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Desi Aliefia
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Nursing

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GAMBARAN KLINIKOPATOLOGI KARSINOMA PAYUDARA DI RSUP DR. M. DJAMIL PADANG TAHUN 2023 Muhammad Rifki; Nana Liana; Irwan Triansyah; Roland Helmizar; Lismawati Lismawati; Desi Aliefia; Muhammad Rizki Saputra; Ruhsyahadati Ruhsyahadati; Rahma Triyana
Nusantara Hasana Journal Vol. 5 No. 12 (2026): Nusantara Hasana Journal, May 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i12.2046

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Background: Breast cancer is a malignancy originating from epithelial cells of the breast ducts or lobules. Clinicopathological characteristics are important in determining prognosis and treatment. Understanding these features is essential to support early detection and improve management strategies. Objective: This study aimed to describe the clinicopathological features of breast cancer patients at RSUP Dr. M. Djamil Padang in 2023. Methods: This descriptive observational study used a cross-sectional design with secondary data. A total of 114 samples were collected using the total sampling technique. Data were analyzed using univariate analysis with Statistical Product and Service Solution (SPSS) version 25. Results: Among 114 breast cancer patients, the most common age group was 35–44 years, accounting for 37 patients (32.5%). The predominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma in 37 patients (32.5%). Histopathological grading was most commonly grade 2 in 79 patients (69.3%). Positive lymphovascular invasion was identified in 76 patients (66.7%). The most frequent molecular subtype was Luminal B, found in 51 patients (44.7%). Conclusion: Breast cancer was most prevalent in patients aged 35–44 years. The dominant histopathological subtype was Mixed Infiltrating Duct NST with Lobular Carcinoma, with grade 2 and positive lymphovascular invasion most frequently observed. Luminal B was the predominant molecular subtype. Increasing awareness of early detection through breast self-examination is recommended.
DIABETES GESTASIONAL SEBAGAI PREDIKTOR DINI PENYAKIT KARDIOMETABOLIK JANGKA PANJANG: TINJAUAN LITERATUR Wisda Widiastuti; Dessy Abdullah; Aryaldy Zulkarnaini; Arief Rinaldy; Desi Aliefia; Gangga Mahatma
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1864

Abstract

Gestational diabetes mellitus (GDM) has long been regarded as a transient metabolic disorder limited to pregnancy. However, growing scientific evidence indicates that GDM represents an early marker of long-term metabolic vulnerability in women. This literature review aims to synthesize current evidence on the association between GDM and the risk of type 2 diabetes mellitus, cardiovascular disease, and other metabolic disorders after pregnancy, as well as its implications for postpartum care and interdisciplinary collaboration. A literature search was conducted using the PubMed, Scopus, and Web of Science databases, focusing on articles published over the past ten years. The review findings show that women with a history of GDM have a significantly increased risk of developing type 2 diabetes mellitus, as well as a higher risk of cardiovascular disease compared with women without a history of GDM, even among those who do not progress to overt diabetes. The underlying mechanisms include persistent insulin resistance, pancreatic β-cell dysfunction, chronic low-grade inflammation, the role of the placenta, and the potential contribution of the gut microbiota. In conclusion, GDM should be understood as an early predictor of long-term cardiometabolic disease. Structured and collaborative postpartum care involving obstetrics and internal medicine is essential to reduce the future burden of disease.
Co-Authors Arief Rinaldy Aryaldy Zulkarnaini Dessy Abdullah Gangga Mahatma Irwan Triansyah Lismawati Lismawati Muhammad Rifki Muhammad Rizki Saputra Nana Liana Rahma Triyana Roland Helmizar Ruhsyahadati Ruhsyahadati Wisda Widiastuti