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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
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Articles 8 Documents
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Search results for , issue "Vol. 12 No. 2 (2024)" : 8 Documents clear
Epidemiological, Clinical, And Occupational Characteristics of Migrant Workers Confirmed with COVID-19 At Udayana University Hospital Paramita, Ni Putu Pradnya; Wirawan, I Made Ady; Purnamasidhi, Cokorda Agung Wahyu; Florensia, Maria; Akatsu, Haruko
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.44596

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has prompted Indonesian expatriates to return home. Travel history, including migrant repatriation, was thought to spread COVID-19. These factors increased COVID-19 transmission. This study examined the epidemiological, clinical, and occupational characteristics of migrant workers with COVID-19 at Udayana University Hospital. This descriptive study utilized a cross-sectional methodology. The research samples consisted of 97 migrant workers diagnosed with COVID-19 who had been treated at Udayana University Hospital between March to August of 2020, using the total sampling technique. The median age (IQR) of migrant workers is 30, and 84.53% are male. Before returning to Indonesia, many worked and visited the US (20.6%). 87.63% of respondents worked in hospitality sector, and mostly worked in 8–12-hour shifts. All respondents have insurance; most employers are provided with PPE and information regarding COVID-19 prevention. At the airport, COVID-19 screening revealed fever (70.6%) and cough (76.3%) as the most common symptoms. A 94.8% of migrant workers had no comorbidities, and 87.6% had normal chest X-rays. From this research, we discovered that amongst migrant workers, positive-COVID-19 results were mostly found in young, mobile men. Most of them worked for 8–12 hours per day, and majority worked in hospitality sector. Almost all of them did not have any comorbidities and the most common symptoms found were fever and cough. The findings suggest that male workers in their productive age with high mobility and working in the hospitality sector are at higher risk of infection. 
Effectiveness of Vaccines Booster Against Infection, Severe Disease and Death Related to COVID-19 : A Systematic Review and Meta-Analysis Khalisha, Mujahidah; Putri, Melvanda Gisela; Ramadhani, Zulfa Nurfitri; Siahaan, Paulus Parholong; Razan, Rafi Alfian; Antari, Ratna Devi; Hanifah, Adiba Hasna; Utomo, Budi; Fauziyah, Shifa; Muthu, Pandaram
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.45606

Abstract

COVID-19 is an infectious disease as a result of a kind of corona virus. COVID-19 is now a pandemic affecting many countries. This study aims to know the effectiveness of booster vaccines to reduce the severity of illness, confirm infection, hospitalization, death in humans infected with COVID-19. For Specific purpose, to analyze the severity of COVID-19 disease in humans by booster and without booster. The design of this study was a systematic review and meta-analysis based on observational studies, published in databases such as Pubmed, Embase, MedRxiv, Nature and Scopus. In the search for articles, the limitations of 2021 to 2022 are used. This research was analyzed quantitatively through the Review Manager 5.4.1 program. Study was taken from 13 journals that met the criteria for a meta-analysis. With the population aged over 18 years, and using the type of vaccine BNT162b2 or mRNA. The population of this study came from Israel, Italy, England, Qatar, Brazil, Turkey, Puerto-Rico, Northern Bangkok, Vicinities and Thailand. Significant results were obtained for each outcome. The OR values of BNT162b2 booster vaccine against confirmed infection OR 0.16 (95% CI 0.06 – 0.45), against symptomatic disease 0.22 (95% CI 0.11 – 0.44), against asymptomatic disease OR 0.72 (95% CI 0.69 – 0.74), against hospitalization OR 0.12 (95% CI 0.06 – 0.22), against severe disease OR 0.15 (95% CI 0.07 – 0.33), and against death OR 0.10 (95% CI 0.04 – 0.31). Administration booster vaccines is effective in reducing infection rates, disease severity, and deaths from COVID-19. 
Comparative Analysis of Essential Oil Profiles From Emprit Ginger Rhizome (Zingiber officinale var. amarum) Grown in Different Locations and Antibacterial Activity Againts Staphylococcus aureus Styawan, Anita Agustina; Purwanto; Susidarti, Ratna Asmah; Windarsih, Anjar; Rohman, Abdul
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.50423

Abstract

Indonesia, as a tropical country, boasts significant biodiversity, particularly regarding its flora and fauna. The country's medicinal plants are one inherited natural resource passed down through generations. The "emprit ginger” (Zingiber officinale var. amarum), a native Indonesian medicinal plant, is often employed in treating various diseases. Scientifically, the primary constituent of emprit ginger is the phenolic ketone homolog compound, gingerol, known for its antioxidant activity. In addition to its antioxidant potential, emprit ginger exhibits potential as an antibacterial agent. However, herbal substances used for therapeutic purposes often yield inconsistent effects due to the fluctuating chemical composition in the plants, typically a result of varying growing locations. These location differences can cause discrepancies in the content of active metabolites. Therefore, data on the chemical profile of medicinal plants is paramount for the standardization process. This study was conducted by obtaining essential oils from the rhizomes of emprit ginger, extracted via steam distillation obtained from various cultivation lands in Ponorogo, Magetan, Pacitan, Wonogiri, Karanganyar, Boyolali, Semarang, Magelang, Purworejo, Temanggung, Wonosobo, Banyumas, Bantul, and Kulonprogo. One of the efforts in standardizing natural materials involves the analysis of their metabolite profiles. The emprit ginger essential oil profile was obtained through Gas Chromatography-Mass Spectrometry (GCMS) testing. The emprit ginger essential oil profile was analyzed using a multivariate calibration of Principal Component Analysis utilizing SIMCA 17 software. Antibacterial activities were assessed using the microdilution method on Staphylococcus aureus bacteria. The analysis of antibacterial activity was determined using the Probit analysis method to ascertain the Minimum Inhibitory Concentration (MIC) 50 value. This study also involved the extraction of essential oils from emprit ginger rhizomes. The individual profiles of these essential oils were determined via Gas Chromatography Mass Spectrometry. The essential oil profiles of emprit ginger were subjected to a multivariate calibration using Principal Component Analysis facilitated by the SIMCA 17 software. Antibacterial activity tests were conducted using the microdilution method on Staphylococcus aureus bacteria. The antibacterial activity was ascertained using probit analysis to derive the Minimum Inhibitory Concentration 50 (MIC 50) values. The highest MIC 50 of emprit ginger rhizome on Staphylococcus aureus bacteria was found in samples from Wonogiri, with a concentration of 0.3408%. Compounds displaying significant discriminative influence on Staphylococcus aureus bacteria included Z-Citral, Geranyl acetate, Zingiberenol, Beta-Myrcene, (1S0-2,6,6-Trimethylbicyclo [3.1.1] hept-2-ene, and Bicyclo [2.2.1]heptan-2-ol, 1,7,7-trimethyl, exo-(CAS)
Early Detection of Infectious Diseases among the Refugees of UNHCR in South Tangerang, Banten; the Problems and Strategies to Prevent the Disease's Transmission Nasution, Silvia Fitrina; Nisa, Hoirun
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.51708

Abstract

The previous study at Puskesmas Pisangan, Ciputat had reported that among 23.8 % patient of the UNHCR was infected by malaria Plasmodium vivax, and one patient with bacterial urinary infection. However, the result can not represent the actual case of the disease, because of the lack number of participant to visit the Puskesmas  since the Covid-19 pandemic which had been contributing to decrease number of the patients. The study purposed to improve data and information about parasitic infection, and to design strategy in early detection and prevention to the disease. Design of the study was approached in cross-sectional with a total sampling method of the UNHCR out patients visiting the Puskesmas Pisangan and Cirendeu.We collected specimen of feces, urine, and blood, and performed blood diff-count, rapid diagnostic, microscopic, dipstick, and bacterial culture. The study revealed some parasitic and bacterial infections as defined: five cases (17.24%) of malaria, which is suspected as imported cases; Enterobacteriacea family as non-specific bacteria of negative gram in urine; also Entamoeba coli in stool. This finding was confirmed 17.24% of leucocytosis in blood diffcount and 24.14 % in urinalysis.  By nationality, Sudanese was detected the most prevalent 10.34% of parasitic infections, followed by Somalia (6.9%), Yaman (3.45%), and Afghanistan (3.45%) respectively. While mosquitoes and poor living conditions were also contributed as the major potential risk of transmission to the diseases. In conclusion, early detection, health screening, vaccination, access to primary, and upgraded levels of healthcare are important for diseases control and management to prevent transmission. 
Predictive Positive Value Xpert MTB/RIF in Detecting Mycobacterium tuberculosis on Adult Pulmonary Tuberculosis Patients in Dr. Soetomo Referral Hospital Surabaya Indonesia Akirasena, Mayoori; Mertaniasih, Ni Made; Soedarsono; Permatasari, Ariani
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.52755

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and transmitted via droplets. Southeast Asia is the largest contributor of TB, and Indonesia itself has the second-highest number in the world with an incidence of approximately 824000 cases. The most common symptoms of active TB are cough, fever, weight loss, and night sweats. The diagnosis can be established upon the confirmation that one of the specimens contains M. tuberculosis. Xpert MTB/RIF provides results in less than 2 hours, whereas culture takes approximately 2-6 weeks. This research aims to evaluate the characteristics and determine the Predictive Positive Value (PPV) percentage of GeneXpert MTB/RIF, utilizing parameters derived from the gold standard examination results, namely culture. This research method is descriptive- analytic based on secondary data extracted from medical records of patients receiving care at the multi-drug resistant TB (MDR-TB) Outpatient Management at Dr. Soetomo Referral Hospital Surabaya from the period January 2019 – April 2022. The results showed that the PPV level of GeneXpert MTB/RIF in detecting the presence of M. tuberculosis is 90%. The diagnosis of pulmonary TB is also supported by the chest X-ray infiltrate's appearance and clinical symptoms of cough, weight loss, fever, and night sweats. Smoking and diabetes are the most common comorbid and risk factors in TB. The conclusion of this study is that the PPV for diagnosing adult pulmonary TB using the Xpert MTB/RIF is relatively high. This suggests the potential use of this method as a diagnosing tool for accurately diagnosing pulmonary tuberculosis.
Effect of Immunization of The Pili Protein 65.5 kDa Klebsiella pneumoniae on IFN-γ Levels of Spleen BALB/c Mice Sa'adah, Ajeng Samrotu; Mufida, Diana Chusna; Dini Agustina; Pulong Wijang Pralampita
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.54026

Abstract

Klebsiella pneumoniae is a Gram-negative bacterium that poses a threat to the global community. Currently, no vaccine for K. pneumoniae is licensed by the Food and Drug Administration (FDA). The delay in the manufacture of the K. pneumoniae vaccine was because many vaccine candidates failed at the clinical trial stage due to adverse cross-reactions. Pili can be used as a choice as a vaccine candidate. Pili K. pneumoniae is an immunogenic substance that triggers an immune response, one of which is the cytokine IFN-γ. Splenic splenocytes are the main source of IFN-γ-producing cells. The aim of this study is to determine the effect of immunization pili protein 65.5 kDa K. pneumoniae on IFN-γ levels from spleen BALB/c mice. There were 3 groups, K1 as control given PBS, K2 given pili protein 65.5 kDa + adjuvant, and K3 given adjuvant. IFN-γ was then measured by the ELISA method and analyzed by the ANOVA test. The results of measuring IFN-γ levels using One-way ANOVA showed that the total for all groups was 243.50 ± 43.7 with p < 0.05, the Post Hoc LSD test was continued. The Post Hoc test showed significant differences between K1 control and K2 groups, and between K1 and K3 groups, but not between K2 and K3 groups. It can be concluded that immunization with 65.5 kDa of pili protein does not affect the increase in IFN-γ levels in the spleen of BALB/c mice. 
Efficacy of Shampoo Made from Bangle Rhizome Extract (Zingiber montanum) Against Head Lice (Pediculus humanus capitis) Susilowati, Rina Priastini; Sari, Monica Puspa; Santoso, Adit Widodo
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.54832

Abstract

Head lice is a major public health problem worldwide. Its treatment is challenging due to product failures resulting from rapidly emerging resistance to existing treatments, incorrect treatment application, and misdiagnosis. Various head lice treatments with different mechanisms of action have been developed and explored over the years, with limited reports on systematic assessments of their efficacy and safety. The head lice shampoo currently in circulation is 1% permethrin-based. Side effects of using permethrin-based shampoos include skin irritation and high resistance. The research conducted aims to present strong evidence that the use of shampoo made from bangle rhizome extract against head lice mortality is safer to use. The study used 240 head lice taken from elementary school students aged 8-12 years in a school in Bekasi. The study group was divided into 6 groups: negative control group (using baby shampoo), positive control group (using permethrin-based anti-lice shampoo), shampoo treatment group made from bangle rhizome extract with dose of 0.5%, 1%, 2% and 4%. In addition to calculating the number of head lice deaths per group, the time of death was also calculated to determine LC50 (Lethal Concentration 50), LC90 (Lethal Concentration 90), LT50 (Lethal Time 50), and LT90 (Lethal Time 90). The results showed a highly significant difference between the number of head lice deaths in the control group and the shampoo treatment group made from bangle rhizome extract (p<0.01). Likewise, there was a highly significant difference for the time of death of head lice in the control group and the shampoo treatment group made from bangle rhizome extract. Statistical analysis showed LC50 of 0.96%, LC90 of 2.84%, LT50 of 57.72 minutes, and LT90 of 28.79 minutes. It can be concluded that the effective dose of shampoo made from bangle rhizome extract is 4%, which can kill 100% of head lice within 27 minutes.
Correlation Between MTB/RIF Gene Xpert Cycle Threshold Values and Clinical Radiological Severity of Pulmonary Tuberculosis Rachmi Merrina; Yanti, Budi; Yunita Arliny
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.55560

Abstract

The determination of bacterial load was essential for assessing disease severity, transmission rate, and prognosis. Gene Xpert is a diagnostic test that provides Cycle Threshold (Ct) value as a potential measure of Mycobacterium Tuberculosis (Mtb) load. Despite its potential, there are limited reports exploring the relationship between Ct value and clinicoradiological severity. This study aimed to correlate Ct value and clinicoradiological severity of pulmonary tuberculosis (TB). The study was a retrospective design using medical record data of confirmed TB patients from January to December 2022. These patients were identified based on Gene Xpert test and classified as high, moderate, or low detection Mtb when Ct value was <16, 16-22, and 22-28, respectively. In assessing the severity of clinical using the Bandim score, thoracic TB lesions was categorized by Chest XRay into minimal, moderate, and advanced. The total of 90 TB patients and the majority were males (78.9%) aged 46-65 years (59.0%), with comorbidities (95.0%). The most of the participants had mild clinical severity (44.4%), with Ct value of 16-22 (52.2%), and moderate lesions (35.6%). The most common lesions were fibroinfiltrates on the chest X-ray (61.1%). The Ct value of <16 had a significant correlation with clinical severity of TB (p<0.05) but no significant association with advanced lesions (p>0.05). Based on the results, Ct value had a strong correlation with clinical severity in pulmonary TB. In addition, it could be used as a predictor for managing pulmonary TB patients and an important indicator for control programs. 

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