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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Education,
Computer Science & IT Education
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Articles 11 Documents
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Search results for , issue " Vol 18 No 1 (2013)" : 11 Documents clear
Uji Aktivitas Beberapa Subfraksi Etil Asetat dari Herba Meniran (Phyllanthus niruri Linn.) Terhadap Reaksi Hipersensitivitas Kutan Aktif Aldi, Yufri; Mahyudin, Mahyudin; Handayani, Dian
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the activity of some ethyl acetate subfraction of meniran herbs (Phyllanthus niruri Linn.) on the cutaneous active hypersensitive reaction has been conducted. The subfraction (1,2, and 3) were at the dose of 50 mg/Kg BW and 100 mg/Kg BW dispersed with 1% tween 80: Chicken egg albumin at concentration 25% and 30% were used as control, all of which were given for 10 days. The Hipersensitivity reaction was observed at day 10th. Result Showed that subfraction 1,2, and 3 at doses 50 mg/Kg BW and 100 mg/Kg BW inhibited hypersensitivity, reaction significantly, the onset of blue skin bump were best given by subfraction 3 (dose 100 mg/Kg BW), the diameter of blue skin bump were best given by subfraction 2 (50 mg/Kg BW) and the intensity of the blue skin bump was besy given by subfraction 2 (100 mh/Kg BW). In summary, the ethyl aceble subfraction of meniron herbs (Phyllanthus niruri Linn.) showed an immunostimulan activity
Pengaruh Pemberian Ekstrak Gambir Terhadap Kadar EDRF (Endothelial Derrivat Relaxing Factors)/Nitrogen Mono Oksida (NO) pada Hiperkholesterolemia Suhatri, Suhatri; Aldi, Yufri; Dharma, Nikita Surya
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Nitrogen mono oksida (NO) dikenal juga dengan Endothelial Derrivat Relaxing Factors) merupakan molekul sederhana yang berperan dalam regulasi sistem kardiovaskular. Nitrogen mono oksida yang dihasilkan oleh NOS type III didalam endotel akan berdiffusi kedalam sel otot polos pembuluh darah yang akan mengaktifkan enzim guanylate cyclase menyebabkan terjadi relaksasi dari otot polos pembuluh darah. Nitrogen mono oksida yang dihasilkan dari metabolisme obat antiangina menyebabkan vasodilasi pembuluh darah koroner yang mengalami aterosklerosis dan memperbaiki aliran darah koroner jantung. Pada penelitian ini diteliti pengaruh ekstrak gambir terhadap kadar EDRF (Endothelial Derrivat Relaxing Factors)/Nitrogen Mono Oksida (NO) pada keadaan hiperkolesterol. Hiperkolesterol di induksi dengan koktail aterogenik. Koktail atrogenik terdidri dari Lemak sapi : Miyak sawit (1:5) PTU 0,1 %, empedu ayam 2 %. Ekstrak gambir diberikan dengan dosis 10, 20 dan 40 mg/Kg BB selama 2 bulan bersamaan dengan koktail yang diberikan secara oral. Kadar NO ditentukan dengan metoda ELISA Spektrofotometer Ukur Optikal Densiti nya pada λ 550 nm. Hasil penelitian menunjukan ekstrak gambir dengan dosis 10 dan 20 mg/Kg BB dapat meningkatkan kadar NO, 20 mg/Kg BB merupakan dosis terbaik untuk. Dosis 40 mg/Kg BB tidak dapat meningkatkan NO.
Pola Penggunaan Isdn pada Penderita Angina Pektoris di Suatu Rumah Sakit Pemerintah Kota Padang Almasdy, Dedy; Darwin, Deswinar; Kurniasih, Nina; Handayani, Vivi
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Telah dilakukan kajian ketepatan penggunaan ISDN (isosorbit dinitrat) pada pasien angina pektoris di suatu rumah sakit pemerintah Kota Padang. Evaluasi ketepatan didasarkan kepada kriteria standar yang telah ditetapkan, meliputi; ketepatan indikasi, ketepatan pasien, ketepatan regimen dosis, serta adanya duplikasi terapi dan interaksi obat. Hasil kajian memperlihatkan bahwa telah terjadi ketidaktepatan frekuensi penggunaan dan duplikasi terapi berturut-turut 17.31% dan 5.77%. Sementara interaksi farmakodinamik dan interaksi farmakokinetik terjadi masing-masingnya sebesar 98.07% dan 75.00%. Ketepatan lama terapi sebesar 76.92% dan 23.08% tidak cukup informasi.
Identifikasi dan Penetapan Kadar Merkuri (Hg) dalam Krim Pemutih Kosmetika Herbal Menggunakan Spektrofotometri Serapan Atom (SSA) Armin, Fithriani; Zulharmita, Zulharmita; Firda, Dinda Rama
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Telah dilakukan penelitian analisis kandungan merkuri dalam 3 sampel krim pemutih kosmetika herbal. Sampel diekstraksi dengan cara digesti basah selama 3 jam pada suhu ±95°C sampai diperoleh larutan bening. Selanjutnya merkuri ditentukan secara kualitatif dan kuantitatif dengan pereaksi warna dan menggunakan metoda spektrofotometri serapan atom. Hasil analisis kualitatif menunjukkan bahwa semua sampel mengandung merkuri. Kadar merkuri pada sampel 1, 2, 3 berturut-turut adalah sebesar 0,56%; 0,28% dan 0,45 %. Kadar Hg pada sampel tersebut melanggar Peraturan Menkes RI No.376/MenKes/Per/VIII/1990 dan PerMenKes RI No.445/MenKes/Per/V/1998 yang isinya melarang penggunaan merkuri dalam sediaan kosmetika.
Pengaruh Kombinasi Surfaktan Natrium Lauryl Sulfat dan Benzalkonium Klorida Terhadap Kelarutan Ibuprofen Syofyan, Syofyan; Safari, Tuti Agustia; Azhar, Rieke
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the influence of sodium lauryl sulfate and benzalkonium chloride combination on the solubility of ibuprofen has been done. The solubility of ibuprofen with sodium lauryl sulfate, benzalkonium chloride and it’s combination was determined by surface tension method with Du Nouy Tensiometer and by refractive index method with Refractometer ABBE. The solubility was determined at surfactant concentration above the CMC value. Results showed that formula 4 gave the highest solubility of ibuprofen (96,25 %). Combination of the surfactants caused precipitation.
Pengaruh Pemberian Jus Jambu Biji Merah (Psidiumguajava L.) Terhadap Jumlah Sel Eritrosit, Hemoglobin, Trombosit dan Hematokrit pada Mencit Putih Arifin, Helmi; Agustina, Agustina; Rizal, Zet
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Evaluation of the effect of red guava juice (Psidiumguajava, L.) on hematology parameters (red blood cell, hemoglobin, thrombocyts, and hematocrit) to female white mice has been done. The juice was administered orally with variation of doses at 25, 50 and 100 % one times a day for 7, 14, and 21 days respectively. As a control group was female white mice administered aquadest.  Results showed that administration of guava juice with a variation of dose did not influence red blood cell counts, hemoglobin and hematocrit, but increased thrombocytes  levels.
Mikroenkapsulasi Metformin Hidroklorida dengan Penyalut Etilsellulosa Menggunakan Metoda Penguapan Pelarut Noviza, Deni; Harliana, Tita; Rasyad, Ade Arinia
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Metformin hydrochloride is a biguanide class of oral antidiabetic drugs that have a half-life 1.5 to 3 hours, and it administration was repeated. In order to support the treatment of diabetic disease, metformin hydrochloride was made into microcapsules as a maintenance dose using solvent evaporation method using ethyl cellulose as a coated. The comparison between metformin hydrochloride and ethyl cellulose were 1: 0.75; 1: 1 and 1: 1.25. Microencapsulation evaluated by microscopic photograph, assay and dissolution test. At the microscopic picture shows metformin hydrochloride veiled by a layer of ethyl cellulose. The amount of metformin hydrochloride in F1 is 20.73%, 15.40% at FII and FIII is 10.11%. The biggest drug release inhibiton was achieved in formula 3 (1; 1.25) with dissolution efficiency was 0.170.
Kajian Penggunaan Obat Intravena di SMF Penyakit dalam RSUD Dr. Achmad Mochtar Bukittinggi Nasif, Hansen; Yuned, Monalisa; Muchtar, Husni
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Injeksi merupakan salah satu cara pemberian obat yang biasa digunakan dalam mengobati penyakit. Injeksi saat ini telah menjadi prosedur pengobatan yang paling umum ditemukan di dunia dengan 16 milyar injeksi diberikan setiap tahunnya. Pasien sebaiknya tidak diberikan injeksi intravena bila terapi per oral dapat dilakukan.Penelitian ini bertujuan untuk mempelajari ketepatan pilihan penggunaan obat secara intravena mengacu pada sembilan kriteria penggunaan obat secara intravena (Scot, 2003; Mycek, 2001; Ansel, 1989). Penelitian dilakukan dengan metode observasi prospektif melalui pengamatan langsung pada kondisi pasien yang mendapatkan obat dalam bentuk sediaan intravena dengan memperhatikan juga data rekam medik nya. Teknik pengambilan sampel menggunakan metoda purposive sampling di SMF Ilmu Penyakit dalam RSUD Dr. Achmad Mochtar Bukittinggi dari Mei sampai Agustus 2009.Setelah dilakukan penelitian di dapatkan penggunaan sediaan intravena untuk 81 orang pasien dengan 134 kali pemberian injeksi. Dalam penelitian ini masih ditemukan pemilihan penggunaan sediaan intravena yang tidak tepat yaitu pada 21 kali pemberian (15,7%) pada penggunaan furosemid, metoklopramide dan ranitidin.Farmasis sangat di butuhkan di ward/bangsal untuk memberikan rekomendasi farmasis supaya tidak terdapat keraguan dalam pemilihan penggunaan sediaan intravena sehingga peran farmasis sebagai drugs therapy advisor dapat dijalankan.
Formulasi Granul Mukoadhesif Dispersi Padat Ketoprofen-Pvp K-30 Menggunakan Kitosan Salman, Salman; Meryza, Meryza; Noviza, Deni
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on mucoadhesive properties of ketoprofen – PVP K-30 solid dispersion granules using chitosan had been done. Solid dispersion of ketoprofen and PVP K-30 was made at ratio 1:1 using solvent method. Granules were made by wet granulation method at various concentrations of chitosan (10%, 20% and 30%). The granules were evaluated including photomicroscopy, flow rate, angle slides, water content, particle size distribution, dissolution test, in-vitro test bioadhesif and wash off test. The release of ketoprofen from the granules was determined using basket dissolution test in pH 7.5 phosphate buffer medium for 8 hours. Mucoadhesive properties were tested by in-vitro bioadhesif tests and wash off test. The dissolution test showed the dissolution effeciency value of formula 1, 2, and 3, respectively, was 78.9890 ± 1.1398; 77.3889 ± 1.4312, and 75.8869 ± 0.2210 %. Results showed a decrease in the release of the active substance from the granules, with the increase in chitosan concentration. Statistical analysis of the efficiency of dissolution showed a significant difference among the three formulas with (P <0.05). In vitro bioadhesif tests showed that granules were able to attached to the stomach and intestinal mucosa of rabbits.
Pengaruh Perbandingan Pelarut Etanol-Air Terhadap Kadar Senyawa Fenolat Total dan Daya Antioksidan dari Ekstrak Daun Sirsak (Annona muricata L.) Rivai, Harrizul; S, Ernita Widiya; Rusdi, Rusdi
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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A Study has been conducted to determine the influence of ethanol-water ratio on the concentration of total phenolic compounds and antioxidant activities of extract of soursop leaves. Ethanol-water ratio used were ethanol 96%, ethanol-water 2:1 and ethanol-water 1:1. Concentration of phenolic compounds were determined by Folin-Ciocalteau method and antioxidant activities were detemined by diphenylpicrylhydrazyl method. Results showed that the ratio of ethanol-water had a significant influence on the total content of phenolic compounds (p < 0.05). Highest content of total phenolic compound was obtained by using ethanol-water 1:1, whereas the highest antioxidant activity was obtained by using ethanol 96%.

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