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Contact Name
Rifky Ananda
Contact Email
fkg@ulm.ac.id
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dentino.ulm@gmail.com
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Kota banjarmasin,
Kalimantan selatan
INDONESIA
Dentino: Jurnal Kedokteran Gigi
ISSN : 23375310     EISSN : 25274937     DOI : 10.20527
Core Subject : Health,
Dentino [P-ISSN 2337-5310 | E-ISSN 2527-4937] is the journal contains research articles and review of the literature on dentistry which is managed by the Faculty of Dentistry, Lambung Mangkurat University. Dentino published twice a year, every March and September.
Arjuna Subject : -
Articles 530 Documents
ANGKA KEJADIAN DIATEMA SENTRAL PADA ANAK BERKEBUTUHAN KHUSUS DISERTAI KEBIASAAN MENGHISAP IBU JARI Rizki Hadi; Rosihan Adhani; Widodo Widodo
Dentino : Jurnal Kedokteran Gigi Vol 1, No 2 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i2.569

Abstract

ABSTRACT  Finger sucking habit is oral habbit most common, the incidence of finger sucking habit is reported at between 13% to 100%. According Muthu and Sivakumar prevalence of this practice decreases with age, especially at the age of 3.5-4 years. The central diastema is a malocclusion that often appear with the characteristic form of a gap that exists between the maxillary central incisor. This study aims to calculate the incidence of children with special needs as thumb-sucking, calculate the incidence of central diastema on boys and girls with special needs children and large knowing the incidence of central diastema at the age of children with special needs. This study was a descriptive study by total sampling metode. The population in this study were students SDLB C Dharma Wanita Banjarmasin. The results showed 34 (53.96%) children who had a central diastema with 14 men, 20 women and 29 people who did not have a central diastema of a total of 63 students were examined. The habit of thumb sucking 28 people (44.44%).The central diastema thumb sucking habit with no male 11 people (17.46%) and 9 women (14.29%). The incidence of central diastema by age 6-8 years who had a central diastema as many as 15 (44.12%), 9-10 years who had diastema as many as 8 (23.53%), 11-14 years old who have a diastema as many as 11 (32 , 35%) of the total of 34 (53,96%). Thumb sucking by age found that children aged 6-8 years who had a habit of thumb sucking has 9 children (32.15%), 9-10 years amounted to 8 children (28.57%), 11-14 years amounted to 11 children (39.28%) of the total of 28 children.  Keyword:Central Diastema, With Special Needs, Thumb Sucking ABSTRAK  Kebiasaan menghisap jari merupakan oral habbit yang paling sering terjadi, insidensi kebiasaan menghisap jari dilaporkan mencapai antara 13% sampai 100%. Menurut Muthu dan Sivakumar prevalensi kebiasaan ini menurun seiring pertambahan usia, terutama pada usia 3,5-4 tahun. Diastema sentral merupakan suatu maloklusi yang sering muncul dengan ciri khas berupa celah yang terdapat diantara insisif sentral rahang atas.Penelitian ini bertujuan untuk menghitung angka kejadian anak berkebutuhan khusus menghisap ibu jari, menghitung angka kejadian diastema sentral pada siswa laki-laki dan perempuan pada anak berkebutuhan khusus dan mengetahui besar angka kejadian diastema sentral pada usia anak berkebutuhan khusus. Penelitian ini merupakan penelitian deskriptif dengan metode total sampling. Populasi dalam penelitian ini adalah siswa siswi SDLB C Dharma Wanita Banjarmasin. Hasil penelitian didapatkan 34 orang anak (53,96%) yang memiliki diastema sentral dengan 14 laki-laki, 20 perempuan dan 29 orang yang tidak memiliki diastema sentral dari total 63 siswa yang diperiksa. Kebiasaan menghisap ibu jari sebanyak 28 orang (44,44%). Diastema sentral disertai kebiasaan menghisap ibu jari laki-laki sebanyak 11 orang (17,46%) dan perempuan sebanyak 9 orang (14,29%). Angka kejadian diastema sentral berdasarkan umur 6-8 tahun yang memiliki diastema sentral sebanyak 15 (44,12%), 9-10 tahun yang memilki diastema sebanyak 8 (23,53%) , 11-14 tahun yang memiliki diastema sebanyak 11 (32,35%) dari total 34  orang (100%). Menghisap ibu jari berdasarkan umur didapatkan anak yang berumur 6-8 tahun yang memiliki kebiasaan menghisap ibu jari berjumlah 9 anak (32,15%) , 9-10 tahun berjumlah 8 anak (28,57%), 11-14 tahun berjumlah 11 anak (39,28%) dari total 28 anak.  Kata-kata kunci: Diastema Sentral, Anak Berkebutuhan Khusus, Menghisap Ibu Jari
FABRICATION OF POROUS CARBONATE APATITE BASED ON THE DISSOLUTION-PRECIPITATION OF CALCIUM SULFATE HEMIHYDRATE Dede Arsista; Yosi Kusuma Eriwati; Siti Triaminingsih; Sunarso Sunarso
Dentino : Jurnal Kedokteran Gigi Vol 4, No 2 (2019)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v4i2.7055

Abstract

Background: Carbonate apatite (C-Ap) has been used as a bone replacement material because it has osteoconductive properties. The pores contained in C-Ap are useful so that cells can diffuse during new bone formation. Calcium sulfate hemihydrate (CaSO4.1/2H2O) precursor has been used as it possesses Ca2+ ions, while polymethylmetacrylate (PMMA) is chosen because it is easily burned out at low temperatures. Objectives: To fabricate porous carbonate apatite based on a calcium sulfate hemihydrate precursor using the dissolution-precipitation method and identify its phases by X-ray diffraction. Methods: The pores were made by crushing polymethyl methacrylate (PMMA) granules and sieving them to sizes of 300–500 µm. Specimens of porous carbonate apatite were prepared from a mixed calcium sulfate hemihydrate precursor with different quantities of porogen: 0 wt% PMMA (n = 60 ), 25 wt% PMMA ( n = 60 ), and 50 wt% PMMA ( n = 60 ). Calcium sulfate hemihydrate containing PMMA was mixed with distilled water at a water: powder ratio of 0.5 ml: 1g. Calcium sulfate dihydrate specimens were placed in an oven at 700˚C for 4 h to burn out the PMMA, resulting in porous calcium sulfate anhydrate. This was then immersed in phosphate mixed solution (Na3PO4) and carbonate solution (Na2CO3) for 1, 3, and 5 days to obtain carbonate apatite through a precipitation-dissolution process. An X-ray diffraction technique (X-Ray Diffractometer, PANalytical XPert PRO) was used to analyze each group of specimens to identify the phase formation of porous carbonate apatite. Results: The X-ray diffraction pattern showed peaks of carbonate apatite in all specimens with 0, 25, and 50 wt% PMMA in 1, 3, and 5 days of immersion, except in the 0 wt% specimens at 1 day. The carbonate apatite diffraction peaks were at 2q = 25.9°, 29.2°, 32°, and 34°. The earliest complete formation of the carbonate apatite phase was identified from the preparation of porous anhydrous CaSO4 with porogen of 50 wt% PMMA immersed for 1 day. Conclusion: Porous carbonate apatite can be produced from precursors of calcium sulfate hemihydrate and porogen of PMMA via a precipitation-dissolution method.
CORRELATION BETWEEN THE RADIOGRAPHERS WORKING TIME WITH PROCEDURES COMPREHENSION OF INTRA ORAL PERIAPICAL RADIOGRAPHIC IMAGING TECHNIQUE (Analytical Observation at Ulin Hospital and Gusti HasanAmanof Dental Hospital in Banjarmasin) Afifah Rahmiati; Bayu Indra Sukmana; Isnur Hatta
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5375

Abstract

Background: Radiography is an examination to observe the internal body using wave radiation. Radiography can be performed with oral and extra oral projection. The appropriate results of radiographic images and quality are influenced by the radiographers comprehension. Objective: Analyze the correlation between radiographers working time with procedures comprehension of intra oral periapical radiographic imaging technique at Banjarmasin Hospital. Method: This study is analytical observation with Cross Sectional approach. In this study 17 respondents became the study subject. Respondents at RSUD Ulin and RSGM Gusti Hasan Aman in Banjarmasin were given a questionnaire. Results: From 17 respondents, 6 people (85.7%) have less comprehension with working time ≤ 5 years, 1 person (50%) has good comprehension with working time ≤ 5 years, 1 person (50% ) has good understanding comprehension with working time > 10 years, 4 people (50%) have sufficient comprehension with working time > 10 years, 2 persons (25%) have sufficient comprehension with working time ≤ 5 years, 2 persons (25 %) have sufficient comprehension with working time 6-10 years, and 1 person (14.3%) has less comprehension with working time 6-10 years. Analysis using Spearman Rho test obtained p = 0,033 (p˂0,05) with correlation value equal to 0,520. Conclusion: It can be concluded that there is  a moderate relationship between the working time of the radiographers with the procedures comprehension of intra oral periapical radiographic imaging technique at Banjarmasin Hospital.
PERBANDINGAN DAYA LENTING PEGAS JARI DENGAN DIAMETER KAWAT 0,5 mm dan 0,6 mm PADA ALAT ORTODONTI LEPASAN Dinie Muthia Iflah; Diana Wibowo; Widodo Widodo
Dentino : Jurnal Kedokteran Gigi Vol 2, No 1 (2017)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v2i1.2597

Abstract

ABSTRAKLatar Belakang: Pegas jari merupakan pegas yang dapat menggerakkan gigi anterior ke arah mesial atau ke arah distal. Gaya yang diberikan dalam perawatan ortodonti tidak boleh melebihi tekanan darah kapiler yaitu 20-25 gr/cm2, jika lebih dari itu maka dapat terjadi nekrosis pada jaringan sekitar. Untuk menggerakan gigi yang berakar tunggal diperlukan kekuatan antara 25-40 gram, kekuatan dibawah dari 25 gram tidak memungkinkan terjadinya pergerakan gigi dalam waktu yang optimal, sedangkan kekuatan yang besar diatas 40 gram akan dapat mengakibatkan kerusakan jaringan periodontal dan akan menimbulkan rasa sakit yang berlebihan. Tujuan: untuk mengetahui perbandingan daya lenting pegas jari antara diameter kawat 0,5 mm dengan 0,6 mm pada alat ortodonti lepasan. Metode: Jenis penelitian ini merupakan pre- experimental dengan metode one- shot case study menggunakan simple random sampling, terdiri dari 2 kelompok perlakuan dengan diameter kawat 0,5 mm dan dengan diamter kawat 0,6 mm, masing-masing sampel diaktivasi sebanyak 3 mm kemudian dilakukan pengukuran daya lenting yang dihasilkan dengan menggunkan gauge force meter. Hasil: Rata-rata daya lenting yang dihasilkan dari sampel pegas jari diameter kawat 0,5 mm (70gr/mm²), dan rata-rata daya lenting yang dihasilkan dari sampel pegas jari diameter kawat 0,6 mm (129,6 gr/mm²). Hasil uji independen T-test menunjukan bahwa terdapat perbedaan yang bermakna antara pegas jari dengan diameter kawat 0,5 mm dan 0,6 mm. Kesimpulan: Pegas jari dengan diameter kawat 0,5 mm lebih efektif digunakan karna daya yang dihasilkan lebih kecil dibandingkan dengan diameter kawat 0,6 mm.
THE EFFECT OF ACIDITY LEVEL AND SUBMERSION DURATION OF TEETH IN PEATLANDS TO DETERMINE BLOOD-GROUP ACCURACY THROUGH DENTAL PULP Study of postmortem blood-group identification technique through dental pulp Irnamanda DH; Iwan Aflanie; Meka Aulia Raban; Ainul Habibah
Dentino : Jurnal Kedokteran Gigi Vol 2, No 2 (2017)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v2i2.3949

Abstract

Background: Indonesia has peatlands which spread all over the state and one of them is in Borneo(Kalimantan). More than three million hectares of peatland spreads in South Borneo. Peatlands have relativelyhigh acidity level with pH range of 3-5. The peatlands in South Borneo is generally used for farming or publiccemetery. In certain situation, peatlands is often used as a dumping ground for criminal victims. Sometimes, theauthority finds it hard to identify the victim because the body is already decomposed. To identify the victim andto analyse the cause of death, identification process is necessary. Teeth can be used to help the identificationprocess. Biological elements from the teeth namely dental pulp contains antigens that were useful to bloodgroupsdetermination by absorption elution method. Purpose: The objective of this research is to discover theeffect of peatlands acidity level and teeth submersions durations in determining blood-group accuracy fromdental pulp. Method: The method of this research used a quasi-experimental method to discover the effect ofpeatlands acidity and pre-experimental method to discover the effect of teeth submersions duration. Thisresearch used 48 pieces premolar teeth that were divided into 8 groups, control group, group submerged onpeatlands with pH 3,0-3,9, pH 4,0-4,9 and pH 5,0-5,9 to discover the effect of peatlands acidity and 1-day, 3-day, 5-day and 7-day groups to discover the effect of teeth submersions time. Result: Fisher's Exact test resultsshowed p value 0,314 (p > 0,05) for the effect of peatlands acidity and p value 0,410 (p > 0,05) for the effect ofteeth submersions duration. Conclusion: It could be concluded that there are no effect of the peatlands acidityand teeth submersions time to determine blood-group accuracy from dental pulp.
THE EFFECT OF IMMERSING BAY LEAF 25% ON THE MEAN SURFACE ROUGHNESS ACRYLIC RESIN TYPE HEAT Debby Saputera; Dewi Puspitasari; Andrew Tedjohartoko
Dentino : Jurnal Kedokteran Gigi Vol 2, No 2 (2017)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v2i2.4006

Abstract

Background: Surface roughness is one of the factor which reduce the strength of dentures. Denture cleanser that can be used is chlorhexidine, however it may cause surface roughness acrylic resin type heat cured. Natural materials that can be used as a denture cleanser is Bay leaf. Bay leaf was known to have antibacterial and antifungal activity. Purpose: This research aims to analyze the effect of immersing extract bay leaf 25% for 5 days and 15 days compared with chlorhexidine gluconate 0.2% and aquades as denture cleanser. Method: This research is true experiment using post test-only with control group design. The sample used were forty-two samples, divided into six groups immersed in extract bay leaf 25%, chlorhexidine gluconate 0.2% and aquades for 5 days and 15 days. Surface roughness was measured using Surface Roughness Tester. Results: This research shows that the mean surface roughness of acrylic type heat cured soaked for 5 days and 15 days in extract bay leaf 25% (0,45 ± 0,019) and (0,55 ± 0,012), chlorhexidine gluconate 0.2% (0,53 ± 0,024) and (0,64 ± 0,012), aquades (0,37 ± 0,015) and (0,43 ± 0,013). The One-Way Anova test showed p=0,000 (p<0,05) that there was a meaningful difference on immersing extract bay leaf 25%, chlorhexidine gluconate 0.2% and aquades. Conclusion: Immersing bay leaf 25% has lower effect on surface roughness compared with chlorhexidine gluconate.
THE EFFECT OF BAGASSE FIBER ADDITION IN FLEXURAL STRENGTH OF BULK FILL COMPOSITE RESIN Siti Farida Rizki Ananda; Isyana Erlita; Irnamanda DH
Dentino : Jurnal Kedokteran Gigi Vol 3, No 1 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i1.4605

Abstract

Background: Bulk fill composite resin is a packable composite resin that has been modified to solve the deficiency of conventional composite resin. The addition of fiber can increase the mechanical properties, one of them is flexural strength. Fiber is consisted of two types which are synthetic fiber and natural fiber. In Indonesia, there are many natural fibers, one of them is from the plant of sugarcane. The baggase is the residual from sugarcane plant that had been processed for the making of sugar. Purpose: To acknowledge if the addition of baggase fiber affect the flexural strength of bulk fill composite resin. Methode: This study wastrue experimental studywith post-test only control group design and used simple random sampling that consisted of 3 groups, which are group with addition of baggase fiber, group without addition of baggase fiber as the negative control and group with addition of synthetic fiber as the positive control. Flexural strength tested with Universal Testing Machine. Result: The average value of flexural strength on group with addition of baggase fiber, group without addition of baggase fiber and group with addition of synthetic fiber were 123,549 MPa; 118,125 MPa and 144,442 Mpa respectively. One Way Anova and Post Hoc Bonferroni test showed that there is significant difference between all treatment groups. Conclusion: Based on this study, it can be concluded that addition of baggase fiber can increase the flexural strength but cannot replace the synthetic fiber.
UNDERSTANDING THE INTERACTION BETWEEN GLUTATHIONE AND ACETAMINOPHEN: A DOCKING STUDY APPROACH Mohammad Rizki Fadhil Pratama; Eko Suhartono
Dentino : Jurnal Kedokteran Gigi Vol 3, No 2 (2018)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v3i2.5381

Abstract

Background:Acetaminophen (PCT) is known for its pro-oxidant properties, which neutralized by the presence of internal antioxidants such as glutathione (GSH). GSH has two forms: monomers and dimers, mainly distinguished by the presence of thiol group. Purpose:This study aims to see the difference in interaction between PCT with both forms of GSH. Method:Molecular docking was performed using Autodock Vina 1.1.2 on whole GSH surfaces. The main parameter used was the free energy of binding as affinity marker, as well as the position of PCT toward GSH. Result:The docking results show that PCT has a slightly higher affinity to the dimeric form of GSH than its monomeric form with the free energy of binding -2.7 kcal/mol and -2.2 kcal/mol, respectively. The interesting thing is the acetyl group of PCT is in a position far from the thiol group in the monomeric form of GSH, in contrast to its dimeric form. Conclusion:These results show that difference in affinity of PCT to both GSH forms is influenced by the position of the acetyl group against the thiol group of cysteine in GSH. The proximity of the pro-oxidant group to the thiol group leads to an increase in the affinity of the pro-oxidant to GSH.
HOLLOW PARTIAL DENTURE ANTERIOR RAHANG ATAS POST HEMIMAXILLECTOMY Debby Saputera; Sukaedi Sukaedi
Dentino : Jurnal Kedokteran Gigi Vol 1, No 1 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i1.428

Abstract

ABSTRACT Background : The hollow partial denture is a prosthesis commonly used as an effective means for rehabilitating post hemimaxillectomy patients. The size and location of the defect usually influences the extent of impairment and difficulty in prosthetic rehabilitation. Retention, stability and support are the three majors factors in the management of rehabilitation patients. Purpose : Provide information about the management of patients post hemimaxillectomy with hollow partial denture. Case : Male patient aged 40 years came to the clinic specialist Prosthodontics Faculty of Dentistry Airlangga University with complaints want to made a new maxillofacial prosthesis because the old prosthesis fracture and often loose when chewing food and to talk feel disturbed. Case Management : Print maxilla and mandible, then make bite record,  teeth arrangement and do the scraping on the palate area and some area were taken for cover hollow, acrylic procesing, reduction in denture hollow and hollow cover, hollow cover attachment process with hollow denture followed by the installation of hollow maxillary denture. Conclusion : hollow partial denture can be used as a rehabilitation post hemimaxillectomy. ABSTRAKLatar belakang : Gigi tiruan sebagian hollow adalah protesa biasa digunakan sebagai cara yang efektif untuk merehabilitasi pasien post hemimaxillectomy. Ukuran dan lokasi yang cacat biasanya mempengaruhi tingkat gangguan dan kesulitan dalam rehabilitasi prostetik. Retensi, stabilitas dan dukungan adalah tiga faktor utama dalam pengelolaan pasien rehabilitasi. Tujuan : Memberikan informasi tentang pengelolaan  pasien post hemimaxillectomy dengan gigi tiruan sebagian hollow. Kasus : Pasien laki-laki berusia 40 tahun seorang buruh datang ke klinik spesialis prostodonsia Fakultas Kedokteran Gigi Universitas Airlangga dengan keluhan ingin dibuatkan protesa maksilofasial yang baru karena protesa yang lama klamernya patah serta sering lepas saat mengunyah makanan dan untuk bicara merasa terganggu. Tata laksana kasus : Mencetak rahang atas dan rahang bawah, kemudian membuat galangan gigit, menyusun gigi dan melakukan pengerokan pada daerah palatum dan sebagian malam diambil buat penutup hollow, procesing akrilik, pengurangan pada gigi tiruan hollow dan penutup hollow, proses perlekatan penutup hollow dengan gigi tiruan hollow dilanjutkan dengan pemasangan gigi tiruan hollow rahang atas. Kesimpulan : gigi tiruan sebagian hollow dapat dipakai sebagai rehabilitasi post hemimaxillectomy.
PENGARUH EKSTRAK KULIT MANGGIS (Garcinia mangostana Linn.) TERHADAP JUMLAH MAKROFAG PADA INFLAMASI PULPA Studi In Vivo Pada Gigi Molar Rahang Atas Tikus (Rattus norvegicus) Wistar Jantan Cindy Dwintanandi; Muhammad Yanuar Ichrom Nahzi; Suka Dwi Raharja
Dentino : Jurnal Kedokteran Gigi Vol 1, No 2 (2016)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v1i2.562

Abstract

ABSTRACK  Background: Treatment of dental pulp is a basic treatment in dentistry. Nowadays dental pulp treatment used adhesive resin substance, but adhesive resin substance is irritative and expensive thus alternative substance is needed to use. Pericarp of mangosteen containing to be rich in various pharmacys and antioxidant activity so that called queen of fruits. Xanthone, flavonoid, tanin, and saponin compound can working as antiinflammatory that very important in open dental pulp healing. Purpose: This research to investigate the effect pericarp of mangosteen extract to amount of macrophag on pulp response inflammatory and compare with calcium hydroxide. Methods: This study used true experimental method with post-test only group design and simple random sampling, consist of 39 male wistar rats were divided into 3 groups.  Perforated each dental pulp rats were treated with pericarp of mangosteen extract as treatment group, with calcium hydroxide as positive control group, and no treatment indeed (no medicine) as negative control group. On the day 1 to day 7, sampels for hystological analysis should be done after treatment, inflammatory reactions occured in all of groups. Result: Inflammatory reactions reckoned from scoring of macrophage. Two way Anova and Post Hoc LSD test indicated that pericarp of mangosteen extract more effective than calcium hydroxide in decrease scoring of macrophage. Based on research could be concluded that significantly the treatment process pericarp of mangosteen extract could be usefull to decrease scoring of macrophage in pulp inflammatory.  Keywords: open dental pulp, pulp inflammatory, macrophage, pericarp of mangosteen, calcium hydroxide  ABSTRAK   Latar Belakang: Perawatan pulpa terbuka merupakan perawatan dasar dalam kedokteran gigi. Perawatan pulpa terbuka pada saat ini dengan menggunakan bahan resin adesif, namun  resin adesif bersifat iritatif dan  mahal sehingga diperlukan bahan alternatif yang lebih aman digunakan. Kulit manggis mengandung senyawa yang memiliki berbagai aktivitas farmakologi dan antioksidan sehingga disebut queen of fruits. Senyawa golongan xanton, flavonoid, tanin, dan saponin dalam kulit buah manggis dapat berfungsi sebagai antiinflamasi yang penting dalam penyembuhan pulpa terbuka. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit manggis terhadap jumlah makrofag pada inflamasi pulpa dan membandingkannya dengan kalsium hidroksida. Metode: Penelitian ini merupakan penelitian eksperimental murni dengan post-test only group design, menggunakan Rancangan Acak Sederhana, terdiri dari 39 tikus Wistar jantan yang dibagi menjadi 3 kelompok. Pulpa gigi tikus diperforasi yang kemudian diberi perlakuan ekstrak kulit manggis sebagai kelompok perlakuan, dengan diberikan kalsium hidroksida sebagai kelompok kontrol positif, dan tidak diberikan aplikasi apapun (tanpa obat) sebagai kelompok kontrol negatif. Sampel dianalisis secara histologis pada hari ke -1 hingga hari ke -7 setelah aplikasi, reaksi inflamasi terjadi pada seluruh kelompok. Hasil: Reaksi inflamasi dihitung dari jumlah makrofag. Uji two way Anova dan uji Post Hoc LSD menunjukkan bahwa ekstrak kulit manggis lebih efektif menurunkan jumlah makrofag dibandingkan kalsium hidroksida. Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa pemberian ekstrak kulit manggis secara bermakna dapat menurunkan jumlah makrofag pada inflamasi pulpa. Kata-kata kunci: pulpa terbuka, inflamasi pulpa, makrofag, kulit manggis, kalsium hidroksida