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INDONESIA
Indonesian Journal of Cancer Chemoprevention
Published by Indonesian Society for Cancer Chemoprevention
ISSN : 23558989     EISSN : 20880197     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products.
Arjuna Subject : -
Articles 339 Documents
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Acute Toxicity and Genotoxic Activity of Leunca (Solanum nigrum L.) Herb Ethanolic Extract Rumiyati Rumiyati; Laili Nailul Muna; Devi Nisa Hidayati; Riris Istighfari Jenie
Indonesian Journal of Cancer Chemoprevention Vol 6, No 1 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss1pp30-34

Abstract

Previous studies showed that Leunca herb ethanolic extract (LHE) has cytotoxic activity in several cancer cell lines such as HepG2 and HT-29. The extract also demonstrated as potential agent to be developed as co-chemotherapeutic in combination with doxorubicin and cisplatin. The combination is supposed to reduce occurance of cell resistance and  toxicity towards normal cell. In order to verify safety before being applied to human, toxicological and genotoxic evaluation of the extract is important to be done. This research was therefore aimed to investigate acute toxicity and genotoxic activity of LHE. The acute toxicity study was carried out in three groups of 5 mice that was orally administrated by LHE at different doses consisting 300, 2000 and 5000 mg/kgBW. Mortality and sign of toxicity were observed during 7 days. Genotoxic activity was carried out using Mononuclear Polychromatic Erythrosite (MNPCE) assay at a doses range of 250, 500, and 1000 mg/kgBW. Cyclophosphamide (CYP) at the dose of 50 mg/kg was used as positive control. The result showed that LHE did not cause lethal effect on animal model up to doses of 5000 mg/kgBW. However, toxicity signs were found in animal model on day 0-6 of the observation. LHE had lower genotoxic activity compared to cyclophosphamide at the doses of 250, 500, and 1000 mg/kg. The low genotoxic activity and acute toxicity of LHE suggested that the extract might be safe to be used as medicine.Keywords: leunca herb ethanolic extract, genotoxicity, acute toxicity
Anticancer Evaluation of Plants from Indonesian Tropical Rain Forests Jamilah Abbas
Indonesian Journal of Cancer Chemoprevention Vol 2, No 3 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss3pp310-318

Abstract

The anticancer activities of medicinal plants from Indonesia’s tropical rainforests were investigated against Hela cell line. Maytenfoliol from leaves of Calophyllumtetrapterum 3-epibetulinic acid from stem bark of C. tomentosum Wight and D.A-friedo-oleanan-3-on from stem bark of C. moonii showed anticancer activity. The compound 3-epibetulinic acid showed the more potent anticancer activity than maytenfoliol and D.A-friedo-oleanan-3- with thean IC50 value were 3.17 μg/mL, 4.89 μg/mL and 5.63 μg/mL, respectively.Keywords: Anticancer evaluation, Hela cell line, Calophyllumtetrapterum. C. tomentosum Wight and C. moonii
Apoptosis and Antioxidant Activities of Catharanthus rosues [L] G.Don Extract on Breast Cancer Cell Line Wahyu Widowati; Tjandrawati Mozef; Chandra Risdian; Hana Ratnawati; Susi Tjahyani; Ferry Sandra
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss2pp99-107

Abstract

Tapak dara or Madagascar Periwinkle (Catharanthus roseus [L] G.Don), a natural plant, is empirically reported to have promising anticancer activity. To elucidate its mechanism, a research was conducted to investigate the possible ethanol extract of  C. roseus in inducing apoptosis on breast cancer cell line (T47D). Antioxidant activity of C. roseus was investigated as well. Sub-G1 flowcytometric apoptotic analysis result showed that extract of C. roseus at 6.25 μg/mL induced apoptosis for 26.365%. Increasing extract concentration resulted an increasing apoptotic level as well, extract at concentration of 12.5 μg/mL induced apoptosis for 22.235%.  Meanwhile doxorubicin at concentration of 10 μg/mL induced apoptosis for 36.055%. The antioxidant activity was determined by using in vitro assay: inhibition of  2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Antioxidant activity of C. roseus extract were compared to quercetin and butylated hydroxyanisol (BHA), as positive controls.  The results showed that DPPH IC50 of C. roseus extract, quercetin and BHA were 358.411 μg/mL, 19.200 μg/mL  and  94.178 μg/mL, respectively. We suggest that C. roseus extract had a potential anticancer activity by inducing apoptosis.Key words : antioxidant, DPPH, Catharanthus roseus, apoptosis, breast cancer, T47D
Estrogenic Activity of Ethanolic Extract of Papaya Peels (Carica Papaya L.) on Uterine Weight and Mammae Gland Proliferation on Ovariectomy Rats Dhania Novitasari; Devyanto Hadi Triutomo; Fitriana Hayyu Arifah; Anselma Ivanawati; Zahrotul Ulum; Retno Murwanti
Indonesian Journal of Cancer Chemoprevention Vol 9, No 2 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss2pp86-91

Abstract

Papaya bark is one of Indonesia's natural wealth that contains flavonoid compounds such as myricetin and kaempferol that included in the phytoestrogen compounds. The aim of this study is to examine the estrogenic effects of ethanolic extract of papaya peels (EEPP) on the development of mammae gland and the increasing of uterine weight. The in vivo test was performed in ovariectomized Sprague Dawley female rats. After 30 days of treatment, animals were sacrificed to take the uterus and mammae glands. Measurement of uterine weight and mammae gland was observed by hematoxylin-eosin staining method to know the lobulus development and AgNOR staining to determine the proliferation level of mammae gland epithelial cells. The results showed that EEPP at the concentrations of 500 and 1000 mg/kgBW were able to increase uterine weight and proliferation of mammae gland. In conclusion, papaya bark has the potential as phytoestrogen compound to maintain female reproductive health and woman beauty.Keywords : Ethanolic extract of papaya peels (EEPP), phytoestrogen, ovariectomized rats, uterine weight, mammae proliferation
Evaluation of Anti-angiogenic Activity of Centella asiatica Water Extract on Chick Embryo Chorioallantoic Membrane Induced by bFGF Iwan Sahrial Hamid; Ngakan Made Rai Widjaja
Indonesian Journal of Cancer Chemoprevention Vol 4, No 1 (2013)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev4iss1pp463-469

Abstract

Angiogenesis is a physiological process that involves the formation of new blood vessels. In the cancer growth process, angiogenesis acts by supplying nutrition and oxygen for the cancer cells, carries metabolic waste and biological end product of cancer cells. Therefore the spread of cancer cells to the surrounding cells and tissues is accelerated. The occurrence of angiogenesis shows a change in cancer cell status, from dormant to malignant. Cancer cells induce the formation of angiogenesis through the secretion of various growth factors such as Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF).Currently many people turn into treatment using natural materials. One of the natural materials used for cancer therapy is pegagan (Centella asiatica). In this research 25 embryonated chicken eggs (ECE) were divided into five treatment groups. Treatment group I as the control received 60 ng bFGF, treatment group II received neither bFGF nor pegagan leaves (Centella asiatica) water extract, and  treatment groups III-V received 60 ng bFGF and  C. asiatica leaves water extract of 75, 90 and 110 µg.  Nine days old ESE were inoculated with bFGF and extract at the same time and then were incubated at 380C for three days to allow the formation of blood vessels in embryonated chicken egg chorioallantoic membrane.  Observations were performed microscopically and macroscopically by counting the new blood vessels formed around paper disc. Analysis on VEGF expression were conducted to define the role of angiogenesis growth factor.Research results showed a significant difference of treatment with Centella asiatica water extract on the number of new blood vessels formed. Centella asiatica water extract at the dose of 110 µg was the highest in inhibiting the formation of new blood vessels. Centella asiatica water extract also inhibited the expression of VEGF.Keywords : Centella asiatica, antiangiogenic, Corio Allantois Membran, VEGF
The Enhancement Quality of Squalene as a Marine Chemopreventive Agent and Vitamin A Level In The Shark Liver Oil at The Territorial Ocean of Cilacap Yuhansyah Nurfauzi; Wahyu Kurniawan; Tusrianto Tusrianto
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss2pp261-266

Abstract

Recently, shark liver oil is developed as mainstay product for the Cilacap fishermen proceed to be traditional supplemental foods and health product that contains squalene and Vitamin A. Squalen is one of marine natural products has demonstrated proliferative activity in animal cancer studies and may have some radioprotective effects. This observation is aimed to enhance and improve squalene acquirement quality organolepthically. This observation uses experimental observation design. Shark liver in the bottle will be proceed by the tool that specially designed to produce shark liver oil. Its result is analyzed quantitatively to gain the squalene and vitamin A level. The comparison of squalene level that has been produced in this observation is approximately from 141 to 191 higher than standard squalene product in the market. The vitamin A level in this observation is approximately 3,6 higher than shark liver oil product in the market without processing by the observation tool. The technology in the observation uses heating principle from perfect black tool that causes it more constantly hot and causes oil flow out from shark liver organ. The oil in the bowl of the tool was filtered by zeolit, so that the unpleasant or fishy smell of the oil will decrease if compared with traditional production process.Keywords : Squalene, vitamin A, Shark liver oil, Cilacap
Mangifera indica L. Leaves Extract Induced Intrinsic Apoptotic Pathway in MCF-7 Cells by Decreasing Bcl-2 Expression and Inducing Bax Expression Fitriasih Fitriasih; Siti Mega Komariyah; Ferry Sandra; Nenni Pratiwi; Devi Nisa Hidayati
Indonesian Journal of Cancer Chemoprevention Vol 10, No 1 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss1pp1-6

Abstract

Extract of Mangifera indica L. has been investigated to have cytotoxic activity against MCF-7 cells.  Current research was conducted to determine the cytotoxic activity of methanol extract of M. indica leaves (MEML) on MCF-7 breast cancer cells and to investigate on the MEML's effect on Bcl-2 and Bax expressions. M. indica leaves were extracted using soxhletation with methanol. The cytotoxic test was perfomed using MTT assay with various MEML concentrations: 15.625, 31.25, 62.5, 125, 250 and 1000 μg/mL. Meanwhile, Bax and Bcl-2 expressions of MCF-7 breast cancer cells were detected with immunocytochemical staining after treatment of MEML with concentrations of ¼ IC50, ½ IC50 and IC50. The results showed that IC50 of cytotoxic activity was 308.12 µg/mL. MEML could influence Bax and Bcl-2 protein expressions. After treatment of MEML, Bcl-2 expression was decreased while Bax expression was increased.Keywords : Mangifera indica L., Cytotoxic, Bax, Bcl-2, MCF-7
Curcumin and Extract of Plantago major, L Increased SPF Value of Cold Cream Base Nining Sugihartini
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp43-47

Abstract

Octyl methoxycinnamate as the active material of the sunscreen would be degradated after being exposed to the sunlight. Curcumin, rice flour and the  extract of Plantago  major, L was the material that could function as the sunscreen. The aim of this research was to know the SPF value and the physical characteristics of cream of the sunscreen with the active material octyl methoxycinnamate after the addition of the optimum composition of curcumin and the extract of Plantago major, L and the optimum composition of rice flour and the extract of Plantago major, L.In this research three formulas was examined, i.e. the  formula I with the active material octyl methoxycinnamate, the formula II with the active material octyl methoxycinnamate  and the optimum composition curcumin and the extract of Plantago  major, L, Formula III with the active material octyl methoxycinnamate and the optimum composition rice flour and the extract of Plantago major, L. SPF value of each formula was determined by using the Petro method (1981) using UV spectrofotometric method at a l 290 nm-320 nm. The physical characteristics i.e. the power spread, the adhesiveness and the viscosity were also examined analysed with Anova one way at a confidence level  95%. Result of the research show that SPF value increased after the addition of the optimum composition of curcumin and the extract of Plantago major, L. The physical characteristics of cream of the sunscreen do not change after the addition of the optimum composition curcumin and the extract of Plantago major, L and the optimum composition rice flour and the extract of Plantago major, L.Key words: Octyl methoxycinnamate,curcumin,flour rice,extract of Plantago major, L,sunscreen
Cytotoxic and Antimetastasis Effect of Ethyl Acetate Fraction from Caesalpinia sappan L. on MCF-7/HER2 Cells Riris Istighfari Jenie; Sri Handayani; Ratna Asmah Susidarti; Zalinar Udin; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 8, No 1 (2017)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev8iss1pp42-50

Abstract

Overexpression of HER2 in breast cancer cell is found on invasive breast cancer and correlated with worse prognosis. Caesalpinia sappan L shows cytotoxic activity on various cancer cells. The goal of this research is to determine the cytotoxic activity and inhibition of migration and invasion of ethyl acetate fraction of Caesalpinia sappan L. (FEA) on HER2 overexpression-breast cancer cells (MCF-7/HER2). The MTT and flow cytometry assay showed that FEA revealed cytotoxic effect in a dose-dependent manner (IC50= 34 ± 3.1 µg/ml) and induced apoptosis, S and G2/M phase accumulation. Wound healing assay, gelatin zymography and immunoblotting assay showed that FEA inhibited migration and suppressed MMP2, MMP9, HER2 and Rac1 protein level. Thus, ethyl acetate fraction of Caesalpinia sappan L. is potential to be developed on future research especially to treat metastatic breast cancer with HER2 overexpression.Keywords: Ethyl acetate fraction of Caesalpinia sappan L, cytotoxic effect, migration and invasion, MCF-7/HER2 cells
Antiproliferative Effect of Electric Fields on Breast Tumor Cells In Vitro and In Vivo Firman Alamsyah; Izzatun Niswah Ajrina; Fitriya Nur Annisa Dewi; Diah Iskandriati; Silvia Arin Prabandari; Warsito P. Taruno
Indonesian Journal of Cancer Chemoprevention Vol 6, No 3 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss3pp71-77

Abstract

Our research focused on the antiproliferative effect of low intensity (18 Vpp) and intermediate frequency (100 KHz) electrostatic wave between two capacitive electrodes on breast tumor cells in vitro and in vivo. In vitro study has been conducted by using MCF-7 cell lines treated with external electrostatic for 24, 48, and 72 hours of treatment and the cells number were calculated during treatment by using hemocytometer and presented as Growth Inhibition (GI)% efficacy. For in vivo, we used female mice (Mus musculus) strain C3H as animal model. The mice were injected with either MCF-7 cells, mammary tumor cells from C3H donor, or NaCl 0.9% (placebo) subcutaneously into the axilla area and exposed by external electrostatic in each cage for 12 hours in 2 weeks before necropsied. The adjacent and breast tissue were collected and stained with Hematoxylin – Eosin then analyzed for histopathological profile. In vitro study revealed the number of exposed cells decreased with lower proliferation rate than the non-exposed cells. Moreover, the external electrostatic caused 28-39% growth inhibition efficacy of MCF-7 cells. After 2 weeks of exposure, placebo mice were physically normal, whereas the tumor undergone significant shrinkage of more than 67% in size. Histopathological analysis of the mammary glands indicated infiltration of macrophages into the tumor area through the blood vessel. No abnormality was found in the skin layer and mammary glands of the breast tissue of placebo mice. Here, we present new knowledge of electro-capacitive cancer therapy (ECCT) as a novel treatment modality.Keywords : ECCT, tumor, in vitro, in vivo, breast cancer cells, antiproliferative

Page 13 of 34 | Total Record : 339

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