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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 17 Documents
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Search results for , issue "Vol 12, No 3 (2025)" : 17 Documents clear
Shallot (Allium ascalonicum): An overview of antidiabetic activity by α-glucosidase inhibition Ramadaini, Tiara; Sumiwi, Sri Adi; Febrina, Ellin
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.52104

Abstract

Allium ascalonicum (shallot) is a medicinal plant with promising potential in the management of type 2 diabetes mellitus (T2DM). This review summarizes the phytochemical constituents, mechanisms of action, and existing research gaps that warrant further exploration for targeted drug development. A systematic literature search was performed using PubMed, ScienceDirect, and Google Scholar to identify relevant studies published between 2013 and 2023. Only full-text original research articles in English were included, while reviews and incomplete studies were excluded. The search strategy employed the keywords: “Allium ascalonicum OR shallot AND α-glucosidase.” The findings indicate that A. ascalonicum demonstrates significant antidiabetic activity across in vitro, in vivo, and limited human studies, primarily through inhibition of the α-glucosidase enzyme. This activity is largely attributed to quercetin and other flavonoid compounds, which play an essential role in reducing blood glucose levels and mitigating oxidative stress. Collectively, the evidence highlights the therapeutic potential of A. ascalonicum as a natural α-glucosidase inhibitor. However, further clinical investigations and comprehensive toxicity assessments are required to establish its efficacy and safety as a standardized herbal medicine and future phytopharmaceutical candidate for diabetes management.
Antidiabetic Activity of Ethyl Acetate Compounds from Gayam (Inocarpus fagiferus): In Silico and In Vivo Studies Ifaya, Mus; Ridwan, Bai Athur; Laugi, Putri Salsabila; Utami, Apriliani Putri; Abdurrahman, Syawal
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.58070

Abstract

Diabetes mellitus is characterized by high blood sugar levels. Though many drugs are available, blood glucose control is still challenging to achieve due to decreased beta cell function and side effects of long-term use. Gayam tree bark (Inocarpus fagiferus) has the potential to inhibit digestive enzymes, although the molecular mechanism of its antidiabetic effect has not been ascertained. This study aims to determine the activity of compounds from ethyl acetate extract as antidiabetics, tested in silico and in vivo. The study used molecular docking and in vivo activity analysis. LC-MS analysis was used to determine the content of compounds in the ethyl acetate fraction of gayam bark. Through molecular interaction prediction and ADME-Toxicology, compounds in gayam bark showed antidiabetic activity. In the molecular docking interaction study, the Cochliophilin A compound had a lower binding energy than acarbose on the α-amylase receptor: -9.76 kcal/mol and -8.95 kcal/mol. The ADME-Tox model predicted good skin permeability, absorption, and distribution for Cochliophilin A. The ethyl acetate extract showed antidiabetic activity in lowering blood sugar levels in rats on day 14, respectively by 74% (IV), 72% (V), and 74% (VI). Collectively, compounds in gayam bark are useful in treating diabetes.
Combination of Gmelina arborea and Falcataria moluccana Extracts in Reducing Glucose and Improving Histology in Hyperglycemic Mice Model Rumidatul, Alfi; Fadilah, Tyas I.; Rahayu, Amalia; Mawangi, Neng W. L.; Sandy, Pracilia S.; Kodariah, Liah; Mayuri, Nindya S.
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.61846

Abstract

The White Teak plant (G. arborea) and Sengon (F. moluccana) contain flavonoids that act as antioxidants and have the potential to lower blood sugar levels. This study aims to examine the effects of G. arborea and F. moluccana extracts with polar and non-polar (methanol and n-hexane) solvents on blood glucose levels as well as the histological condition of the pancreas and liver in mice. The extract was obtained through maceration, and its effectiveness was tested by measuring blood glucose levels and conducting histological analysis of the organs. Data were analyzed using SPSS. The research results show that extracts of G. arborea and F. moluccana lower blood glucose levels and improve the histology of the pancreas and liver in mice. Polar solvents (methanol) are more effective in lowering blood glucose levels, while non-polar solvents (n-hexane) have a greater impact on improving organ histology. In conclusion, the extracts of these two plants have a positive effect on the liver condition of hyperglycemic mice.
Gastroprotective Effect of Galangal, Turmeric and Their Combination on Rats’ Gastric Ulcers Ekowati, Heny; Anwar, Amalia Meisya; Audina, Fuzilestari Nur; Utami, Esti Dyah
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.49741

Abstract

Galangal (AG) and turmeric (CL) have potential gastroprotective activity. Both have been shown to prevent oxidation by scavenging free radicals and blocking oxidative enzymes. This study evaluated the gastroprotective effects of galangal, turmeric, and their combination extract against gastric mucosal lesions induced by ethanol-hydrochloric acid (HCl). The experimental design comprised 5 groups: group I was administered with Tween 80 (1%), and group II was administered ranitidine (50 mg/kgBW) orally. The other three groups were administered AG and CL, and their combination was administered (1:1) (100 mg/200 kg BW) orally for six days. On the 7th day, the rats were induced by ethanol-HCl (1: 1 v/v) 8 mL/KgBW. Six hours later, the rat was sacrificed and dissected for their gastric. Gross ulcer area, lesion length, histology, pH, and ulcer index were observed. There were improvements in pH, lesion score, ulcer index, and curative ratio. The histopathological profile showed ulcer repairment and lowering of neutrophil inflammatory cell infiltration. Statistical analysis showed the potential equivalence of the single and combination treatments in their gastroprotective effects. Galangal, turmeric, and its combination have gastroprotective activities by repair of ulcer and gastric pH, increasing the curative ratio, and decreasing the ulcer index in the rat model.
Formulation and Antibacterial Activity of Basil (Ocimum basilicum Linn.) Essential Oil Emulgel Nilmawati, Nilmawati; Novitasari, Putri Rachma; Nuraisyah, Fatma; Rusdi, Niswa Fadilah; Widiyastuti, Lina
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.60016

Abstract

Basil (Ocimum basilicum Linn.) essential oil contains methyl chavicol, which exhibits antibacterial properties. Basil essential oil has volatile and hydrophobic properties, so it is necessary to have an emulgel preparation that can stabilize and enhance its topical activity. This study aims to formulate an emulgel of basil essential oil and investigate its antibacterial activity against Staphylococcus aureus. Basil essential oil was analyzed using the GC-MS. The formulas of Basil essential oil emulgel were created through concentration variations of 5%, 7.5%, and 10%, respectively. These formulas were then tested for organoleptic properties, viscosity, pH, spreadability, and adhesion time. Additionally, antibacterial activity tests were conducted using the well diffusion method. Basil essential oil analysis identified methyl chavicol at 81.34%. All formulas had the white semi-solid form and they had specific basil odours, viscosity 1013.83 ±714.29; 1644.68 ± 888.68; 1923.26 ± 1733.67 cps, pH 5.73; 6.02; 6.90, spreadability 19.61 ± 0.24; 18.28 ± 0.32; 17.57 ± 0.26 gram.cm/second and adhesion time 8.03 ± 1.85; 5.07 ± 0.43; 5.51 ± 0.14 second. Furthermore, all the formulas inhibited the growth of Staphylococcus aureus (p<0.05). The 7.5% basil essential oil emulgel’s formula provides optimal results in terms of physical stability and antibacterial activity.
Pengembangan Formula dan Karakterisasi Nanostructured Lipid Carriers Tretinoin Menggunakan Compritol dan Tegocare Jafar, Garnadi; Sofian, Ryan; Pratama, Reza; Putriyanti, Al-fira
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.53058

Abstract

Tretinoin memiliki sifat fisiko kimianya yaitu memiliki bobot molekul sebesar 300.4 dengan titik lelehnya yaitu 181°C serta memiliki LogP yaitu 6,3 dan nilai Pka sebesar 4,76. NLC adalah generasi pembawa baru yang memiliki potensi besar untuk penghantaran topikal. Sediaan NLC memiliki beberapa keunggulan dibandingkan formulasi topikal tradisional seperti pelepasan obat yang berkepanjangan, mengurangi iritasi kulit, dan kontak yang sangat baik dengan lokasi kulit yang terkena karena jangkauan pengiriman obat dalam skala nano. Penelitian ini untuk mengembangkan formula dan mengkarakterisasi NLC tretinoin dengan formula compritol, myritol dan tegocare. Formulasi NLC tretinoin dilakukan dengan metode homogenisasi panas kemudian disonikasi menggunakan probe sonikator. Formula NLC dikarakterisasi dengan mengukur ukuran partikel, indeks polidispersitas, zeta potensial, efisiensi penjerapan dan morfologi. Hasil karakterisasi menunjukkan bahwa NLC tretinoin memiliki ukuran partikel semua formula memiliki ukuran partikel <350 nm dengan 2 kali pengukuran selama 30 hari, indeks polidispersitas semua formula memiliki nilai <0,5, nilai zeta potensial semua formula memiliki nilai dengan rentang nilai (+->20 mV), %EE semua formula memiliki nilai >80%. NLC tretinoin diuji morfologinya menggunakan TEM dengan hasil berbentuk bulat. Hasilnya menunjukkan bahwa NLC Tretinoin menunjukkan hasil yang baik.
Plasma Fractionation: Conditions and Challenges Rambia, Ikhsan; Insyirah, Ariani; Claudiana, Nur Shelly Ester; Fath, Zulfa Tavira Al; Permadi, Najla Eksakta; Sriwidodo, Sriwidodo; Rustan, Mas Rahman
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.63343

Abstract

Plasma is a blood component that has a role in treating various diseases, such as haemophilia and blood-clotting disorders. Plasma used for treatment is referred to as plasma-derived drug products (PDMPs), which are obtained through the plasma fractionation process. This study aims to explore the conditions of plasma fractionation in various countries and highlight some of the challenges faced by the plasma fractionation industry. The methods used include searching for articles published over the past decade from trusted sources, such as Google Scholar, PubMed, and ScienceDirect, using specific keywords. The results of literature studies related to plasma fractionation were obtained from 20 countries spanning several continents. The conditions and challenges faced in plasma fractionation in those countries differ. Some of the challenges faced are related to technology, regulation, plasma sources, human resources, and the economy. Currently, Indonesia is working with South Korea to build the first plasma fractionation facility. Therefore, the conditions and challenges faced by various countries can serve as a reference for Indonesia in preparing the factors that influence plasma fractionation development, in accordance with the World Health Organization (WHO) recommendations.

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