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INDONESIA
Berkala Ilmu Kesehatan Kulit dan Kelamin
Published by Universitas Airlangga
ISSN : 19784279     EISSN : 25494082     DOI : 10.20473
Core Subject : Health, Science,
Immunology & microbiology Public Health
Arjuna Subject : -
Articles 12 Documents
 1   2 
Search results for , issue "Vol. 37 No. 3 (2025): DECEMBER" : 12 Documents clear
Incontinentia Pigmenti In A Male Infant: A Case Report Kartika Dewi, Arifiana Wungu; Indraswari, Anindia; Citrashanty, Irmadita; Iskandar Zulkarnain; Sawitri; Yuri Widia
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.218-221

Abstract

Background: Incontinentia pigmenti (IP), also known as Bloch-Sulzberger syndrome, is a rare X-linked dominant genodermatosis with an estimated incidence of 0.7–1.2 per 100,000 live births. It is caused by mutations in the IKBKG gene. Affected women have a 50% chance of transmitting the defective gene, while male fetuses usually do not survive due to the lethal effect of the mutation. Purpose: This report aims to present a rare surviving male case of incontinentia pigmenti with early dermatological manifestations and to highlight the importance of clinical recognition and multidisciplinary follow-up. Case: A 4-day-old male newborn presented with blisters on the left leg since birth. Dermatological examination showed multiple papules and vesicles arranged along Blaschko’s lines on erythematous macules without erosion. Based on clinical findings, the patient was diagnosed with stage 1 incontinentia pigmenti. Management included the use of moisturizers, topical antibiotics, and parental education regarding potential multi-organ involvement. Regular monitoring for neurological and ophthalmological manifestations was advised. Discussion: Incontinentia pigmenti is caused by an IKBKG gene mutation that disrupts NF-κB signaling, leading to increased apoptosis. It mainly affects ectodermal tissues such as the skin, hair, teeth, eyes, and CNS. The disease progresses through four skin stages: vesiculobullous, verrucous, hyperpigmented, and atrophic/alopecic. Diagnosis is mostly clinical, with histopathology or genetic testing used in atypical cases. Skin lesions usually resolve on their own, but preventing secondary infections is important. Conclusion: Incontinentia pigmenti in male infants is exceedingly rare. Early recognition, supportive care, and vigilant multidisciplinary monitoring are crucial to detect and manage possible systemic complications
Successful Treatment of Burn Wounds with Combined Astaxanthin and Gentamycin Topical: A Serial Case Report Sari, Ninda; Bulqiah, Mikyal
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.222-227

Abstract

genodermatosis with an estimated incidence of 0.7–1.2 per 100,000 live births. It is caused by mutations in the IKBKG gene. Affected women have a 50% chance of transmitting the defective gene, while male fetuses usually do not survive due to the lethal effect of the mutation. Purpose: This report aims to present a rare surviving male case of incontinentia pigmenti with early dermatological manifestations and to highlight the importance of clinical recognition and multidisciplinary follow-up. Case: A 4-day-old male newborn presented with blisters on the left leg since birth. Dermatological examination showed multiple papules and vesicles arranged along Blaschko’s lines on erythematous macules without erosion. Based on clinical findings, the patient was diagnosed with stage 1 incontinentia pigmenti. Management included the use of moisturizers, topical antibiotics, and parental education regarding potential multi-organ involvement. Regular monitoring for neurological and ophthalmological manifestations was advised. Discussion: Incontinentia pigmenti is caused by an IKBKG gene mutation that disrupts NF-κB signaling, leading to increased apoptosis. It mainly affects ectodermal tissues such as the skin, hair, teeth, eyes, and CNS. The disease progresses through four skin stages: vesiculobullous, verrucous, hyperpigmented, and atrophic/alopecic. Diagnosis is mostly clinical, with histopathology or genetic testing used in atypical cases. Skin lesions usually resolve on their own, but preventing secondary infections is important. Conclusion: Incontinentia pigmenti in male infants is exceedingly rare. Early recognition, supportive care, and vigilant multidisciplinary monitoring are crucial to detect and manage possible systemic complications, improving survival and quality of life.
Clinical Characteristics and Microbiological Profile of Oral Candidiasis among HIV-Positive Patients in Indonesia: A Literature Review Prameshvari, Putu Lovina Indra; Permana, Putu Bagus Dharma; Hidayati, Afif Nurul; Murtiastutik, Dwi; Arfijanto, Muhammad Vitanata
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.209-217

Abstract

Background: As the country with the highest identified active cases of HIV/AIDS across Southeast Asia, Indonesia faces a massive challenge in providing adequate antiretroviral therapy (ART) coverage to prevent disease progression and mortality.  Oral candidiasis (OC) is the most frequently identified oral manifestation of HIV infection and represents the degree of immunosuppression, treatment failure, and prognosis among people living with HIV/AIDS. Demographic characteristics, clinical types, and causative pathogens of OC vary between different geographical and socioeconomic settings. Hence, the role of oral candidiasis is crucial in developing effective strategies to address the HIV-related burden in Indonesia. Review: This literature review evaluated 11 descriptive studies conducted across eight major cities in Indonesia, comprising 764 HIV-positive patients diagnosed with OC. Most affected individuals were male and exhibited advanced immunosuppression, with the majority presenting CD4+ counts below 200 cells/mm³. Six clinical variants of OC were identified, with pseudomembranous candidiasis being the predominant form, followed by angular cheilitis, erythematous candidiasis, hyperplastic candidiasis, and sporadic cases of atrophic candidiasis and denture stomatitis. Microbiological findings showed Candida albicans as the leading etiologic species; however, non-albicans Candida (NAC)—particularly C. krusei, C. glabrata, and C. tropicalis—demonstrated notable prevalence, including mixed colonization with C. albicans. The rise of NAC species highlights concerns regarding antifungal resistance in the ART era. Conclusion: Oral candidiasis serves as an important clinical finding among patients living with HIV/AIDS, and its appropriate management is necessary not only to prevent further complications but also to mitigate the recent development of antifungal resistance.
The Effectiveness of Sexual Transmitted Disease Education among Healthcare Workers and Non-Healthcare Workers Prakoeswa, Flora Ramona Sigit; Dzikri, Dykall Naf'an; Wahidah, Wahidah
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.203-208

Abstract

Background: Sexually transmitted diseases (STDs) remain a significant global health concern. Education plays a crucial role in prevention, but its effectiveness may vary among different groups. Purpose: The purpose of this research was to determine how well both medical and non-medical staff at Dharma Wanita Orthopaedic Hospital Soeharso Surakarta understood sexually transmitted diseases, as measured by the STD-KQ questionnaire. Methods: This research employed a cross-sectional analytic observational design, involving 46 participants. Data were gathered through a sequence of pre-intervention assessment, educational program, and post-intervention evaluation. Statistical analysis was performed using paired t-tests and independent t-tests. Results: Prior to the intervention, healthcare workers possessed a significantly greater understanding of the subject matter (p=0.022). Both groups exhibited substantial improvements in their knowledge after participating in the educational program (p<0.05). The average scores for healthcare workers improved from 8.19 (± 4.80) to 16.15 (± 4.70), a statistically significant increase (p=0.001). Similarly, non-healthcare workers' scores rose from 13.40 (± 5.92) to 18.10 (± 4.24) (p=0.013). After the intervention, the initial difference in knowledge between the two groups was no longer statistically significant (p=0.154), indicating a closing of the knowledge gap. Conclusion: The educational intervention effectively improved STD knowledge in both groups and reduced the knowledge disparity between HCWs and NHCWs. The research points out the need for thorough and accessible sexual health instruction to improve STD understanding within diverse populations.
Characteristics of Scabies Patients in Pediatric Population at Dermatology and Venereolgy Polyclinic Dwizella, Nandya; Ganeswari, Putu Ayu Dewita; Suyanto, Firly Clarissa; Wicaksono, Andrew; Tanoto, Suma Pratiwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.163-166

Abstract

Background: Scabies has affected over 200 million individuals and remains one of the most commonly encountered skin diseases in developing countries, including Indonesia, due to limited access to water, food, and infrastructure. Therefore, scabies poses a significant problem, particularly among children in Indonesia. Severe itching symptoms along with stigma and social isolation can disrupt the quality of life. Purpose: This study aims to investigate the prevalence and characteristics of pediatric patients with scabies in the local population, specifically at the Dermatology and Venereology Polyclinic of Prof. Dr. I.G.N.G. Ngoerah Denpasar Hospital. Methods: A retrospective descriptive study conducted in a cross-sectional manner. Data were obtained from the medical records of all pediatric patients diagnosed with scabies at the Dermatology and Venereology Polyclinic of Prof. Dr. I.G.N.G. Ngoerah Denpasar Hospital from January 2021 to December 2023. The outcomes sought included the number of cases, gender, age, nutritional status, parents' education level, and treatment administered. Result: This study included a total of 53 pediatric patients. The majority of patients were male, comprising 34 patients (64.2%). There were 20 children (37.7%) with normal nutritional status, 16 children (30.2%) classified as underweight, 9 children (17%) classified as overweight, and 8 children (15.1%) classified as obese. Based on parental education level, 29 parents of the patients had completed high school education (54.7%), while the remainder had completed undergraduate (37.7%) and junior high school (7.5%). A total of 52 patients (98.1%) received 5% permethrin as scabies treatment. Conclusion: This study has provided important dst.
The Effect of 0.2% Hyaluronic Acid Cream on the Severity of Acute Radiodermatitis in Breast Cancer Patients: a Double-Blind Randomized Controlled Trial Muchamad Apriyanto; Sigid Santosa, Novita Permatasari; Mira Oktarina, Dyah Ayu; Ekaputra, Ericko; Trisnowati, Niken; Budiyanto, Arief; Soebono, Hardyanto; Waskito, Fajar; Indrastuti, Niken
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.195-202

Abstract

Background: Radiotherapy is an essential treatment in reducing the risk of breast cancer but can cause side effects such as acute radiodermatitis. This condition is the result of ionizing radiation damaging deoxyribonucleic acid (DNA) through reactive oxygen species (ROS) and inducing inflammatory responses, which lead to variable degrees of skin damage. Hyaluronic acid (HA) plays a role in triggering cell proliferation and keratinocyte differentiation while inhibiting lipid peroxidation caused by oxidative stress. Purpose: This study aims to determine the effectiveness of hyaluronic acid in reducing the degree of acute radiodermatitis using the Radiation Therapy Oncology Group (RTOG) score in breast cancer patients undergoing radiotherapy. Methods: This study was a double-blind randomized controlled trial. The samples were from patients diagnosed with breast cancer receiving radiotherapy. The treatment group received 0.2% HA cream, while the control group received a placebo The clinical appearance was evaluated weekly from the beginning of radiotherapy until two weeks post-radiotherapy using the RTOG score. Result: A total of 41 subjects were divided into two groups. RTOG score evaluation with intention-to-treat analysis and per-protocol analysis at weeks 3, 4, and 5 showed that the hyaluronic acid cream group experienced delayed onset of acute radiodermatitis compared to the placebo group. The log-rank test showed a significant difference in effectiveness between 0.2% HA cream compared to base cream in reducing the degree of acute radiodermatitis (p=0.035). Conclusion: The use of 0.2% HA cream was effective in reducing the severity of acute radiodermatitis in breast cancer patients undergoing radiotherapy.
Prevalence and Profile of Adolescents with Sexually Transmitted Infections at the Dermatology and Venereology Polyclinic of Ngoerah Hospital, Bali, Indonesia Intaran, Kadek Devi Aninditha; Puspawati, Ni Made Dwi; Elis Indira, I Gusti Ayu Agung; Pemana, Aditya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.190-194

Abstract

Background: Sexually Transmitted Infections (STIs) have been considered a public health threat in all countries, both in developed and developing countries. STIs have a direct impact on sexual and reproductive health through stigmatization, infertility, cancer, and pregnancy complications that can increase the risk of HIV. Purpose: This study aims to identify cases of adolescent patients with STIs at Ngoerah Hospital, Denpasar, Bali in the period 2021 to 2023. Methods: This study uses a descriptive observational study with a cross-sectional design. The research was conducted at the Dermatology and Venereology Polyclinic and the Medical Record Installation of Ngoerah Hospital, Denpasar, Bali. After the data was collected, it was tabulated in tabular form and grouped descriptively. Result: A total of 46 patient samples were obtained, with an average age of 16.7 years. Adolescents with STIs were more commonly found in female (63%). Based on their last education, the highest number of patients were junior high school graduates (58.7%) with a history of multipartner sexual intercourse (56.5%). Only 15.2% claimed to be married. The most common type of STIs was syphilis (50%), followed by condyloma acuminata (45.6%). A total of 67.4% of adolescents were known to have HIV-positive status. Conclusion: The picture of STIs in teenagers is more common in female with a junior high school education. Most teenagers have multi-partner partners with a history of having sexual relations with commercial sex workers (CSWs). The most common type of STIs in teenagers is syphilis (50%), and 67.4% are infected with HIV.
Factors Influencing Loss to Follow-Up in HIV Patients: a Retrospective Study Theresia Natalia Seimahuira; Johan Weinand Lepertery; Azzahra, Fatimah; Ahmad Rabitha Alam Arfah; Chelvano Yason Matitaputty
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.179-184

Abstract

Background: HIV has become a global health problem, causing millions of deaths since its discovery. The success of antiretroviral therapy (ART) depends heavily on patient adherence, yet the lost-to-follow-up (LTFU) rate remains high. Purpose: This study aims to identify the characteristics of HIV patients experiencing LTFU and analyze the influencing factors at the Karang Panjang Community Health Center in Ambon City. Methods: This study employs a cross-sectional design with secondary data analysis from theedical records of HIV patients from 2018 to 2024. The sampling technique used was total sampling, with a total sample size of 152 patients. Data analysis was conducted descriptively and inferentially using the chi-square and Fisher’s exact test. Result: The prevalence of LTFU among HIV/AIDS patients at the Karang Panjang Community Health Center is 15.1%. Most LTFU patients are female, over 30 years old, and married. Statistical tests show significant associations between LTFU and age (p = 0.0468), sex (p = 0.0433), and marital status (p = 0.0355), while education and religion are not significant. Among LTFU cases, 8.3% had died, 50% were alive but had stopped therapy, and 41.7% were untraceable. Additional contributing factors identified through discussions and medical record reviews include inadequate counseling and education, poor documentation of ARV side effects, limited financial resources, and insufficient peer or family support. Conclusion: The study concludes that age, sex, and marital status contribute to LTFU among HIV patients. It recommends improving ART retention through education, stricter monitoring, and community-based strategies to reduce future LTFU rates.
Characteristiscs of Syphilis Patient at Dermatology and Venereology Polyclinic Tanoto, Suma Pratiwi; Permana, Aditya; Suyanto, Firly Clarissa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.167-171

Abstract

Background: In 2022, the United States reported 207,255 syphilis cases, marking a 17.3% increase from 2021, and the highest incidence since 1950.  In Indonesia, early and late-stage syphilis cases reached 2,981 and 1,144 cases respectively in the first quarter of 2023. Purpose: This study aims to describe the characteristics of syphilis patients at the Dermatology and Venereology Polyclinic at Prof. Dr. I.G.N.G Ngoerah General Hospital. Methods: A retrospective descriptive study was conducted using secondary data from medical records of syphilis patients between January 2021 to December 2023. Data were obtained from the Sexually Transmitted Infection divisions. The study examined patient characteristics, including age, sex, occupation, comorbid conditions, syphilis stage, HIV status, sexual orientation, and sexual behaviour. Result: Out of 346 cases, the highest new syphilis cases recorded in 2021 (133 cases, 86%). The majority of patients were diagnosed with late latent syphilis (211 cases, 61%). The majority of patients were male (59%). The most affected age group was 25–44 years (174 cases, 51%). Private-sector employees represented the largest occupational group (118 cases, 34%). The most common comorbid condition was condyloma acuminatum, 45 patients (50%). In terms of sexual behavior, 62 patients (36%) engaged in receptive sexual activity. Heterosexual orientation was the most frequently reported (176 cases, 51%). Additionally, 205 patients (60%) were HIV-positive. Conclusion: This study has provided important characteristic data in mapping the population to the stages of syphilis, especially in the Bali region.
Comparison of the Effectiveness of Topical 5-Fluorouracil, Topical Calcipotriol, and Liquid Nitrogen Cryosurgery in Seborrhoeic Keratosis Sutedja, Eva Krishna; Suwarsa, Oki; Febrina, Dia; Wibowo , Raka Ghufran; Tasbun, Felix
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.172-178

Abstract

Background: Seborrhoeic keratosis (SK) is a benign tumor composed of epidermal keratinocytes occurs most frequently in the elderly. The action of 5-fluorouracil (FU) cream and calcipotrienes on keratinocyte development and has been shown beneficial for SK. Purpose: To compare the effectiveness of 5-FU and calcipotriol topical with cryosurgery. Methods: Eighteen SK patients with 54 skin lesions were enlisted, which were separated into three groups. The first group received topical 5-FU twice daily, the second group received one 10-second freeze-thaw cycle of liquid nitrogen cryosurgery, and the third group received topical calcipotriol twice daily. The success of therapy was assessed based on the reduction in baseline lesion size, and observations were made every two weeks for three months. Result: This study found that at the 12th week, the mean percentage of decrease in lesion size in group I was 34.6%, group II was 100%, and group III was 6.18%. Statistically, there was a significant difference in the decrease in lesion size in groups treated with cryosurgery (p value<0.001). The most common side effect in group I was discomfort, whereas in group II it was hyperpigmentation. Patients from group III reported no negative effects. Conclusion: Topical 5-FU and topical calcipotriol are less effective than cryosurgery in SK in terms of reducing lesion size. However, topical 5-FU reduced the size of lesions more than topical calcipotriol.

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