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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 505 Documents

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Profile of Malassezia Folliculitis Dwi Nurwulan Pravitasari; Sunarso Suyoso; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Malassezia folliculitis (MF) is a chronic infection of the pilosebaceous follicles caused by a skin fungus Malassezia sp. most often in teenagers who marked the onset of itchy erythematous perifolicular papules and pustules, especially in the upper body area and rarely on the face. The clinical appearance must be distinguished from acne vulgaris which has a similar clinical picture, so often have the wrong diagnosis that will affect the prognosis of the disease. Objective: To evaluate the profile of MF in Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital. Methods: A cross-sectional, observational, descriptive study, total samplingin three months of forty-five new patients with acne vulgaris appearance visiting Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital according to inclusion and exclusion criteria. Diagnosis based on history, clinical examination, Wood's lamp and KOH 20%. Malassezia sp. identification using Mycobiotic culture that is added to the olive oil. Results: Forty five patients with a clinical appearance of acne vulgaris in the upper body and slightly exposed on the face area, the new MF patients showed a total of 36 patients (80%) and the remaining 9 patients (20%) were diagnosed with acne vulgaris. Conclusions:Thirty six MF patients with the highest age range 15-24 years, anamnesis obtained itching is moderate grade, predilection in the area of the upper body, and Wood's Lamp examination produces greenish yellow color, KOH 20% examination obtained spores, whereas culture is not required for the diagnosis of MFKey words: Malassezia sp., Malassezia folliculitis, acne vulgaris, Wood's lamp, KOH 20%.

Increase of Serum Zinc Levels in Patients with Vitiligo Dinar Witasari; Hari Sukanto; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Vitiligo is a common acquired depigmentary disease characterized by depigmented patches of the skin, hair, and mucous membranes due to selective destruction of melanocytes. Zinc is one of the trace element that suspected to play an important role in pathogenesis of vitiligo. Previous research showed a controversial result in zinc level of vitiligo. Purpose: To compare serum zinc between vitiligo and control in Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital Surabaya. Methods: Analitic observational case control research was conducted, with 19 vitiligo patients in Dermatology and Venereology Outpatient Clinic Dr. Soetomo hospital and 19 age-sex matched controls (non-vitiligo subjects) that were qualified with inclusion and exclusion criteria. Serum zinc level was measured in both groups using atomic absorbtion spectrophotometer. Results: Mean serum zinc in vitiligo groups were 254.53 µg/dL and 109.53 µg/dL in control groups. This results showed that mean serum zinc in vitiligo group significantly higher compared to control group (p<0,05). There was a statistically significant association between serum zinc level and progressivity of the lesion as patient with active vitiligo lesion showed higher values of serum zinc. Stress is the most common predisposing factors (36%), meanwhile stress can also induce the increasing of serum zinc. Conclusion: Serum zinc in vitiligo patient is higher than control and showed correlation with course of the disease. It is required further research to reveal the role of zink in vitiligo and the connection between the degree of stress and serum zinc.

A Retrospective Study: Bartholin Cyst and Abscess Tjokorde Istri Nindya Vaniary; Sunarko Martodihardjo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Bartholin cyst is an enlargement of the duct gland as a result of some blockade. Infected Bartholin cyst can develop into an abscess. The diseases are common in reproductive women but the ideal treatment for this disease remains controversial. Purpose: To evaluate the management of Bartholin cyst and abscess in new patients according to diagnosis approach by anamnesis and physical examination. Methods: This study is a retrospective descriptive study. The data were drawn from medical records of new patients Bartholin cysts and abscesses in the Division of Sexually Transmitted Infections in Outpatient Clinic of Dermatovenereology Dr. Soetomo General Hospital during 2012-2014. Results: During 2012-2014, there are 46 patients with Bartholin cyst and 25 with Bartholin abscess. Visit times tend evenly throughout the year without a distinctive pattern. Most patients were in the age group 25-44 and married. Based on the history, 65.2% and 80.0% of patients with Bartholin cyst and abscess complained for a lump. From the physical examination, 39.1% and 44.0% of patients with Bartholin cyst and abscess had a lump size of 1-3 cms, most have a flat surface properties, a rubbery consistency, and obtained inflammatory signs. Gram and a wet mount examination performed at 84.8% and 72.0% of patients with Bartholin cyst and abscess, and showed normal results. Most treatment given to the patients with Bartholin cyst were antibiotics (60.9%) and patients with Bartholin abscess were given more than one treatment and most treatments given were antibiotics (64.0%) and non-steroidal anti-inflammatory drugs (72%). Conclusion: The diagnosis approach of Bartholin cyst and abscess was obtained by anamnesis, physical examination, and additional examination. Most of Bartholin cyst and abscess treated with antibiotics and NSAID, most of surgical treatment is marsupialization.

Condylomata Acuminata in Children: Report of Two Rare Cases Yuri Widia; Shinta Dewi Rahmadhani; Sawitri Sawitri; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Condylomata acuminata are mostly found in adult patients through sexual contact. Non-sexual transmission should be considered in children with condylomata acuminata. There are no Food Drug Administration (FDA) guidelines approved for condyloma acuminata in children less than 12 years old. Purpose: To report two rare cases of condylomata acuminata in children. Cases: Two girls, aged 1 and 2 years old came at different times to Dermatology and Venereology Outpatient Clinic Dr. Soetomo General Hospital with perianal tumors. Both were born by vaginal delivery. There was no history of the same disease on the genital or the skin of both parents. Physical examinations on the perianal area were multiple flesh-colored papules with ‘cauliflower’ appearance. There was no sign or symptom of sexual abuse. Histopathological examinations in both patient show epidermis with hyperkeratosis, acanthosis, papilomatosis, some epithelial cell show koilocytosis. On the dermis layer there were proliferation from capillary blood vessel, infiltration mononuclear, intact membrane basale and no sign of malignancy. Human papillomavirus (HPV) subtypes examination results were type 11. Discussion: Trichloroacetic acid (TCA) was giving different results on both cases. The patient who did not show improvement with TCA was consulted to pediatric surgery to get electrodessication therapy by hefrycauter. Conclusion: Accurate history and physical examination isneeded to determine the mode transmissions of condylomata acuminata in children. Human papillomavirus (HPV) subtypes examination is not routinely performed and has limitation to determine the mode of transmission, especially in children. Perinatal transmission should be considered in children up to 2 years old. Multiple modalities are available for the treatment of warts in children.

Tinea Capitis Favus-Like Appearance: Problem of Diagnosis Dwi Ratna Adisty; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Tinea capitis (TC) is an infection of scalp, hair follicles, and the surrounding skin, caused by dermatophyte fungi. Favus, a chronic inflammatory tinea capitis typically seen in Trichophyton schoenleinii infection. Favus is characterized by ‘scutula’. Favus may result in cicatricial alopecia. Purpose: To understand the clinical manifestation and management of tinea capitis. Case: A girl, 8 year-old, 18 kg, with thick crust located at the center of the head since 3 months, became spreading overtime. There were itchy sensation, no fever, no pain. There was history of an itchy red patch on her neck which diminished with topical antifungal. Dermatological examination revealed multiple thick brown-yellow crust sharply marginated, there were erosion and alopecia area beneath the crust. There were no sign of inflammation, no pustule, no enlargement of cervical and occipital lymphnodes on palpation. Discussion: Wood’s light examination showed no fluorescence and potassium hydroxide (KOH) showed no spores. Result of fungal culture was no colony growth. Patient was given griseofulvin 20 mg/kg body weight/day, wet dressing, and ketoconazole 2% shampoo twice weekly. Good clinical result shown after 10 weeks. Conclusion: Diagnosis of TC established based on history taking, clinical findings, Wood’s light examination, KOH preparation, fungal culture. A negative culture may arise because antifungal treatment had been used prior to collection of the specimen. Griseofulvin still became the drug of choice for tinea capitis even there are new generations of antifungal.

Oral Antibiotic in Acne Vulgaris Patients: Retrospective Study Marina Rimadhani; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Antibiotic resistance is one of the health problem in Indonesia, the one of the reason is using combination of antibiotic, so that clinician should prevent resistance to any selected combination antibiotic therapy. The use of long period oral antibiotics in acne therapy can cause Propionibacterium acne resistanceto antibioticsincreasedfrom 20% in 1979to67% in 1996. Purpose: To describe and evaluate management of oral antibiotic in new patient with acne vulgaris. Methods: Retrospective study in patients with acne vulgaris who received oral antibiotic in Cosmetic Division Dermato-Venereology Department Outpatient Clinic of Dr. Soetomo General Hospital in period of January 2010 to December 2012. Results: Obtained 481 new patients receive oral antibiotic from the total visit of 3519 acne vulgaris patient. The proportion of the largest group of 15-24 years, female patient were found having higher incidence than male. The most clinical feature found was grade 2 papulopustular (49.6%). The most common treatment which were given to the patient were doxycycline (98.8%) for systemic treatment with topical combination therapy as sunscreen (24.8%), facial cleansers(23.6%), tretinoin(20.99%), clindamycin gel (19.3%), and benzoylperoxide(5.4%). Highest proportion of long duration use of antibiotics is 2 weeks(57.5%). Conclusions: Selection of combination therapy is appropriate, but the use oftopical antibioticsalong withoral antibioticsshould be considered. Combination therapy, duration, and education still play an important role in preventing resistance Propionibacterium acne to antibiotics.Key words: acne vulgaris, antibiotic resistance, combination therapy, retrospective.

Retrospective Study: Characteristic of Papular Pruritic Eruption in HIV/AIDS Patients Afria Arista; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acquired immunodeficiency syndrome(AIDS) is a symptoms caused by infection of Human immunodeficiency virus (HIV) that may cause the decreasing of immune system. Skin disorder that can occurin patients with AIDS are papular pruriticeruption (PPE), which often lead toimpaired quality of lifein patients. Purpose: To evaluate the general overview and management of PPE, hence better management can be provided. Methods: Retrospective study of PPE patien in UPIPI (Unit Perawatan Intermediate Penyakit Infeksi) Dr. Soetomo General Hospital Surabaya during 2014. Results: The number of PPE patients was 15.4% of hospitalized patients. The largest age group was 25-44 years (56.9%), sex most were male (65.5%). Patients mostly from Surabaya (72.4%). Most of the patients worked asprivate sector workers (43.1%), and 73.2% of those with high school education. The main complaints include itching (83.62%), the location is in the limbs (55.2%). The most effloresensi is +multiplepapuleshyperpigmentation sharply marginated (58.6%). Mosttypes oftransmissionarefree sex (78%), CD4 highest 3value is 1-100 cells/mm (32.7%), 56.9% of patients received ARV treatment. Skin treatment is topical steroids (73.3 %). Conclusion: PPE is a skin disorderthat often arises in patients with HIV/AIDS.Keywords: papular pruritic eruption , HIV/AIDS, retrospective.

Zinc Plasma Levels in Recurrent Vulvovaginal Candidiasis Patients Deryne Anggia Paramita; Kristina Nadeak; Richard Hutapea
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Recurrent vulvovaginal candidiasis (RVVC) is episodes of thrush vulvovaginalis 4 times or more within 12 months. Some exogenous pathogenic factors and host are known to be associated with RVVC including sex hormones, contraceptives, obesity, cellular immune responsses which could influenced by zinc. Purpose: To compare differences between plasma zinc levels of RVVC patients with controls. Methods: The study was cross involving 30 people with RVVC and 30 controls. Each study subjects vaginal smear examination and blood examination to measure the levels of zinc. Results: Mean value of plasma zinc levels in the case group (22.85 цg/dL) was lower than the control group (22.96 цg/dL). However, this difference was not statistically significant (p = 0.270). Conclusion: There is no difference between the plasma zinc level of vulvovaginalis recurrent candidiasis patients with controls.

Profile of Serum Interleukin-31 Levels in Atopic Dermatitis Dewi Kusumawati; Cita Rosita Prakoeswa; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic skin lesion. Pathogenesis of AD is not fully understood, but recent studies demonstrate the role of interleukin-31 (IL-31). This cytokine is considered to be a potential mediator inducing pruritus in AD. Several studies reported a direct correlation between serum IL-31 level and severity of AD, probably due to the ability of this cytokine to increase the inflammatory response through the initiation of the expression of proinflammatory cytokines and chemokines. Purpose: To evaluate the serum level of IL-31 in AD patients. Methods: Thirty-four AD patients who defined according to the criteria of United Kingdom (UK) Working Party were included in this descriptive observational cross-sectional study. Samples were taken from peripheral venous blood and IL-31 serum levels were measured using ELISA. Results: Mean IL-31 serum level was 99.43±72.91 pg/mL, with the lowest level of 6.84 pg/mL and the highest level of 281.25 pg/mL. Conclusion: IL-31 seems to have a role in atopic dermatitis but further investigation is required.

The Positive Skin Prick Test not Correlate with Disease Severity and Quality of Life in Atopic Dermatitis Patients Oki Suwarsa; Erfina Rohana Sormin; Endang Sutedja; Hartati Purbo Dharmaji
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a skin disease which cause stress to the patients. The chronic process of AD can cause physical, social, and psychological impairments. The severity of AD can also be affected by allergen exposures, which in turn will affect the quality of life of the patient. Skin prick test (SPT) can be used to evaluate allergen sensitization. Purpose: To evaluate correlation between SPT positivity to severity and quality of life of AD patients. Methods: The study was an observational cross-sectional study. Twenty five AD patients were recruited based on inclusion and exclusion criteria. Questionnaire was used to measure the quality of life of patients, and Scoring of Atopic Dermatitis (SCORAD) to measure the disease severity. Most of participants were women (80%), with median of age 26.84±13.71. Results: Positive SPT was obtained in 68% of patients, most of them were caused by house dust mites (55.2%). Seventy six percent of patients experienced mild AD, 12% moderate AD, and also 12% patients experienced severe AD. Significant correlation was observed between the severity and quality of life (p=0.001;r=0.617), while the SPT positivity has no correlation with the severity (p=0.912;r=-0.023) and quality of life (p=0.959;r=0.011). Conclusion: This study revealed that the severity of the disease has a correlation with quality of life, but SPT positivity has no significant correlation with severity and quality of life.

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