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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
Arjuna Subject : -
Articles 345 Documents
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POTENSI EKSTRAK ETANOL DAN FRAKSI-FRAKSINYA DARI TIGA VARIETAS JAHE SEBAGAI AGEN ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS Dianasari, Dewi; Puspitasari, Endah; Ningsih, Indah Yulia; Triatmoko, Bawon; Nasititi, Fauzia Ken
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ?emprit ginger (Zingiber officinale var. Amarum), ? gajah? ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 ?g (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Pola Pengobatan Antidiabetik Oral pada Pasien Diabetes Mellitus Tipe 2 Rawat Jalan di RSUD Kajen Pekalongan Muthoharoh, Ainun; Safitri, Wiga Arum; Pambudi, Dwi Bagus; Rahman, Fadila
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10841

Abstract

Diabetes mellitus is a chronic disease with long-term and routine treatment therapy. Combined or single oral antidiabetic therapy is given to be able to get normal and controlled blood sugar levels every month. The purpose of this study was to determine the treatment patterns in patients with type 2 diabetes mellitus outpatient at Kajen Regional Hospital in Pekalongan Regency. This study used an observational cross sectional approach which was conducted retrospectively. A total of 97 samples were taken from the medical records of type 2 diabetes mellitus patients who received oral antidiabetic drug therapy, who had routine medical treatment for 3 consecutive months in the Outpatient Installation of Kajen Regional Hospital in Pekalongan Regency for the period January-December 2017. Data analysis was conducted descriptively. The results of this study that patients with uncomplicated diabetes mellitus receive the most oral antidiabetic drugs with metformin, patients with diabetes mellitus with the most complications receive oral antidiabetic drugs pioglitazone and acarbose, and the type of drugs other than oral antidiabetics is aspilet. The need for special assessment of individual doses in patients with diabetes mellitus without or with pharmacokinetic and pharmacogenomic perspective complications
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 70% BUNGA TELANG (CLITORIA TERNATEA L) DARI DAERAH SLEMAN DENGAN METODE DPPH Andriani, Disa; Murtisiwi, Lusia
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9321

Abstract

Telang flower (Clitoria ternatea L.) contains phenolic compounds which can act as antioxidants by donating hydrogen so as to stabilize the lack of electrons in free radicals. This study aims to determine the antioxidant potential of telang flower ethanol extract by looking at the IC50 value. Telang flowers were extracted by maceration method using 70% ethanol solvent. The potential for antioxidants was determined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a comparison of vitamin C which had been shown to have the potential of free radicals which were very potent. The results showed the IC50 value of telang flower ethanol extract was 41.36 ± 1.191 ?g / mL, based on that value the telang flower extract from the Sleman area was in the very potent category so that it could be developed as a source of antioxidants from natural ingredients.
Optimalisasi Penggunaan Obat yang Bijak dalam Keluarga dengan Program Gema Cermat Mursiti, Handri; Embri, Galau Menanti; Prasanti, Ana; Maysha, Agnez; Rosvita, Vivin; Bashori, Yusuf Muamar; Farida, Yeni
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10106

Abstract

Self-medication practices has been widely reported in various developed and developing countries which is increasing globally so that it may potentially causes various problems. WHO emphasized that education and supervision of self-medication practices are needed. The Indonesian Ministry of Health has launched the “GeMaCerMat” program to encourage public awareness and understanding of proper drug uses. This study aims to analyzed the effect of GeMaCerMat's socialization on community knowledge and behavior about the correct use of drugs through a family approach. Survey research was conducted using questionnaire instruments and interview respondents. Respondents are Surakarta’s people in the fostered area of the Agent of GeMaCerMat (AoC) which is determined by purposive sampling. The results of the knowledge assessment before and after the intervention were compared and the differences were analyzed by paired t tests. Among 206 respondents involved,  the results show that the average respondent has very less knowledge (52.48). Posttest value indicates an increase in knowledge of the average respondent to 80.24 (good). GeMaCerMat's socialization influenced peoples’s knowledge that prooven by significant differences between pretest and postest (P=0,000; P 0,05).  Behavioral assessment shows that after socialization, the average respondent has good behavior (89.02%) in applying how to get drugs, use, store and dispose of drugs properly.
EVALUASI PENGGUNAAN ANTIBIOTIK PADA BALITA PENDERITA PNEUMONIA RAWAT INAP DI RSUD “Y” DI KOTA “X” TAHUN 2016 'Utsman, Panji; Karuniawati, Hidayah
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.5991

Abstract

Pneumonia was pulmonary lung disease called parenchyma caused by microorganism, Pneumonia can be cured byantibiotic to prevent the resistantof bacteria and to improve the effective of the treatment, the right antibiotic must be determining. This research purpose is to determine the accuracy of using antibiotic in toddler patients suffering pneumonia who hospitalized in RSUD ?Y? ?X? City, in 2016. This is nonexperimental research. Data collected retrospectively and was analized descriptively. Samplestaken by purposive sampling method which searched the medical report of toddler patient suffer pneumonia hospitalized in RSUD ?Y?X City, in 2016 which met the inclusion criteria. Reseach accuracy was analized used ?Pedoman Pelayanan Medis Ikatan Dokter Anak Indonesia year 2009? and ?British National Formularium for Children 2011-2012?, Such as indication accuracy, precision medicine accuracy, patient accuracy and drug dose accuracy. The result of the research was found that in 49 toddler patient suffering pneumonia, the kind of antibiotic used was cefotaxime (89,80%), Ampicillin (4,08%), combination of cefotaxime + gentamicin (4,08%) and ampicillin + gentamicin (2,04%). Evaluation of accuracy of the use antibiotic 100% right in indication, precision medicine by 93,87%,100% patient accuracy, and 10,20% drug dose accuracy.
Hubungan Tingkat Pengetahuan dan Sikap terhadap Kebiasaan Konsumsi Jamu pada Mayarakat Magelang Tahun 2019 Kusuma, Tiara Mega; Wulandari, Endaryanti; Widiyanto, Taufik; Kartika, Diah
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10857

Abstract

Jamu is a cultural heritage of Indonesia that needs to be preserved. Jamu is classified as traditional medicine which is widely used by the community as an alternative treatment, especially Magelang city’s. This study aims to show relationship between the level of knowledge and attitudes towards the consumption habits of jamu in the community of Magelang. This research is included in a quantitative descriptive study with cross sectional approach with random sampling techniques. Data were obtained by surveying through the distribution of questionnaires and analyzed using the chi-square test (X2) to see each effect of the level of knowledge or attitudes towards herbal consumption habits based on p-value, and logistic regression tests to see the OR (Odds Ratio). The level of knowledge and attitudes about herbal medicine has a significant influence on the consumption habits of herbs with p-values of 0.003 and 0,000 ( 0.005). Attitude is proven to have the highest chance to improve the consumption habits of routine herbal medicine (23,262x) compared to the level of knowledge (1,273x).
UJI AKTIVITAS ANTIINFLAMASI INFUSA DAUN AFRIKA (VERNONIA AMYGDALINA) PADA TIKUS PUTIH YANG DIINDUKSI KARAGENAN Setiani, Lusi Agus; Moerfiah, Moerfiah; Yulianita, Yulianita
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9322

Abstract

Inflammation is one of the immune system's main responses to infection and irritation. One of the medicinal plants that can be used as anti-inflammatory is African leaves because there have flavonoid compounds. Flavonoid compounds have anti-inflammatory effects that can regulate arachidonic acid metabolism by inhibiting cyclooxygenase (COX) and lipooxygenase activity.This study aims to determine the effectiveness and determine the effective dose of African leaf infusion as anti-inflammatory in sparague dawley strain  induced carrageenan male white rats. The method used is measurement of udema with subplantar 1% carrageenan induction.Test animals used were 20 male rats divided into 5 groups. Each group consisted of 4 rats. Group I as a negative control was given CMC-Na solution, the second group as a positive control was given diclofenac sodium with 1.26 mg/200 gBB body weight, group III, IV and V were given African leaf infusion with three dose ratings namely 100, 150, 200 mg/kgBB bodyweight. The results showed that the infusion of African leaves had Antiinflammatory Activity with dose 200 mg/kg body weight as the most effective dose against inhibition of inflammation.           
Aktivitas Antibakteri Ekstrak Etanol Daun Sukun (Artocarpus altilis) Terhadap Bakteri Staphylococcus aureus Dan Escherichia coli Fiana, Fuan Maharani; Kiromah, Naelaz Zukhruf Wakhidatul; Purwanti, Ery
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10108

Abstract

Diarrhea is caused by bacterial infections, especially Staphylococcus aureus and Escherichia coli. The breadfruit leaves (Artocarpus altilis) are known contain flavonoid compounds, alkaloids, saponins, and tannins which can be used as antibacterial. This research was conducted to determine the ethanol extract of the breadfruit leaves against Staphylococcus aureus and Escherichia coli bacteria. The manufacture of the breadfruit leaf extract was using a maceration method with 96% ethanol solvent. The result of the tube test and the TLC test was positive, the breadfruit leaf extract containing flavonoids and tannins which have potential as antibacterial. The antibacterial test was carried out using the disc diffusion method (Kirby-Bauer test) against Staphylococcus aureus and Escherichia coli bacteria incubated for 1 x 24 hours. The extract concentrations tested were 10%, 15% and 20%. The positive control was using erythromycin antibiotics and the negative control was using aquades. The identification of the chemical content of plants is done by tube test and the TLC test. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Staphylococcus aureus bacteria, the average diameter of inhibitory zones respectively were 3.67, 3.50 and 2.67 mm with the positive control diameter of inhibition zone was 18.5 mm, the negative control diameter of inhibition zone was 0 mm. The results of incubation of the breadfruit leaf extract with concentrations of 10%, 15% and 20% against Escherichia coli bacteria, the average diameter of inhibitory zones respectively were 5.33, 3.17 and 3.33 mm with the positive control inhibition zone diameter of 28.5 mm and the negative control of inhibition zone diameter of 0 mm. The activity of ethanol extract of the breadfruit leaves against the Staphylococcus aureus and Escherichia coli bacteria is included in the weak category.
ETHANOLIC EXTRACT OF PAPAYA LEAVES (CARICA PAPAYA) AND ITS FRACTIONS HAVE NO POTENTIAL CYTOTOXICITY ON T47D CELLS Yuliani, Ratna; Syahdeni, Faisal
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10760

Abstract

Breast cancer is one type of cancer that causes high mortality rate in women. Plants produce secondary metabolites with a wide range of activity, one of which is as an anticancer. This research was conducted to investigate the cytotoxic effect of ethanolic extract of papaya leaves (Carica papaya) and its fractions on T47D cell line. Extraction of the natural compounds from papaya leaves was carried out by soaking the leaf powder in 96% ethanol followed by filtration and solvent evaporation. Liquid partition was done to obtain hexane, ethyl acetate, and water fractions. The cytotoxicity of the extract and the fractions was tested using MTT assay. Identification of chemical compounds in the ethyl acetate fraction was conducted using a thin layer chromatography method that used silica gel GF 254 as the stationary phase and acetone and hexane (4:6) as the mobile phase. The MTT assay result shows that the extract does not inhibit the growth of T47D cells. The viability of T47D cells can be reduced by the hexane, ethyl acetate, and water fractions with IC50 values of 2,231.30, 557.33, and 2,112.81 ?g/mL, respectively. The ethyl acetate fraction contains flavonoids, alkaloids, phenolics, and terpenoids. The ethanolic extract of papaya leaves and the fractions has no potential cytotoxicity on T47D cells due to high IC50 values.
Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG Wikantyasning, Erindyah Retno
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.11443

Abstract

Page 13 of 35 | Total Record : 345

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