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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Therapeutic Potential of Kaempferia galanga L. Extract in Ameliorating Oxidative Stress and Metabolic Dysregulation in a Rat Model of Metabolic Syndrome Hasimun, Patonah; Muzaki, Yoga Adi Restu; Sukmawati, Ika Kurnia; Zahra, Nadhira Aulia; Kusriani, Herni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60514

Abstract

Metabolic syndrome is associated with an increased risk of hypertension, diabetes, and cardiovascular disease, which are often triggered by oxidative stress and inflammation. This study evaluated the effects of Kaempferia galanga L extract (ERK) on oxidative stress and metabolic dysfunction using a fructose-induced male Wistar rat model. A total of 25 rats were divided into five groups: normal control, positive control, allopurinol group, and two ERK treatment groups at doses of 50 and 100 mg/kg body weight. All groups, except the normal control, were given 25% fructose in the drinking water and an injection of potassium oxonate (4.5 mg/kg body weight) for 28 days. Evaluation was done by measurement of glucose, triglyceride, malondialdehyde (MDA) and nitric oxide (NO) and histological analysis of aortic tissue. The results showed that ERK, especially at a dose of 100 mg/kg, significantly reduced glucose, triglyceride and MDA levels and increased NO levels. ERK administration also reduced the body weight of mice and prevented the formation of foam and inflammatory cells in aortic tissue. The total flavonoid content of ERK also supports its biological activity. This study concludes that ERK has potential as a natural therapeutic agent to treat metabolic syndrome through antioxidant and anti-inflammatory mechanisms.
Antioxidant Activity of VCO-Clove Topical Oil and Predictive Interaction toward Prostaglandin-endoperoxide Synthase 2 Pramitha, Dewa Ayu Ika; Wibawa, Agung Ari Chandra; Adrianta, Ketut Agus; Samidya, Ni Wayan Rias
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.48983

Abstract

Pain is a prevalent symptom of various diseases, characterized by subjective sensory and emotional experiences, often triggered by nerve irritation and pain receptor activation. Prostaglandins play a crucial role as chemical mediators in pain mechanisms. Clove oil-based liniment is commonly used for pain relief, with eugenol as its main active compound. This study investigates the antioxidant activity of VCO-clove liniment with different clove proportions using the DPPH method and evaluates the analgesic potential of eugenol through its interaction with the PTGS2 receptor through in-silico analysis. VCO-clove liniment was formulated with varying clove weight ratio (1:10, 5:10, and 10:10 w/v). Antioxidant activity was evaluated in-vitro using DPPH assay, while the interaction between eugenol and PTGS2 (PDB code: 5KIR) was predicted using molecular docking. The results demonstrated that the 10:10 ratio exhibited the highest antioxidant activity, with an IC50 value of 40.33 µg/mL and an antioxidant activity index (AAI) of 0.99, classified as moderate. In-silico analysis revealed strong binding between eugenol and PTGS2, with a binding energy of -5.22 kcal/mol, suggesting its analgesic potential. In conclusion, VCO-clove liniment shows promise as an antioxidant and analgesic agent, with the 10:10 ratio displaying optimal antioxidant properties, and eugenol contributing significantly to its analgesic effects through PTGS2 interaction.
Phytochemical Screening and Antimicrobial Activity of Combination of Piper betle and Moringa oleifera Extracts Arifin, Siti Hakimah Aprilia Garini; Firdhausi, Nirmala Fitria; Hidayati, Irul; Faizah, Hanik
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45288

Abstract

The inappropriate use of antibiotics can lead to pathogenic bacteria developing multiple drug resistance, making infectious disease treatment crucial. Thus, the discovery of novel antibiotics from natural materials, such as plant extracts or their combinations, is critically needed. Extracts of green betel (Piper betle) and Moringa (Moringa oleifera) leaves are known to have antimicrobial activity. This study aimed to determine the chemical content and antimicrobial activity of ethanol extracts of the combination of green betel leaves and Moringa leaves against Staphylococcus aureus, Escherichia coli, and Candida albicans. Green betel and Moringa leaves were macerated in 96% ethanol to extract secondary metabolites. Secondary metabolites were analyzed using phytochemical screening. Antimicrobial activity was tested using disk diffusion using various concentrations: EF1 (25% betel leaves + 75% moringa leaves), EF2 (50% betel leaves + 50% moringa leaves), and EF3 (75% betel leaves + 25% moringa leaves). Phytochemical tests showed that the ethanol extracts of betel leaves contained flavonoids, alkaloids, tannins, and saponins, and no terpenoids, while moringa leaves contain flavonoids, tannins, saponins, and terpenoids, but no alkaloids. S. aureus and E. coli had the highest inhibition zones at EF3 (75% betel leaves + 25% moringa leaves) concentrations, with average inhibition zones of 21.72 mm and 20.98 mm, respectively, and C. albicans at EF2 (50% betel leaves + 50% moringa leaves) concentration, with an average inhibition zone of 26.52 mm, with a very strong inhibition category.
Formulasi dan Evaluasi Sediaan Mikrohidrogel dengan Kandungan Piperin sebagai Anti Jerawat Handayani, Retty; Auliasari, Nurul; Khaerunnisa, Clarissa F.; Kusumawardhana, Adith P.; Febriyanti, Raden Maya
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.57781

Abstract

Jerawat adalah kondisi peradangan kulit yang ditandai dengan pembentukan papula, komedo, pustula, jaringan parut, dan nodul. Meskipun perawatan jerawat secara konvensional telah tersedia yaitu dengan antibiotik, tetapi penggunaannya memiliki efek samping dan dalam penggunaan jangka Panjang menyebabkan resistensi antibiotik. Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi mikro hidrogel topikal yang mengandung piperin sebagai obat anti jerawat yang potensial. Tiga formulasi yang mengandung piperin dengan variasi konsentrasi 10% (F1A), 20% (F1B), dan 30% (F1C) dibuat dengan menggunakan kitosan dan NaTPP sebagai basis mikrohidrogel. Konsentrasi hambat minimum (KHM) piperin terhadap Propionibacterium acne diuji dengan metode dilusi padat. Karakterisasi terhadap sifat fisikokimia mikrohidrogel dilakukan terhadap parameter organoleptic, homogenitas, daya sebar, pH, dan viskositas, pH. Uji stabilitas terhadap formula dilakukan selama 28 hari. Dari ketiga formula, F1A menunjukkan aktivitas yang sedang terhadap Propionibacterium acne (diameter hambat 10.26 ± 0.57 mm) dan memenuhi persyaratan mutu untuk sediaan mikrohidrogel.
Pharmacy Student Recommendations on Self-Medication for Headaches: A Cross-Sectional Study in Surabaya Halim, Steven Victoria; Pratama, Jeffry Refananto; Karinda, Itsna Laudzy; Setiadi, Adji Prayitno; Aditama, Lisa; Wibowo, Yosi Irawati; Brata, Cecilia; Setiawan, Eko
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.53546

Abstract

Assessing students’ ability to provide appropriate recommendations for self-medication requests is key in developing course materials for future pharmacists. Until recently, the number of published articles evaluating the appropriateness of recommendation provided by pharmacy students towards headache cases, as one of the most common symptoms urging people to seek advice from professional healthcare, is still limited. This observational study with cross-sectional design aims to identify the type and appropriateness of recommendation given by pharmacy professional degree students on two types of headache cases, i.e., tension type headache and migraine due to adverse drug reaction (ADR). The students characteristic data, type, and recommendation appropriateness were analyzed descriptively. In total, 86 students were involved in this research (response rate 82.7%) with different recommendation profiles for two different headache cases. The majority of the participants recommended a pharmaceutical product for tension type headache while referral to physicians was advised for migraine due to ADR. The appropriateness analysis findings revealed that students gave more appropriate recommendations for tension type headache (89.5%) compared to migraine due to ADR (77.9%) case. Therefore, students’ ability to provide relevant recommendations for headaches due to ADR requires further improvement by giving some cases accordingly during the learning process.
Pengaruh Lama Pemanasan Terhadap Kandungan Zat Aktif dan Antibakteri pada Black Garlic Nurulloh, Tsurayya Nafisah Dika; Adriani, Lovita; Widjastuti, Tuti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.56587

Abstract

Bawang putih (Allium sativum) adalah tumbuhan yang berasal dari Asia Tengah dan telah menjadi bagian penting dari masakan dan obat-obatan tradisional. Black garlic merupakan hasil fermentasi bawang putih yang memiliki sifat antioksidan yang kuat dan juga sebagai antibakteri yang dapat meningkatkan fungsi kesehatan. Tujuan penelitian ini untuk mengetahui berapa lama pemanasan yang optimal pada black garlic yang menghasilkan zat aktif, aktivitas antioksidan, dan aktivitas antibakter terbaik. Penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 6 ulangan. Perlakuan yang dilakukan pada penelitian yaitu P1 = fermentasi 15 hari; P2 = fermentasi 20 hari; P3 = fermentasi 25 hari. Parameter yang diukur meliputi kandungan zat aktif, antioksidan dan antioksidan. Hasil penelitian dianalisis ANOVA. Apabila terdapat perbedaan yang nyata maka dilakukan uji lanjut dengan Uji Jarak Berganda Duncan. Hasil pengujian zat aktiv terdeteksi kandungan flavonoid pada black garlic serta menunjukan hasil berpengaruh nyata (P<0,05) pada kandungan polifenol, antioksidan, dan antibakteri. Kesimpulan penelitian ini menunjukan bawah lama fermentasi selama 20 hari merupakan waktu optimal untuk pembuatan black garlic.
In Silico Study of Nigella sativa L. on HMG-CoA Reductase Inhibition as an Anti-Dyslipidemic Agent Margaret, Adeline; Andini, Tania Nur; Fahlevi, Zakia Aurora; Najib, Muhammad; Claudiana, Nur Shelly Ester; Colin, Michelle Natasha; Nuwarda, Rina Fajri
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60787

Abstract

Dyslipidemia is a condition of lipid metabolism characterized by an imbalance of total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride levels in the blood. This biosynthesis process can occur through a mechanism modulated by β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase. The most commonly used drug that works by inhibiting this enzyme is simvastatin. However, there are still significant side effects. In this work, in silico studies were performed on compounds from black cumin (Nigella sativa L.), namely alpha-pinene, p-cymene, nigellimine N-oxide, nigellidine, carvacrol, alpha-hederin, dithymoquinone, thymohydroquinone, thymoquinone, thymol, and nigellicine to predict their activity against HMG-CoA reductase as drug candidates in the treatment of dyslipidemia. The experiments were carried out using computational approaches, such as Lipinski's Rule of Five and ADMET prediction, pharmacophore modeling, and molecular docking simulation. Based on the molecular docking results, there are three compounds that exhibit strong interactions with amino acid residues on HMG-CoA reductase, which have the lowest binding energy values and inhibition constants: nigellicine (-6.84 kcal/mol, 9.71 μM), nigellidine (-6.44 kcal/mol, 19.16 μM), and nigellimine N-oxide (-6.14 kcal/mol, 31.34 μM). These three compounds have potential and can be modified to become candidates for antidyslipidemic drugs with a competitive inhibitor mechanism.
Formulation of Nanoemulsion Gel Pogostemon cablin Benth. And Anti-acne Activity Heroweti, Junvidya; Mindiono, Imam Arif; Mahmud, Nurlela; Pradasari, Frisya; Fresiva, Urva; Prihantini, Malinda
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.60143

Abstract

Patchouli oil (Pogostemon cablin Benth.) contains patchouli alcohol, a compound known for its antibacterial properties, including activity against Propionibacterium acnes (Cutibacterium acnes), a key bacterium implicated in the pathogenesis of acne. This study aims to evaluate the anti-acne potential of a nanoemulsion gel formulation of patchouli oil using three different gelling agents: HPMC (F1), Na CMC (F2), and Carbopol 940 (F3). Each formulation was assessed for its physicochemical characteristics, including color, odor, texture, pH, adhesion, spreadability, viscosity, particle size, polydispersity index (PDI), and zeta potential. All formulations appeared milky white, retained the characteristic aroma of patchouli oil, and exhibited a smooth gel texture. Among the three, F1 demonstrated the highest viscosity, while F3 exhibited superior adhesion. The average pH value (6.19 ± 0.23) was within the acceptable range for topical application. In vivo evaluations indicated that F3 exhibited the most significant reduction in erythema and edema, with minimal irritation potential. Additionally, F3 received the highest respondent satisfaction rating (77.6%), indicating better acceptance. Based on these findings, Carbopol 940 is identified as the most suitable gelling agent for the development of a patchouli oil nanoemulsion gel with promising anti-acne efficacy and favorable respondent acceptability.
Pengaruh Arang Aktif Cangkang Sawit (Elaeis guineensis J.) dan Natrium Monofluorofosfat pada Sediaan Pasta Gigi Antiplak Perokok Lestari, Uce; Syamsurizal, Syamsurizal; Vaseline, Quichtylichta; Septima, Nurul Rizqan
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.38609

Abstract

Arang aktif cangkang sawit memiliki daya serap terhadap iodine sebesar 761,46 mg/g lebih baik dibandingkan arang aktif tempurung kelapa yakni sebesar 460,30 mg/g. Hal ini membuktikan bahwa arang aktif cangkang sawit mampu menyerap kotoran dan racun sehingga sangat potensial diformulasi menjadi pasta gigi. Natrium monofluorofosfat pada pasta gigi bekerja menghambat metabolisme bakteri, sehingga kombinasi ini sangat baik sekali digunakan sebagai pasta gigi antiplak bagi perokok. Penelitian bertujuan untuk melihat pengaruh arang aktif cangkang sawit dan sodium monofluorophosphate dalam menghambat pertumbuhan bakteri dan mengurangi akumulasi plak perokok pada formula pasta gigi. Perbandingan konsentrasi antara arang aktif cangkang sawit dan sodium monofluorophosphate yakni F1= 3%: 0,06%; F2= 6%: 0,09%; F3= 9%: 0,12% dan F4= 12%: 0,15%. Formula 3 (F3) dan 4 (F4) merupakan formula yang memiliki sifat fisik dan stabilitas yang baik dari seluruh formula sedangkan uji daya hambat bakteri Streptococcus mutans dalam mengurangi akumulasi plak dan uji skor plak gigi kedua formula tergolong kategori kuat dan sangat baik dibandingkan pasta gigi komersil. Dari hasil dapat disimpulkan bahwa arang aktif cangkang sawit dan sodium monofluorophosphat memiliki pengaruh sebagai antibakteri dan antiplak.
Aktivitas Antibiofilm Ekstrak Etanol Kulit Citrullus lanatus terhadap Porphyromonas gingivalis Natassya, Priska; Wijaya, Johanna A.; Soesanto, Sheila
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.52928

Abstract

Salah satu bakteri red complex, Porphyromonas gingivalis, dapat membentuk biofilm dan menginisiasi terjadinya periodontitis. Klorheksidin sebagai obat kumur gold standard dalam perawatan periodontitis dapat menyebabkan beberapa efek samping. Dibutuhkan pengobatan berbahan dasar alam seperti semangka (Citrullus lanatus) sebagai pengobatan alternatif di bidang kedokteran gigi. Ekstrak etanol kulit C. lanatus mengandung senyawa aktif seperti saponin, alkaloid, flavonoid, tanin, dan fenolik. Penelitian ini dilakukan untuk mengetahui aktivitas antibiofilm ekstrak etanol kulit C. lanatus terhadap P. gingivalis. Metode penelitian ini adalah eksperimental laboratoris in vitro dengan rancangan post-test only control group design. Uji antibakteri menggunakan metode plate count dan uji antibiofilm menggunakan metode microtiter plate biofilm assay. Larutan uji mencakup ekstrak etanol kulit C. lanatus konsentrasi 3,125%, 6,25%, 12,5%, 25%, 50%, dan 100%, akuades dan BHI-B (kontrol negatif), dan klorheksidin (kontrol positif). Seluruh konsentrasi ekstrak menunjukkan efek antibiofilm terhadap P. gingivalis. Efek antibiofilm yang lebih efektif daripada klorheksidin ditunjukkan oleh ekstrak 12,5% hingga 100% pada inkubasi 1 jam, 100% pada inkubasi 3 jam, dan 25% hingga 100% pada inkubasi 24 jam. Dari penelitian ini dapat disimpulkan bahwa ekstrak etanol kulit C. lanatus memiliki aktivitas antibiofilm terhadap P. gingivalis.

Page 48 of 50 | Total Record : 494

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