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All Journal Science and Technology Indonesia Journal of Islamic Medicine SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Ramadhani, Firmansyah Ardian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Molecular Docking of Flavonoids from Extract of Roselle (Hibiscus sabdariffa L.) Calyx on PBP2a as the Basis for Antibacterial Activity Against Methicillin Resistant Staphylococcus aureus Ramadhani, Firmansyah Ardian; Prastika, Marsha Fendria; Fikriyah, Nuril; Isnaeni; Diyah, Nuzul Wahyuning
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.487-493

Abstract

The increasing bacterial resistances to antibiotics are serious threat to world health. In Indonesia, there are resistant bacteria such as Methicillin Resistant Staphylococcus aureus (MRSA). In order to overcome the problem, the compounds contained in the Hibiscus sabdariffa L. are potential to be developed as new antibacterial against MRSA. To confirm the antibacterial activity, the extract of roselle calyx was tested against MRSA. The twelve compounds contained in the extract was docked into binding site of PBP2a using Autodock 4.2.6. The results showed MIC 2.5% of roselle extract. Two flavonoid compounds comply the Lipinski’s rules and the docking results showed all compounds had higher binding affinity than reference ligand ceftobiprole. The quantitative structure-physicochemical property relationship (QSPR) found that steric property (CMR) and energy (Etotal) of ligand contributed to the binding affinity against PBP2a. It concluded kaempferol-rutinoside was the most potential compound from H. sabdariffa that could be selected as lead compound to be develop as antibacterial agents.
Aktivitas Anti Trombotik dari Genus Curcuma : Kajian Sistematik Sandhori, Fajar Jamaluddin; Kusumawati, Idha; Samirah, Samirah; Rullyansyah, Subhan; Ramadhani, Firmansyah Ardian; Prasetyawan, Hanif Rifqi; Warsito, Mega Ferdina
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.25929

Abstract

Background : The Curcuma genus has various pharmacological activities, one of these is antithrombotic activity by preventing thrombus formation. Some of its chemical contents are also known to inhibit thrombus formation including curcumin, bisdemethoxycurcumin, ar-turmerone, and xanthorrizhol compounds. Antithrombotic drugs are used for the prevention and treatment of thrombosis whose mechanisms are divided into anticoagulants, thrombolytics, and antiplatelets. Objective: This review article discusses the potential of Curcuma genus as antithrombotic, including anticoagulant, antiplatelet, and thrombolytic, Methods: This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method using four databases : PubMed, ScienceDirect, Scopus, and Google Scholar from July to December 2023. The inclusion criteria used were articles on antithrombotic activity, including anticoagulants, antiplatelets, and thrombolytics from the genus Curcuma. Results: The number of articles obtained from four databases was 3413 articles. Furthermore, based on the results of filtering duplicate articles from all databases, 2771 articles were selected and then continued with screening based on inclusion and exclusion criteria until 15 articles were selected as material for systematic review. Conclusion: Curcuma species that have potential as antithrombotic are Curcuma longa, Curcuma zedoaria Rosc., Curcuma amada, Curcuma caesia, Curcuma aeruginosa, Curcuma latifolia, Curcuma aromatica Salisb, Curcuma wenyujin, and Curcuma xanthorrhiza
Peningkatan Nilai Guna Limbah Kulit Jeruk Nipis melalui Produk Sederhana Guna Mendukung SDGs bagi Petani Jeruk di Kecamatan Ujung Pangkah, Gresik Sari, Retno; Hendradi, Esti; Rijal, Agus Syamsur; Retnowati, Dini; Suzana, Suzana; Ramadhani, Firmansyah Ardian; Miatmoko, Andang; Sulistyowati, Melanny Ika; Sukardiman, Sukardiman; Ekowati, Juni
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 1 (2025): Volume 8 No 1 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i1.18244

Abstract

ABSTRAK Permasalahan di Desa Bolo Ujung Pangkah Gresik produksi jeruk nipis yang tinggi/melimpah. Sehingga harga jual menjadi rendah dan banyak produk panen tidak dapat terserap oleh pasar. Selain itu limbah kulit jeruk nipis yang terbuang juga akan meningkat. Hal ini akan mengakibatkan kerugian bagi petani. Permasalahan tersebut akan dibantu dengan kegiatan pengabdian kepada masyarakat dengan tujuan untuk menambah pengetahuan masyarakat dengan meningkatkan nilai guna limbah jeruk nipis di kecamatan Ujung Pangkah, Gresik, khususnya di desa Bolo melalui pengolahan produk berbahan ekstrak kulit jeruk nipis. Hal ini sesuai dengan tujuan Sustainable Development Goals (SDGs) 12 yaitu pemanfaatan sumber daya alam yang efisien. Kegiatan pengabdian masyarakat diawali dengan pre-test yang dilanjutkan dengan pemaparan materi dan demo pembuatan produk micellar water dan hand sanitizer dari ekstrak kulit jeruk. Selanjutnya dilakukan post-test untuk mengukur perubahan pengetahuan peserta setelah pelatihan. Berdasarkan hasil pre-test dan post-test terdapat peningkatan kemampuan dan pengetahuan peserta tentang khasiat bahan yang terkandung dari kulit jeruk. Peserta dapat meningkatkan nilai guna dari limbah kulit jeruk nipis dalam bentuk produk sederhana kaya manfaat seperti micellar water dan hand sanitizer dari kulit jeruk nipis. Kata Kunci: Kulit Jeruk Nipis, Micellar Water, Hand Sanitizer, SDGs 12  ABSTRACT The problem in Bolo Ujung Pangkah Gresik Village is the high/abundant production of limes. So that the selling price is low and many harvested products cannot be absorbed by the market. In addition, the waste of lime peels that are thrown away will also increase. This will result in losses for farmers. The problem will be helped by community service activities with the aim of increasing public knowledge by increasing the utility value of lime waste in Ujung Pangkah sub-district, Gresik, especially in Bolo village through processing products made from lime peel extract. This is in accordance with the objectives of Sustainable Development Goals (SDGs) 12, namely efficient utilization of natural resources. Community service activities began with a pre-test followed by a presentation of materials and a demonstration of making micellar water and hand sanitizer products from orange peel extract. A post-test was then conducted to measure changes in participants' knowledge after the training. Based on the results of the pre-test and post-test, there was an increase in participants' abilities and knowledge about the properties of the ingredients contained in lime peel. Participants can increase the utility value of lime peel waste in the form of simple, beneficial products such as micellar water and hand sanitizer from lime peel. Keywords: Lime Peel, Micellar Water, Hand Sanitizer, SDGs 12
Inovasi Produk Olahan Tahu dan Pengemasannya serta Pengembangan Pemasaran dalam Upaya Meningkatkan Pendapatan Perajin Tahu di Desa Karanganyar Kecamatan Wates Kabupaten Kediri: Innovation in Processed Tofu Products and Their Packaging and Marketing Development in an Effort to Increase the Income of Tofu Crafters in Karanganyar Village, Wates District, Kediri Regency Purwanto, Bambang Tri; Ekowati, Juni; Widiandani, Tri; Hariyadi, Dewi Melany; Hendradi, Esti; Yusuf, Helmy; Purnomo, Ahmad Toto; Ramadhani, Firmansyah Ardian; Siswandono, Siswandono; Wiyono, Anang Setyo; Yuliati, Ninis; Kristianingsih, Ida; Savitri, Orchidea Meidy Nurintan; Maulia, Arwinda; Rahman, Ave
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 11 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i11.8698

Abstract

MSMEs in the food sector are among the main supporters of Indonesia's economic activities. As a food production center in the form of tofu products, Kediri Regency is well known to the public, with white, yellow, silk, and other tofu products. Most of the tofu production carried out to date is only in the form of tofu products in their original form. This is because tofu craftsmen have not utilized other processed tofu products to increase their income. This community service activity aims to introduce innovations in processed tofu products, packaging, marketing, and processing of liquid tofu waste into new products which are expected to increase the income of tofu makers in Karanganyar village, Wates District, Kediri Regency. This community service activity was carried out using the media of presenting several materials and carrying out two-way interactive discussions. Evaluation of this activity was carried out with pre- and post-tests from the participants by answering 10 questions related to the three materials. The results obtained after being analyzed using the SPSS program showed differences between the pre-and post-tests of the participants, whereas the post-test results showed that the participants had understood the material provided during this activity. Thus, it can be concluded that this activity can be proven to be understood by the participants regarding innovation in processed tofu products and processing of tofu liquid waste.
Edukasi tanaman pojok herbal serta pengembangan produk jahe dan sereh untuk peningkatan ekonomi Desa Pulungdowo Ekasari, Wiwied; Suciati, Suciati; Iswahjuni, Iswahjuni; lahardo, devanus; Ramadhani, Firmansyah Ardian; Fatmawati, Annisa; Hutami, Anisa Tri; Tjandra, Edbert Rafael; Yuliana, Khalifah; Purbiastuti, Putri Ayu; Nugroho, Novreza Avistha; Wijayanti, Galuh Candra; Gerriandi, Aqila Aqhnia; Rahmadani, Andini Putri; Akbar, Jasmine Aulia; Putri, Nindya Tresiana
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 4 (2024): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i4.28178

Abstract

AbstrakDesa Pulungdowo terletak di Kecamatan Tumpang, Kabupaten Malang, Jawa Timur memiliki sumber daya alam melimpah yakni jahe dan sereh. Namun, pemanfaatan sumber daya alam ini belum maksimal, yang disebabkan oleh kurangnya pengetahuan masyarakat mengenai manfaat, pengolahan, serta pemasaran produknya di pasaran. Kegiatan ini bertujuan untuk meningkatkan Indeks Ketahanan Ekonomi Desa menjadi desa mandiri atau maju dengan pemanfaatan produk jahe dan sereh, serta menjadi desa percontohan Pojok Herbal. Pada tahun ke-1, pengabdi telah memberikan pelatihan pembuatan stik daun kelor, sirup dan permen Jarecang (jahe, sereh dan secang). Untuk mengoptimalkan potensi Desa Pulungdowo, maka pada tahun ke-2 dilanjutkan dengan pembentukan Pojok Herbal yang ditanami berbagai jenis tanaman obat keluarga dilengkapi dengan display produk dan buku-buku terkait obat tradisional, serta diversifikasi produk berupa pelatihan pembuatan teh celup Jarecang dan pembuatan simplisia dengan pendampingan fasilitator. Untuk melengkapi keterampilan mitra dalam produksi produk-produk tersebut, mitra diajarkan mengenai cara perhitungan keuangan untuk produk yang dihasilkan. Kegiatan ini juga dilengkapi dengan pemberian materi mengenai pemanfaatan tanaman obat untuk kesehatan dan kemasan serta label produk yang baik. Adapun materi pelatihan diberikan dengan metode ceramah dan Experimental Learning (belajar langsung implementasi). Mitra sasaran yang hadir pada saat pelaksanaan kegiatan adalah Kelompok Pemuda, anggota PKK, pelaku usaha dan perangkat desa dimana pada minggu pertama hadir sebanyak 35 orang dan minggu kedua hadir sebanyak 43 orang.  Evaluasi dilakukan dengan cara pemberian pre-test dan post-test, kemudian dianalisis secara kuantitatif. Berdasarkan hasil pre-test dan post-test, diperoleh nilai rata-rata sebesar 52,86 dan 82.43, yang menunjukkan adanya peningkatan pengetahuan mitra terhadap materi penyuluhan yang diberikan. Kata kunci: Desa Pulungdowo; pojok herbal; tanaman obat; jahe; sereh AbstractPulungdowo Village is located in Tumpang District, Malang Regency, East Java, has abundant natural resources, namely ginger and lemongrass. However, the utilization of these natural resources has not been maximized, which is caused by the lack of public knowledge about the benefits, processing, andmarketing of the products in the market. This activity aims to increase the Village Economic Resilience Index to become an independent or advanced village by utilizing ginger and lemongrass products, as well as becoming a model village for Herbal Corner. In the 1st year, the community service provided training in making moringa leaf sticks, syrup and JARECANG candy made from ginger, lemongrass and secang, and to optimize the potential of Pulungdowo Village, in the 2nd year it was continued with the establishment of a Herbal Corner planted with various types of medicinal plants equipped with product displays and books related to traditional medicine, as well as product diversification in the form of training in making JARECANG tea bags and making simplicia with facilitator assistance. To complement the skills of participants in the production of these products, participants are also taught how to calculate the selling price of the products produced. This activity is also equipped with the provision of material on the use of medicinal plants for health and good product packaging and labels. The training materials are provided using lecture and Experimental Learning methods. The target partners who attended the activity were Youth Association, PKK members, business owners and village officials, where in the first week 35 people attended and in the second week 43 people attended.The evaluation was conducted by giving pre-test and post-test, then analyzed quantitatively. Based on the results of the pre- test and post-test, the average value obtained was 52,86 and 82.43, which indicated an increase in participants knowledge of the extension materials provided. Keywords: Pulungdowo Village; herbal corner; medicinal plants; ginger; lemongrass
Co-Authors Akbar, Jasmine Aulia Anang Setyo Wiyono Anisa Tri Hutami Bambang Tri Purwanto Dini Retnowati Diyah, Nuzul Wahyuning Esti Hendradi Fatmawati, Annisa Fikriyah, Nuril Gerriandi, Aqila Aqhnia Hariyadi, Dewi Melany Ida Kristianingsih Idha Kusumawati Isnaeni Iswahjuni, Iswahjuni Juni Ekowati Lahardo, Devanus Maulia, Arwinda Miatmoko, Andang Ninis Yuliati, Ninis Nugroho, Novreza Avistha Prasetyawan, Hanif Rifqi Prastika, Marsha Fendria Purbiastuti, Putri Ayu Purnomo, Ahmad Toto Putri, Nindya Tresiana Rahmadani, Andini Putri Rahman, Ave Retno Sari Rijal, Agus Syamsur Samirah Samirah, Samirah Sandhori, Fajar Jamaluddin Savitri, Orchidea Meidy Nurintan Siswandono, Siswandono Subhan Rullyansyah Suciati Suciati Sukardiman Sulistyowati, Melanny Ika SUZANA, SUZANA Tjandra, Edbert Rafael Tri Widiandani Warsito, Mega Ferdina Wijayanti, Galuh Candra Wiwied Ekasari Yuliana, Khalifah Yusuf, Helmy