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INDONESIA
Science and Technology Indonesia
Published by Universitas Sriwijaya
ISSN : 25804405     EISSN : 25804391     DOI : -
Core Subject : Science, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics
An international Peer-review journal in the field of science and technology published by The Indonesian Science and Technology Society. Science and Technology Indonesia is a member of Crossref with DOI prefix number: 10.26554/sti. Science and Technology Indonesia publishes quarterly (January, April, July, October). Science and Technology Indonesia is an international scholarly journal on the field of science and technology aimed to publish a high-quality scientific paper including original research papers, reviews, short communication, and technical notes. This journal welcomes the submission of articles that covers a typical subject of natural science and technology such as: > Chemistry > Biology > Physics > Marine Science > Pharmacy > Chemical Engineering > Environmental Science and Engineering > Computational Engineering > Biotechnology Journal Commencement: October 2016
Arjuna Subject : -
Articles 26 Documents
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Search results for , issue "Vol. 9 No. 2 (2024): April" : 26 Documents clear
Formulation and Evaluation of Gambier (Uncaria gambir)-Chitosan Microparticle Intranasal Delivery for Alzheimer’s Diseases Fithri, Najma Annuria; Mardiyanto; Fitrya; Rahmah, Asfaraeni; Annisa, Novilia Megi
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.284-298

Abstract

Alzheimer’s Disease (AD), the most common form of dementia continues to be the deadliest neuro degenerative disease in recent years. Despite significant efforts to mitigate the progression of the disease, there is no known cure and development towards a more effective treatment is still lacking. AD is marked by exceptionally low amount of acetylcholine in the brain, formation of tau protein, and amyloid beta plaque. Current drugs of choice for treating AD, namely donepezil and memantine, are acetylcholinesterase (AChE) inhibitors which focused on delaying the onset of cognitive decline by maintaining acetylcholine concentration. Gambier water extract (GWE) contains high level of polyphenols which act as an antioxidant, exhibit strong correlation with AChE inhibitor. The aim of this research is to formulate and encapsulate GWE inside a microparticle system composed of chitosan and different crosslinkers, STPP (IMGS) and CaCl2 (IMGC), which were then characterized as AChE inhibitor using Ellman’s method. Variations of the formula were designed following Box-Behnken experimental design with chitosan and crosslinker concentration, crosslinker type, and stirring speed as variables. Initial activity of GWE, IMGS and IMGC as antioxidant were confirmed with DPPH method, obtaining a strong activity of 88.01, 82.11, and 84.99% DPPH inhibition at 100 ppm respectively. Promisingly, at concentration of 100 ppm GWE demonstrated AChE inhibition of 30.36%. However, this activity reduced after encapsulation into IMGS and IMGC, with 14.63% and 18.65% AChE inhibition, which can be linked to the relatively sustained diffusion of GWE from the polymer matrix. IMGS and IMGC diffusion profile showed release of 23.24% and 21.89% after 6 hours, with significant increase in diffusion after 24 hours with 74.92% and 71.19% respectively. Despite showing sustained release behaviour, both IMGS and IMGC ex-vivo diffusion significantly improved when compared to GWE which only diffused 51.84% after 24 hours. This result indicates encapsulation of GWE into a polymeric carrier could increase gambier diffusion through the nasal mucous membrane, significantly improving the potential to penetrate into the brain systemic circulation. Combined with desirable intranasal delivery characteristics, this research was able to demonstrate the promising potential of gambier water extract polymeric system as AChE inhibitors for AD therapy.
Anti-Inflammatory Activity and Phytochemical Profile from the Leaves of the Mangrove Sonneratia caseolaris (L.) Engl. for Future Drug Discovery Rozirwan; Ade Siswanto; Nadila Nur Khotimah; Redho Yoga Nugroho; Wike Ayu Eka Putri; Fauziyah; Rezi Apri; Hartoni
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.502-516

Abstract

The increasing demand for effective and natural anti-inflammatory agents prompts an investigation into the properties of Sonneratia caseolaris (L.) Engl., a plant traditionally used in medicine. This study aimed to explore the ability of S. caseolaris leaves extract to inhibit inflammation and accelerate wound healing. S. caseolaris leaves were collected from Tanjung Api-Api area, Banyuasin, South Sumatra. The method involved carrageenan induction in rat paws as an inflammatory model. The results showed that the most effective dose was found in the group with a dose of 150 mg/kg BW measured using a digital caliper and plethysmometer. The qualitative phytochemical test contain alkaloids, steroids, flavonoids, and phenols. The results GC-MS analysis were thought to contain aldehydes, glucosinolates, coumarins, esters, terpenoids, alcohols, lipids, tocopherols, and steroids. Due to their diverse range of mechanisms of action, coumarins show significant promise in mitigating inflammation and hold potential for treating inflammatory conditions. This study provides new insights related to the potential of S. caseolaris as a source of natural anti-inflammatory agents, supporting public comprehension regarding the utilization of traditional herbal remedies.
ZnAl LDH-based Derivative Materials as Photocatalysts: Synthesis, Characterization, and Catalytic Performance in Tetracycline Degradation Rohmatullaili; Ahmad, Nur; Erviana, Desti; Zultriana; Savira, Dila; Mohadi, Risfidian; Lesbani, Aldes
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.457-469

Abstract

Layered Double Hydroxide (LDH)-derived materials exhibited different characteristics from LDH precursors. The conversion of ZnAl LDH into its derivative material has been carried out to find the best catalyst for TC degradation. ZnAl (LDH)-based catalysts in this study have been effectively synthesized using coprecipitation, calcination, and restacking procedures. ZnAl Layered Double Oxide (LDO) is derived from the calcination of ZnAl LDH at 500°C. ZnAl LDH was also modified by adding Garcinia mangostana pericarp extract (GME). XRD, FT-IR, UV-DRS, and SEM-EDX were used to investigate the synthesized catalyst. ZnAl LDH exhibited the typical LDH FT-IR spectra, whereas ZnAl LDO showed metal oxide-like spectra, and the ZnAl-GME composite displayed the combination spectra of precursor material. The ZnAl LDH XRD diffraction pattern exhibited the attributes of a layered material, whereas the other three catalysts did not. Calcination destroyed the layered structure of ZnAl LDH, whereas the addition of GME to LDH and LDO generated a single-layered composite. The modified ZnAl-GME composite showed a decrease in both particle size and bandgap energy. At an ideal pH of 5, the synthesized catalyst was used in a batch system photodegradation of 5 mg/L Tetracycline (TC), employing solar light irradiation. ZnAl LDO holds the most significant catalytic activity and structural stability through the fifth regeneration cycle, degraded TC up to 100% in 90 minutes.
The Effects of Beta-Ionone Addition in Perfume on Behavior and Serum Cortisol Level of Stress-Induced Mice Budiman, Clarissa; Miatmoko, Andang; Tyas, Veronika Earline Pudji Setianing; Ardianto, Chrismawan; Retnowati, Dini
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.470-479

Abstract

Stress is a condition that triggers a change in behavior and physiological state, affecting mental health. Beta-Ionone is a monocyclic terpenoid compound that can lower stress levels. However, there is a lack of studies about the anti-stress capability of Beta-Ionone inhalation, although Beta-Ionone is commonly used as a fragrance in perfumes. This study aimed to evaluate the effect of Beta-Ionone addition as the fragrance in perfumes on mice stress. The Beta-Ionone perfume was formulated with Bergamot Oil, Lavender Oil, Eucalyptus Oil, Tea Tree Oil, and Patchouli Oil to produce Fem, Fem-Ion (Fem + Beta-Ionone), Masc, and Masc-Ion (Fem + Beta-Ionone), which had different preferable odors. The anti-stress effectivity was then evaluated in stress induced mice, which were restrained for one hour every day for one week. The perfumes were then given by inhalation every alternate day. The stress level of the mice was evaluated using a tail suspension test and serum cortisol level assays. The results showed that inhalation of the perfumes lowered the immobility time of mice in the tail suspension test, albeit the addition of Beta Ionone did not give a significant difference. Based on the results of serum cortisol level, there was a substantial decrease in serum cortisol by inhaling the Fem and Fem-Ion, showing decreases in stress level. However, there were increases in serum cortisol levels for Masc and Masc-Ion, indicating stress induction, which was suggested to be caused by 1,8-cineole, a compound in the Eucalyptus oil as the perfume oil components.
Assessment of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Albizia saponaria L. Bark Extract Lukman, Lukman; Rosita, Noorma; Widyowati, Retno
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.494-501

Abstract

Langir (Albizia saponaria L.), belonging to the family of the Fabaceae, is a medicinal endemic plant of South Sulawesi, Indonesia. The Albizia genus shows antioxidant, antibacterial, anthelmintic, antidandruff, and anti-inflammatory properties. In this study, total phenolic (TP) and total flavonoid (TF) extracts from the bark of A. saponaria were screened for robust antioxidant activity in order to identify potential sources of new compounds for use in pharmaceutical formulations in the future. TP and TF of the 96% ethanol extract and fractions (hexane, ethyl acetate, butanol, and water) were calculated by the Folin–Ciocalteu and aluminum chloride procedures, respectively. Furthermore, the antioxidant activity was determined by DPPH free radical scavenging method and ABTS assay. Generally, both extract and fractions showed significant radical scavenging activities. Ethyl acetate fraction exhibited more potent radical scavenging activity in the DPPH method (IC50 35.27 ± 2.85 µg/mL) and ABTS assay (IC50 60.04 ± 0.98 µg/mL), followed by 96% ethanol extract, and hexane, butanol, and water fractions. Furthermore, the highest TP (4.50 ± 0.01 mg/g GAE) and TF (3.55 ± 0.04 mg/g QE) were obtained from ethyl acetate fraction. There was a strong correlation between antioxidant activity with TP (DPPH, R2 = 0.6436; ABTS, R2 = 0.7676) and TF content (DPPH, R2 = 0.5533; ABTS, R2 = 0.5961). The extract’s antioxidant properties may be attributable to its higher phenolic and flavonoid content. In summary, the phenolic and flavonoid content of the ethyl acetate fraction indicates its potential utility as a source of antioxidants.
Molecular Docking of Flavonoids from Extract of Roselle (Hibiscus sabdariffa L.) Calyx on PBP2a as the Basis for Antibacterial Activity Against Methicillin Resistant Staphylococcus aureus Ramadhani, Firmansyah Ardian; Prastika, Marsha Fendria; Fikriyah, Nuril; Isnaeni; Diyah, Nuzul Wahyuning
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.487-493

Abstract

The increasing bacterial resistances to antibiotics are serious threat to world health. In Indonesia, there are resistant bacteria such as Methicillin Resistant Staphylococcus aureus (MRSA). In order to overcome the problem, the compounds contained in the Hibiscus sabdariffa L. are potential to be developed as new antibacterial against MRSA. To confirm the antibacterial activity, the extract of roselle calyx was tested against MRSA. The twelve compounds contained in the extract was docked into binding site of PBP2a using Autodock 4.2.6. The results showed MIC 2.5% of roselle extract. Two flavonoid compounds comply the Lipinski’s rules and the docking results showed all compounds had higher binding affinity than reference ligand ceftobiprole. The quantitative structure-physicochemical property relationship (QSPR) found that steric property (CMR) and energy (Etotal) of ligand contributed to the binding affinity against PBP2a. It concluded kaempferol-rutinoside was the most potential compound from H. sabdariffa that could be selected as lead compound to be develop as antibacterial agents.

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