cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kab. bantul,
Daerah istimewa yogyakarta
INDONESIA
Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 10 Documents
 1 
Search results for , issue "Vol 22, No 1 (2022): January" : 10 Documents clear
The Role of Family Function and Support to Nutritional Status in Autistic Children Muhammad Khotibuddin; Riska Shellia
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.11598

Abstract

The role of the family is substantial in determining the nutritional status of children. However, not many studies have revealed this role in autistic children in Indonesia. This study aims to assess the role of family function and family support for the nutritional status of autistic children in Yogyakarta. This study used a cross-sectional design to observe at least 14 children divided into three groups: autistic-overweight, autistic-normal, and non-autistic-normal. The APGAR score measured the family function, while family support was measured by a questionnaire consisting of 5 aspects: information, respect, instrumental, emotional, and social. The difference test between the three groups used the Anova test. Total family support in the autistic-overweight group (73.17±4.45) was lower than autistic-normal (80.6±3.36) and non-autistic (78.33±3.21). This difference was significant between autistic-overweight and autistic-normal (p 0.022), but not with the non-autistic group. Furthermore, there was no difference in family function (APGAR score) between the three study groups. There was less family support among autistic-overweight children.
Hyperlipidemia Diet Reduces Superoxide Dismutase Inhibition Rate in the Brain Organ of Rattus norvegicus Muhammad Luthfi Adnan; Miranti Dewi Pramaningtyas; Dini Islamiana; Hilmi Ardian Sudarto
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.8167

Abstract

Quail (Coturnix coturnix japonica L.) egg yolk is one of the high-fat foods which can trigger hyperlipidemia. The condition of hyperlipidemia can have an oxidative stress effect on the brain. Superoxide dismutase (SOD) is a natural antioxidant that acts as a defense mechanism against oxidative stress. The inhibition rate of SOD decreases when oxidative stress occurs. This study aims to determine the effect of quail egg yolk on the SOD inhibition rate of brain organs on a rat. This study used male Wistar rats aged 2-3 months with 200-300 grams of weight. The rats were divided into two groups. Each group was fed with ad libitum for two weeks. The A groups as control continued ad libitum consumption, and the B group was given additional quail egg yolk 5 ml / 200 g BW for 2 weeks. At the end of the study, the rats were terminated. The brain organs were examined for SOD inhibition rate with spectrophotometry. The mean SOD inhibition rate in the A and B groups was 74.14% ± 6.16 and 24.14% ± 5.65, respectively. The independent t-test showed significant differences in SOD inhibition rate between groups (p 0.001). Furthermore, quail egg yolk significantly reduced the SOD inhibition rate in the brain organ of the rat.
Anticoagulant Therapy in Moderate to Severe COVID-19 Patients Achmad, Agus Fitriyanto; Raharjani, Yuni Iswati; Setyaningrum, Zidni; Pramono, Bagus Andi; Selvyana, Dita Ria; Negoro, Sri Pramesthi Wisnu Bowo
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.11634

Abstract

Coronavirus disease-19 (COVID-19) has a spectrum of severity from no symptoms to serious complications. Coagulopathy is a serious complication of COVID-19, and that condition is a marker of poor prognosis. Anticoagulant drugs are often used as prophylaxis and thrombosis therapy to treat COVID-19 patients. Anticoagulant therapy is indicated for moderate-severe COVID-19 patients. Low molecular weight heparin (LMWH) and Unfractionated Heparin (UFH) are anticoagulant drugs of choice for prophylaxis and thrombosis therapy in COVID-19 patients. When administering anticoagulant drugs, monitoring bleeding, renal function, and platelet count needs to be done, even if only as thromboprophylaxis. LMWH and UFH have good clinical efficacy with minimal side effects in managing COVID-19 patients.
Correlation between Head Computed Tomography Scan Examination and Cranial Index Measurement in Pediatric Hydrocephalus Zulfariska, Nony; Anandasari, Pande Putu Yuli; Margiani, Ni Nyoman; Sitanggang, Firman Parulian; Patriawan, Putu; Widiana, I Gde Raka
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.12464

Abstract

Hydrocephalus in children can inhibit child growth. However, if treated immediately, the patient will develop normal intelligence. In radiology, the most important problem is to detect hydrocephalus early. Currently, radiology examinations can detect hydrocephalus accurately with a CT scan to identify the presence of blockages and assess the degree. Skull radiography is used to assess the presence of advanced hydrocephalus. A comparison is carried out and assesses the relationship between hydrocephalus measurement on the ventricular and cranial index by scanogram. The study used a cross-sectional analytics design, using Picture Archiving and Communication System (PACS) data. There were 68 samples taken using consecutive sampling, obtaining ventricular index measurement results above 0.30, and patients under 12 years old. Spearman rank test showed a correlation between the ventricular index measurements and cranial index, with Spearman’s Rho (r) = 0.856 and p0.001 with linear equation Y= 2.973 + 0.005X. It revealed that the constant 2.973 indicated that if there is no B coefficient value, the participation value will be 2.973. Furthermore, regression coefficient X of 0.005 indicated that the participation value grows by 0.005 for every 1 addition of the B coefficient value with R2= 0.340.
Effect of LMP-1 and mutant p53 on the Prognosis of Undifferentiated Type of Nasopharyngeal Carcinoma Atikah, Atikah; Sadhana, Udadi; Miranti, Ika Pawitra; Puspasari, Dik; Karlowee, Vega
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.13035

Abstract

Undifferentiated carcinoma is a subtype of NPC with a higher EBV antibody titer than healthy people. The carcinogenic effect of EBV involves LMP-1 associated with poor prognosis, and mutant p53 predicts tumor recurrence. This study aims to assess the effect of LMP-1 and mutant p53 on the prognosis of NPC patients. 40 paraffin blocks were stained with LMP-1 and p53 mutant. LMP-1 was positive when the cytoplasm and tumor cell membranes were brown, and mutant p53 was positive for the brown tumor cell nucleus. Pearson correlation test was performed. Most respondents were in the age group 40 years, males, regional lymph node involvement (N) in group N1, and no metastasis (M). The expression levels of LMP-1 and mutant p53 were strongly positive. The study showed the correlation between LMP-1 with age (p 0.327), gender (p 0.599), category N (p 0.512), category M (p 0.019) and the correlation between mutant p53 with age (p 0.329), gender (p 0.981), category N (p 0.013), category M (p 0.705). LMP-1 expression with mutant p53 (p 0.760). It can be concluded that LMP-1 and mutant p53 could be used as prognostic factors in NPC patients.
Social Environment of Friends, Family, Communities, and HIV/AIDS Cases Indri Lestari; Dyah Wulan Sumekar Rengganis Wardani; Jhons Fatriyadi Suwandi; Samsul Bakri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.12505

Abstract

Control of HIV/AIDS infection can be done by screening at-risk groups in the social environment to prevent transmission. This study aims to determine the social environment of friends, family, and society’s influence on HIV/AIDS incidence. The study was conducted in December 2020–January 2021 at six Bandar Lampung health centers. The 111 respondents were divided into case/reactive and control/non-reactive groups, with a 1:2 ratio (37:74). Data were obtained by interview. The independent variables were the social environment of friends, family, and community, while the dependent variable was HIV/AIDS incidence. The data were analyzed bivariate and multivariate with the Binary Logistics Regression test utilizing Minitab 16 application, with CI 90% and α 0.1 significance level. The results showed that friends with HIV’s social environment had p 0.087; friend's education p 0.542; risky behavior from friends p 0.853; friends with risky behavior p 0,172; HIV family social environment p 0.999; family education p 0.999; risky behavior from family p 0.998; families with risky behavior p 0.999; HIV community social environment p 0.999; public education p 0.330; risk behavior from the community p 0.690; community with risky behavior p 0.862. Thus, only friends with HIV’s social environment affected HIV/AIDS incidence. Furthermore, having friends with HIV’s social environment will increase the risk of getting HIV/AIDS.
The Anti-proliferative Ability of the Ethanol Extract of Annona muricata Leaves on Widr Cancer Cells Yoni Astuti; Agus Suharto; Sabtanti Harimurti; Wahyu Joko Priambodo
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.13345

Abstract

Soursop (Annona muricata) leaves are widely distributed in the tropics, including Indonesia. Soursop leaves are known to contain many anticancer compounds. Research from various countries using soursop leaves provides a different picture of the size of the dose. This research is qualitative research to determine the antiproliferative properties of soursop leaf alcohol extract on Widr cells as a model of colon cancer cells. The soursop leaves were provided from Medicinal Plant and Traditional Medicine Research and Development Center inTawangmangu. The thin-layer chromatography method was used to analyze the profile of soursop leaf extract. Microtetrazolium (MTT) proliferation test was used to analyze antiproliferative effects. The result showed that the essence quality of soursop leaves in aquoes solution was (20.65 ±0.07) % ; in ethanol solution was (19.22±0.34 ) %. The profile of ingredient soursop leaves was more visible in 366 than in 254. The ethanol extract of soursop leaves showed an antiproliferation effect at IC 50 at a dose 450 ug/ml. In conclusion, the ethanolic extract of Annona muricata showed antiproliferative properties at a dose of 450 ug/ml and having a half cell dose of IC 50.
Correlation between Lipid Profile and Kidney Function in Ambulatory Heart Failure Patient Sidhi Laksono Purwowiyoto; Hengkie Frankie Lasanudin; Budhi Setianto; Steven Philip Surya; Wincent Candra Diwirya
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v1i1.9969

Abstract

Heart failure contributes to a high number of hospitalizations. Currently, the number of outpatients is more dominant than hospitalized heart failure patients. Unfortunately, a study in the outpatient setting is still limited. This study aims to evaluate the correlation between lipid profile and kidney function in ambulatory heart failure patients. This study is a single-center cross-sectional study. Data were collected from August to September 2020. Data were extracted from 62 medical records of heart failure patients with ejection fraction 45%. Exclusion criteria were life-threatening comorbidity and patient with routine hemodialysis. Data were analyzed with Pearson or Spearman correlation test. Most of the heart failure patients in our outpatient clinic are elderly (60 years old) and male (58%). The researchers found positive correlation of total cholesterol (r 0.39; p 0.001) and triglyceride (r 0.59; p 0.001) to serum creatinine. On the other hand, LDL and blood cholesterol ratio negatively correlated with serum creatinine, r - 0.31; p 0.016; and r - 0.46; p 0.001; respectively. All of this analysis was statistically significant. It concluded that lipid profiles were correlated with kidney function in heart failure patients
Nanotechnology in Metformin Delivery: Fasting Blood Glucose and Neutrophil-Lymphocyte Ratio of Diabetic Rat Model David Pakaya; Laurents Christovel Iban Demen; Haerani Harun; Sarifuddin Anwar; Gabriella Bamba Ratih Lintin
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.13358

Abstract

Diabetes Mellitus (DM) is a chronic inflammatory disease characterized by hyperglycemia and increasing the neutrophil-lymphocyte ratio (NLR). Metformin has been widely used to treat hyperglycemia. Metformin nanoparticles can improve bioavailability and may reduce inflammation. This study aims to analyze the effectiveness of metformin nanoparticles delivery through fasting blood glucose (FGB) level and NLR in the diabetic rat model. This study used 16 white male Wistar rats, 8 weeks of age, and body weight (BW) 250-350 grams. The streptozotocin (STZ) 40 mg/kg BW were injected i.p. Rats were divided into 4 groups; K1: normal control; K2: negative control (diabetes model); K3: diabetes model treated with metformin 100mg/Kg BW; K4: diabetes model treated with nanoparticle metformin 100mg/kg BW. Blood analysis tests were conducted using the Pentra hematology analyzer. Data were analyzed using the Graphpad Prism program with the nonparametric Kruskal Wallis test. The K3 group showed a periodical decrease in FBG level from day 7 to day 28 by 122 ± 11.31 mg/dL, and the mean NLR value was 0.48 ± 0.3 x 103/uL. Group of K4 periodically decreased in FBG level, indicating that it was closer to normal than K3. The result showed that at day 28.79 ± 15.39 mg/dL, the mean NLR value slightly increased compared to the K3 group by 0.54 ± 0.3 x103/uL. The statistical tests showed a significant difference between the level of FBG (p 0.0089) but no significant difference in NLR (p 0.347). Metformin nanoparticles could decrease FBG levels and effectively reduce the NLR in the diabetic rat model.
Overview of Gadget Utilization and Its Effect on Growth and Development in Preschool Children Rini Andriani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v1i1.11435

Abstract

The gadget utilization among preschoolers in connection with technological advances is known to have positive and negative effects on growth and development. This study aims to identify the overview of gadget utilization and its effect on growth and development in preschool children. An analytic survey with a cross-sectional design was conducted by filling out questionnaires carried out by parents. The anthropometric measurements and developmental assessments were carried out using Indonesia Developmental Pre-screening Questionnaire (IDPQ). A hundred children and their parents participated in this study. It was found that 82% of parents lent their gadgets, and 89% taught their children to use gadgets. There were similarities in gadget utilization between parents and children, namely watching videos (73% and 90%) and communicating (92% and 40.4%). The duration of the gadget utilization by children was high, 3.7±2.2 hours/day. However, no significant correlation in the analysis between the duration of smartphone usage and nutritional status (p: 0.599). In children with different IDPQ values, there was no significant difference in the duration of device usage (p: 0.991). It can concluded the duration of the gadget utilization in children carried out by their parents did not affect the growth and development of the children.

Page 1 of 1 | Total Record : 10

 1 

Filter by Year

2021 2022


Reset
Filter By Issues
All Issue Vol. 25 No. 1 (2025): January Vol 24, No 2 (2024): July Vol 24, No 1 (2024): January Vol 23, No 2 (2023): July Vol 23, No 1 (2023): January Vol 22, No 2 (2022): July Vol 22, No 1 (2022): January Vol 21, No 2 (2021): July Vol 21, No 1 (2021): January Vol 21, No 1: January 2021 Vol 20, No 2: July 2020 Vol 20, No 2 (2020): July Vol 20, No 1: January 2020 Vol 20 No 1: January 2020 Vol 20, No 1 (2020): January Vol 19, No 2: July 2019 Vol 19, No 2 (2019): July Vol 19 No 2: July 2019 Vol 19, No 1 (2019): January Vol 19, No 1: January 2019 Vol 19 No 1: January 2019 Vol 18 No 2: July 2018 Vol 18, No 2: July 2018 Vol 18, No 2 (2018): July Vol 18, No 1: January 2018 Vol 18 No 1: January 2018 Vol 18, No 1 (2018): January Vol 17 No 2: July 2017 Vol 17, No 2: July 2017 Vol 17, No 2 (2017): July Vol 17, No 1: January 2017 Vol 17 No 1: January 2017 Vol 17, No 1 (2017): January Vol 16, No 2 (2016): July Vol 16 No 2: July 2016 Vol 16, No 2: July 2016 Vol 16 No 1: January 2016 Vol 16, No 1: January 2016 Vol 16, No 1 (2016): January Vol 15, No 2 (2015) Vol 15, No 2 (2015) Vol 15, No 2 (2015): July Vol 15, No 1 (2015): January Vol 15, No 1 (2015) Vol 15, No 1 (2015) Vol 14, No 2 (2014) Vol 14, No 2 (2014): July Vol 14, No 1 (2014): January Vol 14, No 1 (2014) Vol 14, No 1 (2014) Vol 13, No 3 (2013) Vol 13, No 3 (2013) Vol 13, No 2 (2013) Vol 13, No 2 (2013) Vol 13, No 1 (2013) Vol 13, No 1 (2013) Vol 12, No 3 (2012) Vol 12, No 3 (2012) Vol 12, No 2 (2012) Vol 12, No 2 (2012) Vol 12, No 1 (2012) Vol 12, No 1 (2012) Vol 11, No 3 (2011) Vol 11, No 3 (2011) Vol 11, No 2 (2011) Vol 11, No 2 (2011) Vol 11, No 1 (2011) Vol 11, No 1 (2011) Vol 10, No 2 (2010) Vol 10, No 2 (2010) Vol 10, No 1 (2010) Vol 10, No 1 (2010) Vol 9, No 2 (2009) Vol 9, No 2 (2009) Vol 9, No 2 (s) (2009) Vol 9, No 2 (s) (2009) Vol 9, No 1 (2009) Vol 9, No 1 (2009) Vol 9, No 1 (s) (2009) Vol 9, No 1 (s) (2009) Vol 8, No 2 (2008) Vol 8, No 2 (2008) Vol 8, No 2 (s) (2008): Oktober Vol 8, No 2 (s) (2008) Vol 8, No 2 (s) (2008): Juli Vol 8, No 1 (s) (2008) Vol 8, No 1(s) (2008): April Vol 8, No 1 (2008) Vol 8, No 1 (S) (2008): Januari Vol 8, No 1 (2008) Vol 8, No 1 (s) (2008): April Vol 7, No 2 (2007) Vol 7, No 2 (2007) Vol 7, No 2 (s) (2007): Oktober Vol 7, No 2 (s) (2007): Juli Vol 7, No 2 (s) (2007) Vol 7, No 1 (2007) Vol 7, No 1 (s) (2007) Vol 7, No 1 (2007) Vol 7, No 1 (s) (2007) Vol 6, No 2 (2006) Vol 6, No 2 (2006) Vol 6, No 1 (2006) Vol 6, No 1 (2006) Vol 5, No 2 (2005) Vol 5, No 2 (2005) Vol 5, No 1 (2005) Vol 5, No 1 (2005) Vol 4, No 2 (2004) Vol 4, No 2 (2004) Vol 4, No 1 (2004) Vol 4, No 1 (2004) Vol 3, No 2 (2003) Vol 3, No 2 (2003) Vol 3, No 1 (2003) Vol 3, No 1 (2003) Vol 2, No 2 (2002) Vol 2, No 2 (2002) Vol 2, No 1 (2002) Vol 2, No 1 (2002) Vol 1, No 2 (2001) Vol 1, No 2 (2001) More Issue