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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
 6   7   8   9   10 
MRNA NFATC1 EXPRESSION IN GENU OSTEOARTHRITIS WITH EFFUSION Reagan, Muhammad; Hermansyah, Hermansyah; Hidayat, Rachmat; Darma, Surya; Muthia, Putri
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10418

Abstract

Based on a study conducted by the WHO Global Burden of Disease in 2010 stated, OA ranks 11th, the cause of disability in the world, and ranks 6th in East Asia and the Asia-Pacific countries, ranked 10th in North America, ranked 7th in Eastern Europe , and ranked 13th in Western Europe. Pathogenesis of osteoarthritis (OA) as degenerative joint disease that was once thought caused by a mechanical process. The prevalence, etiology, pathogenesis and progression of OA are still not understood until now, mainly because of the many influencing factors. This type of research is a analytic study. It was conducted in Rheumatology Polyclinic Dr. Mohammad Hoesin Palembang from February to December 2019. Affordable research population is all genu osteoarthritis sufferers with effusion who go to Dr. RSUP Mohammad Hoesin Palembang as 80 samples. Comparison of NFATC1 mRNA levels in genu osteoarthritis patients with effusion shows that there is no difference in gender and history of diabetes, whereas hypertension history and degree of osteoarthritis based on Lawrence Kalgren shows significantly different expression of NFATC1 mRNA. Age with NFATC1 mRNA expression showed no significant correlation, in contrast to BMI, Stroke Test and joint effusion volume showed a weak significant correlation, even though the direction of the correlation was negative on Stroke Test and joint effusion volume.
MRNA NFATC1 EXPRESSION IN GENU OSTEOARTHRITIS WITH EFFUSION Reagan, Muhammad; Hermansyah, Hermansyah; Hidayat, Rachmat; Darma, Surya; Muthia, Putri
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10418

Abstract

Based on a study conducted by the WHO Global Burden of Disease in 2010 stated, OA ranks 11th, the cause of disability in the world, and ranks 6th in East Asia and the Asia-Pacific countries, ranked 10th in North America, ranked 7th in Eastern Europe , and ranked 13th in Western Europe. Pathogenesis of osteoarthritis (OA) as degenerative joint disease that was once thought caused by a mechanical process. The prevalence, etiology, pathogenesis and progression of OA are still not understood until now, mainly because of the many influencing factors. This type of research is a analytic study. It was conducted in Rheumatology Polyclinic Dr. Mohammad Hoesin Palembang from February to December 2019. Affordable research population is all genu osteoarthritis sufferers with effusion who go to Dr. RSUP Mohammad Hoesin Palembang as 80 samples. Comparison of NFATC1 mRNA levels in genu osteoarthritis patients with effusion shows that there is no difference in gender and history of diabetes, whereas hypertension history and degree of osteoarthritis based on Lawrence Kalgren shows significantly different expression of NFATC1 mRNA. Age with NFATC1 mRNA expression showed no significant correlation, in contrast to BMI, Stroke Test and joint effusion volume showed a weak significant correlation, even though the direction of the correlation was negative on Stroke Test and joint effusion volume.
DRY NEEDLING CAN BE AN ALTERNATIVE TREATMENT FOR HEMIFACIAL SPASM Marisdina, Selly; Sugiharto, Henry; Pradian, A
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.11802

Abstract

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.
DRY NEEDLING CAN BE AN ALTERNATIVE TREATMENT FOR HEMIFACIAL SPASM Marisdina, Selly; Sugiharto, Henry; Pradian, A
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.11802

Abstract

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.
IFN-GAMMA AND IL-2 SECRETION AFTER ESAT-6-CFP-10 (EC-610) FUSION ANTIGEN STIMULATION FROM PATIENTS WITH ACTIVE LUNG TUBERCULOSIS AND LATENT LUNG TUBERCULOSIS Darwin, Bastian; Kurniati, Nova; Rahadiyanto, Kemas Ya'kub; Saleh, Mgs Irsan; Tanoehardjo, Francisca Srioetami; Nugraha, Jusak; Salim, Eddy Mart
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10741

Abstract

The Secretion of IFN-Gamma and IL-2 After ESAT-6-CFP-10 Fusion Antigen Stimulation in Active and Latent TB Patients. This study held to discover how immune responses work and to know the pathogenesis of active TB and latent TB patients. This study used PBMC to stimulate T Cells with ESAT-6 and CFP-10 antigen fusion, and measure the level of IFN-gamma and IL-2 with ELISA antibody sandwich (U-Cytech). 16 ml of blood were drawn to 5 tubes. ESAT-6 CFP-20 inducted one tube with QuantiFERON for IFN-gamma assay. The other four tubes were PBMC isolated using Ficoll-Paque, and pre-incubated with stimulation of ESAT-6 CFP-10 fusion antigen for 24-72 hours at 370 C and measured using T-Spot and ELISA reader. We got from this study that there are no significant differences in IFN-gamma levels for both groups with active TB and latent TB. Measurement of IL-2 levels showed significant differences between the two group.
IFN-GAMMA AND IL-2 SECRETION AFTER ESAT-6-CFP-10 (EC-610) FUSION ANTIGEN STIMULATION FROM PATIENTS WITH ACTIVE LUNG TUBERCULOSIS AND LATENT LUNG TUBERCULOSIS Darwin, Bastian; Kurniati, Nova; Rahadiyanto, Kemas Ya'kub; Saleh, Mgs Irsan; Tanoehardjo, Francisca Srioetami; Nugraha, Jusak; Salim, Eddy Mart
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10741

Abstract

The Secretion of IFN-Gamma and IL-2 After ESAT-6-CFP-10 Fusion Antigen Stimulation in Active and Latent TB Patients. This study held to discover how immune responses work and to know the pathogenesis of active TB and latent TB patients. This study used PBMC to stimulate T Cells with ESAT-6 and CFP-10 antigen fusion, and measure the level of IFN-gamma and IL-2 with ELISA antibody sandwich (U-Cytech). 16 ml of blood were drawn to 5 tubes. ESAT-6 CFP-20 inducted one tube with QuantiFERON for IFN-gamma assay. The other four tubes were PBMC isolated using Ficoll-Paque, and pre-incubated with stimulation of ESAT-6 CFP-10 fusion antigen for 24-72 hours at 370 C and measured using T-Spot and ELISA reader. We got from this study that there are no significant differences in IFN-gamma levels for both groups with active TB and latent TB. Measurement of IL-2 levels showed significant differences between the two group.
CYTOTOXICITY EFFECTS OF BENALU TEA EXTRACT (SCURRULA OORTINA) ON HELLA CELLS Hariyadi, Kusumo; Fatmawati, Fatmawati; Subandrate, Subandrate; Aninditia, Fahira; Dzakiyah, Dzakiyah
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10281

Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina Species Family: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra. Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanol subfraction. The extract was then dried by vacuum distillation at 70oC until a concentrated extract without ethanol was obtained. The results of the study were tea parasite extract, and the extract was tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates, quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory of Biological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells, with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538 ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that the parasite of the tea parasite had cytotoxic and proliferative effects.
CYTOTOXICITY EFFECTS OF BENALU TEA EXTRACT (SCURRULA OORTINA) ON HELLA CELLS Hariyadi, Kusumo; Fatmawati, Fatmawati; Subandrate, Subandrate; Aninditia, Fahira; Dzakiyah, Dzakiyah
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10281

Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina Species Family: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra. Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanol subfraction. The extract was then dried by vacuum distillation at 70oC until a concentrated extract without ethanol was obtained. The results of the study were tea parasite extract, and the extract was tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates, quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory of Biological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells, with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538 ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that the parasite of the tea parasite had cytotoxic and proliferative effects.
The Effect Of Giving Red Dragon Fruit (Hylocereus polyrhizus) Extract On Spermatozo Motility In White Rats (Rattus norvegicus) Wistar Line With High Fat Induction Nuranisa, Kirani; Cut Fauziah; Yuli Suciati
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.232

Abstract

Hyperlipidemia is a condition when high level of blood lipids and causes morphologicalchanges in spermatozoa. Red dragon fruit (Hylocereus Polyrhizus) is one of the plantsas a source of antioxidants and has unsaturated fat content that is needed in thespermatozoa maturation process. The aims of this the study is to determine the benefitsof red dragon fruit extract on the motility of white rat spermatozoa (Rattus norvegius)induced by high-fat diet. The study is design by true experimental research andresearch only testing group design. This research conducted in the Pharmacology andTherapy Laboratory, Padjajaran University Education Hospital, in January 2020 usingwhite rats, male . ± 8 weeks wistar strains weighing ± 200-250. The study sample wasdivided into several groups such group I as a control, group II as a negative control,group III as positive group with simvastatin dose 0.72 mg / day, group IV as researchgroup 1 using red dragon fruit extract dose of 60 mg / 200 grBB / day for 52 days, andgroup V as group 2 therapy using dragon fruit extract dose of 60 mg / 200grBB / dayfor 104 days. The results showed that the mean percentage of motility of ratspermatozoa increased in the relief group with the supplement of red dragon fruitextract by dosing of 60 mg / 200 grBB / day for 104 days, or 51, 2%. This studyconclude that red dragon fruit has a superior effectivity better than simvastatin inincreasing the motility of spermatozoa.
The Effectiveness Of Moringa oleifera L (Moringa oleifera L) Fraction On The Improvement Of Hemoglobine Levels Of Betinine Rat (Rattus norvegicus) Anemia Model Of Iron Deficiency Ricika, Winda
Biomedical Journal of Indonesia Vol. 6 No. 3 (2020): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i3.233

Abstract

The iron deficiency anemia is kind of anemia because the less of iron that make thefunction to tie oxygen is down. Young girl is one of sufferer group who’s prone to getanemia. The long consequence of anemia for the young girl will disturb fatal functionof some organ in their body. In general arise of headache symptoms and pain in thecentre of head. And the in pregnancy will increase some complication risk such asmaternal death. Premature born and perinatal death. One of nature ingredients(herbal) which is reported to have high iron content is kelor leaf (Moringa oleifera L) forabout 28, 29 mg/100 g kelor. The purpose of this research is to know the effectivenessof Kelor leave fraction ((Moringa oleifera L) to increase hemoglobin grade withpreclinical. Experimental research with complete random design (RAL) has been donein February till April 2019 in medical faculty laboratory of universitas sriwijayaPalembang. Sample of the research is female rat that has inclusion criteria as much30 rats. Divided into 5 group. That is negative control group. Positive control (ferrousfumarate 60%), n-heksan fraction, ethyl acetate, and 1% concentration of kelor leaveethanol, the data of Hb all of subject before and after treatment from subject of irondeficiency anemia has collected by using Easy Touch GCHb tool. The analysis data ofthis research used SPSS 2.2 version. The result of the research said that thehemoglobin grade before and after treatment showed significant increasing(p<0,05) forn – hexane fraction and acetate ethyl >45%. While ethanol fraction only 32%.

Page 8 of 40 | Total Record : 392

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