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INDONESIA
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)
Published by Universitas Sriwijaya
ISSN : 25409395     EISSN : 25409409     DOI : -
Core Subject : Science, Social,
Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science
Indonesian Journal of Fundamental and Applied Chemistry (IJFAC) is an international research journal and invites contributions of original research articles as well as review articles in several areas of chemistry. The journal aims to publish refereed, high-quality research papers with significant novelty and short communications in all branches of chemistry. Papers which describe novel theory and its application to practice are welcome, as are those which illustrate the transfer of techniques from other disciplines. IJFAC calls for papers that cover the following fields: Biochemistry Inorganic chemistry Physical chemistry Organic chemistry Analytical chemistry Applied Chemistry All papers are peer reviewed by at least two referees. Papers presented at conferences are peer reviewed and selected with the same standards as individually submitted papers. They therefore have the same archival value. Article should be submitted by the Online Submission Module at www.ijfac.unsri.ac.id or email to ijfac@unsri.ac.id
Arjuna Subject : -
Articles 196 Documents
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Antidiabetic Activity and Analysis Chemical Compound of Fractions of Leucas lavandulifolia leaves Carissa, Restri Diah; Yohandini, Heni; Muharni, Muharni
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

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Abstract

Leucas lavandulifolia is one traditional medicine that has been used for the treatment of rheumatism, skin diseases, wounds, diabetes, and migraine treatment. This research aimed to test the antidiabetic activity of the leaf fractions of Leucas lavandulifolia and to identify the chemical content of the selected column fraction. Fractionation was carried out using the graded extraction method with the solvents n-hexane, ethyl acetate, methanol. Testing of antidiabetic activity was performed using the α-glucosidase inhibition method and analysis of the chemical composition content of the selected fraction was performed using the GC-MS method. The research results showed the Ethyl acetate fraction provided the highest antidiabetic activity (IC50 = 4.985 µg/mL) compared to the other fractions and even higher compared to the positive control acarbose (IC50 = 67.07 µg/mL). Separation of the ethyl acetate fraction showed subfractions F6.3 and F6.5 showed the simplest spot pattern. Identification of chemical content with GC-MS showed subfraction F6.3 contained the main component naphthalenepropanal derivative (17.21%) and subfraction F6.5 with the main component fatty acid. Subfractions F6.3 and F6.5 also showed antidiabetic activities with IC50 values of 17.3 and 36.72 µg/mL, respectively, with a very strong category. This indicates the ethyl acetate fraction of L. lavandulifolia leaves is potential to be developed as a source of antidiabetic compounds
Synthesis of Ag/CeO2 Nanocomposites with Noni Leaf Extract and Its Potential Antibacterial Properties Denada, Laellia; Hariani, Poedji Loekitowati; Aprianti, Nabila
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

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Abstract

This study aims to perform green synthesis of Ag/CeO2 nanocomposites using noni leaf extract and to test their potential antibacterial activity. The synthesis results were characterised using X-ray Diffraction (XRD) to determine crystallite size, Scanning Electron Microscope-Energy Dispersive Spectroscopy (SEM-EDX) to observe morphology and elemental composition, and Fourier Transform Infrared Spectroscopy (FTIR) to identify functional groups. The XRD characterization results showed the formation of typical Ag/CeO2 peaks with an average crystallite size of 15,28 nm. SEM analysis revealed morphology in the form of aggregates with varying sizes. EDX results confirmed the presence of Ag, Ce, and O elements. FTIR analysis showed the presence of typical Ce–O group absorption bands, which supports the successful synthesis of Ag/CeO2. The synthesized nanocomposites were then tested for their antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. Antibacterial activity tests showed the formation of an 8 mm zone of inhibition (ZOI) at a concentration of 5000 ppm, demonstrating the potential of the synthesized green Ag/CeO2 as an antibacterial agent. This study confirms that the use of noni leaf extract as a reducing and stabilizing agent is an environmentally friendly approach and has potential for environmental applications.
Modification of Activated Carbon from Palm Kernel Shells with Fe₃O₄ Magnetic for Water Treatment of Enim River Damayanti, Damayanti; Arita, Susila; Hariani, Poedji Loekitowati
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

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Abstract

The economical, easy-to-implement, and regenerative treatment methods are essential to obtain clean water. In this study, activated carbon was synthesized from palm kernel shells using ZnCl₂ as an activator. The activated carbon was then modified with Fe₃O₄. The resulting activated carbon and activated carbon-Fe₃O₄ product were characterized using XRD, SEM-EDX, VSM, and BET surface area analysis. Furthermore, activated carbon-Fe3O4 was applied to reduce Fe ions, turbidity, and total suspended solids (TSS) and increase the pH value in Enim river water. The resulting activated carbon has met SNI standards, with a moisture content of 8.81%, ash content of 5.475%, and an iodine adsorption capacity of 1763.86 mg/L. The synthesized activated carbon-Fe₃O₄ exhibits strong magnetic properties, with a saturation magnetization value of 68.82 emu/g and a surface area of 355.42 m²/g. Optimal conditions for the treatment of Enim river water were obtained at an adsorbent dose of 40 mg/L, a stirring rate of 120 rpm, and a stirring time of 120 minutes. Under these conditions, the Fe ion reduction efficiency reached 96.95%, turbidity 89.83%, and TSS 80.74%, while the pH increased from 6.23 to 6.74. FTIR analysis showed a change in peak intensity in the activated carbon-Fe₃O₄ after the adsorption process, indicating interaction with contaminants. The adsorption process of Fe ions by activated carbon-Fe₃O₄ follows a pseudo-second-order kinetic model.
Synthesis Of CoFe2O4 Nanoparticle and Antibacterial Activity Test Purwitasari, Listiyani; Hariani, Poedji Loekitowati; Sisca, Vivi
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

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Abstract

Cobalt ferrite (CoFe₂O₄) is a spinel ferrite-based material known for its excellent magnetic properties and chemical stability, making it as a promising candidate for biomedical applications as well as an antibacterial agent. This study aims to synthesize CoFe₂O₄ nanoparticles by a coprecipitation methode and evaluate their antibacterial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The synthesized products were characterized by using several instruments includes X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), FTIR spectroscopy and Vibrating Sampel Magnetometer (VSM) in order to determine its crystal structure, particle morphology, functional groups, and magnetic properties. Antibacterial activity was assessed by using the disk diffusion method. The results showed that CoFe₂O₄ nanoparticles were successfully synthesized with nanometer-scale crystallite sizes and exhibited strong ferromagnetic properties. Antibacterial tests demonstrated inhibition zones against the growth of S. aureus and E. coli, indicating that CoFe₂O₄ has potential as an antibacterial agent. The effectiveness of antibacterial activity was influenced by nanoparticle concentration and the type of tested bacteria. This research opens up further opportunities for the development of CoFe₂O₄ applications in health and environmental fields.
Ecoenzyme Characterization of Fruit Peel Waste Mixture and Test of Antibacterial Activity against Bacteria Causing Dental Caries Julinar, Julinar; Uswati, Dinii; Riyanti, Fahma; Musifa, Eva
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

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Abstract

Ecoenzyme is a product of facultative aerobic fermentation for 3 months from organic fruit and vegetable waste. In this study, ecoenzyme was made from a mixture of fruit peel waste (papaya, orange and pineapple) with the addition of 6 liters of water. Ecoenzyme products were characterized by organoleptic properties, chemical composition, enzyme activity and antibacterial activity tests against Lactobacillus acidophilus and Streptococcus mutans bacteria that cause dental caries. The results of the study show that the ecoenzyme product had a dominant orange peel sour flavor, was cloudy brown in color with a volume of 8.4 liters from 6 liters of added water. The characterization results depict that the chemical composition of ecoenzyme contained acetic acid and lactic acid with a total acid content of 2.26%, 40.45 mg/mL protein, and secondary metabolites in the form of alkaloids, flavonoids, and saponins. The activity of several enzymes from ecoenzyme was protease 0.0246 U/mL, amylase 0.0032 U/mL and lipase 5 U/mL. Antibacterial activity against bacteria that cause dental caries is included in the category of very strong against S. mutans at a concentration of 40 (% v/v) and moderate against L. acidophilus with inhibition zone diameters of 23.33 mm and 8.23 mm respectively. The Mininum Inhibitory Concentration (MIC) and Minimum Killing Concentration (MKC) values of ecoenzyme against S. mutans and L. acidophilus bacteria were 2500 ppm and 5000 ppm respectively.Keywords: ecoenzyme, fruit-peel waste, L.acidophilus, S.mutans, antibacterial
Preparation of Palm Kernel Shell Binchotan for Radio Frequency Energy Harvesting Sya'baniah, Nyimas Febrika; Syarif, Nirwan; Rohendi, Dedi; Rachmat, Addy; Syahputra, Rio Aldo
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

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Abstract

Research on the development of radio frequency energy harvesting slabs from palm kernel shells binchotan has been done. The slabs were characterized by using XRD and FTIR intrumentations to determine their crystallography and functional groups. The electrical response of slabs was measured on impedance spectroscopy instrumentation. The conductivity, impedance, and dielectric constant were calculated from impedance spectroscopy data. Diffractograms showed crystalline carbon and confirmed with the existence of peaks, at 2θ, 24.5° and 44.56°. FTIR analysis showed that carbon palm shells have the absorption length is in the range of wave numbers 1100 – 1200 cm-1 for CO of carboxylic acid, aldehyde, ketone and ester, from 1475 to 1600 cm-1 for C=C aromatic ring and double peaks in 1900 – 2100 cm-1 for conjugated C-C. The slabs conductivity varies from 1 to 7 mScm-1. Impedance values for the slabs vary from 1.5 to 2.4 ohm. Dielectric constants for the slabs range from 0.42 to 140.
Synthesis and Characterization of Schiff Base Compound Benzaldehyde- 2,4-Dinitrophenylhydrazone as a Carbonate Anion Sensor Musyrifah, Arina; Hidayati, Nurlisa; Yuliasari, Nova
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 3 (2025): October 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i3.198

Abstract

Benzaldehyde-2,4-dinitrophenylhydrazone was synthesized via  the condensation of benzaldehyde with 2,4- dinitrophenylhydrazine. The product was analyzed using UV–Vis and FT-IR spectroscopy, and its solvatochromic properties were investigated in DMF, acetone, and ethanol. Its application as a carbonate anion sensor was evaluated under optimized conditions. Schiff base formed orange crystalline solids with a 91.86% yield. UV-Vis spectra showed maximum absorption wavelength at 260 nm (π-π*) and 390 nm (n-π*). FT-IR analysis proves the presence of azomethine band (HC=N) at 1618 cm-1 and the shift of the N-H stretching band region from 3325 to 3284 cm-1. Among the solvents studied, DMF exhibited the highest solubility and color stability, acetone showed the greatest absorbance but poor stability, and ethanol showed low solubility with the formation of a precipitate. Functioning as a carbonate anion sensor, the Schiff base exhibited a noticeable color change from yellow to red, along with a bathochromic shift from 390 nm to 495 nm (π→π*), reaching its maximum response after 30 minutes.
Study of Congo Red Adsorption by Chitosan-Graphene Oxide (Chitosan-GO) Composite Synthesize with Hydrothermal Synthetic Method: Optimization and Determination Condition Desnelli, Desnelli; Safitri, Siska; Musifa, Eva; Hamidah, Afreni; Suheryanto, Suheryanto; Mara, Ady; Said, Muhammad
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 2 (2025): June 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i2.101

Abstract

This research aims to synthesize chitosan-graphene oxide (chitosan-GO) material using the hydrothermal method at varying material ratios and adsorption studies on Congo red. Chitosan-GO composites were synthesized with mass ratios of (1:1), (1:3) and (1:5). The synthesized chitosan-GO composite was applied to absorb Congo red dye. The adsorption process is carried out by varying pH, contact time, concentration and temperature. The chitosan-GO composite was characterized using XRD, BET and SEM-EDS. The results of XRD characterization of the chitosan-GO composite with a ratio of 1:1 showed a diffractogram of 2θ = 22.3°, at a ratio of 1:3 the diffractogram angle was 2θ = 22.1°, while the ratio (1:5) of the diffractogram peak obtained was 2θ = 22.8°. The surface area obtained in chitosan-GO composite was 11.60 m2/g. The morphology of the chitosan-GO composite (1:5) is in the form of crystalline lumps with the constituent elements C (65.98%), O (32.68%), Na (0.22%) and S (0.09%). Adsorption of Congo red dye using chitosan-GO composite obtained optimum conditions at pH 7, contact time 50 minutes, Congo red concentration 45 mg/L and temperature 50°C. The adsorption isotherm is in accordance with the Langmuir isotherm model and the maximum adsorption capacity (Qm) is 10.245 mg/g.
The Effect of Using Wet Ash as a Substitute for Quicklime in Improving the Quality of Acid Mine Drainage from Coal Mining Fikri, Muhammad; Agustina, Tuty Emilia; Hermansyah, Hermansyah
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 2 (2025): June 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i2.154

Abstract

Acid Mine Drainage (AMD) management uses the active treatment method with the addition of alkaline neutralizing chemicals such as lime (CaCO3, CaO) although the cost is more expensive. Several previous studies indicate that the application of boiler ash can increase pH and nutrient content because it is alkaline. The boiler ash used in this study came from the remaining burning of bark at a Medium Density Fiberboard industrial. Boiler ash containing water is known as Wet Ash and is strongly alkaline (pH 11.92). The purpose of this study was to analyze the effect of adding wet ash and to analyze the effectiveness of AMD processing on pH, Total Suspended Solids (TSS), Fe and Mn. The method this study: wet ash samples of 2.5 g, 5 g, 7.5 g, 10 g, 12.5 g and 15 g were mixed with 10 liters of AMD, homogenized for 10 minutes, then analyzed in the laboratory to determine its characteristics. The results of the study on the characteristics of wet ash treatment of 15 g/L with pH = 7.21, TSS = 326 mg/L, Fe = <0.018 mg/L, Mn = 6.42 mg/L is the best treatment because all parameters meet the quality standards.
Antibacterial Activity of Nanocomposite Chitosan-Silver Nanoparticle with Cymbopogon citratus Extract as a Bioreductor Against Staphylococcus aureus Anggraeni, Rezky; Melyda, Ananda Shelly; Pakpahan, Alfred; Ranggaini, Dewi; Halim, Johni; Komariah, Komariah
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 2 (2025): June 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i2.112

Abstract

Nanocomposites are materials formed by combining two components, one or both of which are on the nanometer scale. The nanocomposite in this study is a combination of chitosan and silver nanoparticles produced through the synthesis of silver nitrate using Cymbopogon citratus extract. Silver nanoparticles have antibacterial abilities that can be utilized to overcome various diseases. However, their antibacterial properties may be reduced due to the tendency of silver nanoparticles to agglomerate. This can be overcome by the addition of chitosan as a stabilizing agent to prevent agglomeration and maintain the antibacterial effectiveness of silver nanoparticles. This study aims to evaluate the antibacterial activity of a nanocomposite formed by combining chitosan and silver nanoparticles synthesized using Cymbopogon citratus extract against Staphylococcus aureus through the diffusion method. The samples used included nanocomposites at concentrations of 6.25 mg/mL, 12.5 mg/mL, 15 mg/mL, 25 mg/mL, and 50 mg/mL, amoxicillin as a positive control, Acetic acid, and distilled water as negative controls. The results of antibacterial activity testing showed that all nanocomposite test concentrations had the ability to inhibit the growth of Staphylococcus aureus as evidenced by the formation of an inhibition zone around the disc paper. However, the highest antibacterial activity shown by the nanocomposites was still lower compared to the antibacterial activity of amoxicillin Keywords: Antibacterial activity, Chitosan, Cymbopogon citratus, Silver nanoparticles, Staphylococcus aureus

Page 19 of 20 | Total Record : 196

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