporin group, cefixime, with 17 patients (33%), with the most widely used dose (2 x 20 mg) P.O, sinbiotic with (36 patients, 70%) and the most widely used was dose (1 x 1 sachet) P.O, zinc with (49 patients, 96%) and the most widely used was dose (1 x 1 cth) P.O, vitamin A with (21 patients, 41%), and the most widely used was dose (1 x 500 IU) P.O, antidiarrhea dioctahedral smectite was (43 patients, 84%) and the most commonly used was dose (3 x 1/3 sachets) P.O.

Studi Penggunaan Antiemetik pada Pasien Demam Tifoid Rawat Inap di RSUD Kabupaten Sidoarjo Wardhani, Hety Setya; Surdijati, Siti; Hasmono, Didik
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Typhoid fever is an infection of the small intestine caused by Salmonella thypi bacteria with symptoms of fever at night. This disease is a contagious disease that can affect many people and is still a health problem, especially in developing countries. This study aims to analyze patterns of antiemetic use in typhoid fever patients. This research was conducted at Sidoarjo District General Hospital using a retrospective method in the period of January 1 to December 31, 2015. The sample was typhoid fever patients who were treated at the Sidoarjo District Hospital. The results obtained using the Health Medical Record (RMK) of patients who have been validated, 161 patients was detected and only 30 patients who is using antiemetic therapy. The antiemetic used is ondansetron. Ondansetron in single dose (3x4mg) iv used in 7 patients (23%) and (3x8mg) iv in 23 patients (77%). The duration of ondansetron use in typhoid fever patients in Sidoarjo District Hospital â‰¤ 2 days was 10 patients and â‰¥ 2 days was 20 patients. Antiemetics used were in accordance with the guidelines and no Drug Related Problems (DRPs) were obtained in typhoid fever patients as seen from their interactions with other drugs, the interval of administration, frequency of administration, duration of treatment, and dose of administration.

Standarisasi dari Daun Kirinyuh (Chromolaena odorata) dan Simplisia Kering dari Tiga Daerah yang Berbeda Ance, Paulina Erlianda; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Siam wead (Chromolaena odorata) is used traditionally for treatment lesoin, amenorrhea, antidiabetic and antimicrobial. Based on previous research, there is no reference about the standardization Siam Weed leaves dried powder. This study aims to determine macroscopic and microscopic of siam weed leaves fresh plant obtained from, Surabaya, to determine the spesific and non spesific quality profile of dried powder of siam weed leaves dried powder obtained from different areas (Bogor, Malang and Surabaya). The spesific parameter that used were identity, organoleptic, microscopic, determination of soluble extract, phytochemical screening, determination chromatogram profile using Thin Layer Chromatography, determination spectrum profile using spektrophotometer UV-Vis and Infrared, determination of alkaloid, phenol and flavonoid content. Non spesific parameters that used were the determination of total ash value, water soluble ash value, acid insoluble ash value, drying losses and pH. Based on result of the study, it was concluded that siam weed fresh plant leaves have elliptico-oblongus shape, acutus shape for the upper and lower base, green colored for the top and bottom surfaces, adge shape for the wavy , 6.4-11.8 (L), 3.3-5.9 (W), wavely leaf rib, fluffy leaf texture, and the position of facing a single, microscopically have the fragments as same as the dried powder fragments, ethanol soluble concentration â‰¥ 12%, water soluble concentration â‰¥ 20%, solvent can be used for chromatogram profile in TLC is chloroform : ethyl acetate (15:1), spectral profile with spectrophotometer UV-Vis have wavelength 533.5 nm, 500 nm, 534.5 nm, 501.5 nm, 284.5 nm, 289 nm and 292 nm, spectral profile with IR spectrophotometers have wavenumber 3266.28 cm-1-3282.21 cm-1, 1416.01 cm-1, 1514.53 cm-1, 1514.93 cm-1, 1245.35 cm-1, 1249.52 cm-1 dan 1251.27 cm-1, flavonoid content â‰¥ 0.4%, phenol content â‰¥ 1.0% and alkaloid content â‰¥ 1.0%, total ash content â‰¤ 14%, water ash soluble â‰¤ 5%, acid unsoluble ash â‰¤ 10%, drying losses â‰¤ 11% and range pH 5-7.

Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.

Standarisasi Spesifik dan Non Spesifik Simplisia dan Ekstrak Etanol Bawang Putih Tunggal Terfermentasi (Allium sativum Linn.) Vernanda, Renna Yulia; Puspitasari, Maria Revina; Satya, Hadianto Nur
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Garlic that has undergo a fermentation process (Black garlic) has been shown to have a total content of flavonoids and polyphenols greater than fresh garlic. One of garlic varieties is single bulb Garlic (Allium sativum Linn.) which contains only one small bulb. This study aims to determine specific and non specific standardization of dried fermented single bulb Garlic and ethanol extract of fermented single bulb Garlic (Allium sativum Linn.). Samples were collected from three different regions: Temanggung, Bromo and Banyuwangi. The results of the study showed that dried fermented single bulb garlic have round shape oval, brown color blackish, and aromatic odor; water soluble content >25%, ethanol soluble content >26%, total polyphenols >4.5% b/b, total flavonoids >0.6% b/b; dred fermented single bulb Garlic contain polyphenols, flavonoids, and saponins; total ash content 2% b/b; the ethanol extract contain polyphenols and flavonoids; total ash content

Studi Penggunaan Obat Phenytoin Kurang dari Tiga Bulan terhadap Kadar Magnesium Serum dan Jumlah Kejang Pasien Epilepsi di RSUD DR. Soetomo Surabaya Sanjiwani, Kadek Siska Febri; Sugianto, Paulus; Kasih, Elisabeth
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Epilepsy is a clinical phenomenon associated with an electrical explosion or excessive abnormal depolarization, which occurs in focus in the brain which causes a paroxysmal awakening. One of the anti-epilepsy drugs is phenytoin which belongs to the hydantoin class. This study aims to describe the serum Mg levels in epilepsy patients with phenytoin drug therapy in Dr. Soetomo General Hospital with a treatment period of less than three months and to identify DRP problems (Drug Related Problems). The method used in this study is prospectively presented by descriptive method (observational). The population in this study were epilepsy patients who were treated at the RSUD dr. Soetomo Surabaya with a sample of 28 epilepsy patients treated at the Outpatient and EEG Neurology Room at Dr. Soetomo General Hospital Surabaya. Results showed that Mg2+ levels in 28 patients with the highest magnesium levels were 2.46 mg / dL. While the lowest magnesium content is 1.78 mg / dL. Conclusions Patients' magnesium levels are still within the normal range but it has not been concluded that phenytoin can increase serum Mg2+ levels and there is no significant difference between phenytoin therapy in epilepsy patients

Formulasi Sediaan Pemerah Pipi Ekstrak Air Buah Syzygium cumini dalam Bentuk Compact Powder Letelay, Yulia Riani; Darsono, Farida Lanawati; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

One of the fruits in Indonesia that can be used in the field of decorative cosmetics is Syzygium cumini. Blackish purple appearance of the fruit indicates the high content of anthocyanin, a natural pigment dye in decorative cosmetic formulations, especially for blusher. Compact powder blusher has the advantage of easy to use and has a better adhesion to the skin. Isopropyl myristate is a binder that is commonly used for compact powder blusher because of its properties which can increase adhesivity. The purpose of this study was to determine the effect of the concentration of isopropyl myristate as a binder on physical quality and effectiveness and to determine the best formula that fulfil the requirement of the physical quality, effectiveness, safety and acceptability. The compact powder blusher containing water extract of Syzygum cumini was formulated using wet granulation method with varying concentrations of isopropyl myristate 0.5%, 0.75% and 1.0%. The Evaluation of the product includes organoleptic, homogeneity, particle size, pH, friability and hardness, rubbing test, irritation test and acceptability test. The results showed an increase in the concentration of isopropyl myristate had a significant effect on decreasing the pH value, decreasing particle size, and affecting the ability of the blusher to be smeared. The compact powder blusher with 0.75% isopropyl myristate was the best formula that meets the specifications based on physical quality, effectiveness, and safety parameters.

Pengaruh Jamu Anemia terhadap Fungsi Ginjal di Rumah Riset Jamuâ€œHortus Medicusâ€ Tawangmangu Ardiyanto, Danang; Triyono, Agus; Nisa, Ulfatun
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

The use of herbal medicine in the formal health care requires adequate scientific evidence especially on herbal safety data. The herb could be used for the treatment of anemia. The indicator for the safety of the herb was kidney function by measuring urea and creatinine. A clinical trial study with pre-post test designed was conducted at the Jamu Research Center "Hortus Medicus" Tawangmangu to assess renal function of patients treated anemic with herbal formula for anemia. A total of 35 subjects volunteered to follow this study received therapy with herbal formula for 1 month. Formula was a herbal infusion made up of 5 grams of red amaranth leaves (Amaranthus tricolor L.), 10 grams herbs of tapak liman (Elephantopus scaber L.) and 15 grams of temulawak rhizome (Curcuma xanthorrhiza), taken 3 times a day. Kidney function was observed by measuring the levels of urea and creatinine subjects at baseline (D-0) and at day 28 (D-28). The results of t-test between urea levels in D-0 and D-28, showed the value of p = 0.942 (> 0.05) and creatinine levels in D-0 and D-28, p-value = 0.935 (> 0.05), which means no significant difference. It can be concluded that herbal formula for anemia did not affect renal function.

Studi Penggunaan Antihipertensi Golongan Angiotensin Receptor Blockers Terhadap Pasien Gagal Ginjal Kronik Stadium V di Rumah Sakit Bhayangkara Surabaya Bura, Ursula Dua Klowe; Hasmono, Didik; Surdijati, Siti; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Chronic renal failure is functional or structural kidney damage for more than 3 (three) months with or without a decrease in the Glomerular Filtration Rate (GFR), manifested as one of the pathological abnormalities or a sign of kidney damage, including blood or urine composition abnormalities or radiology abnormalities. In addition, chronic renal failure is also defined as a condition of GFR value of less than 60 ml / minute / 1.73 m2, for more than 3 (three) months with or without kidney damage. One of the risk factor for chronic renal failure is hypertension. The purpose of antihypertensive administration is to prevent further damage to other organs, and also to reduce blood pressure in patients with chronic renal failure with a target of â‰¤ 140 mmHg. Angiotensin Receptor Blockers (ARB) is a first-line therapy used to reduce blood pressure so that it can delay kidney damage. The purpose of this study was to determine the pattern of antihypertensive drug use in the ARB class in patients with stage V chronic renal failure at Bhayangkara Hospital in Surabaya which was associated with clinical and laboratory data. The study was conducted observationally with a descriptive research design and retrospective data collection. The results showed that those who met the inclusion criteria were 30 patients using antihypertensive ARB therapy, where the highest number of sexes were 67% male and 33% female, the highest populations at the age of 31-70 years, the highest populations was 90% for ARB use and other antihypertensive drug and a single ARB use of 10 %, the most common combination ofantihypertensive group is ARB and Calsium Channel Blocker (CCB) 41%. The patientâ€™s blood pressure mostly meets the target of â‰¤ 140 mmHg.

Potensi Antibakteri dan Antibiofilm Ekstrak Etanol Bunga Bintaro (Cerbera odollam) terhadap Staphylococcus aureus ATCC 6538 Lestari, Dwi Rahma Suci; Soegianto, Lisa; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 4, No 1 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

Cerbera odollam was one of the plants that can inhibit the growth of bacteria that cause infectious diseases. The misuse of antibiotic in the treatment of infection frequent caused bacterial resistance. One of the forms of antibiotic resistance was the capability of microorganism forming biofilm. This study was conducted to determine the antibacterial and anti-biofilm activity of ethanolic extract from Cerbera odollam flower against Staphylococcus aureus. The ethanolic extract obtained by maceration method using 96% ethanol as a solvent. The ethanol extract of Suicide tree (10, 20 and 30%) were tested for antibacterial activity against Staphylococcus aureus using well diffusion method and anti-biofilm activity using microdilution method. Based on the results, ethanol extract of flowers Cerbera odollam inhibit the growth of Staphylococcus aureus with inhibition zone of 21.66Â±0.73 mm (10%), 25.66Â±1.50 mm (20%) and 27.10Â±1.06 mm (30%). The ethanol extract of Suicide tree flower inhibit biofilm formation 98.29% at the concentration of 3.75%. The bio autography results showed that alkaloid and tannin responsible as bioactive compounds from the ethanol extract Suicide tree flower.

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