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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Articles 349 Documents

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RENDEMEN KITOSAN LIMBAH CANGKANG KERANG SIMPING (Amusium pleuronectes) DAN KERANG KEPAH (Polymesoda erosa) DARI KENDAL JAWA TENGAH Ariyanti Ariyanti; Eni Masruriati; Arin Widya Nuari; M. Himawan Yoga Syahputra
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTChitosan is the result of the deacetylation process of chitin by removing acetyl groups to obtain polymer compounds and glucosamine. Utilization of chitosan derived from waste of Amusium pleuronectes and Polymesoda erosa has not been maximize. This study aims to determine the highest chitosan yield in Amusium pleuronectes and Polymesoda erosa. The method used in this study was a deacetylation isolation method with five replications. The yield of the yield content was analyzed by univariate and bivariate with spps 19.0 using a ttest. Based on the results of the research on the sample of Amusium pleuronectes and Polymesoda erosa, the highest yield of chitosan at 75% b/v concentration of NaOH was 6,972% b/v for Amusium pleuronectes and 5.972% b/v for Polymesoda erosa. The results showed that NaOH concentrations of 15v, 25, 50, and 75% b/v could affect the chitin change to chitosan against Amusium pleuronectes and Polymesoda erosa.Keywords: Amusium pleuronectes, Polymesoda erosa, deacetylation, chitin, chitosan

STATINS DRUG USE AND DRUG-DRUG INTERACTIONS Maria Caecilia N.Setiawati; Caecilia Mutiarawati; Uswatun Chasanah; Lina Fatin Fauziyyah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Dyslipidemia is the commonest cause of many atherosclerotic diseases. Statins are the mainstay of the management of dyslipidemia, and it is widely prescribed for patients in Indonesia. This study aims to give an overview, the use of statin, and its drug-drug interactions. The study method was descriptive, using a purposive sampling technic. The inclusion criteria were patients who received statins therapy, in the outpatient installation of Tugurejo Regional Public Hospital, Semarang, during April 2017. There were 334 patients meet the inclusion criteria, most of them were women (63,28%). The highest patients’ range was 60-69 years old of 129 patients (38,62%). One hundred and thirty-one patients (39,22%) were diagnosed with dyslipidemia only. The dosage range of simvastatin and rosuvastatin was 10 to 20 mg once daily, but rosuvastatin was only given 10 mg once daily. The most dose was 10 mg simvastatin per day, prescribed for 231 patients (69,16%). There were 177 patients (52,99%) who has the potentiate of statin drug interactions. The most were simvastatin-amlodipine interactions, occurs in 104 patients (31,14%). This study shows that most statin users are elderly patients. Statin is used not only in dyslipidemia patients. There are many potential statin drug-drug interactions, but the statin dose is low and not over the standard doses. Keyword: dyslipidemia, statins, drug interactions

PERBANDINGAN METODE PENETAPAN KADAR SIMETIDIN MENGGUNAKAN SPEKTROFOTOMETRI UV DAN KROMATOGRAFI CAIR KINERJA TINGGI Aqnes Budiarti; Adina Fitria K.W.; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Determination ofdrug substance is one of the drug quality control to ensure the safetyof drug. Determination of cimetidine could use UV spectrophotometry and HPLC. The aim ofthis study were to validate the methode using two instruments, to compare both of the method and to apply it intablet dosage forms. Determination of cimetidin using UV spectrophotometry was set on wave length 219 nm. Determination using HPLC with coloumn C18 and mobile phase mixture of methanol: water-phosphoric acid (30:70, v/v), flow rateat 1mL/min and UV detector. The method was validated in terms of accuracy, precision, linearity, selectivity and sensivity. The method of determination of cimetidine using both instruments were campared by analysis of variant. Validation method using UV spectrophotometry showed precision of 0.94%, recovery from 97.50 to 100.91%, good linearity, LOD 0.76 µg/mL and LOQ 2.52µg/mL.Validation using HPLC method resulted value of precision 0.30%, recovery from 98.42 to 101.83%, good linearity, LOD and LOQ of 0.46 and 0.56 µg/mL. The average concentration of cimetidine in tablets by spectrophotometry UV was 101.95%, while in HPLC was 99.69%.The methods accomplied to the requirements according The Indonesian Pharmacopoeia Edition IV. Both methods provided the same results and did not significantly different. Keyword : validation method, cimetidine, UV spectrophotometry, HPLC

FORMULASI SIRUP EKSTRAK ETANOL DAUN PARE (Momordica charantia L.) DENGAN GELATIN SEBAGAI PENGENTAL DAN AKTIVITAS MUKOLITIKNYA Ririn Lispita Wulandari; Eli Mahmud; Mufrod Mufrod
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTEthanol extract of bitter melon leaves at a concentration of 5% has been shown to have mucolytic activity. For ease of use that is made of dosage forms syrup. Thickening agent serves to increase the viscosity and resist settling process resulting in a stable syrup. Gelatin has the ability to improve settling extract better than other thickening. This study aims to determine the effect of variations in the concentration of gelatin to the physical-chemical properties and activity of ethanol extract syrup mukolitik pare leaves the cow intestine mucus in vitro. Extraction of leaf bitter melon is done by percolation. EEDP was made into three syrup formulas using 1% (FII), 2% (FIII), 3% (FIV) gelatin thickener. There is also syrup without extract and gelatin (FI) as a control. The four syrup formulas were examined for physical chemical properties (organoleptic, homogeneity, pH, viscosity), and tested their mucolytic activity. Data on the results of activity tests in the form of viscosity were analyzed by Kruskal-Wallis followed by Mann-Whitney. Data from organoleptic examination, homogeneity, Ph were analyzed descriptively, while viscosity with Linear Regression. The results showed that EEDP syrup with a gelatin concentration of 1%; 2%; 3% have mucolytic activity. The results of examination of the physico-chemical properties of FII, III, and IV syrups have the same taste and color, sweet and bitter, and are greenish black in color, while FI syrup is sweet and yellowish in color. Homogeneous FI syrup, FIII and FIV syrup are evenly distributed, while FII syrup has coarse particles. Fourth pH normal syrup formula. Increased concentration of gelatin (1%; 2%; 3%) can increase the viscosity of syrupKeywords: ethanol extract of bitter melon leaves, syrup, gelatin

AKTIVITAS ANTIPLASMODIUM EKSTRAK HIDROTROPI DAUN SAMBILOTO (Andrographis paniculata Ness.) SECARA In Vitro PADA Plasmodium falciparum STRAIN G-2300 RESISTEN KLOROQUIN Yance Anas; Rita Dwi Ratnani; Laeli Kurniasari; Indah Hartati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The bitter leaf extract (Andrographis paniculata Ness.) has long been known as an anti-malarial. Our previous research has developed a bitter leaf hydrotrophy extract (BLHE) using a sodium acetate 2 mol/L as a hydrotop compound solution. The extraction process lasts for 2 hours, faster than conventional extraction. The result is two types of BLHE with different stirring temperatures, at 30°C (BLHE1) and 35°C (BLHE2). This study meant to determine and compare the in vitro antiplasmodial activity BLHE1 and BLHE2. The anti-plasmodial activity of BLHE1 and BLHE2 (0.1- 50.0) g/mL performed on a G-2300 strain of P. falciparum (chloroquine-resistant) after incubated for 48 hours (triplicate). The percentage of parasitemia determined through an examination of blood smears stained with Giemsa. The percentage of growth inhibition of P. falciparum evaluates by comparing percentage of growth with the control group and IC50 determine by probit analysis. The results showed that BLHE1 and BLHE2 respectively were able to inhibit the growth of P. falciparum of 14.62% - 43.25% (IC50: 59.689 μg/mL) and 24.06% - 49.48% (IC50: 44.541 μg/mL). Based on these data, BLHE should produce with sodium acetate 2 mol/L, with stirring at 35°C, because this condition will obtain BLHE that active as anti-plasmodial. Keywords: Anti-plasmodial, bitter leaf hydrotrophy extract, P. falciparum strain G-2300, in vitro

EVALUASI WAKTU TUNGGU RESEP OBAT TERHADAP KEPUASAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT ASSYIFA KOTA TANGERANG Ekadipta Ekadipta; Muhammad Zuhriyanto; Siti Nurahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Hospital is an important health service center and is needed to meet health needs. This study aims to evaluate the waiting time for prescription non-concoction and concoction medicines based on the hospital's minimum service standards and their effect on general outpatient satisfaction at the Pharmacy Installation of RSIA Assyifa, Tangerang. This study used a descriptive research design of outpatients who redeemed non-concoction and concoction medicines. Calculation of the waiting time for prescription services for non-concoction and concoction medicine is using a digital clock. Satisfaction was measured using a questionnaire which was analyzed multivariate. The samples taken in the study were 222 respondents. The results showed that the average waiting time for prescription of non-concoction medicine (8.9 minutes) and concoction medicine (16.6 minutes) had met the standards set by the hospital's SPM in the pharmaceutical sector according to the Minister of Health of the Republic of Indonesia NO. 129 of 2008 and by RSIA Assyifa. The results in the multivariate analysis obtained t = 10.126 and the standard coefficient of 0.88, indicating that waiting time has a strong positive effect on patient satisfaction with prescription of non-concoction and concoction medicine services at RSIA Assyifa.

FORMULASI TABLET KUNYAH KALSIUM LAKTAT DENGAN VARIASI KONSENTRASI HPMC SEBAGAI BAHAN PENGIKAT TERHADAP SIFAT FISIKNYA Wida Ningsih; Firmansyah Firmansyah; Nova Jumaynah
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 1 juni 2017
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Telah dilakukan penelitian formulasi tablet kunyah kalsium laktat dengan menggunakan HPMC (Hydroxypropyl Methyl Cellulose) sebagai bahan pengikat menggunakan metoda granulasi basah. Pada penelitian ini dibuat empat formula (FI, FII, FIII, dan FIV) dengan perbedaan konsentrasi bahan pengikat yaitu 1%, 2%, 3%, dan 4%. Evaluasi granul tablet kunyah meliputi organoleptis, kandungan air, kecepatan alir, sudut istirahat, bobot jenis nyata, bobot jenis mampat, bobot jenis benar, porositas, faktor hausner, dan kompresibilitas memberikan hasil yang memenuhi persyaratan. Evaluasi tablet kunyah meliputi organoleptis, keseragaman bobot, kekerasan, kerapuhan tablet dan penetapan kadar kalsium laktat memenuhi persyaratan, sedangkan keseragaman ukuran belum memenuhi persyaratan. Hasil uji terhadap panelis dari keempat formula secara statistik dengan menggunakan metoda Kruskal-Wallis dari segi rasa FII lebih disukai dari pada FI, FIII, dan FIV. Kata kunci : (HPMC), Kalsium Laktat, Tablet Kunyah ABSTRACT Various formulations of the calcium lactate chewable tablets have been done by wet granulation method using HPMC (Hydroxypropyl Methyl Cellulose) as a binding agent. Here, four formulations (FI, FII, FIII, and FIV) were prepared by adding different concentrations of binding agent, it was 1%, 2%, 3%, and 4%. Granules of chewable tablets were qualified based on evaluations for parameters such as organoleptic, water content, flowrate, angle of repose, real density, tapped density, bulk density, Hausner’s ratio, and compressibility index. Chewable tablets evaluations for organoleptic, weight variation, hardness, friability, and determinations of calcium lactate content were within the acceptance criteria, but not for its size variation. The result of panelists test of the four formulations by using Kruskal-Wallis method statistically which in terms of taste obtained FII is preferred than FI, FIII, and FIV. Keywords : HPMC, calsium lactate, tablets

EVALUASI PENGGUNAAN OBAT PADA PASIEN OSTEOARTRITIS DI INSTALASI RAWAT JALAN RSUD DR. M. ASHARI PEMALANG PERIODE MARET-APRIL 2018 Fithri Zahara S; Ebta Narasukma A; Maria Caecilia N.S.H
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Osteoarthritis (OA) is a degenerative joint illness characterized by cartilage destruction and often found on older people. The drugs commonly used to treat OA symptoms is paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), food supplements such as glucosamine and chondroitin. The purposes of these studies are identifying the OA patient's characteristics (including gender and age), drug use evaluation based on the right patient, indication, and dose, as well as the potency of drug interactions on OA patients. This research is non-experimental research with a non-analytical descriptive design. The data was collected retrospectively with a purposive sampling method from outpatients OA medical records in RSUD Dr. M. Ashari Pemalang (March to April 2018 period). The results of this study indicate that patients have suffered OA for 1-2 years (40%), generally women (72.94%) with an age range of 46-55 years (39%). Most patients have an elementary school educational background (41%), and 43.53% of them are overweight (BMI 25.00-29.99). All medicines prescribed for OA patient therapy have been the right indication and patient. As many as 80.95% of the prescribed medicines had the right dose, and 19.05% of prescription drugs case categorized as underdosing. Drug interactions potency occurs in 30.58% of patients, with 29 cases. Keywords: Osteoarthritis, drugs use evaluation, outpatient

AKTIVITAS MUKOLITIK EKSTRAK DAUN ILER (Coleus atropurpureus [L.] benth.) SECARA IN VITRO Sulastri Herdaningsih; Dian Kartikasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Cough is a protective physiological mechanism to stimulate and cleanse the respiratory system of foreign objects that can cause infection. Traditional cough treatment is preferred because of the relatively low side ffects compared tochemical drugs. In some areas, Iler leaves are used as cough medicine. The purpose of this study was to determine the mucolytic activity of ethanol extract of Iler leaves on duck egg white which was added to the test solution every 15 minutes, namely at minutes 0,15,30,45, and 60. Viscosity measurements were carried out in the positive control group, negative control group, 3% group, 4,5% group and 6% group. The results obtained showed that Iler leaves extract was able to significantly reduce the viscosity of duck egg whites compare to the negative control. The ethanol extract of Iler leaves has mucolytic activity against duct egg white in vitro at a concetnration range of 3-6%.

EFEK ANTIDIARE EKSTRAK ETANOL DAUN PARIJOTO (Medinilla speciosa Blume) PADA MENCIT JANTAN GALUR BALB/C Yance Anas; Desi Rakhmawati; Layyinatul Fuadah; Nola Carina Rahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTParijoto is one of a rare plant species in Indonesia, and its leaves have traditionally been utilized to treat diarrhea in the area of Kudus Regency, Indonesia. Parijoto leaves contain active compounds of tannin and flavonoid which have antidiarrheal properties. This investigation intends to demonstrate the antidiarrheal effect of parijoto leaf ethanol extract (EEDP) on male Balb/C mice castor oil-induced diarrheal and reveal its antidiarrheal mechanism through antimotility and antisecretory testing. EEDP made by maceration method. The antidiarrheal effects of three series level EEDP (500; 1,000 and 2,000) mg / Kg BB tested on diarrhea mice induced by castor oil. Concurrently, the antimotility and antisecretory effects of EEDP investigated with the intestinal transit method and castor oil-induced enteropooling. The data in this study were the onset of diarrhea, the weight of liquid-formless stools (for 8 hours), the ratio of digestion tracts passed by norit markers, and the volume of intestinal contents. These data were analyzed statistically at the 95% confidence level. The examination presumed that EEDP was able to respite the onset of diarrhea and diminish the formation of liquid-formless feces in male Balb/C mice induced by castor oil. The antidiarrheal mechanism of EEDP also exhibited in this study through its effects as antimotility and antisecretory.Keywords: Parijoto leaf ethanol extract, antidiarrheal, antimotility, antisecretory

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