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All Journal Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Info Kesehatan
Ihda Dian Kusuma
Department of Anatomical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia/Installation of Anatomical Pathology, Dr. Saiful Anwar Regional General Hospital, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Stem Cells and Exosomes Delivery via Collagen-Based Platform for Advanced Wound Healing: A Systematic Review of In Vivo Studies Ratih Paramita Suprapto; Raras, Tri Yudani Mardining; Kusuma, Ihda Dian
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Chronic wounds remain a global health challenge due to persistent inflammation and impaired cellular function that delay healing. Collagen-based hydrogels are promising delivery platforms for enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) and exosomes. This review aimed to evaluate the efficacy and molecular mechanisms of MSCs and/or their derived exosomes delivered in collagen-based hydrogels in accelerating wound healing in vivo. This review was managed following PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, and Europe PMC for original studies published between 2020 and 2025. Eligible studies provided sufficient data describing in vivo chronic wound models treated with collagen scaffolds loaded with MSCs or exosomes. Three in vivo studies using murine burn, diabetic rat, and diabetic rabbit models were included. Each of them used pullulan-collagen seeded with Adipocyte Stem Cells (ASCs), stem cell-derived exosomes combined with recombinant human collagen-methacrylate, and MSC-derived extracellular vesicles (EVs) loaded into collagen hydrogel. All platforms significantly accelerated wound closure versus controls. Histological analyses confirmed enhanced neovascularization, organized collagen deposition, mature granulation tissue formation, and re-epithelization. These effects were mediated by M1-to-M2 macrophage polarization and downregulation of pro-inflammatory cytokines. Cell-free exosome therapy loaded in collagen hydrogels represents a promising approach for chronic wound management.
Stem Cells and Exosomes Delivery via Collagen-Based Platform for Advanced Wound Healing: A Systematic Review of In Vivo Studies Ratih Paramita Suprapto; Raras, Tri Yudani Mardining; Kusuma, Ihda Dian
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.02.11

Abstract

Chronic wounds remain a global health challenge due to persistent inflammation and impaired cellular function that delay healing. Collagen-based hydrogels are promising delivery platforms for enhancing the therapeutic efficacy of mesenchymal stem cells (MSCs) and exosomes. This review aimed to evaluate the efficacy and molecular mechanisms of MSCs and/or their derived exosomes delivered in collagen-based hydrogels in accelerating wound healing in vivo. This review was managed following PRISMA 2020 guidelines. Literature searches were conducted in PubMed, Scopus, and Europe PMC for original studies published between 2020 and 2025. Eligible studies provided sufficient data describing in vivo chronic wound models treated with collagen scaffolds loaded with MSCs or exosomes. Three in vivo studies using murine burn, diabetic rat, and diabetic rabbit models were included. Each of them used pullulan-collagen seeded with Adipocyte Stem Cells (ASCs), stem cell-derived exosomes combined with recombinant human collagen-methacrylate, and MSC-derived extracellular vesicles (EVs) loaded into collagen hydrogel. All platforms significantly accelerated wound closure versus controls. Histological analyses confirmed enhanced neovascularization, organized collagen deposition, mature granulation tissue formation, and re-epithelization. These effects were mediated by M1-to-M2 macrophage polarization and downregulation of pro-inflammatory cytokines. Cell-free exosome therapy loaded in collagen hydrogels represents a promising approach for chronic wound management.
Co-Authors Agustin Iskandar Aina Angelina Bambang Rahardjo Dewi, Rose Khasana Ery Olivianto Eviana Norahmawati Eviana Norahmawati Gusti, Kharisma Ciptaning Happy Kurnia Permatasari Harun Al Rasyid Hendy Setyo Yudhanto Janasti, Laksmitha Kenty Wantri Anita Kenty Wantri Anita, Kenty Wantri Kusworini Handono Mayangsari, Elly Nanda, Britania Laila Nurdiana Nurdiana Rachmad Sarwo Bekti Rambe, Annisa Fadhila Aurelia Ratih Paramita Suprapto Retnani, Diah Prabawati Riana Trinovita Sari Rifka Ulfa Rosyida Safrina Dewi Ratnaningrum, Safrina Dewi Setyowati, Anisa Situmorang, Melani Chysti Subandi Subandi Sulistiani, Ita Sulistomo, Hikmawan Wahyu Tri Yudani MR Wardani, Dewi Azar Nuria Yudhanto, Hendy Setyo