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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Pengaruh Ekstrak Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis Linn.) terhadap Jumlah, Motilitas, Morfologi, Viabilitas Spermatozoa Tikus Jantan Julia, Dina; Salni, Salni; Nita, Sri
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 3 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Partisipasi laki-laki dalam KB masih relatif rendah bila dibandingkan dengan keikutsertaan perempuan. Salah satu tanaman obat tradisional yang digunakan adalah  bunga kembang sepatu yang bersifat antifertilitas. Penelitian ini bertujuan untuk menguji pengaruh ekstrak bunga kembang sepatu  terhadap jumlah, motilitas, morfologi dan viabilitas spermatozoa tikus jantan (Rattus norvegicus). Penelitian ini merupakan penelitian eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL). Sampel dalam penelitian ini menggunakan 25 tikus jantan strain Sprague Dawley usia 60-70 hari dengan berat badan 200-210 gram. Lama perlakuan 30 hari dengan dosis 200 mg/kgBB, 300 mg/kgBB, 400 mg/kgBB. Data disajikan dalam bentuk tabel dan diagram serta narasi untuk  menginterpretasikan data tersebut. Hasil penelitian ini menunjukkan adanya penurunan jumlah sperma pada kelompok perlakuan dibanding kelompok kontrol (p=0,000), terjadi penurunan motilitas sperma (p=0,001), terjadi peningkatan morfologi abnormal (p=0,000), dan terjadi penurunan viabilitas spermatozoa antara kelompok perlakuan dibanding kelompok kontrol (p=0,000). Dapat disimpulkan  bahwa ada perbedaan bermakna dari pengaruh ekstrak bunga kembang sepatu terhadap jumlah, motilitas, morfologi, viabilitas spermatozoa. 
Hubungan Aktivitas Fisik, Kualitas Tidur, dan Indeks Massa Tubuh dengan Kadar HbA1c Pada Pasien DM Tipe 2 yang Datang ke Poliklinik Endokrin Metabolik Diabetik Bonita, Bella; Asnawi, Herry; Aulia, Hendarmin
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Diabetes melitus merupakan salah satu kelompok penyakit metabolik kronis yang ditandai oleh hiperglikemia karena gangguan sekresi insulin, kerja insulin, atau keduanya. Peningkatan jumlah penderita DM tipe 2 berkaitan dengan faktor risiko yang tidak dapat diubah dan faktor risiko yang dapat diubah. Penyakit DM tipe 2 dapat dipantau melalui pengontrolan glukosa darah jangka panjang dengan melakukan pemeriksaan HbA1c. Penelitian ini bertujuan untuk mengetahui hubungan faktor-faktor resiko DM tipe 2 dengan kadar HbA1c sebagai indikator glikemik. Penelitian ini menggunakan rancangan cross sectional. Populasi penelitian ini adalah semua pasien yang datang ke poliklinik endokrin RSUP Dr. Mohammad Hoesin Palembang pada bulan November-Desember 2016. Didapatkan 47 sampel yang diambil dengan teknik consecutive sampling. Data primer diambil dengan cara wawancara langsung dan data sekunder diambil dari rekam medis di Bagian Instalasi Rekam Medis RSUP Dr. Mohammad Hoesin Palembang. Data yang diperoleh dianalisis menggunakan uji Fisher Test dan uji regresi logistik.  Pada uji Fisher Test diketahui terdapat  hubungan antara aktivitas fisik dan kadar HbA1c (p=0,000), terdapat hubungan antara kualitas tidur dan kadar HbA1c (p=0,001), dan tidak ada hubungan antara indeks massa tubuh dan kadar HbA1c (p=0,128). Pada analisis multivariat diketahui kualitas tidur merupakan faktor yang paling mempengaruhi kadar HbA1c (OR=0,038).Kata kunci Aktivitas Fisik, Kualitas Tidur, Indeks Massa Tubuh, HbA1c 
Efektivitas Ekstrak Etanol Daun Salam (Eugenia polyantha) terhadap GLUT 4 di Jaringan Adiposa dan Kadar Gula Darah Puasa pada Tikus Putih Jantan Zanaria, Rima; Kamaluddin, MT; Theodorus, Theodorus
Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya Vol 3, No 3 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Diabetes Mellitus merupakan penyakit epidemik global, cenderung meningkat dengan berbagai kondisi patologis yang menyertainya, sehingga membutuhkan preparat baru yang poten,tidak toksik, efektif dalam  pemberian dan harga terjangkau untuk mengevaluasi efektivitas ekstrak etanol dalam daun salam (Eugenia polyantha) terhadap GLUT 4 di jaringan adiposa dan kadar gula darah puasa tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi diet tinggi lemak (HFD-dexamethasone. Desain penelitian ini adalah ekperimental, rancangan pre dan post test dengan kelompok kontrol dilakukan di Animal house Fakultas Kedokteran Universitas Sriwijaya. Tiga puluh enam ekor  tikus dengan berat antara 150 - 200 gram secara acak dibagi menjadi 6 kelompok. Setelah di aklimatisasi selama 7 hari dan diinduksi dengan high fat diet 5 ml per oral serta dexamethasone  250 µg/kgbb intraperitoneal selama 35 hari. Kelompok kontrol (-) diberi larutan aquades sebanyak 2 ml, kelompok pertama diberi ekstrak ethanol daun salam dosis 62,5 per kilogram berat badan, kelompok kedua  diberi ekstrak ethanol daun salam dosis 125 mg per kilogram berat badan,  kelompok ketiga diberi ekstrak etanol daun salam dosis 250 mg per kilogram berat badan,  kontrol (+) diberi Pioglithazone dosis 0,02 gram per kilogram berat badan. Semua perlakuan diberikan selama 14 hari. Data diperoleh dengan analisis ANOVA dan post hoct test spss versi 18. Induksi HFD /dexamethasone pada tikus selama 35 hari menujukan peningkatan kadar glukosa darah secara signifikan lalu tikus dieutanasia dengan ketamin 70 mg/kgbb intraperitoneal lalu dilakukan autopsi dan diambil jaringan adiposa. Intervensi ekstrak ethanol daun salam selama 14 hari pada tikus diabetes mellitus efektif meningkatkan kadar GLUT 4 di jaringan adiposa (p<0,05) dibanding kontrol negatif dan Pioglitazone, Ekstrak etanol daun salam dosis 125 mg per kilogram berat badan tikus  merupakan dosis paling efektif dalam meningkatkan GLUT 4 dijaringan adiposa, sedangkan dalam menurunkan kadar gula darah puasa dosis 62,5 mg/kgbb tikus, 125 mg/kgbb tikus,250 mg/kgbb tikus sama efektifnya dengan kontrol positif obat pioglithazone. Ekstrak etanol daun salam  (Eugenia polyantha) berpotensi meningkatkan kadar GLUT 4 di jaringan adiposa tikus dan menurunkan kadar gula darah puasa pada tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi HFD/dexametasone. Kata kunci : Ektrak Etanol daun salam, HFD/Dexamethasone, GLUT 4 di jaringan adiposa, in Vivo
EFFECT OF JATI BELANDA LEAVES EXTRACT ON MYELOPEROXIDASE LEVEL IN WISTAR RAT'S LUNG INDUCED CONTUSION PULMONUM Tamzil, Nia Savitri; Lusiana, Evi; Oktariana, Desi
Biomedical Journal of Indonesia Vol 5, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.10009

Abstract

Pulmonary contusions are injuries to the lung parenchyma that often result from blunt trauma to the chest wall. This injury will activate the inflammatory response which can produce the effects of oxidative stress so that eventually lung damage occurs. Several studies have identified the effects of Jati Belanda leaves extracts related to the inflammatory process and their effects as antioxidants. This research is an in vivo experimental study with a prepost-test with control group design approach that aims to determine the effectiveness of the extracts of Jati Belanda (Guazuma ulmifolia) in its protection against pulmonary alveolar cells by pretreatment pulmonary contusions. The subjects of this study were white rats (Rattus norvegicus) Wistar strain which were divided into 5 groups namely positive control, negative control, Dutch teak leaf extract 125 mg / kgBB, 250 mg / kgBB and 500 mg / kgBW. Rats were induced by dropping a weight of 400 grams as high as 50 cm. The results of the study of Jati Belanda Leaf Extract (EDJB) all doses and positive control can significantly reduce levels of myeloperoxidase expression (p &lt;0.05). Therefore, it can be concluded that the extracts of Jati Belanda leaves (Guazuma ulmifolia) are all effective doses in reducing the expression of myeloperoxidase in pulmonary tissue of Wistar rats induced by pulmonary contusions.
RELATIONSHIP OF BIORHYTHMS CYCLE WITH COMPUTER BASED TEST (CBT) VALUES IN MEDICAL EDUCATION STUDY PROGRAM STUDENTS AT THE FACULTY OF MEDICINE, SRIWIJAYA UNIVERSITY Dita, Nurul Salmah Alia; bahar, Erial; Roflin, Eddy
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7985

Abstract

  The human body has many rhythms, one of which is biorhythms. Biorhythms consist of three cycles namely physical, emotional and intellectual cycles. Each cycle has positive, negative and critical phases. When taking an exam, a person needs good physical, mental, and intellectual condition. By using the biorhythms cycle, one can see these conditions in order to prepare for the exam. This research is an observational analytic study with cross sectional design. The sample consisted of 386 students of the Medical Education Study Program of Sriwijaya University in 2014 and 2015 in total sampling that met the inclusion criteria. Data taken in the form of secondary data consisting of CBT scores, exam dates, and entry points obtained from the academic section of the Faculty of Medicine, Sriwijaya University, while data on birth dates, BMI and IQ scores were taken from the questionnaire. Biorhythm cycle data is retrieved using biorhythm software. Data processing was performed using Kruskal Wallis test analysis and Linear Regression. From the results of bivariate analysis with the Kruskall Wallis test it is found that IQ scores have a relationship with CBT values (p = 0.010), university entrance has a relationship with CBT values (p = 0,000), and the physical cycle of biorhythms is related to CBT values (p = 0.011), However, in multivariate analysis (Linear Regression) the physical cycle of biorhythms has no relationship with the value of CBT. There is no correlation between biorhythms cycles and CBT scores in the Medical Education Study Program students at the Faculty of Medicine, Sriwijaya University.
EVOLUTION OF CARDIOLOGY AS A SPECIALTY Edo Tondas, Alexander; Anwar, Chairil; Agustian, Rolando
Biomedical Journal of Indonesia Vol 5, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.9790

Abstract

Science is a conscious effort to try, find and improve human understanding from various aspects in human nature. The number of medical specialties continues to grow until they reach even smaller branches known as sub-specialties. One type of specialization in medical science is the specialization of cardiology, the science that focuses on the needs of the heart organ. The development of cardiology cannot be separated from the history behind it. The progress of cardiology up to this point is a continuous interrelated journey. Every lesson in the past will be a capital for future experience, as will cardiology, where each phase becomes the foundation for future development.
CORRELATION BETWEEN SERUM FERRITIN LEVELS AND NUTRITIONAL STATUS OF THALASSEMIA-BETTA MAJOR PATIENTS Rafika, Rafika; Marwoto, Djoko; Hayati, Lusia
Biomedical Journal of Indonesia Vol 5, No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i2.7986

Abstract

Thalassemia is a chronic disease that requires repeated blood transfusions, due to impaired hemoglobin synthesis due to mutations of one or more globin genes. Continuous transfusion can cause iron accumulation in the body, especially the heart, liver and endocrine organs, and can cause stunted growth and malnutrition or poor nutrition. This study aims to determine the correlation between serum ferritin levels and the nutritional status of thalassemia-betta major patients in RSUP Dr. Moh. Hoesin Palembang. This research is an observational analytic study with cross sectional design. The sample of this study was thalassemia-betta major patient who was hospitalized in the Department of Pediatrics. Mohammad Hoesin from October to November 2016 who met the participation criteria. Of the 43 patients, the majority (60.5%) had lean bodies according to their weight index according to age (BW / U) and were short stature according to their height index according to age (TB / U), but only 14.0% of patients had undernourished nutrition BB / TB index. Obtained average values of serum ferritin 2837.69 g / L, with a range of 278.7-13867 g / L. The results of the correlation test between serum ferritin levels and nutritional status indicate p = 0.326 and r = 0.153. There was no significant correlation between serum ferritin levels and the nutritional status of thalassemia-betta major patients.
CORRELATION OF PARENTING WITH DELINQUINCY IN JUNIOR HIGH SCHOOL STUDENTS Aini, Syarifah; Rina, khairina; Maramis, Margarita M
Biomedical Journal of Indonesia Vol 5, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.10120

Abstract

Juvenile delinquency is a serious problem in all countries. Adolescent involved in delinquency have the potential to be involved in serious criminality. Many factors are thought to be the cause of juvenile delinquency, one of which is family. Parenting is a parent's act of educating their children, especially in providing values and norms that influencing the child development, including antisocial behavior that is associated with delinquency. To analyze the relationship between parenting towards juvenile delinquency in a private junior high school students in Surabaya. An observational cross-sectional analytic study that correlate between parenting towards juvenile delinquency in a junior high school students in Surabaya. The sampling technique is cluster random sampling. To asses the parenting style used the Alabama parenting questionnaire (Parental Authoritory Questionaire). Juvenile delinquency was assessed by Self-Report Delinquincy questionnaire. It was found that 70% of the subjects involved in delinquency with 52.63% experienced authoritative mothering and 66.18% experienced authoritative fathering. There was no significant relationship between mothering towards juvenile delinquency. There was a significant relationship between fathering, especially authoritative fathering towards mild juvenile delinquency and authoritarian fathering towards moderate juvenile delinquency in private junior high school students in Surabaya.Conclusion:There is relationship between parenting and juvenile delinquency.
IFN-GAMMA SECRETION AND IL-10 AFTER STIMULATION OF ESAT-6-CFP-10 (EC610) FUSION ANTIGEN IN PATIENTS WITH ACTIVE TUBERCULOSIS AND LATENT TUBERCULOSIS Prihantika S., Sabrina; Kurniati, Nova; Rahadiyanto, Kemas Ya'kub; Saleh, M Irsan; Hafy, Zen; Tanoerahardjo, Francisca Srioetami; Nugraha, Jusak; Salim, Eddy Mart
Biomedical Journal of Indonesia Vol 5, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i3.8897

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis which is still a health problem in the world including in Indonesia. TB infection arises due to interference with the regulation of the body's defense system. Cellular immune system plays a role in fighting TB infection, namely the role of T lymphocytes that differentiate into Th1 cells secrete pro-inflammatory cytokines IFN-? and Th2 cells that secrete IL-10 anti-inflammatory cytokines. The EC610 fusion antigen is specific and has a strong antigenicity to T cell stimulation. The aim of the study was to determine differences in the mean levels of IFN-? and IL-10 after EC610 antigen stimulation in patients with active TB and latent TB. The design of this study was a quasi-in vitro experiment with PBMC culture stimulated by EC610 antigens in the active TB and latent TB groups. The research and examination were carried out at the South Sumatra Province SSR and the Health Research and Development Laboratory Center, Central Jakarta. There were 21 subjects with active TB and 28 subjects with latent TB who met the inclusion criteria. Measurement of IFN-levels? and IL-10 was performed using ELISA-Reader. The results showed the levels of IFN-? and IL-10 after EC610 antigen stimulation were higher in active TB than latent TB. High levels of IFN-? active TB patients showed protective immune responses against M.tb germs while high levels of IL-10 showed their role as anti-inflammatory. There is no significant difference in the average level of IFN-? in patients with active TB and latent TB (p = 0.769) and there was a significant difference in the level of IL-10 levels after EC610 antigen stimulation was higher in active TB than latent TB (p = 0,000).
COMPARISON BETWEEN BELUNTAS (PLUCHEA INDICA LEES) FRACTION AND KETOCONAZOLE INVITRO ON CANDIDA ALBICANS Marsasi, Bina; Yuwono, Yuwono; Salni, Salni
Biomedical Journal of Indonesia Vol 5, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v5i1.7974

Abstract

Beluntas leaves are useful as a treatment for flour albus and discharge caused by fungi. This study aims to find the anti-fungal activity of fraction of beluntas (Pluchea indica Lees) leaf extract against Candida albicans. This research is an in vitro experimental study using the Posttest-only Control Group Design study design. Methanol extract is obtained through maceration process while the fraction is through liquid-liquid fractionation. The most active fraction is determined by the antifungal activity test. The most active fractions with concentrations of 10%, 5%, 2.5%, 1.25%, 0.625% and the diameter of the inhibition zone 0.3125% were measured by the liquid dilution method. Equivalence with drugs is assessed through regression analysis, then the class of active compounds is determined through bioautographic testing using thin layer chromatography. The research results obtained methanol-fraction-water can inhibit the growth of Candida albicans while the methanol extract, n-hexane and ethyl acetate do not inhibit. The methanol fraction of water which has inhibition zone diameters starts at a concentration of 0.3125% with an average diameter of 7.34 mm and at a concentration of 10% the largest diameter of 17.10 mm is obtained. Through the diluent liquid and the KHM solid fraction from the methanol-water fraction is inhibited at a concentration of 0.3125%. Equivalence test shows that 1 mg / ml of ketoconazole is equivalent to 39,561 mg / ml of methanol-water fraction of beluntas leaves. Compounds that inhibit fungi are thought to be active groups of flavonoid and alkaloid compounds. The methanol-water fraction of beluntas leaves (Pluchea indica Lees) has antifungal activity against Candida albicans in vitro.

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