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All Journal Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health
Setyo Sri Rahardjo
Faculty of Medicine, Universitas Sebelas Maret
Medicine & Pharmacology Public Health

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Meta-Analysis the Effect of Chlorhexidine and Povidone Iodine Mouthwashes on Viral Load SARS-CoV-2-Saliva Danti Narulita; Setyo Sri Rahardjo; Bhisma Murti
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2022.7.4.589

Abstract

Background: The strategy to reduce the risk of transmission of COVID-19 is to reduce the salivary SARS-CoV-2 viral load. Chlorhexidine and povidone iodine mouthwash are common active ingredients in oral antiseptics that have efficient viral activity against salivary SARS-CoV-2. This study aims to combine the results of several effect sizes regarding the effect of using chlorhexidine and povidone iodine mouthwash on the salivary SARS-CoV-2 viral load from various countries.Subject and Method: This study is a meta-analysis with the following PICO model, P: COVID-19 patients. I: use of chlorhexidine and povidone iodine mouthwash. C: no mouthwash. O: salivary SARS-CoV-2 viral load. A search for the articles used in this study was carried out using the keywords “COVID-19” OR “SARS-CoV-2” OR “viral load” OR “SARS-Cov-2 viral load” OR “Chlorhexidine mouthrinse” OR “Povidone Iodine mouthrinse ” OR “Randomized Controlled Trial” OR “RCT” between 2012-2022 from the PubMed, Springerlink, Elsevier, Google Scholar and Wiley Online Library databases. The inclusion criteria used in this study were full-text articles using a Randomized Controlled Trial (RCT) design. The analysis used was multivariate with Standardized Mean Difference (SMD). The articles collected were then critically reviewed using the PRISMA checklist, then the data were analyzed using the Review Manager 5.4 tool.Results: This meta-analysis examined 10 articles with a Randomized Controlled Trial (RCT) study design originating from Singapore, Saudi Arabia, Iran, Brazil, Italy, South Korea and Malaysia. A meta-analysis of 7 articles showed that the use of chlorhexidine mouthwash could reduce salivary SARS-CoV-2 viral load by 0.12 units lower than without the use of mouthwash (SMD= -0.12; 95% CI= -0.33 to 0.09; p=0.250). Meanwhile, 7 articles showed that the use of povidone iodine mouthwash could reduce the salivary SARS-CoV-2 viral load by 0.64 units lower than without the use of mouthwash (SMD= -0.64; 95% CI= -1.51 to 0.23; p=0.150).Conclusion: The use of chlorhexidine and povidone iodine mouthwashes can reduce the amount of salivary SARS-CoV-2 viral Keywords: mouthwash, chlorhexidine, povidone iodine, COVID-19, salivary SARS-CoV-2 viral load.Correspondence: Danti Narulita. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: dantinarulita@yahoo.co.id. Mobile: +6282158818400.Indonesian Journal of Medicine (2022), 07(04): 387-400https://doi.org/10.26911/theijmed.2022.07.04.04
Mortality of TB-HIV Co-Infection Patients Based on CD4 Level: Meta-Analysis Victoria Husadani Permata Sari; Setyo Sri Rahardjo; Bhisma Murti
Indonesian Journal of Medicine Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.139 KB) | DOI: 10.26911/theijmed.2022.7.4.599

Abstract

Background:  Tuberculosis (TB) is the most common cause of death in patients with the Human Immunodeficiency Virus (HIV). Understanding CD4 as a predictor of mortality from TBHIV coinfection is critical to improving disease management and minimizing mortality. This study aims to examine the mortality risk of TBHIV-coinfected patients based on CD4 values.Subjects and Method:  Metaanalysis was performed according to the PRISMA flow chart and the PICO model (Population: TBHIV coinfected patients, Intervention: CD4 value <200 cells/µL, Comparison: CD4≥200 cells/µL, Outcome: mortality). The databases used are Google Scholar, PubMed, Scopus, Proquest, and Science Direct. Keywords used (coinfection OR "mixed infection") AND (HIV OR "Human Immunodeficiency Virus") AND (TB OR “tuberculosis”) AND ("CD4 count" OR "T4 lymphocyte") AND “mortality”. The inclusion criteria were full-text articles with cohort studies published in 20122022, articles in English, and multivariate analysis using the adjusted hazard ratio. Analysis was performed with Revman 5.3.Results:  17 articles with cohort design originating from Ethiopia, Khayelitsha, Kenya, Cape Town, Uganda, Brazil, Suriname, Sao Paulo, Guinea Bissau, Myanmar, Durban, Ireland, China, and multicountry studies between Europe and Latin America totaling 24,514 research sample. A meta-analysis of 10 study cohorts concluded that CD4<200 cells/µL had a 2.00 times risk of mortality compared with CD4 values ≥200 cells/µL (aHR=2.00; 95% CI 1.44 to 2.78; p<0.001). A meta-analysis of 7 study cohorts concluded that CD4<100 cells/µL had a 2.40 time risk of mortality compared with CD4 values≥200 cells/µL (aHR=2.40; 95% CI 1.61 to 3.57; p<0.001). A meta-analysis of 7 study cohorts concluded that CD4<50 cells/µL had a 3.12 times risk of mortality compared with CD4 values≥200 cells/μL (aHR=3.12; 95% CI 1.51 to 6.46; p<0.001).Conclusion:  Decreased CD4 values increase the risk of mortality.Keywords:  tuberculosis, HIV, CD4, mortality, meta-analysisCorrespondence: Victoria Husadani Permata Sari. Master’s Program in Public Health, Universitas Sebelas Maret. Jl. Ir Sutami 36A, Surakarta 57126, Jawa Tengah. Email: victoriahusadani@gmail.com. Mobile: 081393539020.Indonesian Journal of Medicine (2022), 07(04): 456470https://doi.org/10.26911/theijmed.2022.07.04.11 
The Effect of Organophosphate Pesticides Exposure and Other Factors Associated with Neuropsychiatric Disorders among Rice Farmers: A Path Analysis Evidence from Sukoharjo, Central Java Ayu Laela Fitriyani; Setyo Sri Rahardjo; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 5 No. 2 (2020)
Publisher : Masters Program in Public Health

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Background: Pesticide is a cheap and effective subs
The Effect of Foot Orthosis Use in Reducing Pain in Patients with Plantar Fasciitis: A Meta-Analysis Atika Febri Anggriani; Agus Kristiyanto; Setyo Sri Rahardjo
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health

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Background: Plantar fasciitis is an inflamma
The Effect of Ankle Foot Orthosis Use on the Running Speed in Post Stroke Patients: A Meta Analysis Muhibbah Fatati; Setyo Sri Rahardjo; Hanung Prasetya
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health

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Background: Stroke is a disease that occurs because blood flow to certain locations in the brain is disrupted. One of the main problems that occur in stroke sufferers is the disruption in the ability to walk, which will cause a decrease in the walking speed of post-stroke patients. One of the treatments used to increase the walking speed of post-stroke patients is to provide an ankle foot orthosis. The purpose of this study was to estimate the magnitude of the effect of using ankle foot orthosis on increasing walking speed of post-stroke patients by conducting a meta-analysis in the same articles.Subjects and Method: The meta-analysis was carried out by systematically reviewing the same number of articles from PubMed, Science Direct, Google Scholar, using the search keywords "ankle foot orthosis" OR "AFO" AND "Stroke" OR "patient stroke" AND "walking speed" OR
Social Capital and Factors Related to Stroke Risk in Ponorogo Hospital: Structural Equation Model Application Lailatul Rohmah; Setyo Sri Rahardjo; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health

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Background: Stroke is a non-communicable disease that ranks the second leading cause of death in the world. As many as 17 million pa
Meta Analysis the Effect of Body Mass Index on the Flat Foot Incidence Philipus Prihantiko Kurniagung; Dono Indarto; Setyo Sri Rahardjo
Journal of Epidemiology and Public Health Vol. 5 No. 3 (2020)
Publisher : Masters Program in Public Health

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Background: Musculoskeletal disorders in the form of flat foot, back pain and knee pain are often found in people who are obese. Flat foot is a musculoletal disorder characterized by a decrease or decrease in the height of the medial arch as a parameter, especially those that can be observed and measured in height. This study aims to estimate the average size of the effect of BMI on the risk of flat foot.Subjects and Method: Meta-analysis study and systematic reviews were applied to this study using the electronic database Pubmed, Science Direct, Google Scholar and Springer Link. Keywords to search for articles are as follows: "flat foot", "adult flat foot", "Flexible Flat Foot", "Body Mass Index", "Pediatric flat foot", "pes planus", "obesity", "overweight", "Ado
The Effects of Non-Exclusive Breastfeeding on the Risk of Pneumonia in Children under Five: Meta-Analysis Putu Anggi Widia Karmany; Setyo Sri Rahardjo; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health

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Background: Pneumonia is an inflammation of the lung parenchyma caused by pathogenic microorganisms such as bacteria, viruses, fungi, and parasites that can occur together with lower respiratory tract infections. Pneumonia is the cause of death for more than 800,000 children under five worldwide in 2017. One of the risk factors for pneumonia is a history of breastfeeding (ASI). This study aimed to esti
A Meta-Analysis of the Effects of Secondhand Smoke Exposure toward the Incidence of Pneumonia in Children Under Five Maya Ayu Riestiyowati; Setyo Sri Rahardjo; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health

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Background: Pneumonia is an acute respira
Meta Analysis the Association between Social Support and Quality of Life of People Living with HIV/AIDS Maria Regina Tri Yonita; Setyo Sri Rahardjo; Bhisma Murti
Journal of Epidemiology and Public Health Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.829 KB)

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Background: Social support is a form of interpersonal relationship where the social environment provides assistance in the form of emotional attention, instrumental assistance, providing information, appreciation or assess
Co-Authors Afriza Umami Agus Kristiyanto Agustaria Budinugroho Alifiya Zulfa Indana Ambar Mudigdo Ambar Sari Anindita Hasniati Rahmah Arlina Azka Arum Nuryati Atika Febri Anggriani Atika Mima Amalin Atika Nikmah Aulia Noorvita Ramadani Ayu Laela Fitriyani Azura Arisa Bhisma Murti Bhisma Murti Bhisma Murti Bhisma Murti Bhisma Murti Bhisma Murti Bhisma Murti Bhisma Murti Burhannuddin Ichsan Danti Narulita Dian Surya Kartika Diana Sayidah Dono Indarto Dwi Kurniawati Eka Siti Chasanah Endang Sutisna Sulaeman Erick Zicof Eti Poncorini Pamungkasari Faricha Indra Hapsari Farida Nurhayati Febry Istyanto Firdausi Nuzula Firman Pardosi Gabriela Advitri Febriani Genn Andrean Pratama Gigih Cita Pambudi Hanung Prasetya Hanung Prasetya Hanung Prasetya Hanung Prasetya Hanung Prasetya Hanung Prasetya Harsono Salimo Hermanu Joebagio Herry Putut Cahyono Ika Sumiyarsi Sukamto Ika Sumiyarsi Sukamto Isna Qadridjati Isna Qadrijati Khairina Nur Hidayati Lailatul Rohmah Lidia Aditama Putri Lusia Arina Cahyaningrum Maria Regina Tri Yonita Maya Ayu Riestiyowati Muh. Syaiful Akbar Muhibbah Fatati Natalino de Jesus Varela Niken Kartika Sari Ninik Hartini Ninil Dwi Pangestu Nisrina Nafisa Nur Isniani Ningsih Nurul Ulya Luthfiyana Okid Parama Astirin Pawito Pawito Philipus Prihantiko Kurniagung Puspita Mayangsari Prabowo Putri Pamungkas Putu Anggi Widia Karmany RB Soemanto Retno Sulistyani Revi Gama Hatta Novika Revi Gama Hatta Novika Revi Gama Hatta Novika Ristamaya Danar Dewi Rizki Kurniawan Saputra Ruben Dharmawan Satriyo Fajar Wicaksono Sri Mulyani Sumardiyono Sumardiyono Sumardiyono Sumardiyono Tri Godha Fitriani Victoria Husadani Permata Sari Vitri Widyaningsih Yola Alqorien Mustikarani Yovita Eka Ratna Kumala Yulia Lanti Retno Dewi Yulia Lanti Retno Dewi Yusuf Ryadi