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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 11 Documents
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Search results for , issue "Vol. 11 No. 3 (2025)" : 11 Documents clear
An Extension Form of Chiari 1 malformation: A Case Report Wiryaning Putri, Komang Yunita; Novan Krisno Adji; Ulfa Elfiah; Muhammad Yuda Nugraha
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53709

Abstract

The updated classification of Chiari malformation includes Chiari 1.5 malformation, which explicitly denotes the tonsillar herniation characteristic of Chiari 1 malformation, accompanied by an extended brainstem and a dilated fourth ventricle. We present a Chiari 1 malformation characterized by significant downward herniation of the tonsils and the development of syringomyelia, with no indication of elongation of the fourth ventricle. This example represents an extension of Chiari 1 malformation, which is currently not classified as Chiari 1.5 malformation. A 27-year-old female exhibited cephalic and cervical discomfort for two years. The initial MRI indicated a fall of the cerebellar tonsil beneath the foramen magnum. The midsagittal MRI assessed the degree of tonsillar herniation beneath the foramen magnum. Tonsillar herniation was observed at the C2 level; a spinal MRI revealed syringomyelia affecting the C2 to C3 levels. The patient received a suboccipital craniectomy and C1-C2 laminectomy. There was dural sac pulsation at the C2 level. The patient's cervical discomfort resolved entirely following the surgical procedure. This case represents an extension of Chiari 1 malformation, which is currently not classified as adenotes explicitly 1.5 malformation. 
The Relationship between Sanitation and Personal Hygiene with Seroprevalence of Toxoplasmosis in Pregnant Women at Kaliwates and Banjarsengon Community Health Centers Nabila Putri Anissa; Yunita Armiyanti; Eny Nurmaida; Bagus Hermansyah; Erma Sulistyaningsih; Wiwien Sugih Utami
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Toxoplasmosis is an infectious disease in animals that can be transmitted to humans. Sanitation and personal hygiene are risk factors for toxoplasmosis. Toxoplasmosis can be transmitted from pregnant women to their fetuses. Toxoplasmosis in pregnancy can cause pregnancy, premature birth, and congenital toxoplasmosis. According to the Jember District Health Office in 2023, access to proper sanitation and good hygienic behavior is still low. The purpose of this study was to analyze the relationship between sanitation and individual hygiene with toxoplasmosis seroprevalence in pregnant women at the Kaliwates and Banjarsengon Health Centers. This study used a crosssectional study type. The subjects of the study were 65 pregnant women at the Kaliwates and Banjarsengon Health Centers who were taken using the accidental sampling technique. The serological examination used the Toxoplasma IgM and IgG ELISA kit from Calbiotech®. The results of this study showed that 77% of pregnantwomen were detected positive for toxoplasmosis. The majority of pregnant women have good sanitation and personal hygiene categories of 87.7% and 90.8%, respectively. Based on the results of Fisher's exact test, sanitation and personal hygiene are not related to toxoplasmosis seroprevalence (p>0.05). This study concludes that sanitation and personal hygiene of pregnant women at the Kaliwates and Banjarsengon Health Centers are not significantly related to toxoplasmosis seroprevalence.  
Computational Prediction of Antimalarial Potential of Eurycoma longifolia Phytochemicals Targeting Plasmodium falciparum Awisarita, Wiwara; Farid, Muhammad
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53732

Abstract

Falciparum malaria, caused by Plasmodium falciparum, remains a major global health threat, complicated by the emergence of drug-resistant strains that undermine the efficacy of current artemisinin-based therapies. Eurycoma longifolia Jack (Pasak Bumi), a medicinal plant native to Southeast Asia, has long been used in traditional medicine for treating malaria and infectious diseases. With increasing resistance of Plasmodium falciparum to conventional drugs, the search for novel antimalarial agents is crucial. This study aimed to predicted the antimalarial potential of bioactive compounds from E. longifolia through a computational approach targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Ten phytochemicals were selected and their 3D structures were prepared using PyRx and Open Babel. Molecular docking simulations were conducted using AutoDock Vina, with artemisinin as a control. Docking validation achieved an RMSD of 0.823 Å, confirming protocol reliability. Among the tested ligands, syringic acid showed the highest binding affinity -6.7 kcal/mol, followed by scopoletin -6.6, and fraxidin -6.4, with key interactions involving residues His185, Val532, and Phe188. Toxicological predictions indicated variability, with 1,1′-biphenyl-3,3′-dicarboxylic acid exhibiting the highest acute toxicity. Despite no compound surpassing the native ligand's binding energy -7.9 kcal/mol, several exhibited promising interactions and favorable safety profiles. This study highlights E. longifolia as a promising source of phytochemicals for antimalarial drug discovery. Further experimental studies and molecular dynamics simulations are recommended to validate these findings and optimize compound efficacy.
Occult Hepatitis B infection (OBI) in Indonesia: A Systematic Review Muhammadiy, Noer Sidqi; Senjarini, Kartika; Fajrin, Fifteen Aprila; Velavan, Thirumalaisamy P.; My, Truong Nhat; Song, Le Huu
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53733

Abstract

Hepatitis B Virus (HBV) infection remains a significant global health concern, with various genotypes exhibiting distinct clinical characteristics. Occult hepatitis B infection (OBI) is a latent form of HBV infection that is difficult to detect and poses a risk of transmission, particularly among high-risk populations such as blood donors, hemodialysis patients, and kidney transplant recipients. In Indonesia, studies on HBV genotype diversity and OBI prevalence remain limited, highlighting the need for a systematic analysis better to understand genotype distribution and its implications for public health. This systematic review was conducted using the PRISMA guidelines. Literature searches were performed on Google Scholar, Springer, ResearchGate, ScienceDirect, and PubMed using keywords related to OBI, HBV genotypes, and the Indonesian population. Studies that met the inclusion criteria were analyzed to assess genotype distribution and OBI prevalence. Among 352 screened articles, 35 studies met inclusion criteria. Genotypes B and C were identified as predominant HBV strains, with regional distribution variations. The highest OBI prevalence was recorded in eastern Indonesia (13.03%), followed by central (4.31%) and western (3.36%) regions. Nested PCR was the primary detection method for OBI. The predominance of genotype C in eastern Indonesia may contribute to higher OBI prevalence, emphasizing the need for region-specific diagnostic and management strategies. Further research is necessary to elucidate the association between HBV genotypes and clinical outcomes in OBI patients.
Liver Histopathological Analysis in The Acute Toxicity Test of Shallot (Allium cepa L.) Peel Extract in Rats (Rattus norvegicus) Aprilya Pratiwi, Nadilla; Dewi, Rosita; Agustina, Dini; Helianti, Dina; Rachmania, Sheilla
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53736

Abstract

Shallot (Allium cepa L.) contains bioactive compounds with antioxidant effects. In addition to the tuber, the shallot’s peel is a rich source of flavonoids with demonstrated capacity to mitigate oxidative stress. Prior studies have evaluated the antioxidant efficacy of shallot peel in ameliorating organ damage and have established its maximum effective dose. The subsequent step required for its potential therapeutic application is toxicity test. This study aimed to analyze the liver histopathological changes in the acute toxicity test of shallot peel extract (SPE) in rats based on OECD TG 420. This research was an experimental with a post-test-only control group design. Five female rats were used as the control group administered dimethyl sulfoxide (DMSO), while 5 female rats were used in the treatment group administered SPE at 5,000 mg/kg body weight (BW) (one of them had been used for a preliminary test with the same dosage). On day 15, a necropsy was conducted, followed by histopathological observation of the hematoxylin-eosin (HE)-stained liver histopathological slide. The damage to hepatocytes was evaluated using Manja Roenigk criteria. The average histopathological score per liver cell of the control group was 1.226 ± 0.0065 and the treatment group was 1.235±0.0079. The Mann-Whitney test showed that the liver histopathological score of the treatment group was not different from that of the control group (p>0.05). It can be concluded that SPE 5,000 mg/kg does not show acute toxic effects in rats, with LD₅₀ estimated at >5,000 mg/kg according to OECD standards.
The Forgotten Stoppa Procedure: An Alternative Approach for Incarcerated Groin Hernia Following Prior Anterior Repair Unsuitable for Laparoscopic Surgery – Case Series Normasari, Rena; Fardiansyah, Mochamad Syahroni; Lesmana, Tomy
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53739

Abstract

Incarcerated and recurrent inguinal hernias present complex surgical challenges, particularly in patients with a history of multiple anterior repairs or contraindications to laparoscopic approaches. Although minimally invasive techniques such as Transabdominal Preperitoneal (TAPP) and Totally Extraperitoneal (TEP) repair have become standard practice, not all patients are ideal candidates due to altered anatomy, dense adhesions, or comorbidities that preclude general anesthesia. In such cases, the Stoppa procedure—a classical open posterior approach with wide preperitoneal mesh placement—offers a safe and effective alternative. This case series describes two elderly male patients with incarcerated recurrent inguinal hernias following multiple prior anterior mesh repairs. Both presented in emergency settings with significant comorbidities, making laparoscopic surgery unfeasible. Surgical repair was performed using a lower midline incision and extensive preperitoneal dissection, followed by the placement of a large polypropylene mesh without extensive fixation. In both cases, the incarcerated ileal segments were viable and successfully reduced without bowel resection. Postoperative recovery was uneventful, with both patients discharged within three days and showing no recurrence or major complications during a one-year follow-up. These outcomes demonstrate that the Stoppa technique remains a valuable option in complex cases where anterior or laparoscopic approaches are unsuitable. Its anatomical logic, broad coverage, and reduced risk of chronic pain support its continued role in modern hernia surgery. Surgeons should retain proficiency in this underutilized yet highly effective method, particularly when managing high-risk or reoperative groin hernias.
Effectiveness of Brandt Daroff and Water-Based Exercise In Patients with Vertigo: Case Report Yulianti, Dwi; Pristianto, Arif; Santoso, Totok Budi
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53751

Abstract

The displacement of otoliths into the semicircular canals causes the most common type of peripheral vertigo, known as Benign Paroxysmal Positional Vertigo (BPPV). This condition can disrupt balance and increase the risk of falls, especially when the head position changes suddenly. The purpose of this case report is to determine how effective the combination of Brandt-Daroff exercises and hydrotherapy is in improving balance in BPPV patients. A 69-year-old woman with vertigo underwent the Dix-Hallpike maneuver and an intervention consisting of Brandt-Daroff exercises and hydrotherapy twice weekly under supervision for six weeks. Balance evaluation was conducted before and after therapy using the M-CTSIB (for static balance) and TUG-T (for dynamic balance). Following the intervention, the TUG-T score decreased from 21.5 to 18, indicating improved mobility and patient response. The M-CTSIB score also increased significantly, particularly for eyes closed and unstable surfaces, from 15 to 22. Conditions without visual support also improved, indicating good vestibular adaptation. Patients reported no longer experiencing vertigo when changing positions and being able to engage in activities without fear of falling. These results suggest that Brandt-Daroff exercises and hydrotherapy can serve as non-pharmacological methods to improve balance and quality of life for patients with BPPV.
An Antioxidant and Sunscreen Activity of Bangkal Plants (Nauclea subdita) -, Isnaini; Asnawati; Febriansyah, Febriansyah; Ulfah, Rahmaniah
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53752

Abstract

Skin cancer is the one of leading causes of illness and death worldwide.  The World Health Organization (WHO) state that ultraviolet (UV) radiation can cause cancer because it damages cells and triggers tumour growth.  Bangkal plants (Nauclea subdita (Korth) Steud) which grows widely in South Kalimantan, contain antioxidants such as flavonoids, phenolics, saponins and tannins. These compounds, found in the plant’s fruit and leaves, make Bangkal extract a potential natural sunscreen. This article aims to determine the antioxidant potential of the fruit and leaf extract through scavenging hydrogen peroxide, scavenging hydroxyl radicals and chelating metals activity tests and discover the sunscreen ability based on the sun protection factor (SPF). The extracts were tested at concentrations of 2.5, 5 , 10, 25 and 50 ppm. The study results show that the fruit extract exhibited the most substantial antioxidant activity potential in metal chelating and hydroxyl radical scavenging. Conversely, the bangkal leaf extract demonstrated greater activity in  hydrogen peroxide scavenging than in chelating metal and hydroxyl radical scavenging.   Based on the SPF value, bangkal leaf extract has greater sunscreen activity than the  fruit extract, indicating its stronger potential for development into a sunscreen formula to help prevent skin cancer.
Comparison of APACHE II Score and SOFA Score for Predicting Survival Rate in ICU: A Systematic Review Dananjaya, Vigyan; Adi Santika, Suparno
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53757

Abstract

Predicting mortality in critically ill patients is a key challenge in intensive care units (ICUs), and scoring systems such as SOFA (Sequential Organ Failure Assessment) and APACHE II (Acute Physiology and Chronic Health Evaluation II) are commonly used to estimate prognosis. This systematic review aimed to assess how accurately these two scoring systems predict ICU survival outcomes. The review was conducted in accordance with the PRISMA guidelines and registered on PROSPERO (CRD42024600239). Relevant studies published from 2014 to 2024 were identified through a comprehensive search of PubMed, ScienceDirect, SpringerLink, ProQuest, and the Cochrane Library. After screening 1,427 studies, 25 peer-reviewed articles met the inclusion criteria and were analyzed. The results consistently demonstrated that higher SOFA and APACHE II scores were significantly associated with increased mortality rates and prolonged ICU stays. The APACHE II score thresholds varied from 13 to 18.5, while SOFA score cutoffs ranged from 4.5 to 9. Several studies suggested that combining both scoring systems may enhance prognostic accuracy and inform clinical decision-making more effectively than either system alone. In conclusion, both SOFA and APACHE II scores are valid and dependable predictors of ICU mortality. Their combined use may improve risk stratification, support timely interventions, and optimize outcomes in critical care practice.
Analysis of Risk Factors and Quality of Antenatal Care (ANC) in Pregnant Women with Preeclamsia in Ajung District, Jember Regency tunsiah, tunsiah; Utami, Wiwien Sugih
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53772

Abstract

In 2023 and 2024 Jember Regency had the highest maternal mortality rate (MMR) in East Java. Preeclampsia (PE), a form of hypertension during pregnancy, is the second leading cause of MMR after postpartum hemorrhage. This study aimed to analyze the risk factors and quality of antenatal care (ANC) for pregnant women with preeclampsia at the Ajung Community Health Center in Jember Regency. The study employed a retrospective cohort design. The study sample consisted of 55 pregnant women with preeclampsia from the Ajung Community Health Center between 2020 and May 2025. . A two-sample independent t-test was used to analyze differences in risk factors among women with preeclampsia statistically. An ordinal regression test determined the relationship between preeclampsia risk factors and ANC quality. The results revealed 49 cases of preeclampsia occurring at or after 34 weeks of gestation and six cases occurring before 34 weeks. A significant difference was found in maternal age as a risk factor for preeclampsia. Most of the ANC quality in the study sample was very poor (62.5%), with maternal age and mean arterial pressure (MAP) being the main influencing factors. Age-related risk factors differed among pregnant women with preeclampsia and a relationship was found between maternal age, MAP, and ANC quality.

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