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INDONESIA
Biomedical Engineering
Published by Universitas Brawijaya
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Arjuna Subject : -
Articles 27 Documents
 1   2   3 
Antioxidant and hypoglycemic activities of extract and fractions of Rambutan seeds (Nephelium lappaceum L.) Sylvia Soeng; Endang Evacuasiany; Wahyu Widowati; Nurul Fauziah
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective : This research was done  to measure the antioxidants and hypoglycemic activities of Nephelium lappaceum L. seed (NLS) extract and fractions. Methods: The ethanol extract of rambutan seeds were prepared by maseration method and the fractions (n-hexane, ethyl acetate, buthanol and water) by separation of extract based on the polarity. The antioxidant activity was determined by using  superoxide dismutase value (SOD), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity. The hypoglycemic activity was determined by using inhibition of α-glucosidase test. The DPPHscavenging and hypoglycemic activities were analized by median of Inhibitory Concentration (IC-50). Results: The highest SOD activity showed that ethyl acetate and aqueous fraction of NLS were 3.3771 µg/ml and 3.0374 µg/ml. Meanwhile DPPH assay showed that both NLS extract and fractions had low DPPH scavenging activity. Hypoglycemic activity showed that extract of NLS had highest activity as α-glucosidase inhibitor. Conclusion: Nephelium lappaceum L. seed extract and fractions have high SOD antioxidantvalue but low DPPH scavenging activity and can be used as potential hypoglycemic agent. Key Words: antidiabetic; antioxidants; α-glucosidase; hypoglycemic; scavenging
Antioxidant properties of spice extracts Wahyu Widowati; Hana Ratnawati; Winsa Husin; Maesaroh Maesaroh
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective : This study was conducted to determine the antioxidant activities of spice extracts including clove (Syzygum aromaticum L.), Indonesian cassia (Cinnamomum burmanni (C. Nees& T. Ness)), coriander (Coriandrum sativum L), nutmeg (Myristica fragrans Houtt), java cardamom (Amomum compactum Soland. Ex maton). Methods : This research was to evaluate antioxidant activities including 1,1-diphenyl-2picryl-hydrazyl (DPPH) scavenging activity, the value of superoxide dismutase (SOD), and total phenolic content. Results : The highest DPPH activity is clove and Indonesian cassia extracts with IC value 4.16 μg/ml and 5.46 μg/ml respectively. The highest SOD value are Indonesian cassia extract (9.1432 U/ml) at 500 µg/ml, 7.0045 U/ml at 125 µg/ml and 4.6751 U/ml at 31,25 µg/ml. Clove extract was the highest of phenolic content  (188.35 µg/mg eugenol equivalent). Conclusion : Indonesian cassia extract have high antioxidant activities. Clove extract contain the highest eugenol compared with Indonesian cassia, coriander, nutmeg and java cardamom.  Key Words: antioxidant; free radicals; spice; total phenolic content
Phytochemical assay, potential of antimalarial and antioxidant activities of green tea extract and its fractions Fanny Rahardja; Rita Tjokropranoto; Wahyu Widowati; Siska Lusiana; Adrian Suhendra; Susy Tjahjani; Iwan Budiman; Maesaroh Maesaroh; Nurul Fauziah
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective : The research objective was to evaluate the phytochemical compounds, the antioxidant and anti-malarial activity of green tea extract and its fraction. Methods: The antioxidant activity were measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity used in vitro laboratories prospective experimental design and completely randomized design, using ethanol extract, hexane, ethyl acetate, butanol fraction, and water fraction ofgreen tea in 7 levels of concentration compared to epicatechin (EC). The data were analyzed using linear regression analysis, and were continued by determined Inhibitory Concentration). The anti-malarial activity of green tea fractions were compared to artemisinin. The data were analyzed using probit analysis, and were continued by determined IC. Results: The results showed that the highest antioxidant activity (IC50) was the fraction of ethyl acetate 2,184 µg/ml. The anti-malarial activity IC50 50 of water and ethyl acetate fraction, ethanol extract and butanol fraction were 0,000090 µg/mL,0,003 µg/mL, 0,006 µg/mL, 0,011 µg/ml respectively.Conclusion: Extract and fractions of green tea have potential anti-malarial and antioxidant properties. Key Words: antioxidant; anti-malarial; green tea; free radicals
Carbonated hydroxyapatite inflammation’s responses on local rabbits Aryan Morita; Ngatidjan Ngatidjan; Setyo Purwono
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective: This study aimed to find out the response of mandible inflammation implanted with carbonated hydroxyapatite.  Methods: Sixty local rabbits were divided into three groups, including carbonatedhydroxyapatite (CHA) group; hydroxyapatite (HA) group; and control. Each group divided into 5 sub groups for observation in day-1, 3, 5, 7, and 14. On first day, all rabbits were anesthesized and incised to create cavity in the mandible. CHA or HA powder as much as 0,05 g were put into it. Then it was sutured using silk thread. Von Ebner method for decalcification were used followed by hematoxylin eosin staining to examine the neutrophil and macrophage. Results: The number of neutrophil, macrophage, and edema volumes in CHA group were lower than HA group. There were not any significant difference (p>0,05) between CHA, HA, and control.  Conclusion: There are no mandible inflammation response in CHA implantation and HA.Key Words: CHA; edema volumes; inflammation; macrophages; neutrophils
The effects of regular exercise on the number of osteoclasts in ovariectomized Sprague dawley rat mandibles Rini Maya Puspita; Fitrina Rachmadanty Siregar
Biomedical Engineering Vol 1, No 1 (2014)
Publisher : Biomedical Engineering

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Abstract

Objective: This study aimed to examine the effect of regular exercise on the number of osteoclasts in ovariectomized Sprague Dawley rat mandibles.Methods: Eight female Sprague Dawley rats, 3 months of age, were ovariectomized and divided into control (untreated) and treatment group (regular exercise). The exercise conducted by the rats ran on a specially designed rat treadmill for 12 weeks, 5 times per week, at a speed of 10-18 m/min for 60 minutes per day. At the end of the treatment, the mandible was taken and cleaned out from the tissue for making the histological preparations with Hematoxylin and Eosin (HE) stain. The number of osteoclasts counted from each histological preparation on 10 visual fields and the obtained data were analyzed using independent t-test.Result: The number of osteoclast was lower significantly in ovariectmized rats compared to control group (P < 0.001). Conclusion: Regular exercise can decrease the number of osteoclasts in ovariectomized Sprague Dawley rat mandibles.Key Words: mandibles; menopause; regular exercise; the number of osteoclasts;
BIOMEDICAL ENGINEERING Biomedical Engineering
Biomedical Engineering Vol 1, No 1 (2015): BIOMEDICAL ENGINEERING
Publisher : Biomedical Engineering

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Abstract

The first volume of Biomedical Engineering journal published in this year. Contains 10 scientific journals, with new discoveries and analysis. Bring to you with a intention and hope to deliver a good science work that hopefully could help people. 
Antioxidant properties of spice extracts Wahyu Widowati
Biomedical Engineering Vol 1, No 1 (2015): BIOMEDICAL ENGINEERING
Publisher : Biomedical Engineering

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Abstract

Objective : This study was conducted to determine the antioxidant activities of spice extractsincluding clove (Syzygum aromaticum L.), Indonesian cassia (Cinnamomum burmanni (C. Nees& T.Ness)), coriander (Coriandrum sativum L), nutmeg (Myristica fragrans Houtt), java cardamom(Amomum compactum Soland. Ex maton).Methods : This research was to evaluate antioxidant activities including 1,1-diphenyl-2-picrylhydrazyl(DPPH) scavenging activity, the value of superoxide dismutase (SOD), and total phenoliccontent.Result : The highest DPPH activity is clove and Indonesian cassia extracts with IC50 value 4.16μg/ml and 5.46 μg/ml respectively. The highest SOD value are Indonesian cassia extract (9.1432U/ml) at 500 μg/ml, 7.0045 U/ml at 125 μg/ml and 4.6751 U/ml at 31,25 μg/ml. Clove extract was thehighest of phenolic content (188.35 μg/mg eugenol equivalent).Conclusion : Indonesian cassia extract have high antioxidant activities both DPPH scavenging andSOD activities. Clove extract contain the highest eugenol compared with Indonesian cassia,coriander, nutmeg and java cardamom.
BIOMEDICAL ENGINEERING Vol.1 No.1 Tahun 2015 Biomedical Engineering
Biomedical Engineering Vol 1, No 1 (2015): BIOMEDICAL ENGINEERING
Publisher : Biomedical Engineering

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Abstract

The first volume of Biomedical Engineering journal published in this year. Contains 10 scientific journals, with new discoveries and analysis. Bring to you with a intention and hope to deliver a good science work that hopefully could help people. 
Carbonated hydroxyapatite inflammation’s responses on local rabbits: study of neutrophils’s cell count, macrophages, and edema volumes on mandible Aryan Morita
Biomedical Engineering Vol 1, No 1 (2015): BIOMEDICAL ENGINEERING
Publisher : Biomedical Engineering

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Abstract

Objective: The aims of this study was to find out the response of tissue inflammation implanted CHA thanstandard HA through the amount of neutrophil, macrophage, and edema volumes.Methods. Sixty local rabbits divided into 3 groups that contain 20 rabbits. Each group divided into 5 sub groupsthat observed in day-1, 3, 5, 7, and 14. On first day, all rabbits were anesthesized and incised to create cavity inthe mandible. CHA or HA powder as much as 0,05 g were put into it. Then it was sutured using silk thread. Onthe designated day, the mandibles of 4 rabbits from each sub group were decapitated. The mandibles were fixedwith 10% formalin in PBS pH 7,4. Von Ebner method for decalcification were used followed by hematoxylin eosinstaining to examine neutrophil and macrophage.Results: The number of neutrophil, macrophage, and edema volumes in CHA implantation were lower thanHA. There were not any significant difference (p>0,05) between CHA, HA, and without CHA or HA.Conclusion: There are no differences inflammation respons in CHA implantation and HA.
Phytochemical assay, potential of antimalarial and antioxidant activities of green tea extract and its fraction Fanny Rahardja
Biomedical Engineering Vol 1, No 1 (2015): BIOMEDICAL ENGINEERING
Publisher : Biomedical Engineering

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.267 KB)

Abstract

Objective : The research objective was to evaluate the phytochemical compounds, theantioxidant and anti-malarial activity of green tea extract and its fraction.Methods : The antioxidant activity were measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH)scavenging activity used in vitro laboratories prospective experimental design and completelyrandomized design, using ethanol extract, hexane, ethyl acetate, butanol fraction, and waterfraction of green tea in 7 levels of concentration compared to epicatechin (EC). The data wereanalyzed using linear regression analysis, and were continued by determined InhibitoryConcentration50 (IC50). The anti-malarial activity of green tea fractions were compared toartemisinin. The data were analyzed using probit analysis, and were continued by determinedIC50 .Result: The results showed that the highest antioxidant activity (IC50) was the fraction of ethylacetate 2,184 μg/ml. The anti-malarial activity IC50of water and ethyl acetate fraction, ethanolextract and butanol fraction were 0,000090 μg/mL,0,003 μg/mL, 0,006 μg/mL, 0,011 μg/mlrespectively.Conclusion : Extract and fractions of green tea have potential anti-malarial and antioxidantproperties.

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