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All Journal The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Pendidikan dan Konseling Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Devotion: Journal of Research and Community Service Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Eduvest - Journal of Universal Studies International Journal of Cell and Biomedical Science
Dewi, Dian Andriani Ratna
Universitas Pertahanan RI
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Downregulation of IL-6 and TNF-α Expression with Mesenchymal Stem Cells Therapy in Allergic Rhinitis Rats Models Restimulia, Lia; Dewi, Dian Andriani Ratna; Nazar, Mohammad Ariq; Irawan, Risky Chandra Satria; Ghaissani, Shabrina Syifa; Haryono, Erlina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.13

Abstract

Rhinitis is an inflammatory that characterized by nasal symptoms due to the condition of the nasal mucosa that trigerred by an interaction between environmental allergens and immunoglobulin (Ig)E. It is driven by host factors, infection, pathogens and various inflammatory pathways such as TNF-α that released in allergic responses from both mast cells and macrophages through IgE-dependent mechanisms. Secretome hypoxia mesenchymal stem cells (SH-MSCs) contain anti-inflammatory soluble molecules were able to improve the conditions of endothelial damage, inflammation and oxidative stress by decreasing levels of IL-6, TNF-α, ROS and increasing eNOS. This study will investigate the effect of SH-MSCs at a dose of 300 µL on TNF- and IL-6 expression in rat model ovalbumin-induced rhinitis in vivo. Thirty male Wistar rats were randomly divided into 3 groups: control, treatment and sham group that administrated through intramuscular injection. The results of this study found that SH-MSCs can downregulate the inflammatory cytokines TNF-α and IL-6 in rat model ovalbumin-induced rhinitis in vivo
Cognitive Behavioral Therapy as an Adjunctive Treatment for Anxiety and Depression in Psoriasis Patients Dewi, Dian Andriani Ratna; Wijayanti, Fakhira Ayu; Chen, Sissy; Firmansyah, Roby Syah Putra
Devotion : Journal of Research and Community Service Vol. 4 No. 6 (2023): Devotion: Journal of Research and Community Service
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/devotion.v4i6.481

Abstract

Psoriasis is a skin disease associated with the body's immune system. Mental health is one of the accompanying diseases of psoriasis. The clinical manifestations of psoriasis allow sufferers to experience anxiety and depression. There is a significant correlation between anxiety and depression to psoriasis, therefore, an adjunctive therapy is needed in addition to pharmacological therapy. One of these is Cognitive Behavioral Therapy (CBT), which aims to overcome anxiety and depression. This literature review summarizes recent findings regarding the application of CBT in psoriasis patients. The aim of this review is to summarize the latest findings about CBT as an alternative therapy in psoriasis patients. The literature review method was carried out by conducting literature reviews from various online databases, namely NCBI, Science Direct, Elsevier, and Mendeley using predetermined criteria. The results of the literature review showed that psoriasis causes severe psychological suffering, sadness, stigmatization, and decreased health-related quality of life. Result of this review is psychotherapy can lead to positive results in the development of a patient's condition. When performed regularly, CBT can effectively treat a variety of mental health conditions in individuals experiencing mild to moderate anxiety. CBT includes psychological training, self-monitoring, cognitive reconstruction, the prevention of exposure to negative stimuli, and rigorous training. The implications of writing this review are, CBT can be included in the treatment of psoriasis to obtain faster healing results through therapy methods for anxiety and depression in psoriasis patients.
Terapi Gonore Resisten: Evaluasi Klinis Terhadap Strategi Pengobatan Dan Alternatif Oral Firmansyah, Roby Syah Putra; Pulungan, Elitha Sundari; Lahuwang, Charlos Daniel; Husna, Ismalia; Dewi, Dian Andriani Ratna; Ibrizatun, Amin
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 10 (2025): Volume 12 Nomor 10
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i10.22546

Abstract

Neisseria gonorrhoeae semakin menunjukkan resistensi terhadap antibiotik lini pertama seperti ceftriaxone dan azitromisin, yang mempersulit penatalaksanaan infeksi dan meningkatkan risiko komplikasi serta transmisi berkelanjutan. Situasi ini menuntut pengembangan strategi terapi alternatif yang lebih efektif, aman, dan dapat diterapkan secara luas di berbagai sistem pelayanan kesehatan. Artikel ini bertujuan untuk mengevaluasi bukti klinis primer terkait dua pendekatan terapi alternatif, yaitu modifikasi regimen konvensional dan terapi oral inovatif, dalam menangani gonore resisten. Penelusuran literatur dilakukan melalui database PubMed, ScienceDirect, SpringerLink, MDPI, dan BMC Infectious Diseases. Lima uji klinis primer fase II/III yang dipublikasikan dalam sepuluh tahun terakhir dipilih dan dianalisis secara kualitatif menggunakan pendekatan sintesis tematik naratif. Hasil telaah menunjukkan bahwa regimen ceftriaxone dosis tinggi (1 g IM) dan kombinasi gentamicin-azitromisin memiliki efektivitas eradikasi mikrobiologis yang tinggi (>90%) untuk infeksi urogenital, namun efektivitas menurun pada infeksi faring dan rektal. Gentamicin menjadi alternatif yang layak pada pasien dengan alergi sefalosporin, meski dengan efek samping lebih tinggi. Agen oral baru seperti gepotidacin dan zoliflodacin menunjukkan eradikasi >95% dalam uji fase 2, terutama untuk infeksi urogenital, dengan profil keamanan yang baik, namun efektivitas terhadap infeksi faring masih inkonsisten. Dapat disimpulkan bahwa belum terdapat strategi tunggal yang optimal untuk seluruh kasus gonore resisten. Pemilihan terapi sebaiknya mempertimbangkan lokasi infeksi, profil resistensi lokal, dan ketersediaan obat. Terapi oral inovatif menjanjikan, namun memerlukan validasi klinis lebih lanjut untuk penerapan luas.
Description of The Health Condition of Indonesian Soldiers 1st Infantry Division Kostrad Cilodong Arfiyanti, Arfiyanti; Hayati, Taureni; Widuri, Lila Irawati Tjahjo; Rachman, Arief; Dewi, Dian Andriani Ratna; Aziz, Abdul
Eduvest - Journal of Universal Studies Vol. 3 No. 11 (2023): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v3i11.953

Abstract

Community service aims to determine the health picture of Indonesian soldiers in the 1st Infantry Division of Kostrad Cilodong. Therefore, researchers conduct general health screening by measuring body mass index, blood pressure, and glucose levels in the blood. This study used a descriptive method. This method describes a subject or object under study in depth, detail, and breadth. This study used two types of data: primary and secondary. The results of community service as a whole, when viewed from blood pressure measurement data and glucose levels in the blood, can be said to be normal. The routine of Indonesian soldiers is like regular exercise, a healthy and stable diet, and adequate rest influences to reduce risk factors for diabetes mellitus.
An Integrated Risk Analysis Approach in Military Hospitals: Implications for Public Health Preparedness and Resilience Harefa, Faonaso; Yahdiana Harahap; Dian Andriani Ratna Dewi; R.M. Tjahya Nurrobi; Sutanto Sutanto; Cecilia F. Harsono
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 9 No. 1: JANUARY 2026 - Media Publikasi Promosi Kesehatan Indonesia
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i1.8697

Abstract

Introduction: Military hospitals perform a dual function by providing healthcare services for soldiers and their families while also supporting public health needs during crises. This dual role generates complex hazards spanning biological, chemical, physical, and psychological dimensions, thereby requiring a comprehensive risk analysis framework. The objective of this study is to develop an integrated risk analysis approach comprising risk assessment, risk management, and risk communicationto strengthen occupational safety in military hospitals, with broader relevance for public health and global health security. Methods: A mixed methods design was applied. Data were collected through direct observation and in-depth interviews with healthcare personnel, complemented by a structured survey using standardized questionnaires. Qualitative analysis was conducted using NVivo 12 and quantitative analysis using SEM PLS-4. The study involved 100 respondents comprising medical personnel, health workers, and staff at Rumah Sakit Pusat Pertahanan Negara (RSPPN) and Pusat Kesehatan TNI, selected through random sampling. Results: Qualitative findings derived from NVivo 12 analysis revealed a multidimensional hazard spectrum characterized by weak cross sectoral coordination, limited personnel capacity, and insufficient integration among risk analysis components. Quantitative analysis using SEM PLS-4 further confirmed that Integrated Risk Analysis has a positive and statistically significant effect on Public Health Preparedness and Community Resilience (T-statistic = 11.046 > 1.96; p-value < 0.05); and F-square (0.18- efect moderat). Conclusion: This study concludes that Integrated Risk Analysis exerts a significant influence on public health preparedness and community resilience in military hospitals. The findings underscore the necessity of strengthening management, integration, and cross sectoral communication. Nonetheless, the contextual limitations regarding research setting and sample size suggest the need for future studies with broader scope and institutional diversity to reinforce the generalizability of the findings.
Co-Authors Abdul Aziz Arfiyanti, Arfiyanti Arief Rachman Cecilia F. Harsono Chen, Sissy Evita Isretno Israhadi Farras Sheika Audiary Febriansyah Darus Ferry Sandra Ghaissani, Shabrina Syifa Gunawan Rusuldi Hadi Firmansyah Sidiq Harefa, Faonaso Haryono, Erlina Hayati, Taureni Hayra Diah Avianggi Husna, Ismalia Ibrizatun, Amin Intan Aryanti Irawan, Risky Chandra Satria Lahuwang, Charlos Daniel Mohammad Ariq Nazar Nasser Nasser Pulungan, Elitha Sundari R.M. Tjahya Nurrobi Restimulia, Lia Reza Yuridian Purwoko Roby Syah putra firmansyah Roby Syah Putra Firmansyah, Roby Syah Putra Sutan Finekri Arifin Abidin Sutanto Sutanto Tiarsen Buaton Topane Gayus Lumbuun Waty Suwarty Haryono Widuri, Lila Irawati Tjahjo Wijayanti, Fakhira Ayu Wimpie I Pangkahila Yahdiana Harahap