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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
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Miasthenia Gravis Pada Laki-Laki 60 Tahun dengan Community Acquired Pneumonia : Laporan Kasus Fitriyani, Fitriyani; Nur Azizah, Nabilah
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1030

Abstract

Myasthenia gravis is an autoimmune disease involving the neuromuscular junction (NMJ) of skeletal muscles. It clinically manifests as muscle weakness that worsens with activity or fatigue and improves after rest. It typically involves muscles of the eyes, throat, and extremities. The global epidemiology of myasthenia gravis (MG) affects 30 per 1 million people per year, with an incidence rate of 20 per 100,000 population. In men, the disease often occurs at the age of 60 years. Various conditions can trigger it such as infections, immunizations, surgeries, and medications. Pneumonia is a serious form of acute lower respiratory tract infection in lung parenchyma, encountered in about 15-20% of cases. Case: A 60-year-old male patient presented with complaints of shortness of breath, difficulty swallowing, difficulty opening eyelids, and productive cough. From the history, physical examination, and diagnostic tests, the diagnosis of myasthenia gravis and community-acquired pneumonia was established. The patient received therapy with pyridostigmine bromide 5 x 60mg, methylprednisolone injection 125mg every 12 hours, and levofloxacin injection 750mg every 24 hours.
Hidrosefalus Komunikans akibat Perdarahan Subaraknoid: Sebuah Laporan Kasus Fitriyani, Fitriyani; Adila, Naza Tsasbita Hayuning
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1031

Abstract

Hydrocephalus is one of the most common sequelae after subarachnoid hemorrhage, and is a major cause of high morbidity and mortality from this disease. Changes in cerebrospinal fluid (CSF) dynamics, obstruction of arachnoid granulations by blood products, and adhesions in the ventricular system are some of the mechanisms by which hydrocephalus occurs after subarachnoid hemorrhage. Inflammation, apoptosis, autophagy, and oxidative stress are important causes of hydrocephalus. Transforming growth factors, matrix metalloproteinases, and iron ultimately cause fibrosis and blockage. Surgery is the most common and efficient therapy, although there are risks from different surgical methods, including lamina terminalis fenestration, ventricle-peritoneal shunting, and lumbar-peritoneal shunting. Case report of a 46 year old male patient. A 46 year old man with severe cephalgia that comes and goes and interferes with activities throughout the head such as being pricked since 2 weeks of before coming to hospital. Other complaints of vomiting spraying, slightly black color 6x, fainting 2x for <15 minutes. Physical examination revealed stiff neck and Kernig's sign. CT scan showed subarachnoid hemorrhage filling the interhemispheric fissure, bilateral frontal cortical sulci, left temporal, suprasellar cisterna and Hydrocephalus communicans. In addition, hyponatremia was found, (133 mmol/L).
Seorang Wanita Lansia dengan Vertigo Perifer dan Neuralgia Trigeminal: Laporan Kasus Fitriyani; Nikma Syalsabiela Fauzia
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1032

Abstract

Vertigo is a common complaint presenting frequently in primary care and emergency departments, which is a symptom of vestibular dysfunction and is described as a sensation of movement, most commonly rotational movements. Trigeminal neuralgia (TN) is defined as sudden, severe, brief, stabbing, electric shock-like and repetitive pain that is almost always unilateral in the distribution of one or more branches of the trigeminal nerve, which is highly disruptive and impacts basic human function. The analysis of this study is a case report of Mrs. N, 61 years old, came to the emergency room at Abdul Moloek Regional General Hospital with complaints of spinning dizziness as if the environment around him was spinning which occurred suddenly and pain on the left side of his face like a cut that had been getting worse since 1 day. Complaints of pain on the left side of the face spreading to the chin and left side of the neck have been felt for 2 years. On sensory examination of the Trigeminal Nerve, hyperalgesia and allodynia were found according to the left V1,2,3 dermatomes. The results of the patient's physical examination showed good hearing function, horizontal nystagmus (+), and Romberg's sign (+) balance test, heal to toe walking test (+), past pointing test (+). The patient's clinical diagnosis was vertigo and facial pain (neuralgia). Topis diagnosis, peripheral vestibular system and Trigeminal Nerve. Etiological diagnosis, peripheral vertigo and Trigeminal Neuralgia. The patient's management was infusion of Ringer's Lactate 20 drops/minute, Betahistine 2x24 mg, Omeprazole injection 40mg/12 hours, Carbamazepine 3x200 mg, Amitriptyline 1x25 mg, and Paracetamol 2x1000 mg fls. The prognosis for this patient is quo ad vitam dubia ad bonam, quo ad functionam dubia ad night and quo ad sanationam dubia ad bonam.
Literature Review: Faktor-Faktor Penyebab Kejadian Rehospitalisasi Pada Pasien Congestive Heart Failure (CHF) Kylalona, Gracylia; Suri, Nurma; Aulia Ramdini, Dwi; Sukohar, Asep
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1039

Abstract

Congestive Heart Failure (CHF) is a health disorder with a poor prognosis due to functional or structural heart defects that interfere with ventricular filling or blood ejection into the systemic circulation. CHF remains a significant global health concern with high rates of morbidity and mortality. The number of diagnosed CHF leading to frequent rehospitalization or re-admission due to symptom recurrence. Patients who experience readmitted to the hospital after initial admission have a risk of mortality, with about 50% dying within 6 months and 25-35% passing away within 12. In this review focuses on exploring the factors contributing to rehospitalization among CHF patients. The methodolgy involved analyzing electronic database for relevant studies published over the past decade. Factors identified as leading to rehospitalization in CHF patients include a history of hypertension, non-compliance with taking medication, and an unhealthy lifestyle. Pharmacists play an important role in providing education to patients and helping to fulfill patient medication compliance.
Penatalaksanaan Holistik Laki-laki Usia 22 Tahun Dengan Dermatitis Kontak Alergi Melalui Pendekatan Kedokteran Keluarga: Sebuah Laporan Kasus Canthika Hairil, Nabilla Ayu; Pratiwi, Dian; Nasution, Syahrul Hamidi
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1040

Abstract

Allergic contact dermatitis (DKA) is caused by antigens (allergens) which give rise to type IV hypersensitivity reactions. In Indonesia, it was shown that 97% of 389 cases were contact dermatitis, 66.3% of them were irritant contact dermatitis and 33.7% were allergic contact dermatitis. Applying the principles of a holistic and comprehensive family doctor approach in detecting risk factors, clinical problems, and patient management based on evidence-based medicine and being family-approached and patient-centered. This study is a case report. Primary data was obtained through history taking and physical examination. Secondary data was obtained from patient medical records at the Community Health Center. Assessment is based on a holistic diagnosis of the beginning, process and end of the study quantitatively and qualitatively. Patient Mr. I, 22 years old, came to the Simpur Community Health Center clinic with complaints of red, scaly patches appearing, accompanied by itching on both legs and since 2 months ago until now. Initially, the patient was exposed to stagnant water at his workplace. Over time, the patient complained of reddish rashes accompanied by itching. The patient wore socks and shoes the next day, complaining that the reddish rashes were becoming more numerous and the itching on both feet was getting worse. The patient worked as a construction worker. The patient was diagnosed with allergic contact dermatitis. There are several factors that influence the patient's condition, namely internal and external risk factors. Holistic management with a family doctor approach is needed for patients with allergic contact dermatitis in identifying problems in various aspects to support the success of therapy.
REVIEW ARTIKEL : UJI EFEK ANTI AGING DARI BERBAGAI EKSTRAK TUMBUHAN SECARA IN VIVO DAN IN VITRO Febriyanti, Triana; Sukohar, Asep; Pardilawati, Citra Yuliyanda; Adjeng, Andi Nafisah Tendri
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1041

Abstract

The outermost and largest organ in our body is the skin. Skin can experience aging when exposed to sunlight. Sunlight contains ultraviolet. Exposure to ultraviolet (UV) radiation causes damage to the skin and can lead to photoaging. Photoaging can be prevented with antioxidant compounds. Many plant extracts or synthetic compounds act as anti-aging agents. These plant extracts become active ingredients that can be formulated into pharmaceutical preparations. Plant extracts that have anti-aging potential include red cabbage, kepok banana peel, red pomegranate, moringa leaves, butterfly pea flower, black cumin seeds and libo fruit. To prove this, a test was carried out. The testing carried out can be in the form of in vivo and in vitro testing methods. This research was carried out using the article review method and obtained several journals from online literature, local journals and international journals, namely electronic searches with the keywords anti-aging, in vitro, in vivo on the website, namely Google Scholar. The number of journals used in this review was 11 journals spanning the last eight years. The results of the article review study showed that several methods used were UV-VIS spectrophotometer, DPPH method, anti-elastase, as well as tests on rats, mice and guinea pigs. From the results of the review of articles on plant extracts, most of them use in vivo tests on experimental animals.
Tatalaksana Hipertensi Salshabilla, Annisa; Pardilawati, Citra Yulianda; Sangging, Putu Ristyaning Ayu; Oktarlina, Rasmi Zakiah
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1042

Abstract

Hypertension is called the "silent killer" because there are no specific symptoms for sufferers and it is the main cause of death throughout the world. Hypertension or high blood pressure is a condition where systolic blood pressure increases ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg. According to WHO (World Health Organization), an estimated 1.28 billion adults aged 30-79 years suffer from hypertension worldwide. Riskesdas data for 2018 states that the prevalence of hypertension in Indonesia is 658,201. The pathophysiology of hypertension occurs through the process of forming angiotensin I into angiotensin II by angiotensin I converting enzyme (ACE). Management of hypertension includes non-pharmacological management and pharmacological management. Some non-pharmacological management measures include weight loss, implementing Dietary Approaches to Stop Hypertension (DASH), adopting a low salt diet, consuming potassium supplements, increasing physical activity, and reducing alcohol consumption. Recommended pharmacological therapy in hypertensive patients such as ACEi or ARB with CCB or thiazide/thiazide-like diuretics.
Faktor-Faktor yang Mempengaruhi Health Related Quality Of Life (HRQoL) pada Pasien Penyakit Jantung Koroner Tanpa Penyakit Terminal Lubna Farhana; Ramdini, Dwi Aulia; Himayani, Rani; Junando, Mirza
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1045

Abstract

Coronary heart disease (CHD) is a disorder in heart function caused by narrowing of the coronary arteries and atherosclerotic plaque, leading to inadequate oxygen supply to the myocardial muscle. According to the World Health Organization (WHO) data from 2012, CHD is the number 1 cause of death with a percentage of 38.3% of total deaths. Patients with CHD commonly experience symptoms such as chest pain and shortness of breath, which significantly impact in their health-related quality of life (HRQoL). Additionally, complex treatment can also have a broad impact on HRQoL. The aim of this article is to identify the factors influencing HRQoL in CHD patients. In this study, a literature review method was employed, utilizing online databases such as Elsevier, PubMed, Springer. Factors such as social support, comorbidities, lifestyle, disease condition, self-management, and sociodemographic factors are known to influence HRQoL in CHD patients.
Perbandingan Efektivitas Obat Antihipertensi Golongan ARB versus CCB terhadap Penurunan Tekanan Darah pada Pasien Hipertensi Nuryanti, Eva; Wardhana, M. Fitra; Damayanti, Ervina; Triyandi, Ramadhan
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1047

Abstract

Hypertension is defined as a systolic blood pressure of more than 140 mmHg and a diastolic blood pressure of more than 90 mmHg. Hypertension is a degenerative disease that requires long-term treatment. Hypertension is a silent killer disease because it does not cause symptoms and is only detected during physical examination due to certain diseases so that it can be a major cause of morbidity and mortality. Hypertension management guidelines recommend the use of thiazide/ACEi/ARB/CCB diuretic class drug monotherapy. The purpose of this study is to determine the difference in effectiveness between Calcium Channel Blocker (CCB) and Angiostensin Receptor Blocker (ARB) antihypertensives in reducing blood pressure. The method used in this study is through literature review using a database through Google Schoolar and Pubmed with a time span of 2013-2023 using the PICO method with keywords or keywords tailored to the search topic and articles selected based on inclusion criteria. The results of the literature show that ARB and CCB antihypertensives have similar effectiveness in lowering blood pressure. CCB antihypertensives are vasculoselective. This can be beneficial because CCBs are able to reduce peripheral resistance without reducing heart function so as to reduce the incidence of stroke. However, the use of CCBs can cause edema while ARBs have renoprotective effects or effects that protect the kidneys.
Gangguan Siklus Menstruasi Alghani, Sulthan Rafi; Sari, Ratna Dewi Puspita; Septiani, Linda; Utama, Winda Trijayanthi
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1048

Abstract

The female reproductive system undergoes regular cycles in preparation for pregnancy and fertilization, known as the menstrual cycle. This cycle involves hormonal changes and complex physiological processes, with the follicular phase dominated by estrogen and the luteal phase dominated by progesterone. Menstrual cycle disorders, such as amenorrhea, polymenorrhea, and oligomenorrhea, can be caused by various factors including hormonal imbalances, unhealthy lifestyles, and certain medical conditions. Management of menstrual disorders varies depending on their causes, which may require a holistic and individualized approach. A good understanding of the menstrual cycle and its disorders is crucial for accurate diagnosis and appropriate treatment. It is also important to promote overall women's reproductive health.

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