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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Therapeutic Synergy of Combination of Kaempferia galanga and Zingiber officinale Extracts on Hyperuricemia-Induced Arterial Stiffness Hasimun, Patonah; Muzaki, Yoga Adi Restu; Sodik, Jajang Japar; Sukmawati, Ika Kurnia; Kusriani, Herni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.59175

Abstract

Hyperuricemia, characterized by high uric acid levels, is associated with an elevated risk of cardiovascular diseases. Xanthine oxidoreductase (XOR), an enzyme central to uric acid generation, is implicated in oxidative stress and diminished vascular function. It has become a focal point for potential therapeutic interventions. This investigation aimed to assess the influence of combined ethanol extracts of Kaempferia galanga L. and Zingiber officinale (KGZE) on xanthine oxidase activity and arterial rigidity in hyperuricemic rat models. Furthermore, the research sought to explore these extracts' potential in managing hyperuricemia and its associated vascular disorders. Hyperuricemia was established in Wistar rats by administering potassium oxonate at 4.5 mg/kg via injection. A total of 25 rats were divided into five groups: a normal control group receiving 0.5% CMC, a positive control group with hyperuricemia, a reference group treated with allopurinol (1.8 mg/kgBW), and two experimental groups receiving KGZE at doses of 50 mg/kgBW and 100 mg/kgBW. All rats consumed 25% fructose in their drinking water for 28 days. This study measured uric acid levels and arterial stiffness, revealing that KGZE significantly reduced uric acid levels and improved arterial stiffness, indicating its potential as an XOR inhibitor.
Phytochemical Screening And Antioxidant Activity Test of Lupun Root (Poikilospermum suaveolens (Blume) Merr) from South of Borneo Mardiana, Lia; Milanda, Tiana; Hadisaputri, Yuni Elsa; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51350

Abstract

Lupun root is the local name for Poikilospermum suaveolens (Blume) Merr. in the Aranio region, South of Borneo, Indonesia. P.suaveolens is a medicinal plant traditionally used to treat various ailments and to enhance the body’s immune function. This study aimed to investigate the secondary metabolites and antioxidant capacity of the ethanol extract derived from the root of Lupun (P. suaveolens). Samples were collected from Aranio, South Borneo. Extraction was performed by maceration using 96% ethanol. The analysis included phytochemical screening and evaluation of antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay measured by a UV-Vis spectrophotometer. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and phenolic compounds in the Lupun root extract. The antioxidant assay showed an IC50 value of 20.44 µg/mL, indicating strong antioxidant potential of the ethanol extract. These results highlight the plant’s promise as a candidate for pharmaceutical development.
Formulation of a Spray Gel Containing Asiaticoside and Niacinamide Combination for Anti-acne Nurdianti, Lusi; Gustaman, Firman; Kurniady, Fabillah; Setiawan, Fajar; Firmansya, Ardianes
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.50520

Abstract

Asiaticoside is one of the compounds of the triterpenoid group that functions as an antibacterial by forming a complex with cell membranes that pass through hydrogen bonds, then destroying the permeability of bacterial cell walls. Spray gel is considered a more practical and safer form of gel preparations due to its use, which can minimize microorganism contamination. This study aims to determine the effect of variations in the concentration of asiaticoside combined with niacinamide on its physical properties and antibacterial activity. This research method was carried out experimentally to manufacture spray gel preparations with variations in asiaticoside concentrations of 0%, 1%, 2%, 3%, and 4%. Spray gel preparations were tested for physical properties, stability, and antibacterial activity using the good diffusion method by producing preparations that meet the requirements of physical properties testing, did not cause irritating effects on the skin, good stability and results of antibacterial activity of spray gels produce different inhibitory zone diameters of 1.73 mm ± 2.00 (F0); 5.21 mm ± 1.25 (F1); 6.38 mm ± 1.01 (F2); 12.57 mm ± 4.73 (F3) and 16.20 mm ± 5.04 (F4). The five formulas exhibit good physical properties, stability, and antibacterial activity against Propionibacterium acnes. 
Formulasi dan Evaluasi Sediaan Parfum dari Bahan Pewangi Alami dengan Minyak Nilam Khairan, Khairan; Husna, Nurul; Maisyarah, Hilda; Diah, Muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60116

Abstract

Bau badan adalah aroma tidak sedap yang timbul karena keringat yang bercampur dengan bakteri kulit. Parfum adalah salah satu produk kosmetik yang dapat digunakan untuk mengurangi bau badan. Tujuan dari penelitian ini adalah untuk formulasi dan evaluasi sediaan parfum dengan menggunakan bahan pewangi alami sebagai aroma dan minyak nilam fraksi berat sebagai agen pengikat. Ada dua fase metode yang digunakan dalam pembuatan parfum, yaitu formulasi dan evaluasi sediaan. Formulasi dibuat dalam empat sediaan formula dengan perentase minyak nilam fraksi berat sebagai (MNFB) yang berbeda beda yaitu F0 (0%); F1 (0,25%); F2 (0,5%); dan F3 (0,75%). Evaluasi sediaan parfum yang dilakukan yaitu berupa uji homogenitas, berat jenis, pH, spot, uji SPL (sillage, projection, dan longevity), uji siklus dipercepat dan uji hedonik. Hasil uji homogenitas, berat jenis, pH, dan uji spot memperlihatkan bahwa semua sediaan sesuai dengan standar. Uji SPL memperlihatkan bahwa sediaan F3 mempunyai ketahanan aroma yang paling lama yaitu 96 jam, diikuti oleh F2 (87 jam), F1 (80 jam), dan F0 (68 jam). Uji hedonik memperlihatkan bahwa sediaan F3 mempunyai longevity yang paling baik dibandingkan dengan sediaan lainnya, serta lebih disukai karena memiliki warna, aroma dan kejernihan yang paling baik dibandingkan dengan sediaan lainnya.
Uniformity Test of Total Flavonoid Content in Antidiabetic Capsules from Ethanol Extract of Purple Sweet Potato Leaves (Ipomoea batatas L.) Suhendi, Jessica Rianty; Dewi, Ni Kadek Santi Maha; Warditiani, Ni Kadek; Arisanti, Cokorda Istri Sri; Wirasuta, I Made Agus Gelgel
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.53962

Abstract

The ethanol extract of purple sweet potato leaves (Ipomoea batatas L. or “IBL”) has antidiabetic activity, and the total flavonoid (KTF) is designated as the quality marker (Q-marker) in capsule manufacturing. This research aims to develop KTF As a Q-marker for OHT capsules from ethanol extract of IBL leaves as antidiabetic. KTF Q-marker determination involves: (1) Identification of the absorption peak of the quercetin-AlCl3 complex, (2) Method verification, and (3) Testing OHT capsule content uniformity. The Quersetin-AlCl3 complex provides a bathochromic shift in band I from 380 nm before being reacted towards 430 nm after complex formation. The method verification test resulted in a correlation coefficient of 0.998, intraday RSD of 0.76-2.00%, and interday RSD of 0.87-1.96%, and accuracy of return in the range 82.88-91.83%. The consistency test results of the capsule content of the four bets obtained a ratio of the content of 10 capsules of each bet of 100% and RSD value in the range of 3.22-4.57% The establishment of KTF with a method in accordance with the FHI has met the verification requirements, showing that the method can be used and potentially as a quality control in the manufacture of IBL leaf capsules on a production scale.
Enhancement of Losartan Transdermal Transport Through Incorporation into Chitosan Nanoparticles Efiana, Nuri Ari; Nugroho, Akhmad Kharis; Martien, Ronny
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49978

Abstract

Losartan, an antihypertensive agent, has low oral bioavailability. Therefore, developing a design for transdermal delivery of losartan is interesting. This study aims to enhance losartan in vitro transport by incorporating it into chitosan nanoparticles. Transdermal transport studies were conducted using two experimental groups: the pretreatment group using oleic acid and propylene glycol, and the group without pretreatment. The results showed that losartan incorporated into chitosan nanoparticles resulted in a significantly higher amount of drug being transported than the losartan solution (control) in both experimental groups. In the experiment without pretreatment, the amount of losartan from the control could not be detected in the receptor compartment until 28 hours. In contrast, losartan was detected at 16 hours of transport from chitosan nanoparticles. In pretreatment, chitosan nanoparticles exhibited 6.6fold higher losartan transport than the control. In addition, losartan chitosan nanoparticles showed significant increases in steady-state flux and transport efficiency by 3.3 and 6.6 times higher than the control, respectively. It can be concluded that the incorporation of losartan into chitosan nanoparticles can increase its transdermal transport.
Kajian In Silico Senyawa Turunan Flavonoid Terhadap ER-α Sebagai Antikanker Payudara Dinata, Deden Indra; Muttaqin, Fauzan Z.; Sodik, Jajang J.; Irfani, Abdul M.
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60035

Abstract

Di Indonesia, terdapat 65.858 kasus kanker payudara dengan angka kematian 22.430 jiwa. Pengobatan lini pertama kanker payudara melibatkan penggunaan Selective Estrogen Receptor Modulators (SERM), salah satunya adalah Tamoxifen. Turunan flavonoid telah terbukti secara farmakologi efektif dalam pengobatan kanker dan dapat menginduksi apoptosis sel. Penelitian dilakukan terhadap 103 turunan flavonoid menggunakan metode simulasi molecular docking dan dinamika molekul dengan Autodock versi 4.2.3, dengan parameter observasi Ki dan ∆G, sedangkan simulasi dinamika molekul menggunakan aplikasi AMBER 18 dengan parameter RMSD, RMSF, dan MMGBSA serta ikatan hidrogen. Berdasarkan hasil penambatan molekuler, senyawa scutellarein, maritimin, baicalein, maesopsin, formononetin, calycosin, pratensein, biochanin A, sulfuretin, dan eriodyctiol menunjukkan potensi sebagai antagonis ERα dengan nilai Ki yang lebih baik dibandingkan ligan alami. Berdasarkan parameter simulasi dinamika molekul, stabilitas pengikatan dan aktivitas antagonis dari turunan flavonoid ini terhadap ERα sebanding namun sedikit lebih rendah dibandingkan tamoxifen. Analisis simulasi dinamika molekul mengungkapkan bahwa meskipun senyawa flavonoid ini menunjukkan nilai Ki yang menjanjikan, stabilitas interaksi keseluruhan senyawa-senyawa ini dengan ERα kurang menguntungkan dibandingkan tamoxifen, seperti yang ditunjukkan oleh parameter dinamika molekul gabungan.
Prospective Anti-Aging Benefits of Mackerel Scad Collagen Peptides Through Anti-Hyaluronidase Activity Herawati, Elisa; Agnesia, Pipin
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.56450

Abstract

The increased activity of the hyaluronidase enzymes speeds up the degradation of hyaluronic acid in the skin, leading to reduced elasticity and the formation of fine wrinkles, eventually contributing to skin aging. Mackerel scad (Decapterus macarellus) is a promising candidate as a skin anti-aging substance due to its particular amino acid composition. Native collagen and collagen peptides from mackerel scad skin were extracted using pepsine soluble collagen and hydrolysis with collagenase II enzyme. The amino acid profile of collagen was determined using HPLC analysis. An anti-hyaluronidase activity test was done using the spectrophotometry assay to express the content of N-acetyl glucosaminoglycan, and IC50 was calculated. Results showed that mackerel scad collagen contains 17 amino acids, with the highest content of glutamic acid, 8.20%; aspartic acid, 6.70%; glycine, 5.37%; arginine, 4.24%; and proline, 3.84%. The collagen from the extraction results had relatively low anti-hyaluronidase activity (IC50 326.05 ± 6.77 ppm). However, when it was broken down into smaller collagen peptides, the anti-hyaluronidase activity increased to IC50 100.78 ± 0.17 ppm. This indicated that the hydrolysis of collagen into collagen peptides with a smaller molecular weight increased its capacity to inhibit hyaluronidase. These findings suggest that D. macarellus collagen peptides have the potential to inhibit skin aging by inhibiting hyaluronidase enzyme activity.
Eficacy Red Ginger in Reduce The Risk of Covid-19 Severity in COPD Patients: A Review Lorensia, Amelia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51076

Abstract

Chronic obstructive pulmonary disease (COPD) is a major global health problem and has an impact on increasing healthcare costs and decreasing productivity. Patients with COPD have a higher prevalence of coronary ischemia and other factors that put them at higher risk for COVID-19-related complications. A strong immune system can help increase the body's resistance so as to reduce the risk in the midst of the COVID-19 pandemic. The use of natural therapy in the treatment of chronic diseases is an opportunity for Indonesia as a tropical country that has many variations of plants that have the potential to become herbal medicines. Red ginger (Zingiber officinale var. rubrum) is one of the most widely consumed medicinal plants in Indonesia. Red ginger has greater anti-inflammatory and antioxidant content than other types of ginger. The antioxidant and anti-inflammatory effects of red ginger in addition to helping reduce the effects of reducing the risk of COVID-19 severity, can also help improve lung function. The preparation of red ginger that has been used in the community is steeping. Therefore, red ginger has the potential to effectively reduce the risk of COVID-19 severity in COPD patients with anti-inflammatory and antioxidant effects in reducing NF-B and the effectiveness of improving lung function.
Selective Determination of Tetracycline in Broiler Chicken Meat by Molecularly Imprinted Polymer Suryana, Shendi; Najihudin, Aji; Elivania, Salma; Suherman, Meillia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.58889

Abstract

Tetracycline (TC) residues in poultry meat products can create antibiotic resistance in humans who consume them. Hence, sensitive analytical procedures to evaluate the quantities of tetracycline residues are required to assess the safety of these products for consumption. The study aimed to develop a sorbent using molecular imprinting technology to analyze tetracycline in chicken broiler meat products. The study used several tests and computational techniques to increase the effectiveness of screening for the best MIP systems. According to the bond energybased computational analysis, methacrylate acid (MAA) was the best functional monomer at a TC-to-MAA molar ratio of 1:6. The mixture of methanol and chloroform yielded the greatest Ka. The Job plot showed that a TC-to-MAA-molar ratio of 1:6 was best for synthesizing imprinted polymer in the mixture of methanol and chloroform. We generated MIPs using two alternative production methods: bulk (MIP1) and precipitation (MIP2). Adsorption capacity results revealed that MIP1 matches well with the Langmuir model, whereas MIP2 fits better with the Freundlich. MIP1 application produced recovery rates of 82,74±4.1% and MIP2 results of 92.14±3.2% for TC in spike-chicken meat. The outcomes of the selectivity test also demonstrated that MIP2 is superior to MIP1 and can recover TC from spiked chicken meat while coexisting with another antibiotic drug. The study’s findings indicate that MIP2 helps determine TC in spike chicken meat.

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