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Bioeksperimen: Jurnal Penelitian Biologi
Published by Universitas Muhammadiyah Surakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Education, Agriculture,
Agriculture, Biological Sciences & Forestry Education
Arjuna Subject : -
Articles 484 Documents
 38   39   40   41   42 
Uji Aktivitas Antibakteri Isolat Jamur Endofit Dari Daun Kemangi (Ocimum sanctum) Terhadap Bakteri Penyakit Infeksi Pada Kulit Hasanah, Uswatun; Pratiwi, Dahryana Tiwi
Bioeksperimen: Jurnal Penelitian Biologi Vol 8, No 2: September 2022
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v8i2.16708

Abstract

Penyakit infeksi merupakan salah satu permasalahan kesehatan di masyarakat yang tidak pernah dapat diatasi secara tuntas yang menjadi penyebab utama penyakit di daerah tropis seperti Indonesia. Penelitian ini bertujuan untuk mengetahui jumlah isolat yang ditemukan dari daun kemangi (Ocimum sanctum) yang memiliki daya hambat pertumbuhan pada bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Streptococcus pyogenes. Penelitian ini menggunakan metode eksperimental yaitu dengan menguji senyawa antibakteri yang dihasilkan oleh jamur endofit daun kemangi (Ocimum sanctum) terhadap bakteri Staphylococcus aureus, Staphylococcus epidermidis dan Streptococcus pyogenes. Metode yang digunakan untuk uji antibakteri adalah metode difusi yaitu menurut metode Kirby-Bauer dengan menggunakan kertas cakram kemudian diamati zona bening yang terbentuk dan diukur diameternya. Hasil aktivitas antibakteri isolat JEK 2 terhadap bakteri uji menunjukkan efek paling baik dalam menghambat bakteri uji yaitu pada Staphylococcus aureus sebesar 12, 85 mm yang dikategorikan kuat, pada Staphylococcus epidermidis sebesar 10,6 mm yang dikategorikan kuat, sedangkan Streptococcus pyogenes sebesar 11,75 mm dikategorikan kuat. Penelitian ini untuk memperoleh data ilmiah mengenai aktivitas antibakteri ekstrak daun kemangi sehingga penggunaannya dapat dipertanggung jawabkan secara ilmiah dan dapat menjadi dasar penggunaan untuk menemukan obat-obat baru yang berguna dalam kehidupan manusia.
Komposisi dan Struktur Komunitas Zooplankton di Danau Diatas, Sumatera Barat Setiawati, Sulis; Izmiarti, Izmiarti; Nofrita, Nofrita
Bioeksperimen: Jurnal Penelitian Biologi Vol 4, No 2: September 2018
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v4i2.6880

Abstract

Penelitian tentang komposisi dan struktur komunitas zooplankton pada di Danau Diatas, Solok Sumatera Barat telah dilakukan pada bulan April sampai September 2016. Penelitian ini bertujuan untuk mengetahui komposisi dan struktur komunitas zooplankton di Danau Diatas kabupaten Solok, Sumatera Barat. Penelitian ini menggunakan metoda Purposive Sampling di empat stasiun. Sampel Zooplankton diambil menggunakan pompa air Alkon dan planktonnet.  Zooplankton yang didapatkan 44 spesies dengan komposisi Protozoa 5 spesies, Rotifera 22 spesies, Cladocera 13 spesies, dan Copepoda 4 spesies. Kepadatan total 20683,58 ind/l. indeks diversitas di Danau Diatas yaitu berkisar 1,043 -1,45. Indeks equitabilitas berkisar 0,31-0,54. Berdasarkan strata indeks equitabilitas berkisar 0,42-0,52, dan komunitas antar stasiun relatif seragam dengan indeks similaritas 53,06-61,53%. Study of composition and community structure zooplankton of Diatas Lake, Solok District, West Sumatera, from April until September 2016. The purpose of this research was to know the composition and structure of zooplankton. The research was conducted by using Purposive Sampling method with four research station. the samples by using water pomp machine and plankton net. The result showed that zooplankton it was found 44 zooplankton species with composition of Protozoa 5 species, 22 species of Rotifers, 13 species of Cladocera, and 4 species Copepods. The population diversity average 1723,6 ind/l.  diversity index (H’) ranged from 1,04 – 1,45, Equitability index (E) ranged from 0,31-0,54, Sorensen Similarity index ranged from 53,06 – 61,53 %.  
Potential of Bioactive Compounds in Hepatotoxicity Using Primary Cell Culture Method: A Systematic Review Illahi, Angga Illahi Kurnia; Raihan, Afdhal; Petrovsky, Ivan; Maliza, Rita
Bioeksperimen: Jurnal Penelitian Biologi Vol 10, No 1: March 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v10i1.23548

Abstract

Hepatotoxicity is a condition characterized by liver cell damage caused by toxic chemicals. This article aims to explore the effects of compounds that contribute to mitigating hepatotoxicity, focusing on in vitro studies, particularly primary cell culture. In this systematic review, we conducted searches in the PubMed, Science Direct, and Google Scholar databases to find articles published between 2008 and 2022. Several active compounds were identified, including N-Benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl) piperazine (TFMPP), antimycin A, coenzyme Q (CoQ) substrates, the antioxidant Vitamin C, L-glutamine (Gln), Nimesulide, Luteolin, glutathione, angelica sinensis polysaccharide (ASP) from Angelica sinensis, ammonium glycyrrhizin (CAG) from Glycyrrhiza glabra, L-arginine, silymarin from Silybum marianum, and glucurolactone (GA). However, only six compounds were shown to have remedial and treatment effects on hepatotoxicity and utilized primary cell culture with MTT Assay. These six compounds are Luteolin, Glutathione (GSH), Angelica sinensis polysaccharide (ASP) from Angelica sinensis, Ammonium glycyrrhizin (CAG) from Glycyrrhiza glabra, Antimycin A (AA), and Glutamine (Gln). The mechanism of action of these compounds involves preventing further damage to liver cells and repairing cells that have already been damaged. In summary, these compounds play a significant role in addressing hepatotoxicity caused by toxic substances and drugs.
Tingkat Keanekaragaman Hewan Troblobionts pada Ekosistem Gua di Tajur Bogor Jawa Barat Marhento, Giry; Alamsyah, Mashudi
Bioeksperimen: Jurnal Penelitian Biologi Vol 6, No 1: March 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v6i1.10429

Abstract

The purpose of this study was to determine the level of diversity of Troglobionts animals, species composition, species dominance, and uniformity in the Cave of Tajur Bogor, West Java. The variables in this study consisted of survey methods by calculating diversity, dominance, uniformity, and species composition to find out what types of animals are in the ecosystem of the cave. Based on the results of research on animal species found there were 10 species of biota belonging to 3 transects with a total of 88 species of cavernous biota. The sample in this study used the 10x10 M line transect method three times in different places. Determination of line transect measurements in this study is based on differences in the environmental zone at the outermost point or cave line which is the starting point of line transect measurement. The results of statistical calculations are obtained as follows: diversity biota index (H ') in the range of 0.4168-0.9684, the index of species composition (P) ranges between 0.2386-0.3861, the uniformity index (E) range between 0,4304-1, and the dominance of type (C) ranges between 5,2118-5,2118. Based on the calculation of diversity, composition, uniformity, and dominance of the type of biota in the area of Tajur Bogor, West Java, at the low-moderate level. Overall the types of biota found in this study were 3 transects, generally producing different amounts during the study, the total biota species found in the cave consisted of 88 individuals from 14 families and 14 species while the highest composition of biota types in transect III where of the 34 species found throughout the transect, 33 were in the second transect and the lowest was in transect I with only 21 species.
Inventarisasi Tanaman Buah Di Kawasan Taman Buah Kebun Raya Liwa Chrisnawati, Lili; Putri, Ayu Sasqia; Haryanto, Haryanto
Bioeksperimen: Jurnal Penelitian Biologi Vol 7, No 1: March 2021
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v7i1.10808

Abstract

The Liwa Botanical Garden is one of the new botanical gardens in the Southern Sumatra. Data accuracy is needed in supporting the function of the Liwa Botanical Garden as an ex-situ conservation center. This study aims to obtain data on the diversity of fruit trees in the Liwa Botanical Garden. The inventory results show there are 12 tribes and 15 species of fruit trees, with a total of 572 specimens. The predominant genus is Myrtaceae (46%) and the species most commonly found is Psidium guava L. (25%). Kebun Raya Liwa adalah salah satu kebun raya baru di kawasan Sumatera Bagian Selatan. Akurasi data diperlukan dalam menunjang fungsi Kebun Raya Liwa sebagai pusat konservasi ex-situ. Studi ini bertujuan untuk memperoleh data keanekaragaman tanaman buah di kawasan taman buah Kebun Raya Liwa. Hasil inventarisasi menunjukkan terdapat 12 suku dan 15 jenis tanaman buah, dengan total keseluruhan mencapai 572 spesimen. Suku yang mendominasi adalah Myrtaceae (46%) dan jenis yang banyak ditemukan adalah Psidium gujava L. (25%).
Uji Daya Hambat Pertumbuhan Mikroba Patogen Oleh Streptomyces sp. strain i18 Sebagai Agen Biokontrol Miranda AR, Mesy
Bioeksperimen: Jurnal Penelitian Biologi Vol 8, No 2: September 2022
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v8i2.15609

Abstract

Penyakit yang disebabkan oleh mikroba patogen telah menginfeksi makhluk hidup seperti manusia, hewan, dan tanaman. Hal ini memberikan dampak negatif bagi kesehatan manusia dan menurunkan kualitas produksi di bidang pertanian. Agen biokontrol dapat digunakan untuk mencegah infeksi yang aman dan ramah lingkungan. Penelitian ini bertujuan untuk mengetahui potensi dari bakteri Streptomyces sp. strain i18 sebagai agen biokontrol dalam menghambat pertumbuhan mikroorganisme patogen seperti Candida sp., Fusarium oxysporum, Aspergillus sp., Erwinia sp., dan Eschericia coli. Pengujian antagonis menggunakan metode swab dengan menumbuhkan bakteri patogen pada permukaan atas media Mueller Hinton Agar (MHA), kemudian Streptomyces sp. strain i18  di titik pada bagian tengah media. Indikator yang diamati adalah zona jernih yang terbentuk disekitar koloni bakteri. Hasil penelitian ini menunjukan bahwa Streptomyces sp. strain i18 memiliki aktivitas yang kuat dalam menghambat Erwinia sp. sebesar 18,33 mm, kemudian diikuti Fusarium oxysporum sebesar 17,00 mm, dan Aspergillus sp. sebesar 15,00 mm namun dikatagorikan lemah dalam menghambat pertumbuhan Candida sp. sebesar 3,33 mm. Hasil penelitian ini juga menunjukan bahwa Streptomyces sp. strain i18 tidak dapat menghambat pertumbuhan dari Eschericia coli. Bakteri Streptomyces sp. strain i18 berpotensi dijadikan agen biokontrol pertumbuhan bakteri maupun jamur patogen.
TREN GENETIK PERTUMBUHAN ANTAR POPULASI Hibiscus macrophyllus Roxb.Ex Hornem DI JAWA Susanto, Mudji; Mashudi, Mashudi
Bioeksperimen: Jurnal Penelitian Biologi Vol 4, No 1: March 2018
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v4i1.5926

Abstract

Penelitian ditujukan untuk memperoleh tren genetik pertumbuhan Hibiscus macrophyllus dari beberapa populasi pada tingkat semai. Penelitian menggunakan materia genetik dari 7 populasi atau provenans di Pulau Jawa. Rancanganpenelitian menggunakan Rancangan Acak Komplet Blok dengan menguji 112 famili perkawinan terbuka dari 7 provenans dari Pulau Jawa (Cipatujah, Tasikmalaya; Ciguha-Pagerageng, Tasikmalaya; and Pamarican, Banjar Patroman, Ciamis; Samigaluh, Kulon Progo, Yogyakarta; Banyuasin, Purworejo, Jawa Tengah; Sumberwrigin, Bondowoso, Jawa Timur; and Senduro, Lumajang, Jawa Timur). Hasil penelitian menunjukkan bahwa semua populasi yang diteliti memperlihatkan tren pertumbuhan yang hampir sama. Hertabilitas individu pertumbuhan sangat berfltuasi mulai umur 0,5 bulan sampai dengan umur 2,5 bulan. Estimasi heritabilitas indvidu untuk tinggi semai tergolong tinggi (h2i=0.53) pada umur 2,5 bulan di persemaian. Keragaman genetik pertumbuhan antar populasi maupun antar famili di dalam populasi sangat signifian.
Identification of Anti-Cancer Compounds in Medicinal Plants Using Metabolomic Approaches: A Review Magfiroh, Yani
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 2: September 2023
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v9i2.23017

Abstract

The modern lifestyle despite its comfort has made cancer a second leading public health problem, following cardiovascular disease. As chemotherapeutic has many side effects including resistance, recent attention has focused on plants which may provide a good opportunity for complementary cancer treatment. Several studies have begun to focus on metabolomic research in order to discover the mechanisms of action of diverse medicinal plants, investigate biomarkers, and comprehend cancer progression at metabolic rates. This study aims to analyze and highlight related metabolomic investigations in medicinal plants that demonstrate the potential of biomarker compounds and their processes in cancer disease. The research methodology uses a literature review that is compiled from many connected journals. According to the findings, bioactive substances present in medicinal plants can be used as biomarkers to disrupt the metabolism of enzymes, transporters, and signaling pathways in cancer cells. Utilized analytical platforms include HPLC, GC-MS, FTIR and NMR. Statistical analysis employs the Anova, PCA, and OPLS-DA methods. Finally, we reviewed biomarkers of medicinal plants and metabolomic pathways, with the result that anticancer compounds may exert their activity by various methods affecting DNA replication, cell cycle, migration and apoptosis.
Optimasi Metode 1H-NMR Profiling pada Rimpang Kunyit (Curcuma domestica) Dwiseptianti, Caroline; Susanto, Febri Adi; Purwestri, Yekti Asih; Nuringtyas, Tri Rini
Bioeksperimen: Jurnal Penelitian Biologi Vol 5, No 2: September 2019
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v5i2.9238

Abstract

The use of medicinal plants is increasing due to the lack of side effects caused and the number of bioactive compounds that cannot be represented by synthetic chemical synthesis compounds. However, the management and use of natural medicines for the main handling of diseases are often hampered by the quality of the ingredients which are low and unstable. The standardized quality control system of OAI (Indonesian Natural Medicine) is the main key to improve clinical assurance and safety of the use of herbal medicines in Indonesia. One of the medicinal plants known to the public is Curcuma longa L. (turmeric). The main active components contained in turmeric are curcumin, demetoksikurkumin, bis-demetoksikurkumin, and ar-turmeron. Information about the quality of turmeric is needed in its use as a raw material for drugs so we need an analytical technique that is able to identify the diversity of metabolite profiles of active compounds. In this research, an optimization method is used to improve efficiency in the extraction of turmeric rhizome metabolites so that the best solvent concentration is known for the analysis of fingerprinting secondary metabolites with 1H-NMR 500 MHz spectroscopy in turmeric rhizomes. The results were analyzed with MNOVA software and chemical shift obtained compared with the reference. From the results obtained a concentration of methanol-d4 (CD3OD) 100% able to extract curcumin better than other solvents. The solvent is able to extract saccharide (sugar) compounds in the form of sucrose, amino acids and fatty acids in the form of methionine, glutamine, acetate, and glycero phospho choline.
KAJIAN JENIS POHON DALAM PENGEMBANGAN HUTAN KOTA KIBITAY SUKABUMI Suhendar, Suhendar; Ramdhan, Billyardi; Triana, Ardika Eri
Bioeksperimen: Jurnal Penelitian Biologi Vol 6, No 2: September 2020
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v6i2.8609

Abstract

Penelitian  ini dilakukan untuk menginventarisir jenis tumbuhan, mengetahui struktur dan komposisi vegetasi tumbuhan, menganalisis kesesuaian vegetasi tumbuhan, menduga keanekaragaman jenis serta merekomendasikan jenis-jenis pohon potensial untuk ditanam di Hutan Kota Kibitay Sukabumi. Survey dilakukan untuk mengetahui jenis-jenis pohon dan analisis vegetasi dilakukan untuk mengetahui struktur dan komposisi jenis. Hasil survey menunjukkan bahwa jumlah tumbuhan yang ditemui sebanyak 73 jenis dan 17 jenis diantaranya ditemukan dalam petak contoh seluas 1600 m2. Hasil perhitungan Indeks Nilai Penting (INP) menunjukkan jenis yang mendominasi di tingkat semai yaitu jenis Mimosa pudica dengan INP sebesar 0.75% dan sebagai spesies kodominan yaitu dari spesies Calliandra haematocephala dengan INP sebesar 0.5. Jenis vegetasi yang mendominasi di tingkat pancang yaitu Nephelium lappaceum dengan INP 1.533%. Spesies yang mendominasi pada vegetasi tingkat tiang yaitu Swietenia mahagoni dan Agathis dammara dengan masing-masing INP yaitu sebesar 1.711 dan 1.127%, sedangkan spesies yang mendominasi di tingkat pohon yaitu Agathis dammara dengan INP sebesar 2.47%. Hasil perhitungan Indeks Keanekaragaman Jenis (H’) Shannon-Wienner sebesar 4.71. Secara umum jenis-jenis pohon Hutan Kota Kibitay Sukabumi tergolong cukup sesuai dengan nilai rata-rata 60,232 yang terdiri atas 13 jenis pohon dengan kriteria sesuai, 22 jenis pohon dengan kriteria cukup sesuai dan 25 jenis pohon dengan kriteria tidak sesuai.

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