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INDONESIA
MPI (Media Pharmaceutica Indonesiana)
Published by Universitas Surabaya
ISSN : 25276208     EISSN : 25279017     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Pharmaceutica Indonesiana (MPI) is a journal focusing on pharmaceutical aspects. MPI is dedicated to update and support the development of information and knowledge on pharmaceutical fields. This journal is published twice a year (June and December).
Arjuna Subject : -
Articles 162 Documents
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Optimization of Papaya Leaf Extract Cream Using Stearic Acid and Triethanolamine via Simplex Lattice Design Siwi, Andini Prabandaru; Priyanto, Widodo; Novita, Mega; Marlina, Dian
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7468

Abstract

Papaya leaves (Carica papaya L.) are known to contain bioactive compounds such as flavonoids, alkaloids, tannins, and saponins, which exhibit antiseptic, anti-inflammatory, antifungal, and antibacterial properties, making them promising for topical pharmaceutical preparations. However, achieving optimal physical characteristics in cream formulations requires careful selection and proportioning of emulsifiers. This study investigates the effect of varying ratios of stearic acid and triethanolamine on the physical properties of creams containing ethanol-extracted papaya leaf extract. The extract was obtained via maceration using 96% ethanol and confirmed to contain active compounds through phytochemical screening and thin-layer chromatography. Eight formulations were developed using a Simplex Lattice Design (SLD) with stearic acid concentrations ranging from 15–17% and triethanolamine from 2–4%. Physical evaluations included tests for pH, viscosity, adhesion, and spreadability. All formulations met standard of cream quality requirements, but the optimal formula was identified at 15.20% stearic acid and 3.79% triethanolamine, offering the most desirable physical characteristics. This formulation strategy demonstrates the potential for producing effective and stable papaya leaf creams, with implications for natural-based dermatological product development. Submitted: 05-05-2025, Revised: 18-06-2025, Accepted: 25-06-2025, Published regularly: June 2025
Unraveling The Nephroprotective Potential of Curcuma zedoaria Against Chronic Kidney Disease: A Network Pharmacology Approach Harahap , Emirsyah; Nadapdap, Thomson Parluhutan; Nasution , Ali Napiah
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7508

Abstract

Chronic kidney disease (CKD) remains a major global health concern with limited treatment options. Curcuma zedoaria , a traditional medicinal plant, has shown potential in managing inflammatory and oxidative stress-related conditions. This study aimed to explore its nephroprotective mechanisms through a network pharmacology approach. A total of 12 bioactive compounds were identified from C. zedoaria and screened for drug-likeness. SwissTargetPrediction revealed multiple molecular targets, with curdione, dehydrocurdione, and curcumin showing the highest connectivity. Integration with CKD-associated genes from GeneCards and GSE66494 datasets yielded 241 common targets. Using Cytoscape, a compound–target–disease network was constructed, highlighting key biological processes such as inflammation, apoptosis, and fibrosis. PPI analysis identified top hub proteins including HSP90AA1, STAT3, SRC, AKT1, MAPK1, and MAPK3. Functional enrichment via GO and KEGG pathways revealed significant involvement of EGFR tyrosine kinase inhibitor resistance and HIF-1 signaling pathways. These findings suggest that C. zedoaria exerts protective effects through a multitarget mechanism modulating critical pathways in CKD progression. This study provides a theoretical basis for further experimental validation and supports the potential use of C. zedoaria as a complementary therapy in CKD management. Submitted: 21-05-2025, Revised: 15-06-2025, Accepted: 17-06-2025, Published regularly: June 2025

Page 17 of 17 | Total Record : 162

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