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INDONESIA
MPI (Media Pharmaceutica Indonesiana)
Published by Universitas Surabaya
ISSN : 25276208     EISSN : 25279017     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Pharmaceutica Indonesiana (MPI) is a journal focusing on pharmaceutical aspects. MPI is dedicated to update and support the development of information and knowledge on pharmaceutical fields. This journal is published twice a year (June and December).
Arjuna Subject : -
Articles 193 Documents
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Carboxymethyl Starch (CMS) from Taro (Colocasia esculenta L.) as a Binder in Paracetamol Tablet Syamsidi, Armini; Musili, Silvana; Sultan, Asriana; Yusriadi, Yusriadi
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.8579

Abstract

Taro tubers (Colocasia esculenta L.) are a potential source of starch for use as a tablet binder. However, the limited flowability of native starch necessitates chemical modification to ensure consistent binder performance in tablet formulation. This study evaluated carboxymethyl starch (CMS) derived from taro tubers in comparison with native starch and investigated the effect of CMS concentration on the quality of paracetamol tablet formulation. CMS was synthesized from taro starch, characterized for flowability parameters and angle of repose, then applied as a binder at concentrations of 3% (F1), 5% (F2), 10% (F3), and 15% (F4), with native starch 5% (F0) and HPMC 5% (F5) used as a control. Tablet quality was evaluated in terms of weight uniformity, friability, hardness, disintegration time, and dissolution. CMS exhibited improved flow properties compared to native starch, with a Carr’s index of 16.43% and a flow rate at 1.19 g/s, indicating fairly good flowability. Tablets formulated with CMS demonstrated acceptable physicochemical characteristics, particularly at concentrations 5-10% (F2 and F3), which met pharmacopeial requirements for friability (<1%), hardness (4-8 kg), and disintegration time (<15 min), then showed comparable performance to HPMC. In conclusion, taro-based CMS is a promising natural binder that enhances tablet mechanical strength and reduces friability in paracetamol tablet formulations.
Network Pharmacology-Guided Identification of Antiaging Targets of Lavandula Flower Bioactives Using LC–MS/MS and Molecular Simulation Approaches Syafnir, Livia; Fajarwati, Kania; Faizal, Ibnu Dharsono; Fakih, Taufik Muhammad
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.8597

Abstract

Lavandula flowers are widely used in cosmetic and dermatological formulations, yet the molecular basis of their antiaging activity remains incompletely understood. This study aimed to elucidate the antiaging potential of lavandula flower bioactives through LC–MS/MS-based metabolite profiling integrated with network pharmacology and molecular docking analysis. Metabolites were characterized using LC–MS/MS and annotated based on accurate mass and fragmentation patterns. Predicted targets of selected metabolites were obtained using in silico target prediction and intersected with antiaging-related genes to construct protein–protein interaction networks and identify key regulatory pathways. Molecular docking was performed to evaluate binding affinity and interaction modes between prioritized metabolites against JAK2. LC–MS/MS analysis revealed a diverse chemical profile dominated by carveol (16.12%), methylumbelliferone (8.77%), camphor (3.97%), and two late-eluting high-molecular-weight metabolites contributing 29.86% and 35.36% of the total peak area. Network pharmacology highlighted convergence on kinase-driven signaling, extracellular matrix regulation, inflammatory response, and oxidative stress pathways relevant to skin aging. The docking results against JAK2 showed that the substituted pyridin-4-ol derivative exhibited the strongest affinity among Lavandula metabolites (ΔG = −8.81 kcal/mol), followed by the piperidinyl-substituted trienone (ΔG = −7.92 kcal/mol), while methylumbelliferone (ΔG = −5.93 kcal/ mol) and ferulic acid (ΔG = −5.53 kcal/mol) displayed moderate binding. Lavandula flower bioactives exhibit antiaging potential through multitarget modulation of signaling and matrix-associated proteins, supported by quantitative metabolite profiling and docking-validated target engagement.
Development and Validation of a TLC-Densitometric Method for Quantification of Quercetin in Smallanthus sonchifolius Extract Nurhayati, Rachma; Adhelia, Vanessa; Purwani, Asih Imulda Hari; Pramasari, Nadia; Shoviantari, Fenita
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.8736

Abstract

This study aimed to develop and validate a thin-layer chromatography (TLC)–densitometric method for the quantitative determination of quercetin in insulin leaves (Smallanthus sonchifolius). Dried insulin leaves were extracted using the maceration method with 70% ethanol as the extraction solvent. Quercetin analysis was carried out on silica gel GF254 plates as the stationary phase, using a mobile phase consisting of n-butanol, acetic acid, and water in a ratio of 4:1:5 (v/v/v). A sample volume of 4 μL was applied onto the plate and scanned at a wavelength of 284 nm using a densitometer. Method validation was performed by evaluating linearity, selectivity, accuracy, and precision parameters. The validation results showed a good linear relationship between concentration and peak area with a correlation coefficient (r) of 0.9844. The method exhibited good selectivity with a resolution value of 2.40 and peak purity of 0.99. Accuracy values ranged from 101.4% to 102.5%, while precision testing produced a relative standard deviation value of 3.0%. The average quercetin content in insulin leaves was determined to be 0.191% (w/w). These findings demonstrate that the validated TLC–densitometric method is reliable and suitable for routine quantitative analysis of quercetin in herbal raw materials for quality control purposes.

Page 20 of 20 | Total Record : 193

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