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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
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Articles 5 Documents
 1 
Search results for , issue "Vol. 21 No. 1: March 2024" : 5 Documents clear
Standardization of Paku Lindung extract (Pneumatopteris callosa (Blume)) Fauzi, Muh Fajar; Widyaningsih, Wahyu
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.23941

Abstract

The standardization of the paku lindung extract was carried out to obtain new data regarding the standardization of the hedgehog extract which had not previously been established. In addition, this determination is carried out to obtain quality preparations in the form of a guarantee process, that the extract obtained has certain parameter values that are constant after the data has been determined. Extract standardization test includes specific parameters including organoleptic, soluble compounds in certain solvents. Non-specific parameter tests include drying shrinkage, moisture content, ash content, heavy metal contamination, microbial contamination. Chemical content test includes chromatogram pattern, determination of total flavonoid content. The yield of the resulting extract was 13.88±3.19% g. The test results of non-specific parameters include drying shrinkage 0.47±0.01%, moisture content 8.28±0.16%, total ash content 18.97±3.53%, acid insoluble ash content 1.69± 0.02%, total plate number 7.8x104±12.91 colonies/gram, yeast mold number 1x102±0.24 colonies/gram, heavy metal contamination of Cd, Cr and Pb negative and Fe of 73.88 ppm. The results of the specific parameter test include 85.55±4.29% water soluble compounds, 31.27±5.06% ethanol soluble compounds. The results of the chemical content test included the total flavonoid content of 16.6±17.60 mgEQ/g, the Rf value of the extract was the same as the Rf of quercetin with 5 variations of the mobile phase. The test results were carried out to meet the predetermined determination and provide new data on the standardization of the paku lindung extract.
In Silico Study of the Potency of Purple Yam Anthocyanin Compounds (Dioscorea alata L.) As MAO-B and COMT Inhibitors in Parkinson's Disease Ramadhan, Muhammad Marwan; Utami, Dwi; Yuliani, Sapto
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.26076

Abstract

The purple yam plant (Dioscorea alata L.) is an economically important staple food for millions of people in tropical and subtropical regions. Dioscorea spp. anthocyanin chemicals have been demonstrated to have antioxidant and neuroprotective properties. The purpose of this study was to explore the potency of anthocyanin compounds in purple yam as antiparkinsonian agents via the monoamine oxidase B (MAO-B) receptor (pdb: 2V5Z) and the catechol-O-methyltransferase (COMT) receptor (pdb: 6I3C) using a molecular docking technique. The study was divided into four stages: (1) pharmacokinetic and Lipinski Rule evaluation, (2) protein (receptor) and ligand preparation, (3) docking method validation, and (4) molecular docking for MAO-B and COMT proteins. Pharmacokinetic prediction and Lipinski rule evaluation revealed that cyanidin, delphinidin, and delphinidin-3-glucoside had an ADMED profile and met Lipinski’s rule. The docking results showed that the binding energy (G) of the compounds cyanidin, delphinidin, and delphinidin-3-glucoside to the MAO-B receptor was lower (-9.50 kcal/mol) than that of the natural ligands ((-4.79 kcal/mol). The Cys172, Leu 171, Ile198, Phe168, Pro104, Trp119 and the 'gatekeeper' residue Ile199 are the amino acids that are majoring involved in MAO-B inhibitors. At the COMT receptor, all the tested compounds had a higher binding energy than native ligands (> -4.79 kcal/mol) except for Cyanidin 3,5-diglucoside (-4.64 kcal/mol). The amino acids Trp143 and Pro174, ensure correct substrate orientation, Mg2+ ions, and cofactor SAM, as well as residues Lys144 and Glu199. In conclusion, this study showed that based on the molecular docking approach, the active compounds of purple yam namely cyanidin, delphinidin, and delphinidin-3-glucoside have the potential to be developed as anti-parkinsonian agents through MAO-B and COMT.
Formulation And Evaluation of Preparations Edible Film Combination Gingerol And Curcumin As An Antibacterial Streptococcus pyogenes Causes Of Inflammation Of The Throat Nurdianti, Lusi; Lestari, Tresna; Nurmalasari, Anisa; Wulandari, Winda Trisna; Cahyati, Keni Ida; Setiawan, Fajar; Firmansya, Ardianes
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.27616

Abstract

Jahe (Zingiber officinale) dan kunyit (Curcuma longa L) merupakan tanaman herbal yang terkenal karena manfaat terapeutiknya. Tumbuhan ini mengandung unsur bioaktif yang masing-masing disebut sebagai gingerol dan kurkumin, yang menunjukkan kualitas potensi antibakteri. Tujuan utama dari penelitian ini adalah untuk menguji atribut dan sifat antibakteri dari zat-zat tersebut. potensi Edible Film yang terdiri dari 5% ekstrak jahe gingerol dan kombinasi kurkumin terhadap bakteri Streptococcus pyogenes. Penelitian ini menggunakan metode pengecoran pelarut, evaluasi film yang dapat dimakan melalui analisis sensori, pengukuran ketebalan, penilaian keseragaman berat, penentuan pH, pengujian kerapuhan, pengukuran ketahanan lipat, analisis waktu hancur dan disolusi, penentuan kadar air, penilaian elongasi dan kekuatan tarik, stabilitas pemeriksaan, uji hedonik, evaluasi aktivitas antibakteri terhadap bakteri Streptococcus pyogenes, dan analisis gugus fungsi. Hasil penelitian menunjukkan bahwa Edible Film mempunyai karakteristik berbentuk persegi panjang berukuran 2x3 cm dengan warna berbeda tiap formula, bau yang khas, rasa manis dan pedas, ketebalan 0,11 mm - 0,12 mm, keseragaman berat 60,3 mg-68,87 mg, kerapuhan. 1,14%-2,95%, ketahanan lipat >500x, waktu hancur <30 detik, waktu larut <60 detik, kadar udara 8,58%-12,05%, kuat tarik 2,42 MPa – 16,18 MPa yang sesuai dengan Standar Industri Jepang (JIS) dan teori yang ada, tetapi penambahan persen memberikan hasil yang buruk. Sediaan Edible film baik formula tunggal maupun kombinasi mampu menghambat bakteri dengan diameter zona hambat F2, F3, dan F4 masing-masing 6,56 mm, 6,36 mm, dan 6,92 mm terhadap bakteri Streptococcus pyogenes dengan masing-masing kategori sedang.
The Potential of Sugarcane Bagasse (Saccharum officinarum Linn.) as a Basic Ingredient for Making Cosmetics and Its Effectiveness as an Exfoliator and Skin Moisturizer Suhesti, Iin; Sari, Yunita Dian Permata; Oktofiani, Fauziyah; Janah, Aprillia Nurul
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.27915

Abstract

Sugarcane bagasse (Saccharum officinarum Linn.) contains most of the phenolic compounds including gallic acid, ferulic acid, epicatechin, quercetin, and kaempferol. Various phenolic compounds contained in sugarcane bagasse, especially phenolic acids, have important bioactivity for the cosmetics industry. The aim of this research is to determine the potential of sugarcane bagasse as an active ingredient in cosmetics and its effectiveness as an exfoliator and skin moisturizer. This research method is experimental, using sugarcane bagasse samples with concentrations of 1%, 3% and 5%. The results of phytochemical screening showed that sugarcane bagasse contains phenolic compounds, flavonoids and phytosterols. Based on the research results, sugarcane bagasse exfoliating gel at concentrations of 1%, 3%, and 5% increased skin tone respectively, namely 1.00 ± 0.67; 0.40±0.49; and 0.30 ± 0.39. Sugarcane bagasse moisturizing gel at concentrations of 1%, 3%, and 5% had a percent increase in skin water content, respectively, namely 6.92 ± 11.094; 2.72±10.21; and 3.36 ± 6.49. Based on SPSS analysis, it is known that variations in the concentration of bagasse extract and the time of use have a significant effect on increasing skin tone. Meanwhile, variations in the concentration of bagasse extract did not have a significant effect on increasing skin water content. However, the time of use has a significant effect on the increase in skin water content. So, it can be concluded that sugarcane bagasse extract has the potential to be an active ingredient in making cosmetics and is effective as an exfoliator and skin moisturizer.
Identification of Biomarker for Stunting Through Prioritization of Gene-Assosiated Variants Wibowo, Anisa Devi Kharisma; Puspitaningrum, Anisa Nova; Ma’ruf, Muhammad; Irham, Lalu Muhammad; Supadmi, Woro; Kartikasari, Ayu Lifia Nur; Adikusuma, Wirawan; Chong, Rockie; Firman, Firman; Nugraha, Media Fitri Isma Isma; Siswanto, Lalu Muhammad Harmain; Khairi, Sabiah; Pranata, Satria
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.28297

Abstract

Stunting is a condition of impaired growth and development in children due to chronic nutritional disorders or infections. The risk factor for stunting is dominated by disease during 1000 days of life. The incidence of stunting in Indonesia is 21.6%, according to the Indonesian Nutrition Status Survey (SSGI) results. This study aimed to identify stunting biomarkers based on the priority scoring of gene variants. Identification of stunting risk genes used the Genome-Wide Association Studies (GWAS) approach and Haploreg v4.1. We found 33 genes that identifies as stunting risk gene. And then, we prioritize based on two functional annotation categories: missense-nonsense and cis-expression quantitative trait loci (cis-eQTL). Our analysis found 4 genes as biological stunting risk genes: MTRR, TTF1, CASP1, and CARD17. This research demonstrates the integration of genomic variants and bioinformatics approaches to reveal biological insights for stunting.

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