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INDONESIA
Nexus Kedokteran Translasional
Published by Universitas Sebelas Maret
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
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Articles 123 Documents
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Screening Indonesian Medical Plants Phytochemistry Using Molecular Docking as Hepcidin Antagonis in Iron Deficiency Anemia Dien Adiparadana; Yuliana Heri Suselo; Balgis .
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Iron deficiency anemia is found in clinical practice and community. There is mutasion in a genetic within iron deficency anemia which regulate iron homeostatis.Mutation in the TMPRSS6 resulting in iron refractory iron deficiency anemia The TMPRSS6 genetic encoding matriptase-2 enzymes which regulate hepcidin. The hepcidin is a principal regulator of iron homeostatis. Indonesia have more than 2.000 medical plants which have many roles and function. Some plants have phytochemisty that potentially in hepcidin antagonis. The phytochemistry is screen using molecular docking method Methods: The research design was a biocomputasion. It had been done at Medical Faculty of Sebelas Maret University on August-Oktober, 2014. The data was collected by using purposive sampling method. All data is docked using Autodock Vina in PyRx software. Docked sample is compared with binding energy of furstulhiamine drug. The data was compared its binding energy and their zone interaction with fursulthamine Results: The result were 10 samples has higher its binding energy than fursulthiamine. The binding energy of fursulthiamine was -6,7 kcal/mol. The highest binding energy was -8,5 kcal/mol and the lowest was -8 kcal/mol. All 10 sample interacted with cys 326. The cys 326 was the residue which can inhibit hepcidin interaction with ferroportin Conclusions: The Molecular Docking can be used to intial screening many phytochemisty. The result was 10 phytochemistry Indonesian medical plants which may inhibit hepcidin interaction. Further research is needed to prove the effect of phytochemistry. Keywords: Hepcidin, molecular docking, phytochemistry
Boeravinone F, Withanolide D, and Chitranone are a Potential Antagonist of Angiotensin Receptor 1 Insilico for Hypertension Treatment Febri Ningtyas; Sri Wulandari; Balqis .
Nexus Kedokteran Translasional Vol 6, No 1 (2017): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Hypertension is a silent killer which can cause complications such as heart diseases, stroke, and chronic kidney diseases. Olmesartan is a one of the Angiotensin Receptor Blockers (ARBs) for an alternative treatment of hypertension. However, this drug has low bioavailability, short duration, and partial agonist against angiotensin 1 receptor (AT1). Indonesia has more than 6.000 phytochemicals which are derived from various herbal plants but their therapeutic effects are unknown. Molecular docking is an initial step to find new drug candidates that have shorter time and lower cost. Therefore, this study aimed to identify phytochemicals as an AT1 antagonist through molecular docking for hypertension treatment. Methods: This was a bioinformatics study. Research samples were all phytochemicals registered in HerbalDB, had 3 dimention structure, and met criteria of Lipinski's rule of five. Olmesartan was used as a standard ligand and obtained from PubChem. AT1 receptor was downloaded from Protein Data Bank. Validation of receptor-standard ligand binding complexes was done by using Autodock Vina 1.1.2 five times. Docking results were visualized using Pymol 1.7 and Chimera 1.10. Data were analyzed using docking scores, binding sites, molecular conformation, and criteria of Lipinski's rule of five.Results: Olmesartan had -9.9 Kcal/mol docking score and interacted with the AT1 receptor at Tyr35, Trp84, dan Arg167 residues. Boeravinone F (-10,2 Kcal/mol), Chitranone (-10,5 Kcal/mol), and Withanolide D (-10,8 Kcal/mol) had lower docking score than olmesartan. These phytochemicals had binding sites as same as olmesartan except Chitranone with an additional binding site at Asp281 residue. The phytochemicals had different conformation from olmesartan but had similarity of chemical properties with olmesartan. Conclusions: Boeravinone F, Chitranone, and Withanolide D can be potential as an AT1 receptor inhibitor insilico for hypertension treatment. Keywords: hypertension, AT1 receptor, olmesartan, phytochemicals, molecular docking.
Effect of EthanolicExtract of Centella asiatica againts Adrenal Gland CortexCell Lipid Droplet Feature Induced by Chronic Immobilization Stress in Rats Mochammad Fairuz Zahran; Brian Wasita; Nanang Wiyono; Ratih Puspita Febrinasari
Nexus Kedokteran Translasional Vol 4, No 1 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Chronic stress can increase the lipid droplet in cortex cell and adrenal gland damage. Pegagan extract contains such as asiaticoside, flavonoids and triterpenoid are known have antioxidant effect. The objective of the present study was to investigate the beneficial effects of Ethanolic Extract of Centella asiatica (EEC) on adrenal gland cortexcell lipid droplet feature induced by immobilization stress in male rats. Method: This study was a laboratory experimental study with randomized post test only control group design. Paraffin blocks from thirty five male rats previously subjected with chronic immobilization stress and then divided into 6 groups: control group given distilled water 1 mg/kg, stress + PGA, stress + 150 mg/kg EEC, stress + 300 mg/kg EEC, stress + 600 mg/kg EEC and stress + fluoxetine 10 mg. The treatments were performed for 21 consecutive days. Lipid droplet was evaluated using Scoring Lipid Content from Hematoxylin Eosin staining. Statistic analysis was performed using Kruskall-Wallis test continued by Post Hoc Mann-Whitney Test with Bonferroni correction. Result: Results of Kruskall Wallis test showed significant differences in six groups with p = 0.000. Mann Whitney test with Bonferroni correction showed a significant difference between control group with stress + PGA and stress + 600 mg/kg EEC. Fluexetine as positive control show the most effective dose in this study (p = 0,000). There were no significant difference between fluoxetine as control positive and control group (p = 0,112). Conclusion: Stress + 600 mg/kg EEC has beneficial effect on preventing adrenal gland cortexcell lipid droplet feature induced by chronic immobilization stress in rat. Keywords : Centella asiatica, chronic immobilization stress, adrenal glands lipid droplet feature
The Nefroprotector Effect of Salam Leaf Extract (Syzygium polyanthum) in Mices Renal Cell which is Induced by Paracetamol Asaduddien Faras; Endang Listyaningsih S; Sigit Setyawan
Nexus Kedokteran Translasional Vol 2, No 2 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background : Salam Leaf (Syzygium polyanthum) contains antioxidants such as flavonoids, selenium, vitamin A, vitamin C, vitamin E, triterpenes, tannins, saponins, niacin, and essential oils as an antioxidant compounds. In present study, Syzygium polyanthum leaves extract was evaluated for its protective effect on paracetamol- induced renal damage in mice. Methods: This study was laboratory experimental research with Randomized Controlled Trial design. A total of 28 Swiss Webster mices were equally divided into 4 groups. Mices for control group (KK) and the first group (KP1) will be given aquades for 14 day. The second(KP2) and third (KP3) group will be given Salam leaf extract with dose 7 mg/20 g and 14 mg/20 g weight of mice for 14 days. While paracetamol in toxic dose was given on to KP1, KP2, KP3, with dose 0,1 ml/ 20 g weight of mice on day 12, 13 and 14. Mice were sacrificed with neck dislocation on the 15th day and histological preparation was made to evaluate histological damage on proximal tubular renal cells stained by Hematoxillin Eosin (HE). Renal histological features were assesed by counting the number of proximal tubular renal cells histogical damage. Data were analyzed by One-Way ANOVA test (? = 0,05) continued by Post Hoc Multiple Comparisons test (LSD)(? = 0,05). Results: The results of One-Way ANOVA test showed p < 0.05 that there was significant difference between four-groups. LSD test results showed p < 0,05 there was significant difference between grups. Conclusion: Salam leaf extract can prevent the renal cell damage of mice. The difference dose of salam leaf extract give different effects nefroprotector in mices renal cell. Keywords : salam leaf extract, paracetamol, renal histologic structure damage
The Influence of Brotowali Extract (Tinospora crispa (L.) Miers.)onCholesterol Blood Level of Rattus norvegicus with High Cholesterol Intake Dicky Maulana Lazuardi; Ida Nurwati; Nanang Wiyono
Nexus Kedokteran Translasional Vol 5, No 2 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Coronary Heart Disease is the disease that often suffered by Indonesian people which known with high cholesterol rate.Brotowalis stem contains saponin, flavonoid and polifenol, which potential to inhibit blood total cholesterolincrease. The research is for to know more the influence of the content of the brotowalis stem extract against total blood cholesterol levels. Method: This research is as experimental laboratoric research with Randomized Controlled Trial design that post-test only control group design, have done in Histology Laboratorium of the Sebelas Maret University, Surakarta. The subject are 32 male white rats, Wistar strain, aged 2 months, weighing more or less than 200 grams. Brotowalis stem extract made by using maceration method in Biological Pharmacy Laboratory, Pharmacy Faculty, Gadjah Mada University. The rat were divided randomly into 4 groups, each group consisting of 8 rats. In the negative control group was only given regular feed, propiltiourasil (PTU) and distilled water, the positive control group was given 5 gramduck egg yolk per 4,5 ml of aquadest, regular feed, PTU and distilled water. Whereas in the treatment group I and II was given 5 gram/4,5 ml of duck egg yolk suspense, regular feed, PTU, water and given 50 mg/200 gr and 100 mg/200gr extract of the brotowalis stem. Rats were fasted during 12 hours and then their blood cholesterol levels checked after the 21 days treatment period. The sample measured with TMS 24i Premium spectrophotometer with 600 nm wave. The data were analyzed by one-way ANOVA with SPSS for Windows version 22. Result:Total cholesterol levels of negative control group is 91,0019,46 mg/dl,on the positive control group is 104,1213,66 mg/dl,on treatment group I is 91,5016,08 mg/dl and on treatment group 2 is 84,6213,45 mg/dl.The result of one-way ANOVA test showed there is no significant total cholesterol blood level difference between 4 groups of rats with p=0,120. Conclusion:Brotowalis stem extract has not give an effect on total cholesterol blood levels of Rattus norvegicus with high cholesterol intake. Keywords: Brotowalis stem extract, total cholesterol, Rattus norvergicus
PerbedaanPengaruh Nefroprotektor Ekstrak Kunyit, Ekstrak Temulawak, dan Kombinasinya Terhadap Kerusakan Histologis Sel Ginjal Mencit yang Diinduksi Parasetamol Aulia Agung Sanubari; . Muthmainah; . Isdaryanto
Nexus Kedokteran Translasional Vol 2, No 1 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Turmeric and xanthorrhiza have been known to contain curcumin, and specially xanthorrhiza also contain xanthorrhizol that may exhibit significant protection of kidney cells from free radicals. This study has carried out to evaluate difference nefroprotector effect between turmeric, xanthorrhiza, and combination turmeric and xanthorrhiza on histological damage of kidney cells that induced paracetamol in mice. Methods: Present study was experimental laboratory research with post test only controlled group design.Samples were 30 male Swiss webster mice (2-3 months old) weighing+20 g, and they were divided equally into 5 groups, 6 mice each group. Sampling technique in this research was incidental sampling.KK (-) and KK (+) were given aquadest for 14 days. KP1 was given turmeric extract with the dose of 2,8 mg/20 g body weight of mice, KP2 was given xanthorrhiza extract with the dose of 14 mg/20 g body weight of mice, and KP3 was given combination of turmeric extract with dose 2,8 mg/20 g body weight of mice and xanthorrhiza extract with dose 14 mg/20 g body weight of mice for 14 days.Paracetamol was given to groups ofKK (+), KP1, KP2, and KP3on the 12th, 13th, and 14th day. On day-15th, micewere sacrificedandkidneys weretakento makepreparationsby paraffinblockmethodandHEstaining. Kidney histological features were assessed based on quantifying ofpyknosis, karyorrhexis, and karyolysis. Data were analyzed with the Kruskall-Wallis test (?=0.05) and continued with Mann-Whitney test (?=0.05). Results: Mean KK(-) : 10,331,40, KK(+) : 25,883,19, KP1 : 152,37, KP2 : 11,582,33, and KP3 : 131,92. Result of statistically data analysis showed that there was a significant difference of kidney damage score between all pairs of groups, except KK(-) - KP2 was not significant. Conclusion: There was a difference nefroprotector effect between turmeric, xanthorrhiza, and combination of them on histological damage of kidney cells that induced paracetamol, and xanthorrhiza extract at dose 14 mg/20 g body weight of mice had a better effect than turmeric extract or combination of them. Keywords: turmeric extract, xanthorrhiza extract, nefroprotector, kidney cells damage.
The Influence Of Green Beanss Flesh Extract (Phaseolus vulgaris L.) On Total Cholesterol Blood Level Of White Rat (Rattus norvegicus) Hypercholesterolemia Models Yunindra Ken Shaufika; Siti Aisyah; Danus Hermawan
Nexus Kedokteran Translasional Vol 5, No 1 (2016): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Introduction: Coronary heart disease is often suffered by Indonesiaan which are characterized by excessive cholesterol levels. Beans is a leguminous plant that is widely consumed by Indonesian. Beans have compounds that can lower cholesterol levels in the fruit are flavonoids, saponins and polyphenols. Flavonoids work by inhibiting the action of enzymes that cholesterol forming HMG CoA reductase inhibitor. Saponins inhibit cholesterol absorption in the intestine. Polyphenols work in inhibiting the oxidation of cholesterol. Statins currently used as a causative therapy in cases of hypercholesterolemia. However, use of these drugs gives the adverse side effects of the body. Therefore, researchers wanted to find out more about the influence of the content of the fruit flesh snaps against total blood cholesterol levels. Methods: This research is as experimental laboratoric research with Randomized Controlled Trial design that post-test only control group design, have done in Histology Laboratorium of the University of March Surakarta. The subject are 25 male white rats, Wistar strain, aged 3 months, weighing 200 10 gram grams. Green beanss flesh made by using maceration method. The rats were divided randomly into 5 groups, each group consisting of 5 rats. In the negative control group was only given regular feed and distilled water, the positive control group was given hiperkolesterolemic feed, PTU and distilled water. Whereas in the treatment group was given hiperkolesterolemic feed, PTU and water as well as 50 mg of extract of the green beanss flesh in treatment group I, 100 mg extract of the green beanss flesh in the treatment group II and 150 mg extract of the green beanss flesh in the treatment group III. All rats total blood cholesterol levels checked after the treatment period of 35 days. The data were analyzed by one-way ANOVA with SPSS for Windows version 22. Results: The result of one-way ANOVA test showed no significant total cholesterol blood levek difference between 5 groups of rats with p=0,299. Conclusions: The conclusion of the research is there is no effect between green beans extract on total cholesterol blood levels of white rat. Researcher suggests to do similar researchs with better method. Keywords: Green beanss flesh extract, total cholesterol, white rat, hypercholesterolemia
Perbedaan Efek Ekstrak Etanol Stevia Dibandingkan Madu Terhadap Perubahan Glukosa Darah Tikus Wistar Model Diabetik Siti Fatimah R; Kisrini .; Ratih Puspita Febrinasari
Nexus Kedokteran Translasional Vol 1, No 1 (2012): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background:Stevias leaf contains steviol, stevioside and rebaudioside which have effect to increase secretion insulin. Honey, natural sweetener contains several antioxidant such as propolis, flavonoid and vitamin. It will eliminate free radicals and indirectly improve pankreas glands cells to produce insulin. This research was aimed to know the difference effect of stevias ethanol extract comparedto honey on changing of blood glucoselevel on diabetic model Wistar rats. Methods:This was experimental research with pre and post test controlled group design. Samples were 32 male rats, Wistar Strain, 6-8 weeks and + 200 gweight. Sampling technique used in this research was incidental sampling. Samples were divided into 4 groups: negative control group (aquadest), positive control (glibenclamide dose 0.09 mg/200 g body weight), treatment group 1 (stevias ethanol extract dose 20 mg/200 g body weight), treatment group 2 (honey dose 2 ml/200 g body weight). Data were analyze using Saphiro-Wilks test of normality and Friedmann test (? = 0.05) and Post Hoc Multiple Comparison (Wilcoxon) (? = 0.05) using SPSS 17 for Windows. Results:There was a significant difference (p = 0.002) on the Wistars blood glucose level which was given stevias ethanol extract or honey. Stevias ethanol extract effect more on decreasing the blood glucose than honey. But, the both of them are able to decrease the Wistars blood glucose on diabetic model Conclusions:Stevias ethanol extract has the effect of decreasing blood glucose level on diabetic model Wistar rats better than honey. Keywords:ethanol extract of stevia, honey, alloxan, changes in blood glucose levels.
Antibacterial Activity Test of Aloe vera L. Leaf Extracts on Extended Spectrum ?-Lactamase (ESBL) Producing Bacteria from Surgical Site Infection Isolate . Zakiatunnisa; . Maryani; Sigit Setyawan
Nexus Kedokteran Translasional Vol 4, No 1 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Surgical site infection is clinically defined as a discharge of purulent around wounds or cellulitis inside postoperative wounds. One of the factors that cause surgical site infections is the ESBL producing bacteria that developed a resistance towards most antibiotics. Aloe vera L. is known to possess a lot of antibacterials potent against various bacteria, either gram-positive or gram-negative. This research aims to prove the effects of the administration of Aloe vera L. leaf extracts towards the growth of ESBL producing bacteria from surgical site infection isolates. Method of research: This research was an experimental laboratory research (post test only with control group design) with sampling technique non-probability sampling ; consecutive sampling. The research was done in the UNS Faculty of Medicines Laboratory of Microbiology. Extraction of samples was done in the Dr. Moewardi Public Hospital Laboratory of Microbiology.The independent variable of this research was 70% ethanol extracts of Aloe vera L. leaf with concentrations of 25%, 50%, 75%, and 100%. The research subject was surgical site infection isolate ESBL producing bacteria, standardized with Mc Farland 0.5. Sensitivity test on the Muller-Hinton medium used the diffusion method with cefoperazon/sulbactam as positive control and aquades as negative control. The result of research was tested with Kruskal-Wallis testing method followed by Mann-Whitney testing method. Results: Kruskal-Wallis test results indicates a significant interception potential between two treatment groups (P = 0.000). Mann-Whitney test results indicates a significant difference of interception potentials on every treatment group, with the exception of the interception potential groups of 75% concentration extract and 100% concentration extract, no significant interception potential was found (P = 0.179). Conclusion: Aloe vera L. leaf extract proves to possess potential activity interception towards the growth of ESBL producing bacteria from surgical site infection isolates. The concentrations of Aloe vera L. leaf extract possess a positive correlation towards the interception potentials on surgical site infection ESBL producing bacteria. Keywords: Infection, postoperative wound, ESBL, Aloe vera.
The Effect of Acetone Papaya Leaves Extract (Carica papaya, L.) to Hepatoprotector of Rat (Rattus novergicus) Induced by Paracetamol Dewantari Saputri; Suyatmi .; Kusmadewi Eka Damayanti
Nexus Kedokteran Translasional Vol 3, No 1 (2014): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Acetone papaya leaves extract contains chlorophyll and flavonoids with antioxidative capacity to protect the liver cell from free radicals The aims of this research were to know the hepatoprotective effect of the extract and to investigate the influence of increasing dose of the extract towards the amount of paracetamol-induced liver cells damage of rats. Methods: This study was a laboratory experimental research applying posttest only controlled group design. A total of 24 Strain Wistar rats were equally divided into 6 groups. Rats for control group (KK) and 1st group (KP1) were given aquades for 7 days. The second treatment group (KP2) was given 100mg/kg body weight (bw) of rat dose curcuma tablet. The 3rd (KP3), 4th(KP4), and 5th (KP5) treatment groups ware given acetone papaya leaves extract dose 150mg/kg bw, 300mg/kg bw, 600mg/kg bw, respectively for 7 days. Paracetamol was given to KP1, KP2, KP3, KP4, KP5 with dose 600mg/kg weight of rat on 5th, 6th, and 7th day. Finally on 8th day, rat were sacrificed by neck dislocation. After that, we made histological slides from the liver that stained with Hematoxillin Eosin (HE). The slides were observed and assessed based on the liver histological damage (pyknosis, karyorrhexis and karyolysis). Data were analized by Kruskal Wallis (? = 0,05), and continued by Mann Whithney test(? = 0,05). Results: Kruskal Wallis showed that there was a significant difference between 6 groups. Result of Mann Whithney method showed that there was a significant difference between control group (KK)and treatment group (KP1, KP2,KP4,KP5) as well as between curcuma (KP2) and acetone papaya leaves extract (KP3,KP4, KP5) groups, but there was no any significant difference between groups the increase doses (KP3-KP4,KP5). Conclusion: Acetone papaya leaves extract has hepatoprotective effect to the liver cell histological damage of rats induced by paracetamol.. Key words : acetone papaya leaves extract, paracetamol, liver cell histological damage.

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