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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Duta Abdimas: Jurnal Pengabdian Masyarakat Jurnal Medika: Medika
Anggi, Viani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Effectiveness Test of Mangrove Leaf (Rhizophora Apiculata) on Decreasing Blood Glucose Levels and Pancreas Histopatology Streptozotocin Induced Male White Rats Tandi, Joni; Fahri, Mohammad; Fatma, Nurul; Anggi, Viani; Patala, Recky; Handayani, Tien Wahyu
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3789

Abstract

Hyperglycemia, a symptom of diabetes mellitus, can lead to oxidative stress, which is indicated by elevated malondialdehyde levels. Mangrove (Rhizophora apiculata) contains secondary metabolites of alkaloids, flavonoids, saponins and tanins, this can lessen how much oxidative stress there is in DM. This study intends to demonstrate the efficacy of mangrove extracts in lowering blood glucose levels and detecting pancreatic damage. The study used 30 male Wistar rats which were divided into 6 groups (group I: normal control, group II: negative and group III: positive control given glibenclamide 0.45 mg) and the test group (trial group). group IV: level 25 mg/kg BW, group V: level 50 mg/kg BW and VI: level 75 mg/kg BW) The DM model was made by streptozotocin induction. Pancreatic damage seen at 700 magnification saw pancreatic β cells as well as the islets of Langerhans' endocrine cells. The results of research on ethanol from mangrove leaves at levels of 75 mg/kg BW are substances that are effective at lowering blood sugar levels, which on average were 105 mg/dL with a hazard value of 1.2. When compared with glibenclamide mangrove extract is not equivalent to glibenclamide but has lowered glucose levels.
Anticancer Activity of Rosella Flowers (Hibiscus Sabdariffa l.) In HepG2 cells Anggi, Viani; Patala, Recky; Arfiah, Arfiah; Dewi, Niluh Puspita
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6350

Abstract

The natural ingredients of rosella flowers have the potential as natural anti-cancer and chemopreventive agents, contain secondary metabolite compounds with cancer therapeutic mechanisms with inhibiting and killing cancer cells and their development through inhibition of apoptosis (cell death program) and in vitro inhibited cell flow. The study aims to identification of secondary metabolite compounds and also determine the cytotoxic activity of ethanol extract from the rosemary plant against HepG2 cancer cells. This study used by identification of secondary metabolite compounds of ethanol extract from the rosemary plant (Hibiscus sabdariffa L.) and the cytotoxicity test used with MTT assay on HepG2 liver cancer cells with a test concentration series of 12,5; 25; 50; 100; 200; 250; 500 and 1000 µg/ml. : The results showed the secondary metabolite compounds of rosella flowers have flavonoids, alkaloids, saponins and tannins and data of 50% cell growth inhibition activity, which was showed that rosella flower had IC50 values 629,919 μg/mL. The ethanol extract of rosella flowers have activity on HepG2 cells growth inhibition had considered moderately active anticancer activity
LC-HRMS Analysis of Abelmoschus Manihot Medik from Palu of Central Sulawesi Paliwang, Rafni Mahyudin; Anggi, Viani; Yanuarty, Rezky; Rakanita, Yasinta
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8948

Abstract

Abelmoschus manihot (L.) Medik is one of the traditional medicinal plants from Palu City, Central of Sulawesi with the Malvaceae plant family and commonly is a traditional medicinal plants recognized fot its therapeutic potential, particularly in antioxidant, anti-inflammatory and wound healing applications. This research aims to identify and characterize the chemical compounds present in Abelmoschus manihot (L.) Medik plant from Palu City, Central of Sulawesi using  liquid chromatography high resolution mass spectrometry (LC-HRMS). This research was collected fresh plant, designed using ethanol extraction from Abelmoschus manihot (L.) Medik and analyzed using mass spectroscopy (LC-HRMS) with Processing Software – MZMine Ver. 3.9.0. The results of this study  provide new insights into the chemical composition of Abelmoschus manihot (L.) Medik and confirm its potential as a source of bioactive compounds that could be futher explored for pharmaceutical development, namely that it contains the main compound Quercetin with a mass of 303.04, Gossypetin; Myricetin with a mass of 319.04, Quercetin 3-O-alpha-L-rhamnoside with a mass of 449.10 Isoquercetin; Hyperoside; Hyperin; Hirsutrin with a mass of 465.10, Gossypol with a mass of 519.20 and rutin with a mass of 291.08.
Test of the Effectiveness of Earthworm Flour (Lumbricus rubellus) Gastroretentive Mucoadhesive Granule Formulation on Male White Rats (Rattus norvegicus) Infected with Salmonella typhi Magfirah; Bengkati, Stely Gracia; Tandi, Joni; Anggi, Viani
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8953

Abstract

Lumbricus rubellus contains lumbricin which is efficacious for treating typhoid fever. The aim of the research was to determine the effectiveness of gastroretentive mucoadhesive granule preparations from earthworm flour. This study used 30 male Wistar rats which were divided into 6 groups which were given orally, the normal and negative control groups were given Na-CMC, the positive control group was given chloramphenicol, and the treatment group was given doses of 200 mg/kgBW, 400 mg/kgBW and 800 mg/kgBW. mg/kgBB gastroretentive mucoadhesive granules earthworm flour. The results of body temperature measurements, on day 7 the control group obtained results of ±37.08, ±39.00 and ±38.09 respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07 respectively. On day 21, the control group obtained results of ±37.08, ±39.00 and ±38.09, respectively, and the treatment group obtained results of ±38.09, ±38.09 and ±38.07, respectively. The Widal test results on the 7th day were positive and after 14 days of administering the preparation on the 21st day the results were negative. It was concluded that the effective dose for typhoid fever therapy was a dose of 400 mg/kgBW.
Safety Profile of Abelmoschus Manihot (L.) Medik Ethanol Leaf Extract: Acute Toxicity Study in Animal Models Pantua, Magfira B.; Anggi, Viani; Utami, Indah Kurnia; Rakanita, Yasinta
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.9172

Abstract

Abelmoschus Manihot (L.) Medik, commonly known as Abelmoschus manihot, is a traditional medicinal plant from Palu, Central Sulawesi, Indonesia, widely utilized for its potential health benefits. This research aims to evaluate the acute toxicity of ethanol extract from Abelmoschus manihot leaves, focusing on determining the lethal dose (LD50) in rats. The study involved extracts being administered at a range of doses of 500 mg/kg, 1000 mg/ kg, and 2000 mg/Kg of body weight (BB) in a rat population. Rats were observed for 24 hours to look for signs of toxicity and death. The LD50 value, which determines the dose required to cause death in 50% of the test population, is calculated based on the results. This research provides insights into the safety profile of ethanol extract from Abelmoschus manihot leaves and contributes to understanding its potential risks when used in traditional medicine. No significant deaths were observed at lower doses, but higher doses resulted in observable toxic effects, indicating the need for careful dosing in therapeutic applications. The results show that although Abelmoschus Manihot did not exhibit acute toxic effects on rats at doses of 500 mg/kg, 1000 mg/kg, and 2000 mg/kg body weight. No significant deaths or severe toxic symptoms were observed during the 24-hour observation period up to the 14-day observation, and there were no differences in the body weight of the rats during the 14-day observation
Co-Authors Aisyah Marzuki, Sitti Alaydrus, Syafika Anastasya P, Michele Arfiah, Arfiah Astria, Nani Bengkati, Stely Gracia Fahri, Mohammad Fatma, Nurul Handayani, Tien Wahyu Islamiati, Utami Joni Tandi, Joni Kurnia Utami, Indah Magfirah Magfirah, Magfirah Mariyani, Mariyani Nadila, Nadila Niluh Puspita Dewi, Niluh Puspita Novina, Patricia Nurul Insani, Nabila Paliwang, Rafni Mahyudin Pantua, Magfira B. Puspita Dewi, Niluh Rakanita, Yasinta Recky Patala Sara, Priskila El Tudaan, Leligrafela Utami, Indah Kurnia Wahyu Handayani, Tien Yanuarty, Rezky