cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
pharmacon@ums.ac.id
Editorial Address
Jl. A. Yani 1 Pabelan Kartasura Surakarta 57162 INDONESIA
Location
Kota surakarta,
Jawa tengah
INDONESIA
Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
Arjuna Subject : -
Articles 345 Documents
 10   11   12   13   14 
COST OF ILLNESS DIABETES MELITUS TIPE 2 DAN KOMPLIKASINYA PADA PESERTA JAMINAN KESEHATAN NASIONAL (JKN) DI RAWAT JALAN RUMAH SAKIT CONDONG CATUR YOGYAKARTA Putri, Rr. Erni Kusuma; Darmawan, Endang; Perwitasari, Dyah Aryani
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.8915

Abstract

Type 2 diabetes mellitus is a chronic disease that requires lifelong therapy and high service costs so that the use of antidiabetic drugs affects the patient's therapeutic costs. The purpose of this study was to determine the cost of outpatient type 2 diabetes mellitus therapy for National Health Insurance (JKN) participants in Condong Catur Hospital Yogyakarta. The research method used is observational. The parameters measured are calculating the average direct medical costs (drug costs, doctor's examination and consultation fees, laboratory costs, medical treatment costs), and comparison between the costs of oral drugs, insulin, oral and insulin. The results of normality tests with Shapiro-Wilk (microvascular, microvascular and macrovascular), Kolmogorrov-Smirnov (macrovascular) p<0.05 indicate that data are not normally distributed, the results of the Kruskal Wallis test of the three groups (microvascular, macrovascular, microvascular and microvascular) show that differences are not normally distributed significant (p = 0.001).The results showed that the microvascular group therapy costs Rp 3,164,733.58 per month, the macrovascular group Rp 9,984,566.85 per month, the microvascular and macrovascular groups Rp 11,260,372.39 per month. The cost of therapy is based on the microvascular group drug Rp. 408,567.78 per month, the macrovascular group Rp. 1,245,987.48 per month, the microvascular and macrovascular groups Rp. 1,786,270.68 per month so that statistically from the three complications groups show significant differences p = 0,001 (p <0,005). The difference in the difference between the total real costs and the total INA-CBG's rates, the microvascular group Rp -38,741.14 per patient, the macrovascular group Rp -10,914.03 per patient, while in the microvascular and macrovascular group Rp 3,272.90 per patient shows that from to three groups of complications were not significantly different p = 0.207 (p> 0.005). Statistically it can be concluded that the cost of therapy based on antidiabetic drugs in the three groups of complications shows a significant difference. There is no significant difference in the difference between the real costs in the three groups of complications
HASIL SKRINING AKTIVITAS SITOTOKSIK EKSTRAK ETANOL DAUN KELENGKENG (DIMOCARPUS LONGAN), DAUN KERSEN (MUNTINGIA CALABURA), DAN DAUN ALPUKAT (PERSEA AMERICANA) TERHADAP SEL T47D DAN WIDR Yuliani, Ratna; Santoso, Broto; Permatasani, Bella; Sari, Diah Mukti
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9050

Abstract

Cancer treatments usually cause adverse drug reactions. Therefore, safe anticancer drugs are needed in the treatment of cancer. One source of medicine that can be explored is plant. Extracts of longan leaves (Dimocarpus longan), jamaican cherry leaves (Muntingia calabura), and avocado leaves (Persea americana) have been tested for cytotoxic activity against several cancer cell lines. This study aims to determine the cytotoxic activity of ethanolic extract of longan leaves, jamaican cherry leaves, and avocado leaves against T47D and WiDr cells and to identify secondary metabolites in the extracts which have the highest activity. Ethanolic extract of longan leaves, jamaican cherry leaves, and avocado leaves were tested for their cytotoxic activity using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Identification of secondary metabolites in the ethanolic extract of avocado leaves was carried out by thin layer chromatography method using silica gel GF254 as the stationary phase and a mixture of n-hexane and acetone (6:4) as the mobile phase. Cytotoxic test results show that ethanolic extract of longan leaves and cherry leaves with concentration of up to 1600 ?g/mL do not reduce the T47D and WiDr living cells to 50%. Avocado leaf extract decreases the percentage of living T47D cells and WiDr with IC50 values of  790.679 µg/mL and 1072.2 µg/mL, respectively. The ethanolic extract of avocado leaves contains flavonoid, phenolic, and terpenoid. Ethanolic extract of longan leaves, cherry leaves and avocado leaves do not have cytotoxic activity against T47D and WiDr cells.
FRONT MATTERS VOL 16 NO 2 (2019) Vol 16 No 2, Front Matters
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9785

Abstract

ISOLASI DAN KARAKTERISASI SELULOSA MIKROKRISTAL DARI AMPAS TEBU (SACCHARUM OFFICINARUM L.) Nawangsari, Desy
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9150

Abstract

Microcrystalline cellulose is the result of isolation from alpha cellulose. Woody plants are generally the source of microcrystalline cellulose production. One of the natural ingredients that can be used to make microcrystalline cellulose is bagasse (Saccharum officinarum L.). Bagasse contains 37.65% of cellulose which can be isolated by the delignification stage using a base solution, the process of bleaching and hydrolysis of alpha cellulose by high temperature heating using dilute dilute acid. The yield of microcrystalline cellulose from bagasse 26.03% and fulfilling the characterization based on the literature.
FRONT MATTERS VOL.17 NO.1 Wikantyasning, Erindyah Retno
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.11492

Abstract

PENGGUNAAN OBAT OFF-LABEL DAN UNLICENSED PADA BAYI DAN NEONATUS DI BANGSAL ANAK Cholisoh, Zakky; Rohmah, Siti Alfiatur
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10828

Abstract

The prescription of medications outside the listed marketing authorizations (MA) is considered off-label. This practice is still frequently occurs in clinical practice. One of the reasons is because the lack of clinical trials and research in babies and neonates. This study was conducted to evaluate the off-label and unlicensed medications, their level of use and further describe the level of evidence of the commonly prescribed off-label and unlicensed medication in this population. Medications prescription and administration to hospitalised babies and neonates were recorded. Medication record data in a year were collected. Medication- licensing status of all drugs administered was determined according to marketing authorization information from monograph. The data then were categorised as off-label and unlicensed if the indication, dosage regimens, age category, and route of administration were not listed in the market authorization of the products. Furthermore the administrations of the most commonly used off-label medications were reviewed based on published journal articles to determine their level of evidence. Total medications administered during a year were 2,576 which were obtained from 139 patients. Of all, 15.25% (339) and 2.69% (69) medications administered were categorised as off-label and unlicensed respectively. Off-label of dosage regimens and route of administration were not identified, but 1.63% (42) medications were used for indications that were not listed in the (MA), and 13,63% (351) were prescribed out of age category of the listed marketing authorization. Off-label drug that often prescribed are salbutamol which had no evidence to support its use; valproic acid which had high level of evidence against its use on baby and neonates; and ondancetron which had high level of evidence to be used outside its marketing authorization.
EFEK PEMBERIAN EKSTRAK ETANOL BUAH ADAS (FOENICULLUM VULGARE MILL.) TERHADAP KADAR HORMON PROLAKTIN TIKUS PUTIH BETINA POST PARTUM Abdul, Ahwan; Safitri, Fridah Wahyu; Purbowati, Rantika
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9245

Abstract

Fennel plants are plants that have various traditional properties, such as facilitating breast milk or lactagogum. The aim of this research was to give ethanol extract of fennel fruit to increase the level of the hormone prolactin in lactating mice, so that the milk produced was increased. Subjects consisted of 12 postpartum female rats, divided into 1 control group (1% CMC Na) and 3 treatment groups (doses of 100, 500 and 1000 mg / Kg BW). Fennel fruit extract was given orally for each group for 14 days, after the treatment of blood samples were taken and centrifuged, the serum was read by Elisa Reader. The data obtained were analyzed using the Kolmogorov-Smirnov test, one-way ANAVA and Tukey's Multiple Comparison (post hoc test). Fennel fruit extract given from a dose of 100; 500 and 1000 mg / kg BW can significantly increase levels of the hormone prolactin (p 0.05) in nursing mice, respectively by 42.11; 44.26 and 43.83 ng / mL compared to controls (32.64 ng/mL).
Deteksi Asam Mefenamat pada Jamu Pegel Linu yang beredar di Wilayah Pekalongan Rusmalina, Siska; Khasanah, Kharismatul; Nugroho, Denny Kurniawan
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10111

Abstract

Jamu Pegel Linu is one of the most popular herbs in Indonesia and oftenly the producers added medicinal chemicals (BKO) so that the resulting therapeutic effect is more effective. One of the BKO added is mefenamic acid. The added content of mefenamic acid can cause harmful side effects such as seizures and can even cause coma. This study aimed to detect the BKO content of mefenamic acid in Jamu Pegel Linu distributed in Pekalongan region. This research was a descriptive study with purposive sampling. The sample used was all Jamu pegel linu that were distributing in Pekalongan region that were included the inclusion and exclusion criteria. The analytical method used is Thin Layer Chromatography (TLC) with a mobile phase in the form of ethyl acetate: methanol: ammonia (80:10:10). Spotting detection was carried out under UV light at λ 254 nm. The results of the spots obtained were compared with a comparison standard. To ensure the results obtained are confirmed using the color reaction method. The results of testing of 27 samples by TLC method obtained there are 3 (three) samples of herbal medicine giving positive results indicated by the similarity of rf values with comparative standards. The results obtained were tested qualitatively with color reagents to strengthen the results.
FORMULASI DAN EVALUASI SEDIAAN TABLET NANOPARTIKEL EKSTRAK DAUN SALAM (SYZYGIUM POLYANTHUM) DENGAN VARIASI KONSENTRASI NA ALGINAT DAN AVICEL PH 102 Setiawan, Agung; Kiromah, Naelaz Zukhruf Wakhidatul; Widiastuti, Tri Cahyani
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10107

Abstract

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using  ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into  technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.
Efek Nefroprotektif Ekstrak Etanol Bawang Putih (Allium sativum L.) pada Tikus yang Diinduksi Gentamisin Sujono, Tanti Azizah; Rizki, Fanny Atika
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10510

Abstract

Gentamicin can induce damage to the kidney because of the accumulation of epithelial cells in the cortex. This accumulation can cause an increase in Reactive Oxygen Species (ROS), which in turn can trigger an increase in free radicals which causes a decrease in kidney function, which can be seen with Blood Urea Nitrogen (BUN) and sCr (serum creatinine) parameters. Garlic (Allium sativum L.) contains several bioactive compounds, including alliin, allisin, ajoene, and allil cysteine. The content of allisin has activity as an antioxidant. This study used a nephrotoxic mouse modelling method with 100 mg/kgBW of gentamicin induction intraperitoneally, then BUN and sCr levels were checked 24 hours after the 10th day induction. This study aimed to determine the effect of garlic ethanol extract in preventing the decline of renal function in rats induced by gentamicin with a parameter of BUN and sCr. The animal test were divided into 5 treatment groups, normal control group, negative controls, and three treatment groups at a dose of 50, 120, and 300 mg/kgBW for 10 days of concurrent treatment between extracts with gentamicin. The results of the study showed that garlic ethanol extract with a dose of  50, 120, 300 mg/kgBW was able to prevent a decrease  in kidney function due to the administration of gentamicin significantly when compared with negative controls (p 0,05).

Page 12 of 35 | Total Record : 345

 10   11   12   13   14 

Filter by Year

2010 2024


Reset
Filter By Issues
All Issue Vol 21, Special Issue 1, 2024 Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021 Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2012) Vol 13, No 2 (2012) Vol 13, No 1 (2012) Vol 13, No 1 (2012) Vol 12, No 2 (2011) Vol 12, No 2 (2011) Vol 12, No 1 (2011) Vol 12, No 1 (2011) Vol 11, No 2 (2010) Vol 11, No 2 (2010) Vol 11, No 1 (2010) Vol 11, No 1 (2010) Edisi Khusus: RAKERDA, SEMINAR, PID IAI More Issue