As traditional Islamic educational institutions, Islamic boarding schools (pesantren) hold a strategic position in producing human resources (HR) who are not only intellectually superior but also deeply rooted in religious values and local wisdom. This study highlights how the role of students (santri) can be maximized to develop quality human resources that support the improvement of entrepreneurial performance based on local culture. The method used is descriptive qualitative through a literature review, thus presenting a comprehensive picture of the contribution of Islamic boarding schools (pesantren) in building a competitive and character-based generation. The findings indicate that strengthening the capacity of students (santri) is carried out through systematic entrepreneurship training, the integration of local values into the learning process, and intensive collaboration between the pesantren and the community. This approach not only improves practical skills in facing business challenges but also fosters a resilient, honest, and ethical character. The synergy between the pesantren, the community, alumni, and relevant stakeholders fosters the emergence of a learning ecosystem oriented towards the development of superior human resources grounded in Islamic spirituality. Thus, pesantren are not merely centers of religious education but also vehicles for economic empowerment through entrepreneurship rooted in spiritual and cultural values. To deepen the impact, the program can be expanded to include Islamic boarding school business incubators (santripreneurs), Islamic financial literacy, business licensing assistance, and digital marketing utilizing local MSME networks. Structured internship schemes, alumni mentorship, and partnerships are also possible. Indicator-based evaluations, such as the number of start-ups, sustainability, local workforce absorption, and economic contribution, help monitor the program's effectiveness. Policy recommendations include funding support, access to training, and incentives for cross-institutional collaboration to ensure the sustainability of this empowerment model. Overall, strengthening the capacity of Islamic boarding school students (santri) has the potential to significantly impact the quality of national human resources and the development of an inclusive and resilient local wisdom-based economy.