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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 796 Documents
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VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.743 KB) | DOI: 10.12928/pharmaciana.v4i2.1567

Abstract

High Performance Liquid Chromatography (HPLC) was one of analytical methodscommonly used to determine the concentration of epigallocatechin gallate (EGCG) on green teaextract. The method must be validated in order to fit to its purpose. The aim of this research was toprove that the used method has selectifity, liniearity, precise, accurate and know limit of detection(LOD) and limit of quantification (LOQ) is acceptable. The selectivity of analytical method wasdetermined by calculating the resolution value between two peak. Data from 10 μg/mL and100 μg/mL with 5 replicates would give precition and accuration. Precition was known from CV value and accuration was known from recovery value in each concentration. Liniearity was knownfrom regression linear between concentration and wide area of peak. From regresion linear couldcalculate LOD and LOQ. Research show that method of analyse have selectificity withRs= 2.27>1.5; liniearity with r= 0.99; precision with CV 8.74% at concentration 200 µg/mL and3.74% at concentration 500 µg/mL; accuration with recovery 99.76% at concentration 200 µg/mLand 100.52% at concentration 500 µg/mL and the value of LOD is 33.28 μg/mL and LOQ is110.93 μg/mL.
STUDI KAPASITAS ADSORPSI-REDUKSI ION Au(III) PADA ASAM HUMAT HASIL ISOLASI DARI TANAH GAMBUT RAWA PENING Prasasti, Dian; Juari, Sri; Sudiono, Sri
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.473 KB) | DOI: 10.12928/pharmaciana.v2i2.664

Abstract

Isolation of peat soil humic acid and its application for adsorption-reduction ofAu(III) have been conducted. Humic acid was isolated from peat soil that was collectedfrom Rawa Pening, Central Java. Isolation of humic acid from peat soil was based onconventional alkaline extraction. Humic acid was extracted from peat soil with NaOH0.1 M, then precipitated with 0.1 M HCl, and purified with 0.1 M HCl/0.3 M HF 1/1.The isolated humic acid was characterized by FTIR spectroscopy, then applied foradsorption reduction of Au(III). Isothermic adsorption capacity on adsorptionreduction process of Au (III) also were studied. The gold metal formed was confirmedby XRD diffractogram, and photo optical microscope. The adsorption capacity withLangmuir isothermic model for humic acid was 192 mg/g. Peaks of gold particles in thedifractogram are 2 = 38, 44, and 64.
SINTESIS TURUNAN ASETOFENON DARI 1-(4-ASETOKSIFENIL-3-METOKSI)-2-PROPANIL FORMAT Kusmiyati, Kusmiyati; Matsjeh, Sabirin; Jumina, Jumina
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.782 KB) | DOI: 10.12928/pharmaciana.v2i1.654

Abstract

The Synthesis of acetophenone derivative from 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate through Fries Rearrangement in order to produceortho hidroxy acetophenone derivative as starting material of Flavanoid compound hasbeen done. The reaction of 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate wasdone by heating at 120 °C for 3 hours under AlCl3, dichloromethane as the catalyst andsolvent, respectively. The structure of the compound was identified using Infra Redspectrometry (IR) dan GC-MS. Fries rearrangement of 1-(4-acetoxyphenil-3-methoxy)-2-propanyl formate produce 1-(2-hyidroxy-3-methoxy-5-propenyl)-acetophenone and 1-(2-hyidroxy-3-methoxy-5-propanyl)-acetophenone as sideproduct with product rendemen were 43.26% and 9.48%, respectively.
PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA Witasari, Hardi Astuti; Pinzon, Rizaldy Taslim; Kristin, Erna
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.866 KB) | DOI: 10.12928/pharmaciana.v4i2.1572

Abstract

The secondary prevention of ischemic stroke can be implemented by giving aspirin.However, some cases of aspirin resistance have been found. The purpose of this study was toexamine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic strokepatients at Bethesda Hospital Yogyakarta. This study was using a nested case-control studydesign. The Cases group was subjects who resistance to aspirin therapy. The control group wassubjects who response to aspirin therapy. The factors that affect the incidence of aspirinresistance were analyzed by bivariate analysis chi square test. The proportion of diabetesmellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at BethesdaHospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirinresistance than the patients without diabetes mellitus.
IDENTIFIKASI POTENSI INTERAKSI OBAT PADA PASIEN RAWAT INAP PENYAKIT DALAM DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO DENGAN METODE OBSERVASIONAL RETROSPEKTIF PERIODE NOVEMBER 2009-JANUARI 2010 Sari, Andriana; Wahyono, Djoko; Raharjo, Budi
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.901 KB) | DOI: 10.12928/pharmaciana.v2i2.669

Abstract

The potensial drug interaction is potential action of a drug that changed orinfluced by other drugs concurrenly. Drug interactions are defined as a phenomenonthat occurs when the pharmacokinetic effect of a drug changes due to other drugdelivery. Drug interactions could cause advers drug reactions when the potential for apreviously unknown interaction. The purpose of this study is to identify potential druginteractions in patient hospitalized in the Prof. Dr. Margono Soekarjo PurwokertoHospital. The research method was an observasional retrospective study (November2009-January 2010) by using descriptive methods for the data analysis.The resultshowed that the potential drug interactions in the hospitalized patients in Prof. Dr.Margono Soekarjo Hospital is 56,76% (n= 259). Based on the significance categorieswhich proposed by Tatro (2006): a potential drug interaction with significancecategory 1 in ward patients in prof. Dr. Margono Soekarjo Hospital is 16,67%. Thedrug used thet known potential interaction, especially in the category of significance 1should be tailored to the patient’s need, risk and benefit, and have made efforts tooptimize it.
KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010 Rahmiati, Siti; Supadmi, Woro
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Abstract

Interaksi obat merupakan salah satu Drug Related Problems (DRPs) yang dapatmempengaruhi luaran terapi pasien. Hipertensi terjadi pada sekitar 10% sampai81,5% pasien hemodialisis. Tujuan penelitian ini adalah untuk mengetahui kejadianinteraksi obat antihipertensi pada pasien hemodialisis di bangsal rawat inap RSU PKUMuhammadiyah Yogyakarta periode tahun 2010. Penelitian ini merupakan penelitiandengan rancangan deskriptif. Data diambil secara retrospektif. Pengambilan datadilakukan dengan cara mengambil semua data yang memenuhi kriteria penelitian yangada pada rekam medik pasien hemodialisis di RSU PKU Muhammadiyah Yogyakarta.Pasien mendapat antihipertensi dengan tekanan darah diatas normal atau = 130/80mmHg. Data dianalisis secara deskriptif berdasarkan tingkat signifikansi, onset, danseverity. Hasil penelitian menunjukkan bahwa terdapat 54,79% (40 pasien) dari 73pasien hemodialisis berpotensi mengalami interaksi obat. Obat antihipertensi yangpaling banyak digunakan pada pasien hemodialisis adalah ACEI, CCB, dan diuretik.Kejadian interaksi obat antihipertensi yang paling banyak terjadi adalah pada tingkatsignifikansi 3 terdapat 27 kasus (45,76%), Onset yaitu delayed sebesar 48 kasus(81,36%), dan severity yaitu minor sebesar 44 kasus (74,58%). Mekanisme interaksiterbanyak yaitu farmakodinamik 37 kasus (62,71%) dari total 59 kejadian yangmengalami interaksi obat. Jenis obat yang sering berinteraksi adalah furosemid dankaptopril.Kata kunci : Interaksi obat, antihipertensi, hemodialisis
UJI SITOTOKSITAS DAN ANTIPROLIFERATIF SEL KANKER PAYUDARA T47D DAN SEL VERO BIJI Nigella sativa, L. Nurani, Laela Hayu
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.413 KB) | DOI: 10.12928/pharmaciana.v2i1.637

Abstract

Black cumin seeds contain oil classes atisiri, terpenes, and alkaloids that can beused for traditional medicine as anticancer. The purpose of this study was to assess thecytotoxic effects of ether extract, ethanol, and infusa seed Nigella sativa, L. (Blackcumin) to inhibit the growth of T47D and normal (Vero) cells and its effect on thekinetics of T47D breast cancer cells proliferation. This study were used extracts ofether, ethanol, and black cumin seeds infusa that obtained by maceration method andinfundasi. Cytotoxicity test was performed by incubating T47D breast cancer cells at a2 x 104 density with concentrations series of 2000; 1000; 500: 250: 125; 62.5; 31.25and 15.625 microg/ml for 24 hours. Vero cell with a density of 2 x 104 withconcentrations series of 4000; 2000; 1000; 500; 250; 125 and 62.5 microg/ml. Thenumber of cells was calculated by direct counting method and the calculated the deathpercentage. The LC50 values calculated using probit analysis. Observations on thenature of the growth inhibition were done by observing kinetics of cell proliferationwith the addition of trypan blue at-24, 48 and 72 to determine its doubling time. Theresults showed that the ether extract, ethanol, and black cumin seeds infusa arecytotoxic to T47D breast cancer cells with successive LC50 of 32.63: 10.02, and 23.82mg mL. Vero cell cytotoxicity test to produce successive LC50 of 300.6; 328.41, and778.64 g/ml. Antiproliferative test results showed that in 62.5 ug/ml and 31.625microg/ml prolong the doubling time. Ethanol extract of cumin seeds have a higherpotential due to the highest security index compared to ether extract and infusa.
PENGEMBANGAN POTENSI EKSTRAK DAUN PANDAN (Pandanus amaryllifolius Roxb) SEBAGAI AGEN ANTIBAKTERI Mardiyaningsih, Ana; Aini, Resmi
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.377 KB) | DOI: 10.12928/pharmaciana.v4i2.1577

Abstract

Pandanus amayllifolius Roxb which commonly used as a flavoring and food coloring waspotentially have antibacterial activity. It should be an effort to develop a safe naturalpreservatives to reduce cases of food poisoning (foodborne disease) which mainly caused bybacterial pathogens. This study aims to determine the antibacterial potency of the water extract,ethanol, ethyl acetate, and a mixture of ethanol-ethyl acetate (1:1 v/v) extract againstStaphylococcus aureus and Escherichia coli based on the value of MIC (Minimum InhibitoryConcentration) and MBC (Minimum Batericidal Activity). The antibacterial activity wasevaluated by the Kirby-Bauer diffusion method by making the extract concentration of 25 and50 %, as well as the loading dose tested was 2.5 mg and 5 mg/disc. MIC and MBC wasevaluated by solid dilution method. The results showed that the ethanol extract and water extractdon’t have antibacterial activity against Staphylococcus aureus and Escherichia coli, whereasthe ethyl acetate extract and a mixture of ethanol-ethyl acetate (1:1 v/v) have an antibacterialactivity. Ethyl acetate extract showed the highest inhibitory potency. The MIC and MBC was 186 Pharmaҫiana, Vol. 4, No. 2, 2014: 185-192obtained at a level of 1.1% w/v and 6.7% w/v against Staphylococcus aureus, and 0.5% w/v and4.5% w/v against Escherichia coli.
PERBANDINGAN AKTIVITAS REPELAN ANTARA KRIM MINYAK ATSIRI JAHE (Zingiber offinale, Roxb) DENGAN KRIM MINYAK ATSIRI SERE (Cymbopogon citratus (D.C) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA Ikhsanudin, Azis
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.467 KB) | DOI: 10.12928/pharmaciana.v4i2.1568

Abstract

The one efforts to prevent dengue fever is to prevent mosquito bites by using mosquitorepellent preparations. The nature of the toxicity of synthetic repellent be the reason for theresearch came from the plant. Sere and ginger into one of mosquito repellent plant because it contains of natural essential oils are many. The aim of this study was to determine the comparativeability repelan effects of essential oils cream sere (Cymbopogon citratus (DC) Stapf) and ginger(Zingiber officinale Roxb). The essential oil of sere (Cymbopogon citratus (DC) Stapf and ginger(Zingiber officinale Roxb), obtained by isolation of leaves and rhizome by steam distillation ofwater which is then tested physical properties including test of adhesion, test of spreadability andtest of mosquito repellent activities. The test of mosquito repellent activities using 20 birds Aedesaegypti mosquito female per cage with the using hand of women as volunteers as much as 4people. In this study were divided into sixth formulas of test. The sixth of cream formula withvariations in the concentration of essential oils sere and ginger wherein the formula I, II and IIIcontain essential oils sere as much as 20% v/w; 30% v/ w and 40% v/w, whereas for formula IV; V;and VI contain the essential oil of ginger as much as 6.25% v/w; 12.5% v/w and 25% v/w. Data ofphysical properties test were analyzed statistically using SPSS. The results showed the cream withthe concentration of essential oils sere 40% v/w (FIII) have better outcomes than others formulascream, where than of adhesion test is 0.46 ± 0.04 seconds; of the spreadibility test is 56.32 ± 14.78cm2 and repellent effect of 3014.2 ± 20.16 seconds.
PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL AKAR SAMBILOTO (Andrographis paniculata, Ness) SECARA IN VITRO Septianingsih, Ulfah; Susanti, Hari; Widyaningsih, Wahyu
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.217 KB) | DOI: 10.12928/pharmaciana.v2i2.665

Abstract

Sambiloto root of which contained of flavonoids used by the people fortraditional medicine. In the previous publication, an effective xanthine oxidaseinhibitory activity of flavonoids was reported. In research, in vitro xanthine oxidaseinhibitory activity of etanolic root extract of Andrographis paniculata was determinedand Allopurinol was used as a control. The etanolic extract was succesively extractedin a Soxhlet with petroleum eter. Inhibition of xanthine oxidase by etanolic extract wasmeasured the decrease of uric acid production and monitored by spectrophotometer at295 nm with xanthine as substrat. The enzyme inhibitory activity was calculated, andthen IC50 was determined. The result of analyzed with Kruskal Wallis and MannWhitney at 95% confidental level . The flavonoids of etanolic extract were separated onusing by paper chromatography and the spot changing was determined using UV 366with and without amonia.The result of the research showed that the etanolic extract ofAndrographis paniculata inhibited xanthine oxidase activity with IC50 16,54 µg/mlwhile Allopurinol 4,29 µg/ml. The etanolic extract contained flavon or flavonol.

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