Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Global Medical and Health Communication

gmhc
Website

Published by Universitas Islam Bandung

ISSN : 23019123 EISSN : 24605441 DOI : https://doi.org/10.29313/gmhc

Core Subject : Health, Science,

Dentistry Health Professions Immunology & microbiology Nursing Public Health

Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.

Arjuna Subject : Kedokteran - Epidemilogi

Articles 422 Documents

6 7 8 9 10

Stepping Up to New and Better Us Titik Respati; Herry Garna
Global Medical & Health Communication (GMHC) Vol 6, No 2 (2018)
Publisher : Universitas Islam Bandung

This is another milestone for our Journal, Global Medical and Health Communication (GMHC). Starting from this volume in August 2018, GMHC will only publish in English. This move is following our mission to be involved in the global arena. The best approach is by publishing in one of United Nation Language official and working languages, and we choose English.

Efek Jus Buah Naga Super Merah (Hylocereus costaricensis) dan Simvastatin terhadap Kadar Kolesterol Total Darah dan Bobot Badan Tikus Jantan Galur Wistar Hiperkolesterolemia Fauziyyah Karimah; Sadiah Achmad; Rizky Suganda Prawiradilaga
Global Medical & Health Communication (GMHC) Vol 2, No 2 (2014)
Publisher : Universitas Islam Bandung

Penyakit kardiovaskular terjadi akibat beberapa faktor risiko dan di antaranya kadar kolesterol yang tinggi. Menurut survei WHO pada tahun 2008 sekitar 17,3 juta orang meninggal dunia karena penyakit kardiovaskular. Tujuan penelitian ini untuk mengetahui perbedaan efek pemberian jus buah naga super merah (Hylocereus costaricensis) sebagai terapi herbal dengan simvastatin sebagai obat standar yang telah digunakan dalam dunia medis terhadap kadar kolesterol total darah dan bobot badan tikus jantan galur Wistar hiperkolesterolemia. Penelitian dilakukan di Laboratorium Biomedik Universitas Islam Bandung pada bulan April–Mei 2014 dengan menggunakan metode eksperimental laboratorik pada 20 ekor tikus hiperkolesterolemia dengan memberi diet tinggi lipid dan propil tiourasil (PTU) selama 14 hari. Jus buah naga super merah (Hylocereus costaricensis) diberikan secara oral dengan dosis 3,6 g; 7,2 g; dan 10,8 g. Simvastatin sebagai kontrol positif diberikan dengan dosis 0,18 mg. Kontrol negatif dan kontrol normal tanpa pemberian intervensi. Data penelitian dianalisis dengan uji analysis of variance (ANOVA) dan dilanjutkan uji posthoc. Hasil penelitian dengan uji beda terhadap kelompok jus buah naga super merah dosis 3,6 g dan 7,2 g berturut-turut menurunkan kadar kolesterol total sebesar 42,45 mg/dL dan 41,96 mg/dL (p=0,001), sementara dosis 10,8 g cenderung tidak berubah walaupun terjadi kenaikan hanya 1,22 mg/dL (p=0,535). Kelompok kontrol positif menunjukkan penurunan kadar kolesterol total sebesar 21,32 mg/dL (p=0,001). Perubahan bobot badan tikus pada pemberian jus buah naga super merah dosis 3,6 g; 7,2 g; dan 10,8 g dan simvastatin berturut-turut 1,75 g; 22,16 g; 19,5 g; dan 34,75 g yang tidak berbeda secara bermakna (p=0,823). Simpulan, jus buah naga super merah menurunkan kadar kolesterol total lebih tinggi daripada simvastatin, sedangkan bobot badan tikus jantan tidak berbeda. THE EFFECT OF SUPER RED DRAGON FRUIT JUICE (HYLOCEREUS COSTARICENSIS) AND SIMVASTATIN TO TOTAL BLOOD CHOLESTEROL AND BODY WEIGHT OF MALE WISTAR RATS INDUCED HYPERCHOLESTEROLEMIACardiovascular disease occurs due to several factors including high cholesterol level. According to a survey conducted by WHO in 2008 around 17.3 million people died because of cardiovascular disease. The purpose of this research is to compare the effect of super red dragon fruit juice as herbal therapy and simvastatin as standard drug that have been used in the medical therapy to decrease total blood cholesterol and body weight of male Wistar rats induced hypercholesterolemia. This research was conducted at the Biomedical Laboratory Bandung Islamic University in 2014 Apri–Mei used laboratoric experiment methods using 20 rats that was induced hypercholesterolemia with high-fat feeding and propil tiourasil (PTU) for 14 days. Super red dragon fruit (Hylocereus costaricensis) juice given orally at doses 3.6 g; 7.2 g; and 10.8 g. Simvastatin as a positive control was given at a dose of 0.18 mg. Negative control and normal control without intervention. Research data were analyzed by analysis of variance (ANOVA) test and post hoc test. The results of this research with the different test groups of super red dragon fruit juice dose of 3.6 g and 7.2 g respectively lower total cholesterol by 42.45 mg/dL and 41.96 mg/dL (p=0.001), while 10.8 g doses are unlikely to change despite an increase of only 1.22 mg/dL (p=0.535). Positive control group showed a decrease in total cholesterol levels by 21.32 mg/dL (p=0.001). Changes in body weight of rats in the provision of super red dragon fruit juice dose of 3.6 g; 7.2 g; 10.8 g; and simvastatin were 1.75 g; 22.16 g; 19.5 g; and 34.75 g respectively and were not significantly different (p=0.823). Conclusion, super red dragon fruit juice lowers total cholesterol levels higher than simvastatin, while the body weight of male rats did not differ.

Prevalensi Servisitis Gonore pada Wanita Hamil di Rumah Sakit Khusus Ibu dan Anak Kota Bandung Tahun 2015 Armina Haramaini; Rachmatdinata Rachmatdinata; Rasmia Rowawi
Global Medical & Health Communication (GMHC) Vol 4, No 1 (2016)
Publisher : Universitas Islam Bandung

Gonore adalah infeksi menular seksual (IMS) yang disebabkan oleh Neisseria gonorrhoeae (N. gonorrhoeae). Salah satu manifestasi klinis gonore pada wanita adalah servisitis yang sebagian besar asimtomatik dan bila tidak diterapi servisitis gonore pada wanita hamil dapat menimbulkan komplikasi pada ibu, kehamilan, dan janin. Tujuan penelitian ini mengetahui prevalensi servisitis gonore pada wanita hamil di Rumah Sakit Khusus Ibu dan Anak (RSKIA) Kota Bandung tahun 2015. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang. Subjek penelitian adalah 100 wanita hamil dengan bahan pemeriksaan adalah apus endoserviks. Diagnosis servisitis gonore ditegakkan jika pada sedian apus gram ditemukan jumlah polimorfonuklear (PMN) >30/lapang pandang besar (lpb) dan diplokokus gram negatif intraseluler, serta hasil PCR N. gonorrhoeae positif. Hasil PCR N. gonorrhoeae pada seluruh subjek penelitian negatif. Namun, 41 orang (41%) subjek penelitian ditemukan jumlah PMN >30/lpb, tanpa diplokokus gram negatif intraseluler, dan didiagnosis servisitis nongonore. Simpulan penelitian ini, yaitu prevalensi servisitis gonore pada wanita hamil di RSKIA Kota Bandung tahun 2015 adalah 0%. Hasil tersebut diduga karena karakteristik sebagian besar subjek penelitian tidak termasuk ke dalam risiko tinggi mengidap IMS. PREVALENCE OF GONORRHEA CERVICITIS IN PREGNANT WOMEN IN SPECIAL HOPISTAL MATERNAL AND CHILD BANDUNG YEAR 2015Gonnorhea is a sexually transmitted infection (STI) that is caused by Neisseria gonorrhoeae. One of the clinical manifestation of gonnorhea in female is cervicitis, that mostly asymptomatic. If it is left untreated, gonnorheal cervicitis in pregnant woman will cause complication to the mother, pregnancy, and fetus. The aim of this study was to know the prevalence of gonnorheal cervicitis in pregnant woman in mother and children hospital (RSKIA) Bandung in year 2015. The study design was cross sectional and descriptive. Subjects were 100 pregnant women, which was taken the sample from endocervical swab. Diagnosis of gonnorheal cervicitis was established if more than 30/high power field (hpf) polymorphonuclear (PMN) and extra or intracellular gram negative diplococcus found from gram staining, also positive PCR result for N. gonorrhoeae. The result of PCR in all subjects were negative. But, there were 41 subjects with PMN more than 30/hpf, with no intra or extra cellular diplococcus found, and those subjects were diagnosed as non gonnorheal cervicitis. Conclusion of this study was that the prevalence of gonorrheal cervicitis of pregnant woman in RSKIA Bandung in year 2015 is 0%. This result was suggested due to the subjects characteristics in this study mostly were not high risk for STI.

Merokok dan Penuaan Dini berupa Wrinkles Seputar Wajah Sekuriti Universitas Islam Bandung Deis Hikmawati; Diany Maedasari; Panji Ramdhani Prasetya
Global Medical & Health Communication (GMHC) Vol 5, No 2 (2017)
Publisher : Universitas Islam Bandung

Penuaan dini (PD) adalah proses degeneratif yang melibatkan kulit dan sistem penyokong kulit meliputi tulang, kartilago dan jaringan subkutaneus, berupa perubahan stuktural dan elastilitas kulit yang ditandai dengan wrinkles/kerutan kulit (fine wrinkles, coarse wrinkles), kulit yang kasar, kulit kering, teleangiaektasi, lesi kanker, serta perubahan pigmentasi. Wrinkles adalah permukaan kulit yang mengalami lekukan, dipengaruhi oleh faktor intrinsik dan ekstrinsik. Faktor ekstrinsik berasal dari lingkungan paparan sinar matahari, polusi udara, rokok, pergerakan otot yang berulang terkait ekspresi wajah, serta kebiasaan gaya hidup yang berhubungan dengan pola makan dan posisi tidur. Tujuan penelitian ini adalah apakah merokok sebagai faktor ekstrinsik berefek pada kejadian penuaan dini berupa wrinkles di seputar wajah, yaitu sekitar mata, nasolabial fold, dan bibir pada sekuriti Universitas Islam Bandung (Unisba) usia 20–40 tahun. Penelitian ini merupakan penelitian deskriptif analitik menggunakan metode potong lintang. Subjek penelitian adalah pegawai Unisba, yaitu sekuriti berusia 20–40 tahun yang memenuhi kriteria inklusi dengan jumlah 68 orang selama periode Maret–Juni 2016. Penelitian ini menggunakan formulir penelitian yang terdiri atas 16 pertanyaan. Uji analisis menggunakan uji chi-square. Hasil penelitian berupa wrinkles di dahi (p=0,272), seputar mata (p=0,203), nasolabial fold (p=0,493), dan bibir (0,493) menunjukkan bahwa tidak terdapat hubungan merokok dengan penuaan dini berupa wrinkles di dahi, seputar mata, nasolabial fold, dan bibir (p>0,05). Simpulan, merokok tidak berefek pada penuaan dini berupa wrinkles di dahi, seputar mata, nasolabial fold, dan bibir pada sekuriti Unisba usia 20–40 tahun. SMOKING AND PREMATURE AGING IN FORM OF FACIAL WRINKLES ON UNIVERSITAS ISLAM BANDUNG SECURITY STAFFPremature aging is a degenerative process that involves the skin and the skin support systems including the bone, cartilage, and subcutaneous compartments which is skin structural and elastic change characterized such as wrinkles (fine wrinkles, coarse wrinkles), rough skin, dry skin, teleangiaectasia, cancerous lesions, and changes in pigmentation. Wrinkles are curvature of skin surface. There are two factors influence, namely intrinsic and extrinsic factors. Extrinsic factors associated with exposure to sunlight, air pollution, smoking, repetitive muscle movements, diet and sleep position. The objective of the study was to determine the effects of smoking as external factor in the incidence of premature aging such as wrinkles based on area around the face as forehead, around eyes, nasolabial fold, and lips of 68 Universitas Islam Bandung (Unisba) security staff around 20–40 years old. This study was descriptive analytic using cross sectional method during period March to June 2015. This study used the form in the form consisted of 16 questions. Analyzed test using chi-square method. The result related to wrinkles in forehead was (p=0.272), around eyes (p=0.203), nasolabial fold (p=0.493) and lips (0.493). The result showed that there was no significant relation between smoking and premature aging such as wrinkles on forehead and wrinkles around crows feet, nasolabial fold and lip (p>0.05). In conclusion, smoking has no relation with premature aging such as wrinkles on forehead and wrinkles around the lips, crows feet, nasolabial fold of Unisba security staff aged 20–40 years old.

The Effects of Fermented Rice Monascus purpureus JmbA3'K to Blood Pressure and Heart Rate Elderly Woman Stephanus Kristianto Witono; Nur Siti Fatimah; Novik Nurhidayat; R. Muchtan Sujatno
Global Medical & Health Communication (GMHC) Vol 6, No 2 (2018)
Publisher : Universitas Islam Bandung

Incidence of hypertension is increasing rapidly, in 2000 more than 25% of the world's population of hypertension estimated in 2025 increased to 29%. The incidence of hypertension, especially in women will increase at the age of post menopause so it needs to be prevented in elderly women, especially with giving functional food that has effect to lowering blood pressure. Gamma-aminobutyric acid (GABA) is a compound that has the properties of lowering blood pressure through the regulation of smooth muscle tone of blood vessels contained in seeds fermented by Monascus purpureus sp. This research was a case control study which conducted in June 2013 to 19 women within age range 60–80 years who life in Santana Nursing Home, Cirebon to find out the influence of giving fermented rice M. purpureus JmbA3’K to systolic/diastolic blood pressure and heart rate of elderly women. Subjects were given 3 g of fermented rice M. purpureus JmbA3’K. Blood pressure and heart rate was monitored daily. The Wilcoxon signed-rank test was done to see whether the effect of giving fermented rice from the local M. purpureus JmbA3'K to the systolic and diastolic blood pressure of the elderly and the mean difference test using paired t test was done to see if the effect of fermented rice from M. purpureus JmbA3'K local to the heart rate of the elderly women. At the end of research, blood pressure and heart rate were compared before and after the treatment. At the end of the study there were no significant treatment side effects. There were improvements in aging syndrome such as: anxiety to depression, insomnia, overactive bladder (especially at night), neuralgia, and myalgia. In treatment group was found decrease in sistolic (176 to 152 mmHg) and diastolic blood pressure (90 to 83 mmHg) (p<0.05) without any changing in heart rate (81.68 to 79.32 b/sec) (p>0.05). The conclusion of this research is giving 3 grams of fermented rice M. purpureus JmbA3’K every evening meal for fourteen days decrease the sistolic and diastolic blood pressure of the elderly without any changing in heart rate. EFEK PEMBERIAN BERAS FERMENTASI MONASCUS PURPUREUS JMBA3’K TERHADAP TEKANAN DARAH DAN FREKUENSI NADI USILA WANITAPeningkatan angka kejadian hipertensi sangat pesat, pada tahun 2000 lebih dari 25% populasi dunia penderita hipertensi yang diperkirakan pada tahun 2025 meningkat menjadi 29%. Angka kejadian hipertensi khususnya pada wanita akan meningkat pada usia posmenopause (usila) sehingga perlu diupayakan pencegahan hipertensi pada wanita usila, khususnya pemberian makanan yang mempunyai efek menurunkan tekanan darah. Gamma-aminobutyric acid (GABA) mempunyai sifat menurunkan tekanan darah melalui pengaturan tonasi otot polos pembuluh darah terkandung pada biji-bijian yang ditumbuhi kapang Monascus purpureus sp. Penelitian ini merupakan penelitian case control yang dilakukan Juni 2013 terhadap 19 orang subjek wanita usila rentang usia 60–80 tahun penghuni Panti Wreda Santana, Cirebon untuk mengetahui efek pemberian beras fermentasi M. purpureus JmbA3’K terhadap tekanan darah dan frekuensi nadi. Subjek diberikan 3 g beras fermentasi M. purpureus JmbA3’K selama 14 hari. Tekanan darah dan frekuensi detak jantung dimonitor setiap hari. Pada akhir penelitian tekanan darah dan frekuensi nadi dibandingkan antara sebelum dan sesudah perlakuan. Uji beda Wilcoxon untuk melihat apakah efek pemberian beras fermentasi dari kapang M. purpureus JmbA3’K lokal terhadap tekanan darah sistole dan diastole usila dan uji beda rata-rata menggunakan paired t test dilakukan untuk melihat apakah efek pemberian beras fermentasi dari kapang M. purpureus JmbA3’K lokal terhadap frekuensi nadi usila. Pada akhir penelitian tidak didapatkan efek samping perlakuan yang berarti. Didapatkan perbaikan sindrom penuaan seperti ansietas sampai depresi, insomnia, overactive bladder (terutama malam hari), neuralgia, dan mialgia. Terdapat perbedaan tekanan darah sistole dengan diastole sebelum (176/90 mmHg) dengan sesudah diberi perlakuan (152/83 mmHg) (p<0,05) tanpa perbedaan frekuensi nadi sebelum (81,68 kali/menit) dengan sesudah diberi perlakuan (79,32 kali/menit) (p>0,05). Simpulan, pemberian beras IR-42 fermentasi M. purpureus JmbA3’K menurunkan tekanan darah sistole dan diastole usila tanpa perubahan frekuensi nadi.

Karakteristik Penderita Drop Out Pengobatan Tuberkulosis Paru di Garut Nevi Nurkomarasari; Titik Respati; Budiman Budiman
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Universitas Islam Bandung

Tuberkulosis masih menjadi masalah penyakit infeksi di dunia termasuk di Indonesia. Walaupun penggunaan Directly Observed Treatment Shortcourse Chemotherapy (DOTS) sebagai terapi yang direkomendasikan World Helath Organization (WHO) dipergunakan, kasus drop out masih cukup tinggi. Penelitian ini dilakukan untuk menggambarkan faktor yang mempengaruhi kejadian drop out di Puskesmas Sukamerang, Garut selama tahun 2011. Penelitian ini menggunakan metode cross sectional dengan instrument penelitian berupa kuesioner yang didasarkan pada petunjuk perawatan TB yang diterbitkan oleh Kementrian Kesehatan. Subjek adalah semua penderita TB yang drop out selama pengobatan di Puskesmas Sukamerang, Garut sejumlah 30 orang. Analisis data dilakukan menggunakan statistical programme for social sciense (SPSS) versi 17. Hasil penelitian menunjukkan bahwa pasien TB drop out adalah laki-laki dengan usia <35 tahun, pendidikan tamat SMP, pendapatan di bawah upah minimum regional dan bekerja sebagai buruh. Tingkat pengetahuan tentang TB paru penderita drop out pengobatan TB paru dan sikap mereka termasuk kurang baik walaupun peran pengawas menelan obat (PMO) telah cukup baik. Masalah tersebut ditambah dengan sulitnya akses menuju pelayanan kesehatan. Upaya penting dalam penanganan kasus TB adalah bagaimana memotivasi penderita agar mereka mau menyelesaikan pengobatan sesuai dengan program yang ditetapkan. Untuk mewujudkan upaya tersebut, diharapkan program penanggulangan TB paru dapat meningkatkan upaya penjaringan penderita TB paru dan meningkatkan strategi pelaksanaan pengobatan TB paru melalui penyebaran informasi tentang pengobatan TB paru dan peningkatan peranan PMO. CHARACTERISTICS OF DROP OUT PATIENTS DURING TREATMENT OF PULMONARY TUBERCULOSIS IN GARUTTuberculosis is still one of the major infectious disease in the world including Indonesia. Although the therapy using Directly Observed Treatment Short course Chemotherapy (DOTS) recomended by World Health Organization has been used, the drop out cases is still high. This study aim was to describe factors contributing to drop out cases in Sukamerang Health Center, Garut during year 2011. This was a cross sectional study using standard questionairres based on Ministry of Health Tuberculosis handbook. Subjects were all , 30 drop out patients during medication at Sukamerang Health Center. Statistical Programee for social science (SPSS) version 17 was used to analize the result. The study results showed that majority of drop out cases were male less than 35 years old with junior high school education and monthly earning of less than IDR 800.000. Knowledge of TB and attitude towards medication were not satisfactory although the role of pengawas minum obat (PMO) was quite good. The results showed that the problem was heightened by their difficulty to access the health services. The important aspect in the treatment of tuberculosis is determining how to motivate people to complete the treatment in accordance with the established regiment. To achieve that, various pulmonary TB control programs needs to be enhanced to assist pulmonary TB patients.

Soyghurt Supernatant on Mouse Embryonic Fibroblast (MEF) Cell Lantika, Uci Ary; Khairani, Astrid Feinisa
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Yogurt is a functional food developed with various modifications in the fermentation process. Replacing animal milk into soymilk as raw material is one approach. Yogurt has a good effect on human health. Probiotic and bioactive compounds in yogurt can inhibit cell proliferation and stimulate apoptosis on the cancer cell line. However, there is no report about the effect of yogurt on a normal cell. This research was conducted to examine the impact of soyghurt supernatant intervention toward the viability of mouse embryonic fibroblast (MEF) cell. The is an in vitro study using MEF cell isolated from 10th days gestational age mice embryo conducted at Microbiology Laboratorium and Cell Culture and Cytogenetic Laboratory, Universitas Padjadjaran, Bandung in November 2018–January 2019. Soyghurt made from soymilk fermented by Lactobacillus bulgaricus ATCC 11842. The number of the bacterial colony calculated by total plate count (TPC) method and pH calculated by pH meter. Soyghurt supernatant was made from soyghurt and then intervened into MEF cells by 1–20% concentration. The cell viability showed in the 50% inhibitory concentration (IC50) analysis. The intervention of soyghurt supernatant at 1–20% concentration showed there was no proliferation inhibition until 50% population (IC50). However, from the morphology analysis, there was MEF cell morphology alteration on the group given soyghurt supernatant with >12.5% concentration. Counter mechanism effect from soymilk fermentation by probiotic could be the driver for this result. In conclusion, soyghurt supernatant intervention at 1–20% concentration did not have a cytotoxic effect on MEF cell, but enhancement of soyghurt supernatant concentration can increase cytotoxic potential. SUPERNATAN SOYGHURT PADA SEL MOUSE EMBRYONIC FIBROBLAST (MEF)Yoghurt merupakan functional food yang dikembangkan dengan berbagai modifikasi dalam proses pembuatannya. Mengganti susu hewan dengan susu kedelai sebagai bahan baku adalah salah satunya. Yoghurt memiliki efek yang baik bagi kesehatan manusia. Senyawa probiotik dan bioaktif pada yoghurt dapat menginhibisi proliferasi sel dan menstimulasi apoptosis pada sel lini kanker. Akan tetapi, tidak terdapat laporan mengenai efek yoghurt pada sel normal. Penelitian ini dilakukan untuk menguji pengaruh intervensi supernatan soyghurt terhadap viabilitas sel mouse embryonic fibroblast (MEF). Ini adalah penelitian in vitro menggunakan sel MEF yang diisolasi dari embrio tikus hari ke-10 usia kebuntingan yang dilakukan di Laboratorium Mikrobiologi dan Laboratorium Kultur Sel dan Sitogenetika, Universitas Padjadjaran, Bandung pada November 2018–Januari 2019. Soyghurt dibuat dari susu kedelai yang difermentasi oleh Lactobacillus bulgaricus ATCC 11842. Jumlah koloni bakteri dihitung dengan metode total plate count (TPC) dan pH diukur dengan pH meter. Supernatan soyghurt dibuat dari soyghurt dan kemudian diintervensi ke dalam sel MEF dengan konsentrasi 1–20%. Viabilitas sel ditunjukkan dalam analisis penghambatan 50% (IC50). Pemberian supernatan soyghurt konsentrasi 1–20% menunjukkan tidak terdapat inhibisi proliferasi 50% (IC50). Namun, dari analisis morfologi, terdapat perubahan morfologi sel MEF pada kelompok yang diberi supernatan soyghurt dengan konsentrasi >12,5%. Efek mekanisme yang saling meniadakan dari fermentasi susu kedelai dengan probiotik diduga menjadi mekanisme hasil dari penelitian ini. Simpulan, intervensi supernatan soyghurt pada konsentrasi 1–20% tidak memiliki efek sitotoksik pada sel MEF, namun peningkatan konsentrasi supernatan soyghurt dapat meningkatkan potensi sitotoksik.

Indeks Massa Ventrikel Kiri dengan Disfungsi Diastole pada Pasien Konsentrik Penyakit Jantung Hipertensi Chaerul Achmad; Erwan Martanto; Toni Mustahsani Aprami; Augustine Purnomowati; R. Reni Farenia Soedjana Ningrat; Mega Febrianora
Global Medical & Health Communication (GMHC) Vol 5, No 1 (2017)
Publisher : Universitas Islam Bandung

Hipertrofi ventrikel kiri ditunjukkan secara objektif dengan peningkatan indeks massa ventrikel kiri (IMVK). Peningkatan massa ventrikel kiri dan dilatasi jantung ruang adalah parameter untuk penyakit jantung hipertensi (PJH). Remodeling jantung ini mengubah fungsi jantung yang mengakibatkan disfungsi diastolik. Penelitian ini bertujuan menemukan korelasi antara IMVK dan disfungsi diastolik pada pasien PJH konsentrik. Terdapat 49 pasien PJH konsentrik. Dari 49 pasien, 43 pasien dilibatkan, 15 laki-laki (35%) dan 28 perempuan (65%) memenuhi kriteria inklusi. Penelitian dilakukan di Cardiac Centre RSUP Dr. Hasan Sadikin Bandung periode 1 Oktober 2014–15 February 2015. Pemeriksaan tinggi dan berat badan menggunakan alat SMIC ZT 120. Pemeriksaan ekokardiografi standar dilakukan dan fungsi diastolik dinilai dengan pemeriksaan E/e' menggunakan mesin ekokardiografi Vivid 7. Usia rata-rata subjek adalah 56,56 tahun dan indeks massa tubuh rata-rata adalah 25,96 kg/m2. Tekanan darah sistole rata-rata 145,51 (SD 21,969) mmHg dan diastole rata-rata 85,13 (SD 10,227) mmHg. Frekuensi denyut jantung rata-rata 74,07 kali/menit. Fraksi ejeksi rata-rata 73,02. Obat yang secara teratur diminum oleh subjek angiotensin-converting enzyme inhibitor pada 17 orang (40%), calcium channel blocker 19 orang (44%), beta-blocker 15 orang (35%), angiotensin II reseptor blocker 9 orang (21%), dan diuretik 4 orang (9%). Nilai IMVK rata-rata 130,36 (SD 21,077) g/m2. Nilai E/e' rata-rata 10,56 (SD 2,761). Hasil penelitian menunjukkan tidak ada hubungan yang signifikan antara IMVK dan derajat disfungsi diastolik (p=0,73). Data IMVK dan derajat tingkat disfungsi diastolik terdistribusi normal. Simpulan, tidak terdapat hubungan antara IMVK dan disfungsi diastolik pada pasien PJH jenis konsentrik.LEFT VENTICULAR MASS INDEX WITH DIASTOLIC DYSFUNCTION IN HYPERTENSIVE HEART DISEASE PATIENTSLeft ventricular hypertrophy was shown with increased left ventricular mass index (LVMI). Increased left ventricular mass and cardiac chamber dilatation are parameters for hypertensive heart disease (HHD). This cardiac remodeling causes changes in heart function resulting in diastolic dysfunction. This study aimed to find the correlation between LVMI and diastolic dysfunction in patients with concentric HHD. We enrolled 49 patients with concentric HHD in Cardiac Centre RSUP Dr. Hasan Sadikin Bandung during 1 October 2014 to 15 February 2015, whom 43 met the inclusion criteria, 15 males (35%) and 28 females (65%). The subjects of study height and weight measured using SMIC tool ZT 120. The standard echocardiography examination was performed and diastolic function was assessed by examination of the E/e' using echocardiography machine Vivid 7. The average age of the subjects was 56.56 years with body mass index of 25.96 kg/m2. The average of systolic blood pressure and diastolic blood pressure were 145.51 (SD 21.969) and 85.13 (SD 10.227) mmHg respectivelly. The average frequency of heart beats was 74.07 bpm and average ejection fraction was 73.02. Drugs regularly consumed by subjects according to the percentage were: angiotensin-converting enzyme inhibitor {17 (40%)}, calcium channel blocker {19 (44%)}, beta-blocker {15 (35%)}, angiotensin II receptor blocker {9 (21%)}, and diuretics {4 (9%)}. The average value of LVMI was 130.36 (SD 21.077) g/m2 and the average value of E/e' was 10.56 (SD 2.761). The result show that there was no significant correlation between LVMI and the degree of diastolic dysfunction (p=0.73). The data LVMI and the degree of diastolic dysfunction levels were normally distributed. In conclusion, there is no correlation between LVMI and diastolic dysfunction in patients with HHD concentric type.

Hubungan Polimorfisme SNP8NRG433E1006 Gen Neuregulin 1 (NRG1) dengan Skizofrenia pada Etnik Jawa Cinta Cynthia Rudianto; Gara Samara Brajadenta; Alifiati Fitrikasari; Tri Indah Winarni
Global Medical & Health Communication (GMHC) Vol 6, No 1 (2018)
Publisher : Universitas Islam Bandung

Gen neuregulin 1 (NRG1) berfungsi penting pada perkembangan sistem saraf dan merupakan kandidat gen penyebab skizofrenia. Polimorfisme SNP8NRG433E1006 pada NRG1 merupakan salah satu faktor risiko yang sering ditemukan pada skizofrenia. Penelitian ini bertujuan menganalisis hubungan polimorfisme SNP8NRG433E1006 gen NRG1 dengan skizofrenia pada etnik Jawa. Penelitian dilakukan pada bulan Januari 2016 hingga April 2017. Sebanyak 30 pasien skizofrenia dan 30 kontrol etnik Jawa dari Rumah Sakit Jiwa Daerah (RSJD) Dr. Amino Gondohutomo Semarang memenuhi kriteria inklusi. Informed consent didapatkan dari keluarga pasien. Sampel darah EDTA dilakukan ekstraksi DNA, amplifikasi nested polymerase chain reaction (PCR), dan sekuensing. Hubungan polimorfisme SNP8NRG433E1006 gen NRG1 dengan skizofrenia dianalisis menggunakan Fisher’s exact test. Dari hasil sekuensing pada kelompok kontrol tidak ditemukan polimorfisme, sedangkan pada kelompok pasien skizofrenia ditemukan dua pasien memiliki polimorfisme SNP8NRG433E1006 dengan mutasi homozigot c.172G>A (6%). Hasil Fisher’s exact test menunjukkan tidak ada hubungan antara polimorfisme SNP8NRG433E1006 gen NRG1 dan skizofrenia pada etnik jawa (p=0,246; p>0,05). Simpulan, peran polimorfisme SNP8NRG433E1006 gen NRG1 terhadap kejadian skizofrenia pada etnik Jawa tidak terbukti. CORRELATION OF SNP8NRG433E1006 POLYMORPHISM NEUREGULIN 1 (NRG1) GENE WITH SCHIZOPHRENIA IN JAVA ETHNICNeuregulin 1 (NRG1) gene has some important roles in nervous system development and functioning. This gene leading as one of schizophrenia susceptibility gene. SNP8NRG433E1006 of NRG1 is one risk factors of schizophrenia. The objective of this study was to analyse correlation between SNP8NRG433E1006 of NRG1 and schizophrenia in Java ethnic. The study was conducted in January 2016 until April 2017. Thirty patients with schizophrenia and 30 control in which from Java ethnic at Dr. Amino Gondohutomo Semarang Mental Hospital were recruited. Informed consent was obtained from patient’s family. The blood sample went throught DNA extraction, nested PCR and sequencing. Correlation between SNP8NRG433E1006 of NRG1 and schizophrenia was analysed using Fisher’s exact test. All blood sampling were successfully sequenced. We found two SNP8NRG433E1006 of NRG1 with homozygote mutation c.172G>A in thirty Java ethnic with schizophrenia (6%). There was no significant correlation between SNP8NRG433E1006 of NRG1 and schizophrenia in Java ethnic (p=0.246, p>0.05). In conclusion, the role of SNP8NRG433E1006 of NRG1 polymorphism in schizophrenia is not proven.

Pengetahuan, Sikap, dan Perilaku Mengenai Kesehatan Reproduksi Siswa SMA Swasta dan Madrasyah Alliyah Agam Mayzufli; Titik Respati; Budiman Budiman
Global Medical & Health Communication (GMHC) Vol 1, No 2 (2013)
Publisher : Universitas Islam Bandung

Kesehatan reproduksi (kespro) menjadi perhatian pemerintah Indonesia sebagai salah satu masalah kesehatan yang perlu ditangani dengan baik. Tingkat pengetahuan tentang reproduksi merupakan salah satu faktor yang dapat memengaruhi perilaku seksual remaja. Di beberapa sekolah kesehatan reproduksi telah dijadikan salah satu pengetahuan tambahan untuk siswa, akan tetapi belum semua melakukan hal tersebut. Tujuan penelitian ini untuk mengetahui perbandingan tingkat pengetahuan, sikap, dan perilaku tentang kesehatan reproduksi pada remaja siswa-siswi SMA swasta (SMA BPI 1) dengan siswa-siswi Madrasah Aliyah Sukamiskin Bandung. Penelitian ini adalah penelitian deskriptif analitik dengan pendekatan cross sectional. Penelitian dilakukan pada bulan Mei 2010 dan subjek dalam penelitian ini adalah siswa-siswi SMA BPI 1 dan Madrasah Alliyah Bandung berjumlah 137 responden. Instrumen pengumpulan data berupa kuesioner yang telah divalidasi. Statistical for social science (SPSS) ver 17 dipergunakan untuk mengolah data. Hasil penelitian menunjukkan bahwa komponen pengetahuan, sikap, dan perilaku antara siswa-siswi SMA dan Madrasah Alliyah mengenai kesehatan reproduksi berbeda pada sikap. Sikap siswa-siswi Madrasah Alliyah mayoritas kurang mendukung kesehatan reproduksi tetapi perbedaan ini tidak signifikan. Pengetahuan mengenai kesehatan reproduksi sebaiknya diberikan secara lebih terarah untuk semua remaja agar mendukung tercapainya kesehatan reproduksi yang baik. KNOWLEDGE, ATTITUDES AND BEHAVIOR REGARDING REPRODUCTIVE HEALTH OF HIGH SCHOOL AND MADRASAH ALIYAH'S STUDENTSReproductive health is one of the program that government's focus on. The level of knowledge about reproductive health is one factor that can influence adolescent sexual behavior. The purpose of this study was to determine the comparative level of knowledge, attitudes and behavior regarding reproductive health of adolescent in high school and Madrasah Aliyah. This research used descriptive analytical method with cross sectional approach. The study was conducted in May 2010 and subjects of this study were a total of 137 high school students represented by High School (SMA BPI 1) and Madrasyah Aliyah Bandung. Statistical for social science (SPSS) version 17 was used for analysis data. The results showed that reproductive health knowledge and behaviors between High School SMA BPI 1 and Madrasah Alliyah Bandung were similar. The difference were only in the attitude. The majority of students from Madrasah Aliyah had little suport for reproductive health, however the diferences not significant. It is recomended that reproductive health knowledge be given comprehensively to support a better reproductive health in general.

Page 8 of 43 | Total Record : 422

6 7 8 9 10

Filter by Year

2013 2025

Filter By Issues

All Issue Vol 13, No 1 (2025) Vol 12, No 3 (2024) Vol 12, No 2 (2024) Vol 12, No 1 (2024) Vol 11, No 3 (2023) Vol 11, No 2 (2023) Vol 11, No 1 (2023) Vol 10, No 3 (2022) Vol 10, No 2 (2022) Vol 10, No 1 (2022) Vol 9, No 3 (2021) Vol 9, No 2 (2021) Vol 9, No 1 (2021) Vol 8, No 3 (2020) Vol 8, No 2 (2020) Vol 8, No 1 (2020) Vol 7, No 3 (2019) Vol 7, No 2 (2019) Vol 7, No 1 (2019) Vol 6, No 3 (2018) Vol 6, No 2 (2018) Vol 6, No 1 (2018) Vol 5, No 3 (2017) Vol 5, No 2 (2017) Vol 5, No 1 (2017) Vol 4, No 2 (2016) Vol 4, No 1 (2016) Vol 3, No 2 (2015) Vol 3, No 2 (2015) Vol 3, No 1 (2015) Vol 3, No 1 (2015) Vol 2, No 2 (2014) Vol 2, No 2 (2014) Vol 2, No 1 (2014) Vol 2, No 1 (2014) Vol 1, No 2 (2013) Vol 1, No 2 (2013) Vol 1, No 1 (2013) Vol 1, No 1 (2013) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Agus Chalid

Contact Email
gulid.p@gmail.com

Phone
+6285220013654

Journal Mail Official
gmhc.unisba@gmail.com

Editorial Address
Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location
Kota bandung,

Jawa barat

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Agus Chalid

Contact Email gulid.p@gmail.com

Phone +6285220013654

Journal Mail Official gmhc.unisba@gmail.com

Editorial Address Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location Kota bandung, Jawa barat INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Agus Chalid

Contact Email
gulid.p@gmail.com

Phone
+6285220013654

Journal Mail Official
gmhc.unisba@gmail.com

Editorial Address
Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location
Kota bandung,

Jawa barat

INDONESIA