MEDISAINS
MEDISAINS: Jurnal Ilmiah Ilmu-ilmu kesehatan merupakan sarana penyebarluasan ilmu pengetahuan, riset, teknologi dan inovasi dibidang kesehatan yang diterbitkan tiga kali dalam setahun (April, Agustus dan Desember). Jurnal Medisains adalah jurnal peer reviewed dan Open-Access yang dikelola oleh Fakultas Ilmu Kesehatan Universitas Muhammadiyah Purwokerto dan di terbitkan dibawah Lembaga Publikasi Ilmiah dan Penerbitan (LPIP) Universitas Muhammadiyah Purwokerto.
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<![CDATA[Effect of animated video-based education on mothers’ skills in the early detection of growth and development in children aged 1–5 years ]]>
<![CDATA[Wahyuni, Sri Wahyuni]]>;
<![CDATA[budiyati, arum budiyati]]>;
<![CDATA[Musdalifah, Ulfah Musdalifah]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.23079
<![CDATA[Background: Early childhood is a critical period for growth and development, during which delays in motor and developmental domains remain common. In Indonesia, a considerable proportion of children experience developmental disorders, partly due to limited parental knowledge and suboptimal early stimulation practices. Animated video-based education can enhance learning by delivering information through engaging visual and auditory formats. Purpose: This study aimed to examine the effect of animated video-based education on mothers’ skills in the early detection of growth and development in children aged 1–5 years. Method: A quasi-experimental study with a one-group pretest–posttest design was conducted at Pudakpayung Health Center, Semarang. A total of 33 mothers with children aged 1–5 years were selected using simple random sampling from a population of 93 respondents. Participants received a 10-minute animated video on early detection of child growth and development. Mothers’ skills were assessed using an observation checklist before and two days after the intervention. Data were analyzed using a paired sample t-test. Results: The mean score of early detection skills increased from 75.88 (pretest) to 85.88 (posttest), indicating an improvement of 10 points. Paired sample t-test analysis showed a statistically significant difference after the intervention (p = 0.003). Conclusion: Animated video-based education significantly improves mothers’ skills in the early detection of child growth and development. This approach may serve as an effective educational strategy in community health settings to enhance early detection practices.]]>
<![CDATA[Antimicrobial activity of Etlingera elatior leaf extract in Staphylococcus aureus-induced cystitis: an in vivo study ]]>
<![CDATA[Ridha Nirmalasari]]>;
<![CDATA[Hujjatusnaini, Noor]]>;
<![CDATA[Sari, Mita]]>;
<![CDATA[Wahyuni Nurqadriyani Bustan]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.24470
<![CDATA[Background: Etlingera elatior has been reported to possess antimicrobial properties; however, its therapeutic effects in bacterial cystitis, particularly those caused by Staphylococcus aureus (S. aureus), remain inadequately explored in vivo. Objective: This study aimed to evaluate the antimicrobial and anti-inflammatory effects of Etlingera elatior leaf extract in an experimental model of S. aureus cystitis. Methods: A true experimental posttest-only design was conducted using 28 male BALB/c mice induced with S. aureus. The animals were allocated into control and treatment groups receiving Etlingera elatior leaf extract at concentrations of 40%, 50%, 60%, 70%, and 80%. Therapeutic outcomes were assessed based on urinary tract mucosal fluid secretion and bacterial colony counts. Data were analyzed using one-way ANOVA followed by post hoc testing. Results: Treatment with Etlingera elatior leaf extract significantly reduced cystitis severity compared with the infected control group (p < 0.05). The extract demonstrated both antimicrobial and anti-inflammatory effects, as indicated by reductions in bacterial load and mucosal secretion. Among the tested concentrations, the 40% extract showed the most consistent therapeutic effect, with outcomes comparable to ciprofloxacin. Conclusions: Etlingera elatior leaf extract exhibits potential as an alternative therapeutic agent for bacterial cystitis. Its antimicrobial and anti-inflammatory properties support its further development as a complementary treatment for urinary tract infections.]]>
<![CDATA[Topical Jatropha multifida L. ointment improves perineal wound healing in postpartum mothers: a randomized controlled trial ]]>
<![CDATA[Fera, Fitria Candra]]>;
<![CDATA[Marsum]]>;
<![CDATA[Sri Rahayu]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.26811
<![CDATA[Background: Postpartum perineal wound care may lead to infection if not managed properly. Jatropha multifida L. contains various secondary metabolites that may accelerate wound healing; however, clinical evidence remains limited. Objective: This study aimed to evaluate the effectiveness of Jatropha multifida L. extract ointment compared with standard clean and dry wound care in promoting perineal wound healing. Methods: This was a true experimental study with a pre–posttest control group design. A total of 60 postpartum mothers with second-degree perineal lacerations were randomly assigned into three groups: control, 15% extract, and 20% extract. The interventions were applied twice daily for 7 days. Wound healing was assessed on days 3, 5, and 7 using the REEDA (Redness, Edema, Ecchymosis, Discharge, Approximation) score. Results: The Friedman test showed a significant reduction in REEDA scores across all groups (p < 0.001). The greatest decrease was observed in the 15% concentration group (mean = 0.4). Cohen’s d indicated a very large effect size (d = 1.835). Conclusions: Jatropha multifida L. extract ointment at a 15% concentration was effective in improving perineal wound healing in postpartum mothers.]]>
<![CDATA[Association between nurturing care practices and weight gain among acutely ill children aged 6–24 months: a cross-sectional study ]]>
<![CDATA[Putri, Cechillia Icha]]>;
<![CDATA[Haryanti, Fitri]]>;
<![CDATA[Sandhi, Ayyu]]>;
<![CDATA[Akhmadi, Akhmadi]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28473
<![CDATA[Background: The period between 6 and 24 months represents a critical window for child growth, during which vulnerability to acute illness is high. Acute illness may disrupt normal growth trajectories; however, evidence on the role of nurturing care practices in supporting weight gain during illness remains limited. Objective: This study aimed to examine the association between maternal nurturing care practices and weight gain among acutely ill children aged 6–24 months. Method: A cross-sectional study was conducted at Banguntapan II Primary Health Center, Bantul District, Indonesia. A total of 58 mother–child dyads were recruited using consecutive sampling. Maternal nurturing care practices were assessed using a modified Knowledge, Attitude, and Practice questionnaire based on the World Health Organization nurturing care framework. Child weight gain was evaluated using World Health Organization growth standards. Associations were analyzed using chi-square tests and odds ratios with 95% confidence intervals. Results: No statistically significant association was observed between nurturing care practices and weight gain (p = 0.069; OR = 0.371; 95% CI: 0.126–1.091). However, a higher proportion of children receiving good nurturing care achieved normal weight gain (70.0%) compared with those receiving poor care (46.4%), indicating a potential protective trend. Maternal education and family income were not significantly associated with nurturing care practices or child weight gain. Conclusion: Although no statistically significant association was identified, nurturing care practices showed a potential protective trend in supporting weight gain during acute illness. These findings highlight the importance of integrating nurturing care into sick-child management and underscore the need for longitudinal studies to better understand growth recovery following illness episodes.]]>
<![CDATA[Effect of carbohydrate type on small dense low-density lipoprotein levels in patients with coronary heart disease: a randomized controlled trial ]]>
<![CDATA[Nofia, Vino Rika]]>;
<![CDATA[Angraini , Siska Sakti]]>;
<![CDATA[Herlina , Andika]]>;
<![CDATA[Dewi , Ratna Indah Sari]]>;
<![CDATA[Ibrahim, Ibrahim]]>;
<![CDATA[Yusuf , Rahmi Novita]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28554
<![CDATA[Background: Coronary heart disease (CHD) is closely associated with dyslipidemia, particularly elevated small dense low-density lipoprotein (sdLDL), which contributes to increased atherogenic risk. Evidence from controlled dietary interventions examining the impact of carbohydrate type on sdLDL levels among patients with coronary heart disease in Indonesia remains limited. Objective: This study aimed to evaluate the effect of simple versus complex carbohydrate intake on lipid profiles, with a primary focus on sdLDL levels, in patients with CHD. Methods: A pretest–posttest single-blind randomized controlled trial was conducted among 40 clinically stable patients with coronary heart disease at a community health center in Padang City, Indonesia. Participants were randomly assigned to consume either refined white rice (simple carbohydrate) or unrefined brown rice (complex carbohydrate) for four weeks. Lipid profiles were assessed at baseline and post-intervention. Results: The complex carbohydrate group demonstrated a significantly greater reduction in sdLDL levels compared with the simple carbohydrate group. Significant improvements in total cholesterol, LDL cholesterol, and HDL cholesterol were also observed in the complex carbohydrate group, while triglyceride levels did not change significantly in either group. Conclusion: Complex carbohydrate intake resulted in more favorable modulation of atherogenic lipid profiles than simple carbohydrate intake in patients with coronary heart disease. These findings highlight the importance of carbohydrate quality, particularly unrefined rice-based staples, as a complementary dietary strategy in CHD management.]]>
<![CDATA[Protective effects of atung (Parinarium glaberrimum) seed extract against streptozotocin-induced pancreatic damage: an in vivo experimental study ]]>
<![CDATA[Manuhutu, Oryza Kenan]]>;
<![CDATA[Husein, Anggun Lestary]]>;
<![CDATA[Yuliet Sinanu]]>;
<![CDATA[Nurul Fadhilah Tamzil]]>;
<![CDATA[Ayudyaning Pangesti]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28603
<![CDATA[Background: Hyperglycemia, characterized by elevated blood glucose levels, leads to oxidative stress and pancreatic β-cell dysfunction. Streptozotocin (STZ)-induced hyperglycemia in mice is widely used to model pancreatic injury and evaluate antihyperglycemic agents. Atung (Parinarium glaberrimum) seed extract contains antioxidant compounds; however, its effects on pancreatic histopathology remain unclear. Objective: This study aimed to investigate the effect of atung seed extract on pancreatic histopathology in STZ-induced hyperglycemic mice, focusing on islet diameter and histopathological damage. Methods: Twenty-four male Mus musculus (BALB/c) mice were randomly allocated into six groups: normal control, hyperglycemic control, metformin-treated, and three atung seed extract groups (100%, 75%, and 50%). Hyperglycemia was induced using intraperitoneal streptozotocin (40 mg/kgBW). Treatments were administered orally for 21 days. Blood glucose levels were reassessed on day 22 prior to euthanasia. Pancreatic tissues were collected, fixed in 10% neutral buffered formalin, and stained with hematoxylin–eosin. Results: Islet diameter differed significantly among groups (p < 0.05). The ASE75 group showed a mean diameter of 133.01 µm and a median damage score of 1 (IQR 0), comparable to the metformin group (146.61 µm; 0.5 [IQR 1]), whereas the hyperglycemic control group showed severe atrophy (89.02 µm; 3 [IQR 0]). Conclusion: Atung seed extract at a 75% concentration effectively preserved pancreatic β-cell structure, as indicated by increased islet diameter and reduced histopathological damage, supporting its potential as a natural antioxidant-based adjuvant therapy for hyperglycemia management.]]>
<![CDATA[Protective effects of Gyrinops versteegii leaf ethanol extract on Leydig cells and testosterone under excessive physical activity: an in vivo study ]]>
<![CDATA[Widianti, I Gusti Ayu]]>;
<![CDATA[Wardana, Nyoman Gede]]>;
<![CDATA[Widhiartini, Ida Ayu Alit]]>;
<![CDATA[Pratiwi, Made Sindy Astri]]>;
<![CDATA[Antari, Ni Wayan Sukma]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28611
<![CDATA[Background: Excessive physical activity may lead to overtraining syndrome and increased oxidative stress, which can reduce Leydig cell count and testosterone levels. Gaharu (Gyrinops versteegii) leaf ethanol extract contains strong antioxidants that may counteract oxidative damage. However, the effects of excessive physical activity on Leydig cells and testosterone remain unexplored. Purpose: This study aimed to evaluate the protective effects of Gyrinops versteegii leaf ethanol extract on male reproductive parameters under excessive physical activity conditions. Methods: This experimental study employed a randomized, post-test control-group design. Twenty-five adult male Wistar rats were divided into five groups: normal control, excessive physical activity control, and three treatment groups receiving Gyrinops versteegii leaf ethanol extract at 100, 200, and 400 mg/kg BW. Leydig cell counts and serum testosterone levels were analyzed using ANOVA and correlation tests. Results: The highest Leydig cell count and testosterone level were observed in the 200 mg/kgBW group (28.92 cells and 1.822 ng/mL, respectively). Significant differences in Leydig cell counts were observed among groups (p<0.001), and a positive correlation between Leydig cell number and testosterone levels was observed (p=0.006). Conclusion: Gyrinops versteegii leaf ethanol extract demonstrated protective effects against reproductive impairment induced by excessive physical activity in vivo, with an optimal dose of 200 mg/kgBW.]]>
<![CDATA[Effect of Moringa oleifera leaf powder supplementation on acute respiratory infection in children aged 36–59 months: a quasi-experimental study ]]>
<![CDATA[Nurhi Kefi Nomenci Babu]]>;
<![CDATA[Fitriyono Ayustaningwarno]]>;
<![CDATA[Nuryanto]]>;
<![CDATA[Nur Afifah , Diana]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28615
<![CDATA[Background: Acute Respiratory Infection (ARI) remains a leading cause of morbidity and mortality among children under five, particularly in settings with poor nutritional status and sanitation. Moringa oleifera has been recognized for its nutritional and immunomodulatory properties; however, evidence regarding its effect on ARI incidence in undernourished children is still limited. Objective: This study aimed to examine the effect of Moringa oleifera leaf powder supplementation on the incidence of ARI among children aged 36–59 months. Methods: A quasi-experimental study with a pretest–posttest control group design was conducted from May to July 2025 at Batuputih Public Health Center, South Central Timor District, Indonesia. A total of 40 children were equally allocated into intervention and control groups. The intervention group received 15 g/day of moringa leaf powder combined with eggs, vitamin C, and B complex for 60 days, while the control group received the same supplementation without moringa. ARI incidence was assessed based on clinical diagnosis and hematological parameters, including leukocyte, lymphocyte, and monocyte counts. Data were analyzed using appropriate non-parametric and parametric tests, with statistical significance set at p < 0.05. Results: The intervention group showed a greater reduction in ARI incidence compared with the control group (from 20 to 3 children vs. 20 to 9 children; p = 0.038). Significant changes were also observed in leukocyte levels following supplementation (p = 0.007). Conclusion: Moringa oleifera leaf powder supplementation was associated with a reduction in ARI incidence among children aged 36–59 months and may serve as a potential supportive nutritional intervention in high-risk populations.]]>
<![CDATA[Early initiation of breastfeeding and immediate skin-to-skin contact are associated with lower hyperbilirubinemia risk in newborns from multifetal pregnancies ]]>
<![CDATA[Khairoh, Miftahul]]>;
<![CDATA[Kwarta, Cityta Putri]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28781
<![CDATA[Background: Neonatal hyperbilirubinemia is a common condition and a major contributor to neonatal morbidity, particularly among infants from multifetal pregnancies who are at increased risk due to prematurity and low birth weight. Early initiation of breastfeeding, supported by immediate skin-to-skin contact, may improve neonatal adaptation; however, evidence in multifetal populations within primary healthcare settings remains limited. Purpose: This study aimed to examine the association between early initiation of breastfeeding, supported by skin-to-skin contact, and the incidence of pathological hyperbilirubinemia among newborns from multifetal pregnancies. Methods: An analytic observational study with a cross-sectional design was conducted among 90 newborns from multifetal pregnancies at the Pasean Community Health Center, Pamekasan, between January and September 2025. Early breastfeeding initiation was assessed through direct observation, and total serum bilirubin levels were measured within the first 72 hours using spectrophotometry. Data were analyzed using the Chi-square test and multivariate logistic regression to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs). Results: Early breastfeeding initiation was implemented in 58.9% of newborns, and pathological hyperbilirubinemia occurred in 31.1%. A significant association was observed between early breastfeeding initiation and hyperbilirubinemia (p = 0.003). Newborns who did not receive early breastfeeding initiation had higher odds of developing hyperbilirubinemia compared with those who received it (adjusted OR 6.52; 95% CI: 1.98–21.47), after adjusting for birth weight, gestational age, and mode of delivery. Conclusion: Early initiation of breastfeeding is associated with a reduced risk of pathological hyperbilirubinemia in newborns from multifetal pregnancies. Strengthening its implementation may provide a simple and effective strategy to improve neonatal outcomes, particularly in primary healthcare settings.]]>
<![CDATA[Effect of intradialytic mindfulness-based meditation on spiritual well-being and anxiety in hemodialysis patients: a randomized controlled trial ]]>
<![CDATA[Murwani, Wara Gati]]>;
<![CDATA[Fahrun Nur Rosyid]]>;
<![CDATA[Dian Hudiyawati]]>
<![CDATA[ MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026) ]]>
Publisher : <![CDATA[Universitas Muhammadiyah Purwokerto ]]>
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DOI: 10.30595/medisains.v24i1.28905
<![CDATA[Background: Patients undergoing hemodialysis frequently experience anxiety and reduced spiritual well-being; however, few studies have simultaneously addressed these outcomes using structured mindfulness-based interventions delivered during dialysis sessions. Purpose: To evaluate the effectiveness of intradialytic mindfulness-based meditation in reducing anxiety and improving spiritual well-being among patients undergoing hemodialysis. Methods: A randomized controlled trial was conducted involving 58 patients undergoing routine hemodialysis, randomly assigned to an intervention group (n = 29) or a control group (n = 29). The intervention group received a 2.5-hour mindfulness training session followed by audio-guided mindfulness practice during the first 15 minutes of hemodialysis sessions, twice weekly for four weeks. The control group rested quietly without guided practice. Anxiety was measured using the Zung Self-Rating Anxiety Scale (ZSAS), and spiritual well-being was assessed using the Spiritual Well-Being Scale (SWBS). Data were analyzed using paired and independent t-tests. Results: The intervention group showed a significant increase in spiritual well-being scores (mean change +6.07) compared with the control group (+1.21) (p = 0.021). Anxiety scores significantly decreased in the intervention group (−11.76) compared with minimal change in the control group (+0.69) (p = 0.001). The between-group effect sizes were large (SWB: d = 1.36; anxiety: d = −1.88). Conclusion: Intradialytic mindfulness-based meditation is a feasible and effective complementary intervention that improves spiritual well-being and reduces anxiety among patients undergoing hemodialysis.]]>
