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INDONESIA
Indonesian Journal of Cancer Chemoprevention
Published by Indonesian Society for Cancer Chemoprevention
ISSN : 23558989     EISSN : 20880197     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Indonesian Journal of Cancer Chemoprevention (IJCC) is an open access, peer-reviewed, triannual journal devoted to publishing articles on Cancer Chemoprevention including Experimental and Clinical Pharmacology, especially concerning Anti-Oxidants, Anti-Aging, Anti-Inflammation, Anti-Angiogenesis, and Anti-Carcinogenesis; Cancer Detection; Stem Cell Biology; Immunology; in vitro and in silico Exploration of Chemopreventive Mechanism; and Natural Products.
Arjuna Subject : -
Articles 334 Documents
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Determination of The Active Asiaticoside Content in Centella asiatica as Anti-Cellulite Agent Dewi Sondari; Sri Budi Harmami; M. Ghozali; Ahmad Randy; Athanasia Amanda S.; Yan Irawan
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss2pp222-227

Abstract

Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids. These terpenoids include asiaticoside, centelloside, madecassoside, brahmoside, brahminoside, thankuniside, sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. Preparations of C. asiatica are used in traditional and alternative medicine due to the wide spectrum of pharmacological activities associated with these secondary metabolites, such as anticellulite agent. Asiaticoside was found in Centella asiatica. In this present study, the asiaticoside was extracted using methanolic and ethanolic solvent. Determination of the asiaticoside content in the extract was conducted with High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), and Fourier Transform Infra Red (FTIR). Samples of C. asiatica used in this study came from three different plantation areas, Bogor, Lembang and Solo. Asiaticoside content in the methanolic extract from Bogor, Lembang, and Solo samples were 2.82%; 2.68%; and 2.8% respectively. Asiaticoside in ethanolic extract from Bogor, Lembang, and Solo samples were 2.79%; 2.75%; and 2.91% respectively. Two way ANOVA study showed that there was significant difference between types of solvent used in extraction and the asiaticoside content in the obtained extract, significant difference between varied plantation area and obtained asiaticoside content, and significant difference between interactions of different solvent with different plantation area.  Keywords: Centella asiatica, asiaticoside, anticellulite, medicine, metabolites       
Anti-metastatic Activity of Curcumin Analog Pentagamaboronon-0-Sorbitol Against HER2-overexpressed MCF-7 Breast Cancer Cells Lailatul Qodria; Indah Hairunisa; Rohmad Yudi Utomo; Adam Hermawan; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 9, No 3 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss3pp118-125

Abstract

Breast cancer with Human Epidermal Growth Factor Receptor (HER)2 overexpression increases tumor progession and lead to metastasis, which is primarily cause of mortality in breast cancer. Pentagamaboronon-0 Sorbitol (PGB-0-So) is an aquoeous formulation of curcumin analog, PGB-0, with sorbitol. This compound has been developed as an anti-cancer chemotherapeutic agent and a boron carrying pharmaceutical for boron neutron capture therapy (BNCT). The aims of this study are to investigate antimetastatic activities of PGB-0-So against HER2-overexpressed MCF-7 breast cancer (MCF-7/HER2) cells. The MTT cytotoxicity assay of PGB-0-So exhibited cytotoxic effect with an IC50 value of 35 μM. The testing of anti-migration activity using the scratch wound healing assay demonstrated that PGB-0-So inhibited the closure of the wound on MCF-7/HER2 cells compare to the control. Furthermore, PGB-0-So was able to suppress matrix metalloproteinase (MMP)-9 activities, based on the gelatin zymography assay. In conclusion, PGB-0-So has potency to be developed as an anti-cancer agent against metastatic breast cancer.Keywords : PGB-0-So, anti-metastatsis, cell migration, MMP-9, MCF-7/HER2
Structure Modification of Ethyl p-methoxycinnamate Isolated from Kaempferia galanga Linn. and Citotoxicity Assay of The Products on WiDr Cells Juni Ekowati; Marcellino Rudyanto; Shigeru Sasaki; Tutuk Budiati; Sukardiman -; Adam Hermawan; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp12-18

Abstract

Ethyl p-methoxycinnamate, major ingredient of Kaempferia galanga rhizome, have been reported not only has analgesic – anti inflammatory activities like NSAIDs which inhibited cyclooxygenase, but also inhibit tumor cell proliferation in specimen of mouse epidermis. Therefore, it will be interesting to carry out synthetic studies on the derivates of ethyl p-methoxycinnamate and searching their citotoxic activity on WiDr cell. We wish to report of structure modification on carboxyl moiety of ethyl p-methoxycinnamate  and  evaluation on their citotoxic activity  on WiDr cell. Isolation of ethyl p-methoxycinnamate from Kaempferia galanga rhizome was carried out by percolation with ethanol 96% as solvent. Hydrolysis of ethyl p-methoxycinnamate in basic condition was performed to obtain p-methoxycinnamic acid. Preparation of some thiourea derivates of ethyl p-methoxycinnamate was carried out  by microwave irradiation. Citotoxicity assay was carried out by MTT method for 48 h.Modification of carboxyl group of ethyl p-methoxycinnamate to its thiourea form could be carried out by microwave irradiation gave; (E)-3-(4-methoxyphenyl)-N-(phenylcarba- mothioyl)acrylamide (50%); (E)-3-(4-methoxyphenyl)-N-(4-methoxyphenylcarbamothi- oyl)acrylamide (26%) and (E)-3-(4-methoxyphenyl)-N-(4-methylphenylcarbamothioyl) acrylamide (54%), yield calculated for 2 step from the acid chloride. All compounds showed no citotoxic effect on WiDr cell at 48 h incubation.Keywords :  ethyl p-methoxycinnamate, microwave irradiation, Kaempferia galanga, citotoxicity, WiDr cell
Anticancer Effect of a Typhonium flagelliforme L. in Raji Cells Through Telomerase Expression Endang Purwaningsih; Yulia Suciati; Etty Widayanti
Indonesian Journal of Cancer Chemoprevention Vol 8, No 1 (2017)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev8iss1pp15-20

Abstract

Cancer cells have a relatively high telomerase activity compared to normal cells, so the cancer cells have the ability to continue to proliferate and undergo mitosis uncontrolled. Telomerase is an enzyme which responsible for telomere length, a DNA segment that is at the end of eukaryotic cell chromosomes. Telomeres and telomerase play a role in the incidence of carcinogenesis. Natural materials such as taro mice (Typhonium flagelliforme) have potential as anticancer. The purpose of the study was to determine the effects of plant extracts of rat taro on the expression of telomerase in cancer cell Raji. The research method is experimental studies in some form cancerous cell culture cell line, Raji. Used as a control normal cells is Vero cell. The Culture medium used RPMI for Raji cell  and M199 for Vero cell. The study consisted of three groups, control, doses of 1 ½ IC50 and IC50 doses. Expression of telomerase enzyme was measured by the Immunohystochemistry method (IHC). The results showed that the expression of telomerase in cancer cells showed values significantly higher than the normal cells (Vero). Giving mice taro plant extracts (Typhonium flagelliforme) were able to decrease the expression of telomerase significantly in both treatment doses. It was concluded that rodent tuber extract (Typhonium flagelliforme Lodd) can reduce the expression of telomerase in Raji cells, so that the rodent tuber extract (Typhonium flagelliforme Lodd) has potential as an anticancer through the expression of telomerase.Keywords: telomerase, IHC, Typhonium flagelliforme
The Combination of High Calcium Milk with Citrus maxima Peels Ethanolic Extract Increased Bone Density of Ovariectomized Rats Ragil S. Dianingati; Annisa Novarina; Amanita K. Hana; Laeli Muntafi'ah; Endang Lukitaningsih
Indonesian Journal of Cancer Chemoprevention Vol 6, No 2 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss2pp42-48

Abstract

Osteoporosis is a common problem in menopause woman. The main cause is lack of estrogen hormone. Commonly, prevention therapy is by consuming high calcium milk, but it is not effective. Bali orange’s peel (Citrus maxima Merr.) is a waste material but known contains phytoestrogen according to previous study. Considering of this result, fortification of high calcium milk and Bali orange’s peel is expected to be an effective solution for osteoporosis in menopause woman. This research began with extraction of Bali orange’s peel (BPE) using ethanol 70% by maceration method. Ovariectomized Sprague Dawley female rats as the model of post menopausal woman were treated by BPE for 28 days. The doses of BPE was given to rats is 500 and 1000 mg/KgBW combined with high calcium milk. Bone density was determined using digital microradiography, the profile showed the increase of bone density in group that treated with combination of BPE 1000 mg/Kg BW and high calcium milk compare to control and given only milk groups. Docking molecular showed that BPE’s active compound which are hesperidin and naringin have interaction with estrogen receptor α and β. Docking score of naringin with ER α and β are -19,97; -18,99 respectively. Meanwhile the docking score of hesperidin with ER α and β are -19,98; +49,92 respectively. Overall, the result of this research showed that fortification of BPE with high calcium milk has good prospect to develop as effective therapy of osteoporosis.Keywords : Citrus maxima Merr., phytoestrogen, osteoporosis, high calcium milk, estrogen receptor 
Effect of Various Concentration of Vegetable Protein in Hair Mask on The Hair Texture Ivony Helen; Idajani Hadinoto; Lannie Hadisoewignyo; Lisa Soegianto
Indonesian Journal of Cancer Chemoprevention Vol 2, No 1 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss1pp159-168

Abstract

Effect of various concentrations of vegetable protein in hair mask on the hair texture including hair smoothness, hair shining, hair strength, and morphology of hair had been studied. Concentrations of vegetable protein are made 5%, 7.5%, and 10%. The hair mask was evaluated such as organoleptic, pH, viscosity, and allergy test. Hair mask used in six subjects that have damage hair for 8 times every 2 days. Then, the hair mask was evaluated such as hair smooth and hair shine that used tree trained panel and analyzed using non parametric method Q Cochran. Hair strength was evaluated using autograph then the results were  analyzes using ANOVA test (p<0.05), while hair morphology was evaluated using scanning microscope electron (SEM). The experimental results showed that vegetable protein in hair mask increased hair smoothness, hair strength, and morphology of damaged hair but did not give effect for hair shining. Various concentrations of vegetable protein (5%, 7.5%, and 10%) on hair mask given the same effect in hair texture (hair smoothness, hair strength, and hair morphology).Keywords: vegetable protein, hair mask, hair texture
Fingerroot (Boesenbergia pandurata) : A Prospective Anticancer Therapy Marsya Yonna Nurrachma; Hilyatul Fadliyah; Edy Meiyanto
Indonesian Journal of Cancer Chemoprevention Vol 9, No 2 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss2pp102-109

Abstract

Beside as a spice in Indonesian cooking, Fingerroot (Boesenbergia pandurata) regularly is used as a mixture of herbal medicine. Scientifically, the phytochemical content of the fingerroot rhizome showed some therapeutical effects such as antibacterial, anti-inflammatory, anti or pro-oxidant, and also anticancer. In this article, we summarize some studies especially about anticancer activity of fingerroot and its constituent coumpound. We found that fingerroot is capable of inhibiting various pathways of cell physiology processes. One potential pathway to be inhibited by fingerroot is Poly (ADP-ribose) polymerase (PARP) which has role in apoptotic induction. In the future, it is necessary to purify the extract to obtain maximum efficacy and also formulation studies of fingerroot will be interesting to do to.Keywords : fingerroot, anti-cancer, chemopreventive, herbal medicineBeside as a spice in Indonesian cooking, Fingerroot (Boesenbergia pandurata)regularly is used as a mixture of herbal medicine. Scientifically, the phytochemical contentof the fingerroot rhizome showed some therapeutical effects such as antibacterial, antiinflammatory,anti or pro-oxidant, and also anticancer. In this article, we summarizesome studies especially about anticancer activity of fingerroot and its constituentcoumpound. We found that fingerroot is capable of inhibiting various pathways of cellphysiology processes. One potential pathway to be inhibited by fingerroot is Poly (ADPribose)polymerase (PARP) which has role in apoptotic induction. In the future, it isnecessary to purify the extract to obtain maximum efficacy and also formulation studiesof fingerroot will be interesting to do to.
Effect of Basil Leaves (Ocimum sanctum L.) Infusion as Hepatoprotective Agent Induced by Paracetamol Ni Nyoman Yuliani; Jefrin Sambara; Maria Hilaria; Harlinda Harlinda
Indonesian Journal of Cancer Chemoprevention Vol 7, No 2 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss2pp68-73

Abstract

Indonesia has  biodiversity potential to be developed as medicinal plants, such as basil leaves (Ocimum sanctum L.). Basil was reported to have a very high antioxidant activity in vitro. The aim of this study was to determine the effect of basil leaves (Ocimum sanctum L.) infusion to liver based Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) value in each dose. 18 rats were divided into 6 groups.,  control group,  negative control group treated with CMC Na 0.5%,  positive control group treated with Curcuma 3.6 mg / 200gBB, groups of 4-6 consecutive given a 80 mg  dose infusion basil / 200 gBB, 160 mg / 200 gBB, 320 mg / 200 gBB for 8 consecutive days, on the day of the 4th and 8th all treatment groups induced by toxic doses of paracetamol (500 mg / 200 gBB) except the normal control group 1, The research data in the form of enzyme activity of AST and ALT were analyzed using parametric and nonparametric ANOVA, and Friedman test with the level of trust  then followed by SNK test and Bnj test. The statistical test result with a 95% of level of trust that shown basil infuse with a dose of 80mg / 200gBB, 160mg / 200gBB, 320mg / 200gBB have hepatoprotective effects in rats induced by paracetamol 500mg / 200gBB. Based on the result of changes in average levels of AST on the fourth day and the eighth day of the three treatment infusion, infusion at a dose of 160 mg / 200gBB most effectively reduce average levels of AST and a group that has the average AST closest to the control group is positive, but infusion at a dose of 320mg / 200gBB the group that has the closest average ALT positive control group.Keywords : hepatoprotective, Ocimum sanctum L, Paracetamol
Antiproliferative Effect of Ethanolic Extract Eugenia uniflora Lam. Leaves on T47D Cells Nur Ismiyati; Dyaningtyas Dewi Pamungkas Putri; Siska Andrina Kusumastuti; Rifki Febriansyah
Indonesian Journal of Cancer Chemoprevention Vol 3, No 2 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev3iss2pp370-375

Abstract

Eugenia uniflora Lam. is one of herbal products developed for anticancer. The aim of the present study was to identify the antiproliferative effect of ethanolic extract of Eugenia Uniflora Lam. leaves (EEU) on breast cancer cell line T47D. This Research was initiated by extracting the active contents of Eugenia uniflora Lam. leaves by maceration with ethanol 96%. The extract was then analyzed by thin layer chromatography (TLC). Cytotoxic assay of EEU was carried out by using MTT assay. Apoptosis phenomenon was observed with double staining using acridine orange-ethidium bromide. EEU showed cytotoxic effect on T47D cells with IC50 value of 65 µg/ml. Moreover, EEU 50µg/ml and 100µg/ml induced apoptosis. TLC examination showed that EEU used in this study contain phenolic, flavonoid, and saponin compounds which were suggested to be responsible for antiproliferative effect. Further molecular mechanism underlying EEU antiproliferative effect needs to be done.Keywords: Eugenia uniflora Lam., T47D cells, antiproliferative, apoptosis
Acute Toxicity Effect of The Ethanolic Extract of Watercress Herb (Nasturtium officinale R. Br.) in Mice Herawaty Ginting; Aminah Dalimunthe; Julia Reveny
Indonesian Journal of Cancer Chemoprevention Vol 7, No 1 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss1pp9-16

Abstract

Watercress (Nasturtium officinale R. Br.) is an annual plant of the Brasicaceae family. Watercress has efficacy in the treatment of a hypo-allergenic, anti-diabetic, antioxidant, anticancer, and treatment of tuberculosis.The purpose of this research was to determine the potential for acute toxicity of ethanolic extract of watercress. This study aims to observe the histopathology liver , kidney , heart mice and to determine the LD50. Test animals used were 40 male mice and 40 female mice were divided into 8 groups. Group 1 as the control group were given Na – CMC 0,5 % b/v and groups 2-8 were given ethanol extract of watercress herb with a doses of  0,5; 5; 50 ; 500 ; 1000 ; 2000; and 4000 mg/kg bw . LD50 test is determined by the number of deaths in the test group during the 14 days of treatment in the form of one administration of the test materials. Histopathological results at the highest doses showed necrosis and hydropic degeneration of the liver, serosis the kidneys, and the heart inflammation with myofibril irregular heart. LD50 test demonstrated the practical test material is not toxic because no test animals died.Keywords: acute toxicity, Nasturtium officinale R. Br., Ethanolic extract

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