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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
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Perbedaan antara Video Asissted Thoracoscopy Surgery (VATS) dengan Torakotomi pada Non Small Cell Lung Cancer (NSCLC) : Sebuah Tinjauan Sistematik dan Meta Analisis Putra, Fuad Iqbal Elka; Hanum, Hanifah
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1049

Abstract

Video-assisted thoracic surgery (VATS) lobectomy provides a minimally invasive approach for the management of early-stage lung cancer. This systematic review and meta-analysis is aim to provide the outcomes between VATS and thoracotomy lobectomy. The research is aim to compare between video-assisted thoracoscopis surgery and thoracotomy in non small cell lung cancer patient. Five articles databases were searched via PubMed. Primary outcomes were operative time, postoperative hospital stay, chest drainage volume, chest drainage time, and number of lymph node dissesction. Review Manager (RevMan) [computer program] version 5.4 was used to pool the data. There were significant results VATS has shorter postoperative length of stay (95% CI 1.08 to 4.83) and chest drainage volume (CI 25.83 to 344.98). There were not significant results in terms of operative time (95%CI -30.88 to 40.10), chest drainage time (95%CI -0.95 to 2.50), and number of lymph node rdissection (95%CI -0.67 to 1.740). VATS lobectomy is superior to thoracotomy lobectomy in terms of shorter postoperative length of stay (95% CI 1.08 to 4.83) and chest drainage volume (CI 25.83 to 344.98). The results also showed no significant differences between the two treatment modalities regarding the operative time, chest drainage time, and number of lymph nodes dissected.
Hiperglikemia Pada Terapi Nutrisi Parenteral Dwi Anjani, Galuh; Junando, Mirza; Oktarlina, Rasmi Zakiah; Himayani, Rani
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1050

Abstract

Hyperglycemia is a condition that often occurs in some patients on parenteral nutrition therapy, both with and without a diagnosis of diabetes mellitus. The incidence of hyperglycemia is closely related to an increase in length of stay and mortality in hospital. This literature review aims to provide an overview of the management of hyperglycemia related to parenteral nutrition therapy. The source search method was carried out using the Google Scholar, Pubmed and Elsevier search engines. The keywords used are management of hyperglycemia, risk factors, parenteral nutrition. Based on the results of the literature review, it was found that several factors trigger the incidence of hyperglycemia, including BMI > 25 kg/m2, advanced age, higher HbA1c, history of type 2 DM, use of glucocorticoid drugs and administration of excess carbohydrates and reduced insulin sensitivity. Several strategies to prevent hyperglycemia are carried out by providing low dextrose, hypocaloric parenteral nutrition, or combining parenteral and enteral nutrition. Providing combined nutrition can improve glycemic control in patients with sufficient endogenous insulin stores. Meanwhile, therapeutic measures need to be given if hyperglycemia persists after preventative strategies are implemented. Therapeutic measures that can be taken include administering insulin intravenously or subcutaneously to patients in stable condition. Alternatively, insulin can be added to the parenteral nutrition mixture. It is important to closely monitor blood glucose levels to reduce the risk of hyperglycemia or hypoglycemia.
Aktivitas Antioksidan Pada Temulawak (Curcuma xanthorrhiza Roxb.) Dan Jahe Merah (Zingiber officinale var Rubrum) Fadila, Riska Intan; Iqbal, Muhammad; Triyandi, Ramadhan; Rahayu, Ihsanti Dwi
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Temulawak (Curcuma xanthorrhiza Roxb.) or Javanese turmeric is one of the medicine plants from Indonesia, which contains curcuminoid and xanthorrhizol. These compounds have large biological activity, such as antioxidant capacity. The location of this plant grows, affects the variance of the active compound which causes the changes in its activity. This study aims to evaluate antioxidant capacity, total phenolic, and total flavonoid content (TPC and TFC) of the sample collected from different markets, and to classify the samples into different culsters with chemometric techniques. The antioxidant capacity is determined by using DPPH radical scavenging assay. Red ginger (Zingiber officinale var. Rubrum) is a spice plant as well as a plant that functions as a raw material for medicines. In the health sector, red ginger contains compounds that are antioxidants, one of which is phenol compounds. The phenolic compounds present in the red ginger rhizome have the potential to prevent hemolysis and inhibit free radical oxidation reactions in the body. Red ginger (Zingiber officinale var. Rubrum) is a spice plant as well as a plant that functions as a raw material for medicines. In the health sector, red ginger contains compounds that are antioxidants, one of which is phenolic compounds. The phenolic compounds in red ginger rhizomes have the potential to prevent hemolysis and inhibit the process of free radical oxidation in the body. The phenolic compounds in red ginger rhizomes have the potential to prevent hemolysis and inhibit the process of free radical oxidation in the body. Apart from that, red ginger rhizome contains gingerol which has antioxidant, antibacterial, anti-inflammatory, anticarcinogenic, antimutagenic and antitumor activity.
Apendisitis Akut Pada Pasien Dewasa: Ulasan Singkat Fachmi Aditya; Satria, Muhammad
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1053

Abstract

Acute appendicitis is an inflammatory condition that occurs within 24 hours in the vermiform appendix which is usually triggered by obstruction of the outlet of the appendix and in adult patients the obstruction is caused by lymphoid hyperplasia. The typical clinical manifestation that appears is periumbilical pain which then migrates to the right lower quadrant. Typical physical examination is tenderness at the McBurney point, Rovsing sign, obturator sign and psoas sign. The most important supporting examination is a complete blood test which indicates the presence of leukocytosis. Imaging modalities are performed if the clinical diagnosis is not yet established and to determine the size of the inflamed appendix. The imaging modality often chosen is abdominal ultrasound because it is cheap, easy and suitable for pregnant patients and children. Abdominal ultrasound will show an anteroposterior appendiceal diameter of >6 mm with an abnormal increase in peri-appendiceal fat echogenicity. After the diagnosis of acute appendicitis is made, the next step in treatment is to consider whether an appendectomy, either laparoscopic or open laparotomy, is needed. In addition, administering empirical broad-spectrum antibiotics such as a combination of cephalosporins or fluroquinolones with metronidazole is also important in this case.
Review Article: Pharmacological Activity of Robusta Coffee Plants (Coffee canephora) Virginia, Jesica; Iqbal, Muhammad; Triyandi, Ramadhan; Andrifianie, Femmy
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1054

Abstract

Coffee canephora or robusta coffee is a tree-shaped cultivated plant belonging to the Rubiaceae family and the Coffea genus. This plant is most widely planted in Indonesia, namely 91% more than Arabica coffee plantations and has great potential in its use as an alternative treatment for various diseases. Robusta coffee contains flavonoids, alkaloids, tannins, saponins and polyphenols. The two main polyphenolic compounds found in coffee are chlorogenic acid and caffeine, which each account for about 90% of all phenols found in coffee. This review article aims to determine the various pharmacological activities found in robusta coffee obtained from experimental studies conducted using electronic databases in the form of Google Scholar, Pubmed, and Mendley. The inclusion criteria in the article search were articles in Indonesian and English published in the last 10 years and the exclusion criteria were articles that could not be accessed in full. The results of the study of 25 articles show that the robusta coffee plant in the seeds, leaves and fruit skin has antibacterial, antioxidant, anticancer, anti-inflammatory, antifungal, antidiabetic, and biolarvicide pharmacological activities.
Hubungan Antara Kadar D-Dimer dengan Angka Mortalitas pada Pasien Dewasa Terkonfirmasi Coronavirus Disease 19 di RSUD Abdul Moeloek Bandar Lampung Periode Tahun 2020 – 2021.docx Attila Firjatullah, Muhammad Daffa; Tjiptaningrum, Agustyas; Putri, Giska Tri
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1055

Abstract

Lampung is one of the regions with the highest Case Fatality Rate (CFR) in Indonesia, which was 7.7% on September 16, 2021. Several studies have shown that D-Dimer levels influenced the mortality of confirmed Covid-19 patients. This study aimed to analyze the correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 adult patients. This research was an observational analytic study using a cross-sectional approach. The population of this study was all confirmed covid-19 adult patients who fulfilled the inclusion and exclusion criteria in Abdul Moeloek Hospital Medical Record Installation from 2020 to 2021. The samples were taken using simple random technique. Data collected were D-Dimer level, mortality rate, and patient’s personal information. Data were analyzed by Chi-Square using statistical data processing program. There were 94 subjects admitted in our study, divided into groups of survivors and non-survivors. From the non-survivors’ group, 43 (91%) subjects had a high D-Dimer level. The Chi-Square analysis showed a correlation between D-Dimer levels and the mortality rate of Covid-19 patients (p-value = 0,001). Statistically, there was a significant correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 patients.
Efektivitas Terapi Non-Farmakologi Pada Pasien Hipertensi Nadiya Widda Mawaddah; Damayanti, Ervina; Pardilawati, Citra Yuliyanda
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1056

Abstract

Hypertensive disease is the leading cause of early death worldwide. Hypertension is a common chronic medical condition characterized by sustained increases in arterial pressure. The high risk of side effects in the use of antihypertensive medicine for a long period of time causes non-pharmacological therapy of hypertension to be an alternative choice. This study aims to determine the effectiveness of non-pharmacological therapy in hypertensive patients in reducing and controlling normal blood pressure. The study used a literature review method with data sources of international scientific journals and articles using the PubMed database. The information search strategy used a combination of keywords such as "non-pharmacological therapy for hypertension" and "the effectiveness of non-pharmacological therapy in hypertension". Through the database search, 190 scientific articles and journals were obtained. A total of 12 scientific journals and articles were selected as reference sources for research that met the criteria. The results obtained from 12 journals and scientific articles showed that non-pharmacological therapy for hypertension was effective in reducing systolic and diastolic blood pressure. Non-pharmacological therapies recommended according to the reference sources are lifestyle modification, increasing physical activity such as aerobic exercise, intake of low sodium salt, acupuncture therapy, listening to music, relaxation therapy and increasing compliance with therapeutic interventions.
Herniasi Medula Spinalis Onset Lambat Pasca-Trauma Akibat Cedera Tulang Belakang Jatuh Rendah: Sebuah Laporan Kasus Fitriyani, Fitriyani; Ayu, Zahara; Rizqy, Afifah
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1057

Abstract

Traumatic spinal injuries (TSCI) are often caused by falls. Falls are the main cause of TSCI and high falls are becoming more common. Attention should not only be paid to the high incidence of falls, but also to the low incidence of falls due to the higher rate of neurological injuries and their prevalence in the elderly population. We report the case of a 68-year-old patient who experienced progressive deterioration of his neurological condition 1 month after a traumatic spinal cord injury due to a slip. Investigations revealed post-traumatic spinal cord herniation located at the cervical level. Exploration, decompression and repair were carried out immediately. Late-onset post-traumatic spinal cord herniation is a potentially reversible cause of neurological damage after spinal trauma and should be considered in all cases with late neurological damage after spinal trauma.
Kandidiasis Vulvovaginalis dan Kondiloma Akuminata : Laporan Kasus pada Anak Mareta, Cindy Ayu; Angraini, Dwi Indria
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1058

Abstract

Vulvovaginal candidiasis (CVV) and condyloma acuminata (KA) are sexually transmitted infections (STIs) that are frequently reported. KVV is generally caused by Candida albicans. KA is caused by Human Papilloma Virus (HPV) 6 and 11. The incidence of KA in children has increased in the last few decades. This case report aims to report cases of KVV and KA in children. A 13 year old girl came to the skin and genital clinic at Dr. RSUD. H. Abdul Moeloek, Lampung Province with complaints of white, lumpy and itchy vaginal discharge since 1 month ago. On physical examination, venerological status revealed diffuse erythematous lesions with satellite lesions on the labia majora. In the vulva there is a moderate amount of lumpy, rice-like discharge. In the vulva to perianal region, multiple verrucous papillomatosis papules appeared with positive acetowhite test results. The results of KOH examination of vaginal secretions showed Candida sp. The patient's therapy was given systemic fluconazole and cetrizine, as well as topical myconazole nitrate cream. In this case, there was clinical improvement in CVV after systemic and topical antifungal therapy.
Kajian Polifarmasi Terhadap Keamanan Obat Pada Pasien Geriatri Jessy Dewi Awali; Pardilawati, Citra Yuliyanda; Soleha, Tri Umiana; Oktarlina, Rasmi Zakiah
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1059

Abstract

Geriatric patients an elderly patients suffering from a variety diseases (multimorbidity) caused by a decrease in body organ function. Multimorbidity in geriatric patients tends to lead to increased prescriptions and risks of polypharmacy. Polypharmacy can be defined as the use of five or more types of medications by a patient simultaneously. Polypharmacy is a major concern because of negative health impacts on patients, such as increased incidence of adverse drug reactions, harmful drug interactions, decreased medication adherence, and potentially inappropriate prescribing. Collaboration among doctors, pharmacists, other healthcare professionals, and families plays an important role in ensuring the effectiveness of treatment for geriatric patients, thus making the medications used safe and appropriate and reducing the negative impact of polypharmacy.

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