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All Journal The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Pendidikan dan Konseling Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Devotion: Journal of Research and Community Service Eduvest - Journal of Universal Studies International Journal of Cell and Biomedical Science Holistik Jurnal Kesehatan Khazanah Sosial The ASEAN Journal of Military and Preventive Medicine
Dewi, Dian Andriani Ratna
Universitas Pertahanan RI
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Downregulation of IL-6 and TNF-α Expression with Mesenchymal Stem Cells Therapy in Allergic Rhinitis Rats Models Restimulia, Lia; Dewi, Dian Andriani Ratna; Nazar, Mohammad Ariq; Irawan, Risky Chandra Satria; Ghaissani, Shabrina Syifa; Haryono, Erlina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.13

Abstract

Rhinitis is an inflammatory that characterized by nasal symptoms due to the condition of the nasal mucosa that trigerred by an interaction between environmental allergens and immunoglobulin (Ig)E. It is driven by host factors, infection, pathogens and various inflammatory pathways such as TNF-α that released in allergic responses from both mast cells and macrophages through IgE-dependent mechanisms. Secretome hypoxia mesenchymal stem cells (SH-MSCs) contain anti-inflammatory soluble molecules were able to improve the conditions of endothelial damage, inflammation and oxidative stress by decreasing levels of IL-6, TNF-α, ROS and increasing eNOS. This study will investigate the effect of SH-MSCs at a dose of 300 µL on TNF- and IL-6 expression in rat model ovalbumin-induced rhinitis in vivo. Thirty male Wistar rats were randomly divided into 3 groups: control, treatment and sham group that administrated through intramuscular injection. The results of this study found that SH-MSCs can downregulate the inflammatory cytokines TNF-α and IL-6 in rat model ovalbumin-induced rhinitis in vivo
Cognitive Behavioral Therapy as an Adjunctive Treatment for Anxiety and Depression in Psoriasis Patients Dewi, Dian Andriani Ratna; Wijayanti, Fakhira Ayu; Chen, Sissy; Firmansyah, Roby Syah Putra
Devotion : Journal of Research and Community Service Vol. 4 No. 6 (2023): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v4i6.481

Abstract

Psoriasis is a skin disease associated with the body's immune system. Mental health is one of the accompanying diseases of psoriasis. The clinical manifestations of psoriasis allow sufferers to experience anxiety and depression. There is a significant correlation between anxiety and depression to psoriasis, therefore, an adjunctive therapy is needed in addition to pharmacological therapy. One of these is Cognitive Behavioral Therapy (CBT), which aims to overcome anxiety and depression. This literature review summarizes recent findings regarding the application of CBT in psoriasis patients. The aim of this review is to summarize the latest findings about CBT as an alternative therapy in psoriasis patients. The literature review method was carried out by conducting literature reviews from various online databases, namely NCBI, Science Direct, Elsevier, and Mendeley using predetermined criteria. The results of the literature review showed that psoriasis causes severe psychological suffering, sadness, stigmatization, and decreased health-related quality of life. Result of this review is psychotherapy can lead to positive results in the development of a patient's condition. When performed regularly, CBT can effectively treat a variety of mental health conditions in individuals experiencing mild to moderate anxiety. CBT includes psychological training, self-monitoring, cognitive reconstruction, the prevention of exposure to negative stimuli, and rigorous training. The implications of writing this review are, CBT can be included in the treatment of psoriasis to obtain faster healing results through therapy methods for anxiety and depression in psoriasis patients.
Terapi Gonore Resisten: Evaluasi Klinis Terhadap Strategi Pengobatan Dan Alternatif Oral Firmansyah, Roby Syah Putra; Pulungan, Elitha Sundari; Lahuwang, Charlos Daniel; Husna, Ismalia; Dewi, Dian Andriani Ratna; Ibrizatun, Amin
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 10 (2025): Volume 12 Nomor 10
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i10.22546

Abstract

Neisseria gonorrhoeae semakin menunjukkan resistensi terhadap antibiotik lini pertama seperti ceftriaxone dan azitromisin, yang mempersulit penatalaksanaan infeksi dan meningkatkan risiko komplikasi serta transmisi berkelanjutan. Situasi ini menuntut pengembangan strategi terapi alternatif yang lebih efektif, aman, dan dapat diterapkan secara luas di berbagai sistem pelayanan kesehatan. Artikel ini bertujuan untuk mengevaluasi bukti klinis primer terkait dua pendekatan terapi alternatif, yaitu modifikasi regimen konvensional dan terapi oral inovatif, dalam menangani gonore resisten. Penelusuran literatur dilakukan melalui database PubMed, ScienceDirect, SpringerLink, MDPI, dan BMC Infectious Diseases. Lima uji klinis primer fase II/III yang dipublikasikan dalam sepuluh tahun terakhir dipilih dan dianalisis secara kualitatif menggunakan pendekatan sintesis tematik naratif. Hasil telaah menunjukkan bahwa regimen ceftriaxone dosis tinggi (1 g IM) dan kombinasi gentamicin-azitromisin memiliki efektivitas eradikasi mikrobiologis yang tinggi (>90%) untuk infeksi urogenital, namun efektivitas menurun pada infeksi faring dan rektal. Gentamicin menjadi alternatif yang layak pada pasien dengan alergi sefalosporin, meski dengan efek samping lebih tinggi. Agen oral baru seperti gepotidacin dan zoliflodacin menunjukkan eradikasi >95% dalam uji fase 2, terutama untuk infeksi urogenital, dengan profil keamanan yang baik, namun efektivitas terhadap infeksi faring masih inkonsisten. Dapat disimpulkan bahwa belum terdapat strategi tunggal yang optimal untuk seluruh kasus gonore resisten. Pemilihan terapi sebaiknya mempertimbangkan lokasi infeksi, profil resistensi lokal, dan ketersediaan obat. Terapi oral inovatif menjanjikan, namun memerlukan validasi klinis lebih lanjut untuk penerapan luas.
Description of The Health Condition of Indonesian Soldiers 1st Infantry Division Kostrad Cilodong Arfiyanti, Arfiyanti; Hayati, Taureni; Widuri, Lila Irawati Tjahjo; Rachman, Arief; Dewi, Dian Andriani Ratna; Aziz, Abdul
Eduvest - Journal of Universal Studies Vol. 3 No. 11 (2023): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v3i11.953

Abstract

Community service aims to determine the health picture of Indonesian soldiers in the 1st Infantry Division of Kostrad Cilodong. Therefore, researchers conduct general health screening by measuring body mass index, blood pressure, and glucose levels in the blood. This study used a descriptive method. This method describes a subject or object under study in depth, detail, and breadth. This study used two types of data: primary and secondary. The results of community service as a whole, when viewed from blood pressure measurement data and glucose levels in the blood, can be said to be normal. The routine of Indonesian soldiers is like regular exercise, a healthy and stable diet, and adequate rest influences to reduce risk factors for diabetes mellitus.
Model nekrosis fibroblast terinduksi iskemia sebagai fondasi krusial untuk memahami dan mengatasi cedera vaskular pada jaringan kulit: Sebuah kajian pustaka Hardaningtyas, Kishanty; Marsiati, Himmi; Sobarna, Nenden; Dewi, Dian Andriani Ratna
Holistik Jurnal Kesehatan Vol. 19 No. 10 (2025): Volume 19 Nomor 10
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i10.2136

Abstract

Background: Vascular injury in skin tissue represents a significant clinical challenge in aesthetic and regenerative medicine and is often manifested as ischemia-induced necrosis of human dermal fibroblasts (HDF). This condition is characterized by cell and tissue death resulting from impaired perfusion and may occur as a complication of dermal filler injections, trauma, or other pathological conditions. To accurately elucidate the underlying pathophysiological mechanisms and to evaluate regenerative therapeutic strategies, an in vitro model capable of replicating ischemia-induced necrosis is required. Purpose: To review the literature related to the ischemia-induced fibroblast necrosis model as a crucial foundation for understanding and addressing vascular injury in skin tissue. Method: Literature searches were conducted using PubMed, Scopus, Web of Science, and Google Scholar with relevant keywords. Results: Indicate that HDF necrosis is commonly induced by exposure to hydrogen peroxide (H₂O₂), cobalt chloride (CoCl₂), and hypoxic culture conditions to simulate oxidative stress and ischemia. Model validation is typically performed using cell viability assays (MTT), lactate dehydrogenase (LDH) release, and morphological analysis. Conclusion: Integrating hypoxia, nutrient deprivation, and oxidative stress in in vitro models offers a solid basis for studying ischemia-induced HDF necrosis and improving skin regenerative therapies, with standardized protocols boosting translational relevance.   Keywords: Fibroblast Necrosis Model; Ischemia; Skin Tissue; Vascular Injury.   Pendahuluan: Cedera vaskular pada jaringan kulit merupakan tantangan klinis penting dalam kedokteran estetik dan regeneratif, yang sering bermanifestasi sebagai nekrosis fibroblas dermal manusia (Human Dermal Fibroblasts/HDF) terinduksi iskemia. Kondisi ini ditandai oleh kematian sel dan jaringan akibat gangguan perfusi, dan dapat terjadi sebagai komplikasi injeksi dermal filler, trauma, maupun kondisi patologis lainnya. Untuk memahami mekanisme patofisiologis yang mendasari kondisi tersebut serta mengevaluasi potensi terapi regeneratif secara akurat, diperlukan model in vitro yang mampu mereplikasi kondisi nekrosis akibat iskemia. Tujuan: Untuk menelaah literatur terkait model nekrosis fibroblast terinduksi iskemia sebagai fondasi krusial untuk memahami dan mengatasi cedera vaskular pada jaringan kulit. Metode: Penelusuran literatur dilakukan menggunakan basis data PubMed, Scopus, Web of Science, dan Google Scholar dengan kata kunci yang relevan. Hasil: Induksi nekrosis HDF umumnya dilakukan melalui paparan hidrogen peroksida (H₂O₂), kobalt klorida (CoCl₂), serta kondisi lingkungan hipoksia untuk mensimulasikan stres oksidatif dan iskemia. Validasi model dilakukan menggunakan uji viabilitas sel (MTT), pelepasan laktat dehidrogenase (LDH), dan analisis morfologi sel. Simpulan: Integrasi hipoksia, deprivasi nutrisi, dan stres oksidatif dalam model in vitro memberikan dasar kuat untuk mempelajari nekrosis HDF terinduksi iskemia serta meningkatkan terapi regeneratif kulit, dengan protokol terstandarisasi yang memperkuat potensi translasi.   Kata Kunci: Cedera Vascular; Iskemia; Jaringan Kulit; Model Nekrosis Fibroblast.
Military Health Strategies Against Narcotics Threats within the CBRNE Framework Harefa, Faonaso; Yahdiana Harahap; Dian Andriani Ratna Dewi; Nurrobi, R.M. Tjahya; Sutanto
Khazanah Sosial Vol. 8 No. 1 (2026): Khazanah Sosial
Publisher : UIN Sunan Gunung Djati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ks.v8i1.51928

Abstract

This study positions narcotics as an emerging non-traditional threat within the CBRNE framework due to its chemical nature and its impact on public health and national resilience. Drug abuse in Indonesia has evolved into a multidimensional threat that not only disrupts social stability but also weakens public health resilience. This study aims to analyze the role of military health within its service and health support functions based on existing regulations, particularly its contribution to combating drug threats as a form of non-military threat endangering young generations and national defense. Using a descriptive qualitative method with data analysis conducted through NVivo 12. The findings reveal that regulation based military health support has a positive impact in reducing drug abuse and trafficking while strengthening both public health resilience and national defense. However, the involvement of military health in cross sectoral collaboration remains limited, despite its proven capability and resilience in managing health crises, as demonstrated during the Covid-19 pandemic.: This study emphasizes the need to strengthen the role of military health in drug control through formal cooperation mechanisms, such as a Memorandum of Understanding (MoU) with the leading sectors Badan Narkotika Nasional, the Kepolisian Negra Republik Indonesia, and Kementerian Kesehatan to ensure clear synergy, avoid overlapping authority, and establish an integrated and sustainable national health defense system. However, the study identifies a gap in formal institutional integration, which limits the optimization of military health roles
Angsana sap vs. povidone-iodine for wound healing in tropical and military settings Tessalonika Shinta Ratriani; Astheria Eryani; Surachman AJ Didy; Dian Andriani Ratna Dewi
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 2 (2026): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i2.62

Abstract

Background: Wound infection remains a significant cause of morbidity in trauma patients, especially in battlefield and tropical settings where access to standard antiseptics is limited. Povidone-iodine 10% is commonly used due to its broad-spectrum antimicrobial activity; however, concerns about cytotoxicity and logistical constraints necessitate alternative antiseptic options. Methods: A narrative review was conducted using literature from PubMed, Scopus, and Google Scholar databases. Relevant studies were identified using combinations of MeSH terms and free-text keywords related to Pterocarpus indicus, natural antiseptics, povidone-iodine, wound infection, and trauma care. Findings were synthesized through thematic analysis. Discussion: Angsana (Pterocarpus indicus) sap contains bioactive compounds such as flavonoids, tannins, and terpenoids with antimicrobial and anti-inflammatory properties. These compounds may contribute to bacterial inhibition and enhanced tissue healing. Compared with povidone-iodine, which offers a broader antimicrobial spectrum, angsana sap may provide supportive effects on wound repair with potentially lower cytotoxicity. Evidence suggests it could serve as an alternative or adjunct in resource-limited environments, particularly in tropical and military contexts. Conclusion: Angsana sap demonstrates promising potential as a natural antiseptic for wound management. However, it cannot yet replace povidone-iodine due to limited clinical evidence. Further well-designed studies are needed to confirm its safety, efficacy, and applicability in clinical practice. Keywords: Pterocarpus indicus, angsana sap, povidone-iodine, wound infection, wound healing.
Sumatera Task Force - A Field Report of Final-Year Medical Student Deployment in Flash Flood Disaster Response Arohid Allatib; Hazel Fairuz Shidqi; Abdul Aziz Maulana Ilmi; Muhammad Rakan Kabbani; Rafif Muzakki; Dian Andriani Ratna Dewi
The ASEAN Journal of Military and Preventive Medicine Vol. 3 No. 2 (2026): July
Publisher : Perkumpulan Kedokteran Militer

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/ajmpm.v3i2.68

Abstract

Background: Flash floods are a recurrent public health crisis in Indonesia, causing acute morbidity in communities with limited healthcare access. Final-year medical students represent a potentially valuable yet underutilized workforce in disaster response. This study describes the deployment of the Padang Task Force—25 final-year medical students from Universitas Pertahanan Republik Indonesia (UNHAN)—during flash flood response in Aceh Tamiang, Aceh (11–18 December 2025). Methods: A qualitative descriptive field report with narrative literature review. Data were obtained from patient records, operational logbooks, and field observations during the 7-day deployment. Clinical activities were supervised by specialists from the National Defense Central Hospital (RSPPN) and Tri Matra military physicians. Results: Approximately 240 patients were treated daily (estimated 3,840 total encounters). Predominant conditions included upper respiratory tract infections (URTIs), dermatophyte infections, scabies, acute diarrhea, and traumatic wounds. Key challenges included infrastructure collapse, medication shortages, absent laboratory support, and regulatory gaps regarding unlicensed student practice. Conclusion: Supervised deployment of final-year medical students is feasible and effective in resource-constrained disaster settings. Formal regulatory frameworks, improved logistics planning, and integrated disaster medicine curricula are needed to optimize future responses.
Co-Authors Abdul Aziz Abdul Aziz Maulana Ilmi Arfiyanti, Arfiyanti Arief Rachman Arohid Allatib Astheria Eryani Chen, Sissy Evita Isretno Israhadi Farras Sheika Audiary Febriansyah Darus Ferry Sandra Ghaissani, Shabrina Syifa Gunawan Rusuldi Hadi Firmansyah Sidiq Hardaningtyas, Kishanty Harefa, Faonaso Haryono, Erlina Hayati, Taureni Hayra Diah Avianggi Hazel Fairuz Shidqi Husna, Ismalia Ibrizatun, Amin Intan Aryanti Irawan, Risky Chandra Satria Lahuwang, Charlos Daniel Marsiati, Himmi Mohammad Ariq Nazar Muhammad Rakan Kabbani Nasser Nasser Nurrobi, R.M. Tjahya Pulungan, Elitha Sundari Rafif Muzakki Restimulia, Lia Reza Yuridian Purwoko Roby Syah putra firmansyah Roby Syah Putra Firmansyah, Roby Syah Putra Sobarna, Nenden Surachman AJ Didy Sutan Finekri Arifin Abidin Sutanto Tessalonika Shinta Ratriani Topane Gayus Lumbuun Waty Suwarty Haryono Widuri, Lila Irawati Tjahjo Wijayanti, Fakhira Ayu Wimpie I Pangkahila Yahdiana Harahap