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Berkala Ilmu Kesehatan Kulit dan Kelamin

BIKK
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Published by Universitas Airlangga

ISSN : 19784279 EISSN : 25494082 DOI : 10.20473

Core Subject : Health, Science,

Immunology & microbiology Public Health

Arjuna Subject : -

Articles 505 Documents

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Studi Retrospektif: Karakteristik Dermatofitosis Dyatiara Devy Rahadiyanti; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Dermatofitosis merupakan salah satu penyakit mikosis superfisialis akibat jamur yang menginvasi jaringan yang mengandung keratin seperti stratum korneum epidermis, rambut, dan kuku. Seringkali disebut tinea dan diklasifikasikan menurut bagian tubuh yang terkena. Tujuan: Mengevaluasi gambaran penyakit dermatofitosis di Divisi Mikologi Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya periode tahun 2014 sampai 2016. Metode: Penelitian retrospektif dengan mengevaluasi data rekam medis elektronik Divisi Mikologi URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya periode Januari 2014 – Desember 2016. Hasil: Jumlah kunjungan pasien baru dermatofitosis mengalami peningkatan, yaitu 71,9% dari seluruh pasien yang datang ke divisi Mikologi dibandingkan penelitian retrospektif sebelumnya. Tinea korporis merupakan diagnosis terbanyak yakni sebesar 56,1%. Sebagian besar pasien adalah wanita. Usia terbanyak yang ditemukan sedikit bervariasi yakni 45-64 tahun pada tahun 2014 dan 25-44 tahun pada tahun 2015 dan 2016. Keluhan utama terbanyak adalah gatal dan bercak kemerahan. Pemeriksaan mikroskop langsung dengan larutan KOH 10% merupakan pemeriksaan rutin yang dilakukan pada seluruh pasien dermatofitosis. Sebanyak 51,2% kasus dermatofitosis yang ditemukan disebabkan oleh spesies Trichophyton mentagrophytes. Pengobatan terbanyak dengan griseofulvin. Simpulan: Terdapat peningkatan jumlah pasien dermatofitosis. Usia terbanyak yang terinfeksi adalah kelompok usia produktif, karena pada kelompok usia ini terjadi peningkatan dari aktivitas fisik dan memiliki kecenderungan untuk banyak berkeringat dan lembab.

Salivary Cortisol Levels Representing Serum Cortisol Levels in Atopic Dermatitis Patients Novia Indriyani Adisty; Marsudi Hutomo; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder, recurrent lesion with a distinctive and specific distribution of lesions according phases. Patients with allergic diseases have been known to have a variety of patterns of cortisol. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and the role of cortisol has been studied in patients with DA. Free cortisol adrenal cortex is considered biologically active, which passively diffuses into all body fluids including saliva. Another advantage is the saliva examination is non-invasive, stress free and easy to do anywhere. Purpose: To analyze the correlation between levels of serum cortisol and salivary cortisol in patients with AD. Methods: Analytical, observational, cross-sectional study of the 29 AD patients who underwent blood and saliva samples by the method of "passive drooling" conducted on the hour 8:00 to 9:00 to see the levels of serum cortisol and salivary cortisol. Results: Twenty-nine subjects revealed mean serum cortisol levels 6,703,82g/dL, mean salivary cortisol levels was 1,430,96g/dL. Equation of salivary cortisol = 0,471+0,142*serum cortisol 2 (R=28,5%). Conclusions: The increasing of serum cortisol level of AD patients will result in increased levels of cortisol in saliva. Saliva collection methods by “passive drooling” were able to describe the serum cortisol levels at 28,5%.Key words: atopic dermatitis, serum cortisol, salivary cortisol.

Treatment Options for Postinflammatory Hyperpigmentation in Color Skin Putri Hendria Wardhani; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Post inflammatory hyperpigmentation (PIH) is a reactive hypermelanosis after inflammation. PIH can have a negative impact on a patient’s quality of life, particularly for darker-skinned patient. Although PIH can occur in any skin type, but this type of hypermelanosis is more common in color skin patients. Purpose: Review treatment options for HPI in color skin. Review: Skin of color describes individuals with increased epidermal pigment and darker skin. This subset of patients has unique cosmetic concerns and often requires special consideration for cosmetic procedures. PIH is more frequent, more severe dan more evident in color skin. Conclusion: Treatment for the underlying dermatosis and sunscreens are an effective treatment. Topical treatment is effective for PIH epidermal only. Hydroquinone in combination with topical steroid, retinoid, glycolic acid, lactic acid as well as kojic acid, arbutin, ascorbic acid, soy, and niacinamide. Salicylic acid and glycolic acid chemical peeling as well as quality-switched (QS) neodymium-doped yttrium aluminum garnet (Nd: YAG) laser, QS Ruby, 1550 nm erbium fiber fractional thermolysis, and 1927 nm fractional thulium fiber shows a good efficacy for facial hyperpigmentation treatment.

Association of Serum Testosterone with Various Severity of Acne Vulgaris in Adult Women Umi Miranti; Diah Mira Indramaya; Hari Sukanto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 2 (2017): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Acne Vulgaris (AV) is a chronic and obstructive inflammatory skin disease of the pilosebaceous unit. Testosterone is main androgen hormone that have a role in the pathogenesis of AV. Pevious researches have shown controversial results regarding serum testosterone levels in AV. Purpose: To evaluate the association of serum testosterone levels with AV severity in adult women in Dermatovenereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya. Methods: This is an analitic observational study, with 37 patients based on the inclusion and exclusion criteria. Results: Mean serum testosterone level in mild AV group was 39.16 + 24.18µg/dL, moderate AV group was 39.75 + 23.75 µg/dL, and severe AV group was 52.46 + 24.00 µg/dL. These results indicate that serum testosterone level in severe AV group was higher than moderate and mild AV groups. But there was no statistically significant correlation between serum testosterone levels and the severity of AV. Conclusions: Serum testosterone levels in patients with severe AV was higher than moderate and mild AV. No correlation between serum testosterone levels with AV severity in adult women. Further research ruled out confounding factors is needed to determine hormonal role in the pathogenesis of AV.

Comparison of Malassezia Colonization on Atopic Dermatitis Patients and Control Ardsari Azminingrum; Iskandar Zulkarnain; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic skin disease that often occurs in infancy and children. Skin barrier defect in atopic dermatitis causes the skin susceptible to bacterial, fungal, and viral infection. Antifungal therapy can improve atopic dermatitis by reducing the number of Malassezia colonization on the skin. Purpose: To compare Malassezia colonization of children with AD and non-AD children in Dermato-venereology Outpatient Clinic in Dr. Soetomo general hospital Surabaya. Methods: This was an analitic observational study, 25 atopic dermatitis and 25 non-atopic children (controls) that qualify inclusion and exclusion criteria were eligibled. Skin specimens were obtained by skin scraping and then planted in the culture medium ChromAgar Malassezia. Results: Positive culture of Malassezia in AD group was fewer than the control group, while the average number colony of Malassezia sp.in atopic dermatitis was higher than the control group; but statistic analysis showed the difference was not significant (p>0.05), except in seborrheic area. Conclusions: The average number colony of Malassezia sp. was higher in AD patient than control group in this study. Statistic analysis showed the difference was not significant, except in seborrheic area. This results differ with previous study can be possible due to the difference of using culture medium and methods of skin specimen collection, as well as the influence of tropical climate that occurred in Indonesia.

Mutasi Onkogen dan Tumor Suppressor Gen pada Xeroderma Pigmentosum Shinta Dewi Rahmadhani; Sawitri Sawitri; Willy Sandika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 1 (2018): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Xeroderma pigmentosum (XP) adalah penyakit yang jarang, diturunkan secara autosomal resesif dengan gangguan pada perbaikan deoxyribonucleic acid (DNA) yang sering mengakibatkan keganasan. Pada XP terdapat lesi DNA yang tidak dapat diperbaiki dan mutasi gen yang mengatur perkembangan kanker kulit. Tujuan: Menjelaskan patogenesis molekular dan genetik XP, terutama tumor suppressor gen dan mutasi onkogen. Telaah Kepustakaan: Pasien XP dengan radiasi sinar ultraviolet (UV) menghasilkan perkembangan yang tinggi dari squamous cell carcinoma (SCC), basal cell carcinoma (BCC), dan melanoma maligna (MM). Hal itu bisa dikarenakan hipersensitifitas akut perbaikan DNA yang tidak sempurna karena mutasi tumor suppressor gen (gen p53, INK-ARF, dan PTCH) dan gen Ras pada proto-onkogen (Ha-ras, Ki-ras, dan N-ras). Simpulan: Deteksi mutasi gen dapat dilakukan mengggunakan polymerase chain reaction (PCR) dan single strand conformation polymorphism (SSCP-PCR).

Retrospective Study: Oral Medications for Atopic Dermatitis Yuri Widia; Marsoedi Hutomo
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by recurrent itch. The prevalence of AD in children is 10-20%, while in adults is as many as 1-3%. Several factors are proposed to play role in the pathogenesis of AD as well as genetics, immunological, and environmental factors. There are recent advances in the management of the AD but still not fully satisfactory. Purpose: To evaluate oral medications for AD to improve patient's care in the future. Methods: Retrospective study performed in Allergy Immunology Division of Dermatology and Venereology Outpatient Clinic Dr. Soetomo th stGeneral Hospital within January 1 2009 until December 31 2011. Data was collected from medical records. Results: There were 11.7% AD patients who received oral treatment. The most antihistamine given was mebhydrolin napadisilat in 51.5% of patients. The most corticosteroids given was dexamethasone in 33.6% patients. Dexamethasone was given in tapering off in 7.9% patients. The most oral antibiotics given was erythromycin in 4.8% patients and cloxacillin in 0.3% patients. Conclusions: Oral medications mostly used in AD was antihistamine. Some patients were also given corticosteroids. Antibiotics were used if secondary bacterial infection was assessed.Key words: atopic dermatitis, retrospective study, oral medications.

The Profile of Interferon-ɣ and BCG Scar as an Immune Response Reflection in Children with Leprosy Renata Mayangsari; Iskandar Zulkarnain; Trisniartami Setyaningrum
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy in children are commonly found in Madura, Indonesia. Bacillus Calmette-Guerin (BCG) vaccination and interferon--γ (IFN-γ) level associated with severity of leprosy. Purpose: To evaluate IFN-γ level and BCG scar due to leprosy in child. Methods: A descriptive observational cross sectional research, with leprosy in patients in Bangkalan, Madura as subjects. Subjects has been collected through consecutive sampling, then BCG scars were observed and blood vein samples were taken to measure IFN-γ level. Results: IFN-γ level were below normal range in almost all subjects. Mean level in patients with BCG scar (10,07 pg/ml) were higher than patients with non-scar (6,9 pg/ml). Seventy percents patients without BCG scar tend to be MB type based on percentage BCG scar due to type of leprosy. Conclusion: Immunity status as a result of BCG vaccination measured from IFN-γ level has many confounding factor. BCG vaccination seems to have an important role in severity of leprosy. Patients with BCG scar tend to be PB type. BCG vaccination can be benefits to make milder symptoms of leprosy.

A Retrospective Study: The Profile of New Gonorrhoeae Patients Dewi Puspitorini; Hans Lumintang
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 1 (2017): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Incidence of sexually transmitted infections are still high, gonorrhoeae is one of them. Statistic data on 2008 revealed 25.4 million cases of gonorrhoeae in Southeast Asia. On condition of gonorrhea is not treated adequately can lead to the expansion of the disease, resulting in complications such as pelvic inflammatory disease (PID). Purpose: To evaluate profile of new gonorrhoeae patients. Methods: Retrospective study of profile of new gonorrhoe patients in Sexually Transmitted Infections Division in Dermatovenereology Outpatient Clinic between the year 2010-2012. Results: There were 135 gonorrhoeae patients, the majority were men 125 patients (92.6%) much more than women 10 patients (7.4%) , mostly of the age group 25-44 years old 84 patients (62.2%), and mostly were single 74 patients (54.8%) majority of symptom is dysuria 66 patients (48.8%). Local status from examination with the highest result was erythem and oedem of orificium urethra externum 88 patients (65.2%). The majority of sexual partner is boyfriend or girldfriend 56 patients (41.5%). Laboratory examination showed diplococcus negative gram 135 patients (100%). The most used therapy was combination of doxycycline and cefixime (90 patients). Conclusion: Gonorrhoeae is a sexually transmitted infection that occur mostly on productive-age patients. Right management dan education to the patients are needed for therapy and prevention of the disease.

Pengaruh Hormon terhadap Akne Vulgaris Marina Rimadhani; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

SurabayaABSTRAKLatar belakang: Akne vulgaris (AV) merupakan salah satu kelainan kulit yang sering ditemui dalam kehidupan sehari-hari. Hormon diketahui memiliki peran penting dalam perkembangan akne, namun banyak hal yang masih belum terjawab tentang mekanisme hormon terhadap akne. Tujuan: Memberikan informasi peran hormon pada akne terutama pada kelenjar sebasea sehingga klinisi dapat memberikan edukasi dan penanganan lebih baik kepada pasien. Telaah kepustakaan: Hormon androgen yang berperan penting pada perkembangan terjadinya akne adalah dehidrotestosteron (DHT), testosteron, prekusor adrenaldehidroepiandrosteron sulfat (DHEAS), hormon lainnya seperti glukokortikoid, estrogen, progesteron, dan insulin. Simpulan: Hormon memiliki peran penting dalam pembentukan AV, namun multifaktor lainnya harus dipertimbangkan. Edukasi dan kepedulian pasien terhadap akne merupakan kunci keberhasilan terapi.

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